Pattern of growth development of premature children at the age of two and three years in Alexandria, Egypt [Part II]

Thisis the second part of a paper on a study conducted in Alexandria on 68 premature children. Controls were full-term children, double the number of prematures, and matched by age and sex. The first part presented differences in growth and development in relation to prematurity. This part deals with risk factors for prematurity. The study revealed that low educational level of fathers and parental smoking were significant risk factors for prematurity. The mean age of both parents and mothers’ gravidity were significantly higher for prematures. Other risk factors were identified. Mothers with diabetes and chronic nephritis were more likely to have a premature child

Download Full-text

Characterizing the Magnitude of and Risk Factors for Functional Limb Lengthening in Patients Undergoing Primary Total Knee Arthroplasty

HSS Journal ® ◽

10.1177/15563316211009140 ◽

2021 ◽

pp. 155633162110091

Author(s):

Brian P. Chalmers ◽

Mark LaGreca ◽

Jacqueline Addona ◽

Peter K. Sculco ◽

Steve B. Haas ◽

...

Keyword(s):

Risk Factors ◽

Total Knee Arthroplasty ◽

Significant Risk ◽

Primary Total Knee Arthroplasty ◽

Limb Lengthening ◽

Leg Lengthening ◽

Total Knee ◽

Plane Deformity ◽

The Mean ◽

Primary Total Knee

Background: There is little data on the magnitude and factors for functional leg lengthening after primary total knee arthroplasty (TKA). Questions/Purpose: We sought to determine the incidence of and risk factors for functional leg lengthening after primary TKA. Methods: We retrospectively reviewed consecutive unilateral primary TKAs at a single institution from 2015 to 2018. Of the 782 TKAs included, 430 (55%) were performed in women; the mean age was 66 years, and the mean body mass index was 29 kg/m2. Preoperatively, 541 (69%) knees were varus deformities and 223 (29%) were valgus deformities. Hip to ankle biplanar radiographs were obtained preoperatively and 6 weeks postoperatively for all patients. Two independent researchers measured leg length, coronal plane deformity, lateral knee flexion angle, and overall mechanical alignment on all preoperative and postoperative radiographs. Results: The mean overall ipsilateral functional leg lengthening was 7.0 mm. Seven hundred knees (90%) were overall functionally lengthened, including 462 (59%) knees lengthened >5 mm and 250 (31%) knees lengthened 10 mm or more. A valgus deformity and coronal plane deformity of 10° or more were significant risk factors for increased functional lengthening. Patients with severe valgus deformities (>10°) had the largest amount of functional lengthening, at a mean of 13.5 mm. Conclusion: After primary TKA, 90% of limbs are functionally lengthened, including roughly one-third over a centimeter. Valgus knee deformities and severe deformities (>10°) were significant risk factors for increased limb lengthening.

Download Full-text

Differences in Risk Factors for Retinopathy of Prematurity Development in Paired Twins: A Chinese Population Study

The Scientific World JOURNAL ◽

10.1155/2014/212183 ◽

2014 ◽

Vol 2014 ◽

pp. 1-7 ◽

Cited By ~ 3

Author(s):

Gordon S. K. Yau ◽

Jacky W. Y. Lee ◽

Victor T. Y. Tam ◽

Stan Yip ◽

Edith Cheng ◽

...

Keyword(s):

Risk Factors ◽

Risk Factor ◽

Retinopathy Of Prematurity ◽

Very Low Birth Weight ◽

Significant Risk ◽

The Mean ◽

Record Review ◽

Chinese Twins ◽

Retrospective Medical Record Review

Purpose.To determine the differences in risk factors for retinopathy of prematurity (ROP) in paired twins.Methods.A retrospective medical record review was performed for all paired twins screened for ROP between 2007 and 2012. Screening was offered to very low birth weight (≤1500 grams) and preterm (≤32 weeks) neonates. Twins 1 and 2 were categorized based on the order of delivery. Maternal and neonatal covariates were analyzed using univariate and multivariate regression analyses for both ROP and Type 1 ROP.Results.In 34 pairs of Chinese twins, the mean gestational age (GA) was 30.2 ± 2.0 weeks. In Twin 1, smaller GA (OR = 0.44,P=0.02), higher mean oxygen concentration (OR = 1.34,P=0.03), presence of thrombocytopenia (OR = 1429.60,P<0.0001), and intraventricular hemorrhage (OR = 18.67,P=0.03) were significant risk factors for ROP. For Twin 2, a smaller GA (OR = 0.45,P=0.03) was the only risk factor. There were no significant risk factors for ROP in Twin 1 or Twin 2 on multivariate analysis.Conclusion.In Chinese twin pairs, smaller GA was the only common risk factor for ROP while Twin 1 was more susceptible to the postnatal risks for ROP.

