INFLUENCE OF INTERLEUKIN-1β, INTERFERON-GAMMA ON THE DEVELOPMENT OF ANEMIA OF CHRONIC DISEASES IN PATIENTS WITH MALIGNANT TUMORS

2021 ◽  
pp. 195-203
Author(s):  
Sakhin V.T. ◽  
Kryukov E.V. ◽  
Gordienko A.V. ◽  
Pisarevskaya O.N. ◽  
Rukavitsyn O.A.
Keyword(s):  
Chronic Diseases ◽  
Iron Metabolism ◽  
Strong Correlation ◽  
Malignant Neoplasm ◽  
Interleukin 1Β ◽  
Control Group ◽  
Malignant Neoplasms ◽  
Moderate Correlation ◽  
Weak Correlation

Relevance. Anemia of chronic diseases has a significant impact on the quality of life of patients with malignant neoplasms, as well as on the course of the underlying disease and prognosis. Aim. To study the characteristics of the secretion of interleukin-1β (IL-1β), interferon-γ (INF-γ) in patients with malignant neoplasms with and without anemia of chronic diseases. To study the effect of these cytokines on hemoglobin synthesis, erythropoiesis and some indicators of iron metabolism. To propose a working version of the classification of anemia of chronic diseases based on the leading pathogenetic factor in the development of anemia. Material and methods. The study involved 42 (27 patients with anemia - 19 men, 8 women, average age 65.1 ± 8.1 years, 15 without it, 10 men, 5 women, average age 61.1 ± 10.1 years) patients with II- Stage IV malignant neoplasm. A comparative analysis was carried out between groups with and without anemia and a correlation analysis between IL-1β, INF-γ and indicators of hemogram, iron metabolism, C-reactive protein (CRP), hepcidin. Results. In patients with malignant neoplasms and ACD, in comparison with patients in the control group, a more pronounced inflammation was proved, accompanied by an increase in the synthesis of ferritin, CRP and IL-1β, INF-γ (p <0.05). For IL-1β, a moderate correlation was found with the concentration of iron (r = 0.46), CST (r = 0.48), hemoglobin (r = -0.61) and a strong correlation with the concentrations of hepcidin (r = 0.8), ferritin (r = 0.78), CRP (r = 0.87). A weak correlation was found between IL-1β and the number of erythrocytes, TIBC and transferrin. For IFN-γ, a moderate correlation was established with erythrocytes (r = -0.68), hemoglobin (r = -0.57), CST (r = -0.57), ferritin (r = 0.57) and a strong correlation connection with CRP (r = 0.83), hepcidin (r = 0.9), transferrin (r = -0.83). A weak correlation has been established between INF-γ and the concentration of iron, TIBC. Conclusions. In patients with malignant neoplasms and ACD, a more pronounced inflammation was proved, accompanied by an increase in the synthesis of ferritin, CRP and IL-1β, INF-γ. The influence of the investigated cytokines on erythropoiesis, synthesis of hemoglobin and hepcidin, and iron metabolism has been proved. This reflects the pleiotropic effect of these cytokines and the complex pathogenesis of ACD in patients with malignant neoplasms, including erythropoiesis disorders, changes in iron metabolism, and increased synthesis of proinflammatory cytokines. A working version of the classification of ACD (with a predominant iron deficiency, with impaired regulatory mechanisms of erythropoiesis, with insufficient production of erythropoietin) has been proposed.

scholarly journals Pathogenetic features of anemia of chronic diseases in patients with malignant neoplasms and rheumatic pathology

2020 ◽  
Vol 15 (4) ◽  
pp. 82-90
Author(s):  
V. T. Sakhin ◽  
M. A. Grigoriev ◽  
E. V. Kryukov ◽  
S. P. Kazakov ◽  
A. V. Sotnikov ◽  
...  
Keyword(s):  
Chronic Diseases ◽  
Transferrin Receptor ◽  
Control Group ◽  
Malignant Neoplasms ◽  
Mean Corpuscular Hemoglobin ◽  
Soluble Transferrin Receptor ◽  
Corpuscular Hemoglobin ◽  
Patients With Cancer ◽  
Tnf Α

