DEVELOPMENT OF COMPOSITION, TECHNOLOGY AND ANALYSIS OF GRANULES WITH LARYNX TREE EXTRACT LIQUID
The purpose of the study was to substantiate the optimal composition, development of technology and methods for analyzing a new dosage form - granules with hydrangeas with a liquid tree extract. Optimal auxiliary substances for granule production were experimentally selected and process parameters were determined: fractional composition, abrasion, disintegration, mass loss during drying, bulk density. It was found that for all indicators granules with hydrangea tree extract liquid meet the requirements of GF XIV. Process diagram of granules manufacturing by wet granulation method has been developed. The TLC method made it possible to identify rutin, quercetin, luteolin, chlorophyll, coumarin. The method of differential spectrophotometry was tested for the method of quantitative determination of the sum of flavonoids. The proposed quantification methodology has been found to be suitable for analytical purposes. The content of the sum of flavonoids in the granules in terms of rutin is about 0,0225%. The relative error of the technique does not exceed ± 2,5%.