Download Full-text

Abstract 2877: Ultra-early Endovascular Embolization Of Ruptured Cerebral Aneurysms Increases The Risk Of Hematoma Growth Unrelated To Aneurysmal Rebleeding

Stroke ◽

10.1161/str.43.suppl_1.a2877 ◽

2012 ◽

Vol 43 (suppl_1) ◽

Author(s):

Yusuke Egashira ◽

Shinichi Yoshimura ◽

Yukiko Enomoto ◽

Kiyofumi Yamada ◽

Takahiko Asano ◽

...

Keyword(s):

Risk Factors ◽

Significant Risk ◽

Cerebral Aneurysms ◽

Female Gender ◽

Endovascular Embolization ◽

Anterior Circulation ◽

Hematoma Growth ◽

Group 3 ◽

The Mean ◽

Systemic Anticoagulation

Background and purpose: Hematoma growth unrelated to aneurysmal rebleeding has been poorly studied, but is not a rare complication following endovascular embolization of ruptured cerebral aneurysms. The aim of this study is to elucidate the possible risk factors for this phenomenon. Methods: We included 101 consecutive patients with subarachnoid hemorrhage (SAH) who underwent endosaccular embolization at our institution within 72 hours of symptom onset in this study. All endovascular procedures were conducted under intraprocedural systemic anticoagulation. Age, gender, hypertension, diabetes, preoperative antiplatelet or anticoagulation use, neurological grade, Fisher computed tomography group, location and size of the aneurysm, the grade of aneurysm occlusion, and timing of endovascular procedure were retrospectively analyzed to find the risk factors for hematoma growth. Results: This series included 32 men (31.7%) and 69 women (68.3%), and the mean age ± SD was 65.5 ± 14.0 years. The mean time ± SD from onset to endovascular procedure was 12.1 ± 14.0 hours. Following the procedure, hematoma growth unrelated to aneurysmal rebleeding occurred in 14 patients (13.9%), and 10 of the 14 patients required surgical removal of hematoma and/or ventriculostomy to control intracranial pressure. All 14 patients had an anterior circulation aneurysm and had Fisher group 3 or 4 SAH. Ultra-early embolization (conducted within 6 hours after onset), female gender, history of hypertension, and poor neurological grade (WFNS grades 4 and 5) were significant risk factors of hematoma growth (p < 0.05 for all) by the univariate logistic analysis. In multivariate analysis, ultra-early embolization (OR, 18.0; 95% CI, 3.26-338; p = 0.0002), and female gender (OR, 9.83; 95% CI, 1.73-187; p = 0.0067) were independent risk factors for this phenomenon. Anterior circulation aneurysm and Fisher group 3 or 4 SAH did not suit for the logistic regression model, but were found to be significant risk factors by chi-square test (p = 0.018 and 0.022, respectively). Conclusions: Ultra-early endovascular embolization for ruptured cerebral aneurysm under systemic anticoagulation increases the risk of growth of hematomas unrelated to aneurysmal rebleeding. In addition, women with anterior circulation aneurysm presenting with dense focal SAH or intracerebral hematoma are at higher risk for this phenomenon.

Download Full-text

2272. Evaluation of Clinical Features, Carbapenem Resistance and Risk Factors of Klebsiella Species: A 4-Year Retrospective Study in Turkey

Open Forum Infectious Diseases ◽

10.1093/ofid/ofz360.1950 ◽

2019 ◽

Vol 6 (Supplement_2) ◽

pp. S777-S778

Author(s):

Zuhal Umit ◽

Zumrut Sahbudak Bal ◽

Gizem Guner ◽

Gulhadiye Avcu ◽

Duygu Bozkurt ◽

...