Objective: to study the importance of cytokines, hepcidin, a soluble transferrin receptor, iron metabolism in the development of anemia of chronic diseases in patients with malignant neoplasms and rheumatic pathology, to identify the leading factors in the development of anemia for each of the studied groups and to develop a working classification of anemia of chronic diseases.Materials and methods. 63 patients with rheumatic pathology were examined. The study group included 41 (17 men/24 women, average age 53.4 ± 4 years) patients with anemia, the control group included 22 (9 men/13 women, age 49.3 ± 1.78 years) patients without anemia. The patients (n = 63) with stage II–IV malignant neoplasms were examined. The study group included 41 patients with anemia (34 men/7 women, age 67.1 ± 9.9 years), in the control group 22 patients without it (17 men/5 women, age 60.2 ± 14.9 years). The number of red blood cells, the hemoglobin level, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, concentrations of serum iron, total iron binding capacity (TIBC), ferritin, transferrin, C-reactive protein (CRP), transferrin saturation index (TSI), and soluble transferrin receptor (sTfR), hepcidin, interleukin (IL) – 6, – 10, tumor necrosis factor-α (TNF-α) were determined. Mann – Whitney U Test was applied to check for statistically significant differences in study samples.Results. Compared with the control group, elevated concentrations of ferritin, CRP, hepcidin, sTfR and IL-6 (p <0.05) were found for patients with rheumatic pathology and anemia and no differences were found in the concentrations of iron, TIBC, TSI, transferrin. For patients with solid malignant neoplasms and anemia, lower concentrations of iron, TIBC, TSI and higher concentrations of CRP, hepcidin, sTfR, IL-6, IL-10, TNF-α (p <0.05) are shown in comparison with the control group and there were no differences in the concentrations of ferritin, transferrin (p >0.05).Conclusion. The multicomponent anemia genesis in patients with cancer and rheumatic pathology is shown. The contribution of each mechanism to the development of anemia may vary depending on the specific nosological form. In patients with cancer, functional iron deficiency, activation of IL-6, IL-10, TNF-α synthesis and an increase in hepcidin synthesis lead to the development of anemia of chronic diseases. In patients with a rheumatic profile and anemia, a more pronounced synthesis of hepcidin and an increase IL-6 concentration are indicated. A working version of the classification of anemia of chronic diseases based on the leading pathogenetic factor is proposed (with a predominant iron deficiency, with impaired regulatory mechanisms of erythropoiesis, with insufficient production of erythropoietin).

Chronic pain associated with malignant neoplasm. Modern terms and classification

2021 ◽  
Vol 22 (1) ◽  
pp. 146-151
Author(s):  
V. V. Khinovker ◽  
◽  
A. P. Spasova ◽  
V. A. Koryachkin ◽  
D. V. Zabolotskiy ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Radiation Therapy ◽  
Visceral Pain ◽  
International Association ◽  
Malignant Neoplasm ◽  
Pain Syndrome ◽  
International Classification Of Diseases ◽  
Malignant Neoplasms ◽  
Common Symptom

According to 2019 data, the incidence of cancer in Russia increases by 1.5% annually, 8.5 million people die from malignant neoplasms. Pain is the most common symptom when diagnosed with a malignant neoplasm. In the final stage of the disease, about 66% of patients experience pain, and in most cases the intensity of pain syndrome is regarded as moderate to severe pain. In the international classification of diseases 11 revisions (μb-11), the diagnosis of chronic pain is supposed to be reflected in a separate section. The aim of the review was to present a modern classification of chronic pain associated with malignancy. The search for publications has been carried out by two independent researchers since 01.2010. until 12.2020. in the databases PubMed, MEDLINE, EMBASE, Cochrane, as well as the International Association for the Study of Pain. The International Association for the Study of Pain has established a special group, which, in close collaboration with WHO representatives, has developed a new classification of chronic pain. Chronic pain caused by malignancy: chronic visceral pain caused by malignancy; chronic bone pain caused by malignancy; chronic neuropathic pain caused by malignancy; other chronic pain caused by malignancy. Chronic pain due to treatment of malignant neoplasm: chronic pain caused by drug treatment of malignant neoplasm Chronic polyneuropathy due to chemotherapy; chronic pain caused by radiation therapy of malignant neoplasm; chronic neuropathy due to radiation therapy; Chronic pain caused by surgical treatment of malignant neoplasm. Other chronic pain caused by treatment of malignant neoplasm. Thus, the inclusion in the MKB-11 of a separate classification of chronic pain associated with malignancy will lead to the correct formulation of the diagnosis, which will contribute to individualized treatment (antitumor therapy, surgery), psychological support, the involvement of algologists (intervention methods of therapy), intensified research on the prevention and treatment of pain syndromes, as well as standardization of chronic assessment of pain.

