Cytoreductive surgery and hyperthermal intraperitoneal chemoperfusion in colorectal cancer and cancer of ovaries: our experience and perspectives of a new method

Objective. Studying of results of the cytoreductive operations and hyperthermal intraperitoneal chemoperfusion application for treatment of canceromatosis in colorectal cancer and ovarian cancer. Materials and methods. In 10 patients, suffering colorectal cancer (6 men and 4 women) were performed peritonectomy, diathermo-ablation of implants, made from visceral peritoneum. Average value of the peritoneal canceromatosis index have constituted 18 (14 - 21). In 11 patients, suffering ovarian cancer, panhisterectomy, peritonectomy, omentectomy, and ablation of the visceral peritoneum implants was conducted. Median value of the peritoneal canceromatosis index was 16 (12 - 20). For hyperthermal intraperitoneal chemoperfusion oxaliplatin was used. Results. Complete and optimal cytoreduction (degree CC0-CC1 in accordance to classification of P. H. Sugarbaker) was achieved in 5 patients, while suboptimal one (degree CC2) - in 10, and nonoptimal (degree CC3) cytoreduction - in 6 patients. Intraoperative complications were absent. Postoperative complications have occurred in 5 (23.8%) patients: the wound infection, persisting ileus, episode of partial ileus. Of 10 patients, suffering colorectal cancer, 5 died in 9-12 mo. One-year barrier have had survived 45.5% patients. Of 11 women-patients, suffering ovarian cancer, 7 died in 6-24 mo. One-year barrier have had survived 36.4% women-patients. Conclusion. In patients, suffering colorectal cancer, the survival median was 12 mo, while in the women-patients, suffering ovarian cancer - 18 mo. Cytoreductive operations and hyperthermal intraperitoneal chemoperfusion constitute perspective method for the survival enhancement in patients, suffering canceromatosis, but only if their selection was organized.

Download Full-text

Ascitic ovarian cancer is an adequate preclinical model of carcinomatosis to study intraperitoneal chemoperfusion treatment

Siberian Journal of Oncology ◽

10.21294/1814-4861-2019-18-1-71-78 ◽

2019 ◽

Vol 18 (1) ◽

pp. 71-78

Author(s):

G. S. Kireeva ◽

O. A. Belyaeva ◽

K. Yu. Senchik ◽

V. G. Bespalov ◽

A. N. Stukov ◽

...

Keyword(s):

Ovarian Cancer ◽

Peritoneal Carcinomatosis ◽

Tumor Cells ◽

Ovarian Tumor ◽

Human Model ◽

Greater Omentum ◽

Control Group ◽

Preclinical Model ◽

Visceral Peritoneum ◽

Intraperitoneal Chemoperfusion

To study the mechanisms underlying the effects of intraperitoneal chemoperfusion and to develop the optimal chemoperfusion regimen, an animal model of peritoneal carcinomatosis closely resembles a human model of peritoneal carcinomatosis is required. In our study, the model of peritoneal carcinomatosis in rats with ascitic ovarian cancer was used. material and methods. There were three groups of rats with ascitic ovarian cancer: 1 – the control group (n=15) having no treatment; 2 – rats receiving normothermic intraperitoneal chemoperfusion with cisplatin, 40 mg/kg (n=12); 3 – rats receiving hyperthermic intraperitoneal chemoperfusion with cisplatin, 20 mg/kg (n=14). All animals were euthanized with subsequent autopsy. results. Ascitic ovarian cancer developed in 100 % of the animals injected with the tumor cells. The median overall survival of rats in the control group was 9.5 days. At autopsy, all rats had ascites, and rats surviving 15‒17 days after the tumor cell injection had white tumor nodes measuring 1–3 mm in the greater omentum, intestinal mesentery, parietal and visceral peritoneum. The nodes were histologically verified as metastases of low-differentiated ovarian tumor. In 2 and 5 rats from groups 2 and 3 respectively, metastases in paratracheal lymph nodes and tumor hydrothorax were detected with no evidence of peritoneal carcinomatosis. The median survival of rats in groups 2 and 3 was significantly higher than that in the control group, being 37.5 and 25.5 months, respectively (р=0,256). conclusion. This in vivo study proved that localization of ascitic ovarian tumor, development of the tumor in all animals injected with tumor cells, fast ascites progression and peritoneal carcinomatosis make this ascitic ovarian cancer an adequate preclinical model of peritoneal carcinomatosis to study intraperitoneal chemoperfusion. Further studies are needed to understand the reasons and mechanisms of the tumor hydrothorax development in rats after intraperitoneal chemoperfusion.

Download Full-text

Tissue microarray based classification of early and late stage colorectal cancer in optical and virtual microscopy

Zeitschrift für Gastroenterologie ◽

10.1055/s-2007-982723 ◽

2007 ◽

Vol 45 (05) ◽

Author(s):

F Sipos ◽

S Spisák ◽

T Krenács ◽

O Galamb ◽

B Galamb ◽

...