Keyword(s):

Risk Factors ◽

Hospital Stay ◽

Significant Risk ◽

Carbapenem Resistance ◽

Steroid Use ◽

Carbapenem Resistant ◽

Vitek 2 ◽

The Mean ◽

Klebsiella Spp ◽

Klebsiella Infections

Abstract Background Gram-negative-resistant bacterial infections are increasing due to widespread use of antibiotics. Infections caused by Klebsiella spp. are an important part of healthcare-associated infections and cause morbidity and mortality. The aim of this study was to determine the epidemiological, clinical features, carbapenem resistance rates and risk factors of bloodstream infections of children with Klebsiella spp. Methods In this retropective study, medical records of 85 episodes of 75 patients caused by with Klebsiella spp. bacteriaemia who admitted to Ege University Faculty of Medicine, Pediatric Hospital in Turkey between 2014 and 2017 were evaluated. Conventional biochemical methods were performed using the automated systems of MALDİ-TOFF MS / VITEK 2 (Biomerieux, France). According to EUCAST recommendations, VITEK 2 (Biomerieux, France) automated microdilution method was used in sensitivity tests. Results The mean age of 85 episodes included in the study was 3.49 (±5.4) years. 58% of the patients were male and 42% were female. 18.8% of the patients were premature. The most common service was newborn service (30.6%). Neutropenia was 26% and thrombocytopenia was 55% at the time of diagnosis. Klebsiella pneumonia was 93% and Klebsiella oxytoca was 7%. Carbapenem resistance rate was found to be 30.6% in Klebsiella spp. Carbapenem resistance was found 18% in 2014, 38% in 2015, 42% in 2016 and 25% in 2017. In patients who developed carbapenem-resistant Klebsiella infection, the duration of pre-hospitalization ≥14 days (P = 0.034), the absolute neutrophil count < 100 (P = 0.048) and steroid use (P = 0.025) were statistically significant risk factors. The mean length of hospital stay was 107 (±103) days. Klebsiella spp. attributable mortality due to infection was 14% and crude mortality was 15%. No statistically significant difference was found in patients who developed resistant and susceptible infections. Conclusion Carbapenem resistance in Klebsiella infections was increased. Prolonged hospital stay, neutropenia and steroid use in the last 3 months were identified as significant risk factors for carbapenem-resistant Klebsiella infections. Disclosures All authors: No reported disclosures.

Download Full-text

Extrusion of Femtosecond Laser-Implanted Intrastromal Corneal Ring Segments in Keratoconic Eyes: Prevalence, Risk Factors, and Clinical Outcomes

Journal of Ophthalmology ◽

10.1155/2020/8704219 ◽

2020 ◽

Vol 2020 ◽

pp. 1-7 ◽

Cited By ~ 1

Author(s):

Amr Mounir ◽

Mahmoud Mohamed Farouk ◽

Marwa Mahmoud Abdellah ◽

Engy Mohamed Mostafa

Keyword(s):

Risk Factors ◽

Femtosecond Laser ◽

Corneal Thickness ◽

Significant Risk ◽

Sun Exposure ◽

Vernal Keratoconjunctivitis ◽

Conjunctival Hyperemia ◽

Intrastromal Corneal Ring ◽

The Mean ◽

Belo Horizonte

Purpose. To evaluate the prevalence, possible risk factors, and clinical results of femtosecond laser implanted intrastromal corneal ring segment (ICRS) extrusion in keratoconic eyes. Patients and Methods. This is a retrospective observational study evaluating 333 eyes of 269 patients who were subjected to femtosecond laser-implanted Keraring ICRS in the Sohag Refractive Center, Sohag, Egypt, from January 2014 to January 2019. The study included eyes with channels created by a femtosecond laser (60 kHz IntraLase femtosecond system; Advanced Medical Optics, Santa Ana, California, USA) with implantation of Keraring intrastromal corneal ring segments (Mediphacos, Belo Horizonte, Brazil). Patient data and causes of Keraring extrusions were identified as being those rings that migrated or showed melting of the cornea with no other reason which required segment removal. Results. Seven eyes were found to fit the criteria of ring extrusion (2.1%) out of the 333 eyes which had Keraring implantation. All extruded rings were from patients with keratoconus grade 3, with eccentric cones, and with femtosecond creation of the tunnel. Four eyes belonging to 3 patients (57.1%) had a history of vernal Keratoconjunctivitis, yet they did not show signs of activity at the time of implantation. They reported excessive rubbing just before they presented with conjunctival hyperemia and foreign body sensation. Five eyes (71.4%) showed chronic sun exposure. The mean minimal corneal thickness was 401.85 μm (range 384–420 μm), while the mean maximum keratometry was 61 D (range 55.18–68.96 D). Most of the extruded rings had large arcs. Six eyes had crosslinking (CXL) at the same session of the Keraring implantation. The simultaneous CXL treatment is considered as a possible significant risk factor for ring extrusion. Conclusion. ICRS is an effective reversible option for patients with keratoconus who are intolerant to hard contact lenses, yet the choice of cases and ring segments is mandatory for satisfactory results. Moreover, meticulous history taking and examination reduces the incidence of complications including extrusion.