Results of X-ray endovascular hemostasis in the treatment of malignant neoplasms of the colon and rectum, complicated by bleeding

2016 ◽  
Vol 21 (4) ◽  
pp. 186-189
Author(s):  
Alexey V. Shelekhov ◽  
V. V Dvornichenko ◽  
A. V Munkuev ◽  
R. I Rasulov ◽  
S. I Radostev ◽  
...  
Keyword(s):  
Preoperative Radiotherapy ◽  
Malignant Neoplasm ◽  
Control Group ◽  
Malignant Neoplasms ◽  
Donor Blood ◽  
Rectosigmoid Colon ◽  
Rectosigmoid Cancer ◽  
X Ray ◽  
Colon And Rectum ◽  
And Control

There are present near results of X - ray endovascular hemostasis in patients suffering from malignant neoplasm of rectosigmoid colon and rectum complicated by bleeding. Patients were divided into basic group (n=16) where the X - ray-endovascular hemostasis was performed and control group (17 patients) where the conservative methods of hemostasis were used. For angiography there was used X-raysurgical complex “GE INNOVA 4100” (General Electric, USA) and ”SHIMADZU” (Shimadzu Corporation, Japan). After preformed hemostasis, the patients of the control and basic groups for rectal cancer were undergone to preoperative radiotherapy, then radical surgery, for rectosigmoid cancer - surgical treatment. The quantity, volume of donor blood products in the treatment ofpatients of the control group were used in a significantly greater extent (p

scholarly journals Genetic markers that determine the efficiency of repair of double-strand DNA breaks and DNA mismatch repair under the action of occupational factors

2018 ◽  
Vol 82-83 (2-3) ◽  
pp. 78-84
Author(s):  
T.A. Andruschenko ◽  
S.V. Honcharov ◽  
V.Ye. Dosenko
Keyword(s):  
Mismatch Repair ◽  
Chronic Diseases ◽  
Respiratory System ◽  
Control Group ◽  
Malignant Neoplasms ◽  
Dna Breaks ◽  
Dna Mismatch ◽  
Double Strand Dna Breaks ◽  
Repair Genes ◽  
Double Strand Dna

Introduction. Distribution of the following allelic variants of DNA repair genes: АТМ (rs664677), XRCC7 (rs7003908), and MLH1 (rs1799977) in the population of personnel of harmful and hazardous occupation has been studied. The studied polymorphisms are recognized as cancer-specific markers of various types and localization of malignant neoplasms, as well as markers of radiosensitivity/resistance to radiation exposure. Objectives of the work: to find out the significance of polymorphisms of repair genes of double-strand DNA breaks: XRCC7 (rs7003908), АТМ (rs664677), and mismatch repair: MLH1 (rs1799977) in the formation of an individual predisposition to the development of chronic diseases of the bronchopulmonary system in miners and personnel ofasbestos-cement plants. Materials and methods. Respondents of the study group was the personnel of asbestos-cement plants and miners with chronic bronchopulmonary disease; the control group was made up of personnel without diseases of the respiratory system. The genotypes of the following genes were determined by real-time polymerase chain reaction: АТМ (rs664677), XRCC7 (rs7003908), and MLH1 (rs1799977). Results. It was established that the minor alleles of ATM•T and MLH1•G, minor homozygote ATM•TT and heterozygote MLH1•AG are associated with the risk of developing chronic diseases of the bronchopulmonary system. It has been revealed that the dominant alleles of ATM•A, MLH1•A; dominant homozygotes ATM•AA; MLH1•AA and heterozygote ATM•AT contribute to resistance to the development of the respiratory system conditions. Conclusion. The following alleles: ATM•T (Р<=0,06, χ2=3,44; OR=1,44; 95 % Cl: 0,96–2,17); MLH1•G (Р<=0,002, χ2=5,06; OR=1,61; 95 % Cl: 1,04–2,49) and genotype: ATM•TT (Р<=0,01, χ2=6,61; OR=2,48; 95 % Cl: 1,16–5,31); MLH1•AG (Р<=0,002, χ2=9,00; OR=2,32; 95 % CI: 1,29–4,21) associated with the risk of bronchopulmonary conditions development have been established. Also alleles: ATM•A (Р<=0,06, χ2=3,44; OR=0,69; 95 % CI: 0,46–1,04); MLH1•A (Р<=0,002, χ2=5,06; OR=0,62; 95 % CI: 0,40–0,96) and genotype: MLH1•A/A (Р<=0,003, χ2=8,73; OR=0,43; 95 % CI: 0,24–0,79) that form resistance to the development of pulmonary system conditions in certain occupational groups have been established. Key words: SNP, ATM, XRCC7, MLH1, bronchopulmonary pathology.