Keyword(s):

Colorectal Cancer ◽

Tissue Microarray ◽

Late Stage ◽

Virtual Microscopy

Download Full-text

NOVEL BIOMARKER HE4 IN PREDICTING OPTIMAL CYTOREDUCTION AFTER NEO-ADJUVANT CHEMOTHERAPY (NACT) FOR ADVANCED OVARIAN CANCER

10.26226/morressier.5770e29dd462b80290b4c2b7 ◽

2016 ◽

Author(s):

Francesco Plotti

Keyword(s):

Ovarian Cancer ◽

Adjuvant Chemotherapy ◽

Advanced Ovarian Cancer ◽

Optimal Cytoreduction ◽

Neo Adjuvant Chemotherapy

Download Full-text

Su1228 Increased Risk of Colorectal Cancer in Patients With Prior Ovarian Cancer Diagnosis: A Population Based US Study

Gastroenterology ◽

10.1016/s0016-5085(14)61474-8 ◽

2014 ◽

Vol 146 (5) ◽

pp. S-408

Author(s):

Yezaz A. Ghouri ◽

Sachin Batra ◽

Nirav C. Thosani ◽

Sushovan Guha

Keyword(s):

Colorectal Cancer ◽

Ovarian Cancer ◽

Cancer Diagnosis ◽

Population Based ◽

Increased Risk

Download Full-text

A novel transfer learning approach for the classification of histological images of colorectal cancer

The Journal of Supercomputing ◽

10.1007/s11227-020-03575-6 ◽

2021 ◽

Author(s):

Elene Firmeza Ohata ◽

João Victor Souza das Chagas ◽

Gabriel Maia Bezerra ◽

Mohammad Mehedi Hassan ◽

Victor Hugo Costa de Albuquerque ◽

...

Keyword(s):

Colorectal Cancer ◽

Transfer Learning ◽

Learning Approach ◽

Histological Images

Download Full-text

Stacking and Chaining of Normalisation Methods in Deep Learning-based Classification of Colorectal Cancer using Gut Microbiome Data

IEEE Access ◽

10.1109/access.2021.3094529 ◽

2021 ◽

pp. 1-1

Author(s):

Mwenge Mulenga ◽

Sameem Abdul Kareem ◽

Aznul Qalid Md Sabri ◽

Manjeevan Seera

Keyword(s):

Colorectal Cancer ◽

Deep Learning ◽

Gut Microbiome ◽

Microbiome Data

Download Full-text

Relationships of Hydrological Seasons in Rivers and Groundwaters in Selected Catchments in Poland

Water ◽

10.3390/w13030250 ◽

2021 ◽

Vol 13 (3) ◽

pp. 250

Author(s):

Przemysław Tomalski ◽

Edmund Tomaszewski ◽

Dariusz Wrzesiński ◽

Leszek Sobkowiak

Keyword(s):

River Flow ◽

Geographical Location ◽

Base Flow ◽

Water Shortages ◽

Groundwater Levels ◽

Average Value ◽

Geographical Regions ◽

New Variables ◽

Mixed Types

The study applied the method of hydrological season identification in a time series of river total and base flows and in groundwater levels. The analysis covered a series of daily measurements from the period 2008–2017 in nine catchments located in different geographical regions of Poland. The basis of the classification of hydrological seasons, previously applied for river discharges only, was the transformation of the original variables into a series reflecting three statistical features estimated for single-name days of a year from a multiyear: average value, variation coefficient, and autocorrelation coefficient. New variables were standardized and after hierarchical clustering, every day of a year had a defined type, valorizing three features which refer to quantity, variability, and the stochastic nature of total and base river flow as well as groundwater stage. Finally, sequences of days were grouped into basic (homogenous) seasons of different types and transitional seasons including mixed types of days. Analysis indicated determinants of types, length, and frequency of identified hydrological seasons especially related to river regime, hydrogeological and hydrometeorological conditions as well as physiographical background were directly influenced by geographical location. Analysis of the co-occurrence of the same types of hydrological seasons allowed, in some catchments, periods of synchronic alimentation (groundwater and base flow, mainly in the cold half-year) and water shortages (all three components, mainly in the warm half-year) to be identified.

Download Full-text

Colorectal Cancer Risk in Women with Gynecologic Cancers—A Population Retrospective Cohort Study

Journal of Clinical Medicine ◽

10.3390/jcm10143127 ◽

2021 ◽

Vol 10 (14) ◽

pp. 3127

Author(s):

Szu-Chia Liao ◽

Hong-Zen Yeh ◽

Chi-Sen Chang ◽

Wei-Chih Chen ◽

Chih-Hsin Muo ◽

...

Keyword(s):

Colorectal Cancer ◽

Ovarian Cancer ◽

Cervical Cancer ◽

Cohort Study ◽

Cancer Patients ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Gynecologic Cancer ◽

Ovarian Cancers ◽

Increased Risk

We conducted a retrospective cohort study to evaluate the subsequent colorectal cancer (CRC) risk for women with gynecologic malignancy using insurance claims data of Taiwan. We identified patients who survived cervical cancer (N = 25,370), endometrial cancer (N = 8149) and ovarian cancer (N = 7933) newly diagnosed from 1998 to 2010, and randomly selected comparisons (N = 165,808) without cancer, matched by age and diagnosis date. By the end of 2011, the incidence and hazard ratio (HR) of CRC were estimated. We found that CRC incidence rates were 1.26-, 2.20-, and 1.61-fold higher in women with cervical, endometrial and ovarian cancers, respectively, than in comparisons (1.09/1000 person–years). The CRC incidence increased with age. Higher adjusted HRs of CRC appeared within 3 years for women with endometrial and ovarian cancers, but not until the 4th to 7th years of follow up for cervical cancer survivals. Cancer treatments could reduce CRC risks, but not significantly. However, ovarian cancer patients receiving surgery alone had an incidence of 3.33/1000 person–years for CRC with an adjusted HR of 3.79 (95% CI 1.11–12.9) compared to patients without any treatment. In conclusion, gynecologic cancer patients are at an increased risk of developing CRC, sooner for those with endometrial or ovarian cancer than those with cervical cancer.

Download Full-text