Download Full-text

Long Term Follow-Up of Pediatric Sickle Cell Disease Patients with Conditional Velocities on Transcranial Doppler (TCD).

Blood ◽

10.1182/blood.v106.11.2338.2338 ◽

2005 ◽

Vol 106 (11) ◽

pp. 2338-2338

Author(s):

Lena Coïc ◽

Suzanne Verlhac ◽

Emmanuelle Lesprit ◽

Emmanuelle Fleurence ◽

Francoise Bernaudin

Keyword(s):

Risk Factors ◽

Color Doppler ◽

Significant Risk ◽

Biological Data ◽

Treatment Intensification ◽

Significant Difference ◽

History Of ◽

The Mean

Abstract Abnormal TCD defined as high mean maximum velocities > 200 cm/sec are highly predictive of stroke risk and justify long term transfusion program. Outcome and risk factors of conditional TCD defined as velocities 170–200 cm/sec remains to be described. Patients and methods Since 1992, 371 pediatric SCD patients (303 SS, 44 SC, 18 Sß+, 6 Sß0) were systematically explored once a year by TCD. The newborn screened cohort (n=174) had the first TCD exploration between 12 and 18 months of age. TCD was performed with a real-time imaging unit, using a 2 MHz sector transducer with color Doppler capabilities. Biological data were assessed at baseline, after the age of 1.5 years and remotely of transfusion or VOC. We report the characteristics and the outcome in patients (n=43) with an history of conditional TCD defined by mean maximum velocities ranging between 170 and 200 cm/s in the ACM, the ACA or the ICA. Results: The mean follow-up of TCD monitoring was 5,5 years (0 – 11,8 y). All patients with an history of conditional doppler were SS/Sb0 (n=43). Mean (SD) age of patients at the time of their first conditional TCD was 4.3 years (2.2) whereas in our series the mean age at abnormal TCD (> 200 cm/sec) occurrence was 6.6 years (3.2). Comparison of basal parameters showed highly significant differences between patients with conditional TCD and those with normal TCD: Hb 7g4 vs 8g5 (p<0.001), MCV 82.8 vs 79 (p=0.047). We also had found such differences between patients with normal and those with abnormal TCD (Hb and MCV p< 0.001). Two patients were lost of follow-up. Two patients died during a trip to Africa. Conditional TCD became abnormal in 11/43 patients and justified transfusion program. Mean (SD) conversion delay was 1.8 (2.0) years (range 0.5–7y). No stroke occurred. 16 patients required a treatment intensification for other indications (frequent VOC/ACS, splenic sequestrations): 6 were transplanted and 10 received HU or TP. Significant risk factors (Pearson) of conversion to abnormal were the age at time of conditional TCD occurrence < 3 y (p<0.001), baseline Hb < 7g/dl (p=0.02) and MCV > 80 (p=0.04). MRI/MRA was performed in 31/43 patients and showed ischemic lesions in 5 of them at the mean (SD) age of 7.1 y (1.8) (range 4.5–8.9): no significant difference was observed in the occurrence of lesions between the 2 groups. Conclusions This study confirms the importance of age as predictive factor of conditional to abnormal TCD conversion with a risk of 64% when first conditional TCD occured before the age of 3 years. TCD has to be frequently controled during the 5 first years of life.

Download Full-text

Risk Factors for Recurrent Syndesmotic instability after Syndesmotic Screw Fixation in Rotational Ankle Fractures

Foot & Ankle Orthopaedics ◽

10.1177/2473011419s00048 ◽

2019 ◽

Vol 4 (4) ◽

pp. 2473011419S0004

Author(s):

Sunghyun Lee ◽

Hoiyoung Kwon

Keyword(s):