Features of the secretion of interleukin-6, interleukin-1β, interferon-γ and their influence on the development of anemia of chronic diseases in patients with rheumatic pathology

2021 ◽  
Vol 2 (2) ◽  
pp. 26-33
Author(s):  
V.T. Sakhin ◽  
◽  
E.V. Kryukov ◽  
M.A. Grigoriev ◽  
S.P. Kazakov ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Correlation Analysis ◽  
Chronic Diseases ◽  
Iron Metabolism ◽  
Negative Correlation ◽  
Interleukin 6 ◽  
Interferon Γ ◽  
Hemoglobin Synthesis ◽  
Rheumatic Patients

Aim. To study the characteristics of interleukin-6 (IL-6), interleukin-1β(IL-1β), interferon-γ(INF-γ) secretion in rheumatic patients with and without anemia of chronic diseases. To assess the influence of these cytokines on the development of anemia of chronic iseases in patients with various rheumatic pathologies. To propose a working version of the classification of anemia of chronic diseases based on the leading pathogenetic factor in the development of anemia. Material and methods. 126 rheumatic patients, 34 men (45,8 (36–54,9) years old), 92 women (49,5 (38–60) years old) were examined. Group 1 included 41 patients with ACD, 34 with iron deficiency anemia (IDA). Group 2 had 29 patients with a combination of ACD and IDA, 22 in the control group without anemia. Comparative analysis between groups with and without anemia and correlation analysis of hemogram parameters, iron metabolism, C-reactive protein (CRP), interleukin-6 (IL-6), IL-1β, interferon gamma (INF-γ) were performed. Results. In the ACD group, the concentrations of ferritin, CRP, IL-6 were increased in comparison with other groups. With regard to IL-1β, INF-γ, no intergroup differences were found in the study groups (p>0,05). It was found that the greatest influence on the maturation of erythrocytes is exerted by INF-γ (r=-0,4). The greatest effect on hemoglobin synthesis is exerted by IL-6 (r=-0,6) and IL-1β (r=-0,4). The effect of the studied cytokines on erythropoiesis and hemoglobin synthesis can be realized through their effect on iron metabolism. This is confirmed by the results of the performed correlation analysis. A negative moderate correlation was shown between IL-6 and iron (r=-0,6), total iron binding capacity (TIBС)(r=-0,3), transferrin saturation index (TSI) (r=-0,5), ferritin (r=-0,5), transferrin (r=-0,3), and a moderately positive correlation with CRP (r=0,5). For INF-γ, a negative correlation was found with TIBC (r=-0,3), ferritin and transferrin (r=-0,3). For IL-1β, a moderate negative correlation was shown with TIBC, ferritin and transferrin (r=-0,4). Conclusion. It was found that patients with rheumatic pathology and anemia of chronic diseases had high concentration of IL-6, while the concentrations of INF-γ and IL-1β did not differ from the values in the groups of patients with IDA, a combination of AChD / IDA and without anemia. Despite this, the influence of all three investigated cytokines on erythropoiesis, hemoglobin synthesis and iron metabolism has been proven. The data obtained reflect the complex pathogenesis of ACD in patients with rheumatic pathology, including erythropoiesis disorders, changes in iron metabolism, and increased synthesis of some pro-inflammatory cytokines. A working version of the classification of ACD (with a predominant iron deficiency, with violations of the regulatory mechanisms of erythropoiesis, with insufficient production of erythropoietin) has been proposed.

scholarly journals Integrated sensory motor system in prematurely born children

CoDAS ◽  
2013 ◽  
Vol 25 (5) ◽  
pp. 444-450
Author(s):  
Andrea Monteiro Correia Medeiros ◽  
Graysianne Alves de Jesus ◽  
Leylane Fonseca Almeida ◽  
Oscar Felipe Falcao Raposo
Keyword(s):  
Strong Correlation ◽  
Motor System ◽  
Moderate Correlation ◽  
Weak Correlation ◽  
Premature Newborns ◽  
Left Hand ◽  
Right Hand ◽  
Strong Conclusion ◽  
Sensory Motor ◽  
Gustatory Stimulation

PURPOSE: To investigate about an integrated sensory motor system existence in premature newborns, submitted to gustatory stimulation. METHODS: Analytical and experimental study of contents, double-blind. Being participants 90 premature newborns, divided into two groups (water or sucrose analysis 12%). Recorded by 15 minutes (first and last moments, without stimulation; and second time with gustatory stimulation). Three independent judges analyzed the behaviors in the right hand and left hand in the mouth and suction in the left and right and hand during the various behavioral states, those being inserted in the database of Statistical Package for Social Science, being then considered that the events observed by at least two of them. It was made use of Spearman' s rank correlation test on a significance level by p<0.05. RESULTS: Considering the groups both separately and together, right and left had initially moderate correlation, being right hand in the mouth remained strong at the end and left hand in the mouth finished on moderate and strong correlation, according to each behavioral state. Right hand suction in its total and sucrose showed a strong correlation initially in drowsy state, becoming moderate at the end. In alertness state there was initially a weak correlation in both stimuli ending in moderate correlation in sucrose and strong in water. Left hand suction presented initially moderate correlation on the alert state, ending in weak correlation in sucrose stimuli, which did not occur in the water that started and finished strong. CONCLUSION: The oral stimulation influenced the hand-mouth coordination, showing early motor sensory integration. However, there was no discrimination about the gustatory capacity on the newborns.