Risk Factors ◽

Screw Fixation ◽

Significant Risk ◽

Ankle Fractures ◽

Binary Logistic Regression Analysis ◽

Malleolar Fracture ◽

Syndesmotic Screw ◽

Posterior Malleolar Fracture ◽

The Mean ◽

Recurrence Group

Category: Ankle Introduction/Purpose: Rotational ankle fractures often have unstable syndesmotic injuries the require reduction and stabilization. Though multiple studies have focused on methods to assess accurate syndesmotic reduction, fairly high rates of recurrent syndesmosis diastasis were reported. However, there was no study to investigate possible risk factors for syndesmosis widening after surgical fixation. The purpose of this study was to identify the risk factors for recurrent syndesmosis widening after screw fixation. We hypothesized that risk factors for recurrence syndesmosis widening could be identified from patient demographic, intraoperative variables and the extent of the pathologic condition associated with fractures. Methods: We performed a retrospective review between 2009 and 2015 of consecutive patients who had sustained rotational ankle fractures with intraoperative evidence of syndesmotic instability requiring syndesmotic reduction and stabilization. The exclusion criteria included syndesmosis screws placed for diabetic neuropathy, skeletal immaturity, tibial pilon fractures, polytrauma, open fracture. Patients were sorted into 2 groups according to the presence of recurrent syndesmosis instability which was defined as a difference in the tibiofibular distance of =2 mm between the injured and uninjured ankles on CT at postoperative 1 year and a positive external rotation test. Furthermore, the statistical analysis by binary logistic regression analysis included the significance of various risk factors including age at surgery, sex, diabetes, smoking, body mass index (BMI), dominant side, type of fracture, associated fracture, initial tibiofibular distance on CT, number and size of screws, cortices. The functional outcomes were assessed with the Foot and Ankle Outcome Score (FAOS). Results: A total 126 patients met the study inclusion criteria and underwent analysis. The overall postoperative recurrent instability rate was 25.4% (without recurrence group: 94 patients, recurrence group: 32). It was significantly affected by the BMI (p=0.018; adjusted odds ratio, OR, = 30, 6.21) and concomitant posterior malleolar fracture (p=0.040, adjusted OR 3.31). The other variables were not found to be significant risk factors. There was a significant improvement in the mean clinical scores at one years postoperatively (both p < 0.001), but the mean scores in the group with recurrence were significantly lower than those in the group without recurrence (p=0.021) Conclusion: Among the risk factors, obesity and concomitant posterior malleolar fracture were significant risk factors for the recurrent syndesmotic instability after syndesmotic screw fixation. The overall results suggest meticulous attention to concomitant posterior malleolar fracture, especially in obese patients.

Download Full-text

Differences in limb, age and sex of Chinese deep vein thrombosis patients

Phlebology The Journal of Venous Disease ◽

10.1177/0268355514524192 ◽

2014 ◽

Vol 30 (4) ◽

pp. 242-248 ◽

Cited By ~ 9

Author(s):

Feng Chen ◽

Ji Xin Xiong ◽

Wei Min Zhou

Keyword(s):

Risk Factors ◽

Deep Vein Thrombosis ◽

Age Groups ◽

Significant Risk ◽

Factors Affecting ◽

Vein Thrombosis ◽

Left Limb ◽

Deep Vein ◽

Age And Sex ◽

Compression Ultrasonography

Objective Recently, the differences in age or sex of deep vein thrombosis (DVT) patients have been widely debated. However, close analyses of the differences in limb, age and sex of Chinese DVT patients have been scarcely reported. The purpose of this research is to study the differences in limb, age and sex of DVT patients. Methods A total of 783 consecutive DVT patients were retrospectively reviewed. Patients with an acute presentation of DVT were diagnosed by means of compression ultrasonography or venography. Clinical characteristics and provoked risk factors were analyzed. Results There were three frequency peaks including two smaller peaks at age 20–24 and 70–74 years, and the largest peak at age 45–59 years. The most significant risk factors affecting different age groups were as follows: pregnancy/puerperium for age ≤39; fracture and hysterectomy for age 40–64; fracture and malignancy for age ≥65. DVT frequency rate provoked by malignancy was higher in right DVT than left DVT (15.8% vs. 4.6%; p < 0.001). Left DVT was more common than right DVT (582 vs. 158). Left DVT tended to occur in females (male:female, 40.5%:59.5%), and right DVT in males (male:female, 74.7%:25.3%). DVT provoked by pregnancy/puerperium (56/63, 88.9%) or hysterectomy (27/30, 90.0%) was mostly located in left limb. Conclusion It is necessary to pay more attention to thromboprophylaxis for patients with the risk factors of pregnancy/puerperium, hysterectomy, fracture and malignancy, especially those over the age of 65. And further research into the cause of limb, age and sex differences in DVT occurrence is needed.

Download Full-text

Abstract 2634: A Prospective Study Of Asymptomatic Intracranial Arterial Stenosis In Japanese Healthy Subjects

Stroke ◽

10.1161/str.43.suppl_1.a2634 ◽

2012 ◽

Vol 43 (suppl_1) ◽

Author(s):

Ryukichi Matsui ◽

Hiroaki Oguro ◽

Nagai Atsushi ◽

Hirokazu Bokura ◽

Keiichi Onoda ◽

...

Keyword(s):

Risk Factors ◽

Prospective Study ◽

Healthy Subjects ◽

Significant Risk ◽

Stroke Onset ◽

Arterial Stenosis ◽

Intracranial Arterial Stenosis ◽

A Prospective Study ◽

Age And Sex

Background and purpose: Atherosclerotic stenosis of major intracranial arteries accounts for 5 to 10% of all causes of stroke. The Warfarin versus Aspirin Symptomatic Intracranial Disease (WASID) Study has demonstrated stroke onset in 5 among 100 patients with asymptomatic intracranial arterial stenosis (AIAS) during the follow-up period of 1.8 years. However, there are no prospective studies of intracranial stenosis in healthy subjects with a longer follow-up period. We conducted a 7-years longitudinal study in healthy subjects with AIAS to examine its risk factors and prognosis. Methods: We performed a prospective study on 3,155 neurologically normal subjects without history of stroke (1724 men, 1431 woman, mean age of 59). They were followed up with the mean interval of 83 months to obtain information about their stroke event with a questionnaire by mail or telephone interview and inquiry to the relevant medical facilities. AIAS were assessed on MRA at the time of first visit for all subjects. Result: AIAS was detected in 323 subjects (10.2%; AIAS group) at the initial examination. Significant risk factors for AIAS were older age, female, hypertension, high values of fasting blood glucose and HbA1c. During the follow-up stroke occurred in 77 subjects (2.7%) from the no-AIAS group and 14 subjects (4.3%) from the AIAS group (p = 0.07). Age and sex affected the stroke onset. The Cox's proportional-Hazards regression model after adjustment of age and sex revealed the significant contribution of AIAS on stroke onset (OR 1.9; 95% CI 1.03-3.4, p = 0.039). The stroke types were 11 ischemic and 3 hemorrhagic in the AIAS group. Conclusions: AIAS is a significant risk factor for future stroke even in healthy subjects. Intense management of blood pressure and glucose level might be crucial for preventing asymptomatic intracranial atherosclerotic disease.

Download Full-text

Impact of comorbidity burden on mortality in patients with COVID-19 using the Korean health insurance database

Scientific Reports ◽

10.1038/s41598-021-85813-2 ◽

2021 ◽

Vol 11 (1) ◽

Cited By ~ 2

Author(s):

Soo Ick Cho ◽

Susie Yoon ◽

Ho-Jin Lee

Keyword(s):

Risk Factors ◽

Health Insurance ◽

Roc Curve ◽

Significant Risk ◽

Curve Analysis ◽

Roc Curve Analysis ◽

Comorbidity Burden ◽

Comorbidity Index ◽

The Impact ◽

Age And Sex

AbstractWe aimed to investigate the impact of comorbidity burden on mortality in patients with coronavirus disease (COVID-19). We analyzed the COVID-19 data from the nationwide health insurance claims of South Korea. Data on demographic characteristics, comorbidities, and mortality records of patients with COVID-19 were extracted from the database. The odds ratios of mortality according to comorbidities in these patients with and without adjustment for age and sex were calculated. The predictive value of the original Charlson comorbidity index (CCI) and the age-adjusted CCI (ACCI) for mortality in these patients were investigated using the receiver operating characteristic (ROC) curve analysis. Among 7590 patients, 227 (3.0%) had died. After age and sex adjustment, hypertension, diabetes mellitus, congestive heart failure, dementia, chronic pulmonary disease, liver disease, renal disease, and cancer were significant risk factors for mortality. The ROC curve analysis showed that an ACCI threshold > 3.5 yielded the best cut-off point for predicting mortality (area under the ROC 0.92; 95% confidence interval 0.91–0.94). Our study revealed multiple risk factors for mortality in patients with COVID-19. The high predictive power of the ACCI for mortality in our results can support the importance of old age and comorbidities in the severity of COVID-19.

Download Full-text