scholarly journals Computed Tomography-Derived Occipital–Coccygeal Length and Ilium Wing Distance Correlates with Skin to Epidural and Intrathecal Depths in Dogs

2020 ◽  
Vol 7 (4) ◽  
pp. 196
Author(s):  
Tsim Christopher Sun ◽  
Mariano Makara ◽  
Fernando Martinez-Taboada
Keyword(s):  
Computed Tomography ◽  
Strong Correlation ◽  
Body Condition Score ◽  
Correlation Coefficients ◽  
The Body ◽  
Regression Equations ◽  
Moderate Correlation ◽  
Weak Correlation ◽  
Intrathecal Space ◽  
The Relationship

The current clinical techniques for neuraxial needle placement in dogs are predominantly blind without prior knowledge of the depth required to reach the desired space. This study investigated the correlation and defined the relationship between easily obtainable external landmark variables in the dog; occipital–coccygeal length (OCL) and ilium wings distance (IWD), with the skin to epidural and intrathecal space distances using computed tomography (CT). The CT images of 86 dogs of different breeds were examined in this retrospective observational study. Images of dogs in sternal recumbency were optimized to the sagittal view. The distances between the skin and lumbosacral epidural space (LSE) and skin to sacrococcygeal space (SCE) were measured to the ligamentum flavum surrogate (LFS) line. The distance between the skin and the intrathecal space (ITS) was measured from the skin to the vertebral canal at the interlumbar (L5–L6) space. Measurements of the IWD and OCL were performed on dorsal and scout views, respectively. Linear regression equations and Pearson’s correlation coefficients were calculated between variables. Data were reported as mean (standard deviation). Significance was set as alpha < 0.05. After exclusion of four dogs, 82 CT scans were included. The depths were LSE 45 (15) mm, SCE 23 (10) mm, and ITS 50 (15) mm. There was a moderate correlation between OCL with LSE (=14.2 + OCL * 0.05 (r = 0.59, p < 0.0001)), and a strong correlation with ITS (=11.4 + OCL * 0.07 (r = 0.76, p < 0.0001)), while a very weak correlation was found with SCE (=14.0 + OCL * 0.02 (r = 0.27, p < 0.0584)). Similarly, with IWD, there was a moderate correlation with LSE (=10.8 + IWD * 0.56 (r = 0.61, p < 0.0001)), and strong correlation with ITS (=9.2 + IWD * 0.67 (r = 0.75, p < 0.0001)), while a weak correlation was found with SCE (=11.2 + IWD * 0.2 (r = 0.32, p < 0.0033)). Mathematical formulae derived from the multiple regression showed that the body condition score (BCS) improved the relationship between IWD and OCL and the LSE, SCE and ITS, while the addition of body weight was associated with multicollinearity. Further studies are required to determine the accuracy of the algorithms to demonstrate their ability for prediction in a clinical setting.

scholarly journals Correlation between mitral CT calcium score and Wilkin's score in rheumatic mitral stenosis: added value of cardiac CT

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
B Eka Putra ◽  
C Atmadikoesoemah ◽  
A Soesanto ◽  
E Sahar ◽  
M Kasim
Keyword(s):  
Computed Tomography ◽  
Mitral Valve ◽  
Strong Correlation ◽  
Calcium Score ◽  
Observer Variability ◽  
Moderate Correlation ◽  
Weak Correlation ◽  
Mitral Valve Area ◽  
Inter Observer Variability ◽  
Valve Area

Abstract Introduction Wilkin's score, as one of the predictors used to determine the transcatheter or surgical approach may be lacking in objectivity because of potential inter-observer variability. Materials and methods A cross-sectional pilot study was done to assess the correlation between Wilkin's score and Wilkin's Calcium score to the result of the Mitral Computed Tomography Calcium Score. Result Mitral computed tomography calcium score has moderate to strong correlation to Wilkin's calcium score (Correlation 0.738 (Strong correlation), p 0.01) and Wilkin's score (Correlation 0.626 (Moderate correlation), p 0.039). Two of the samples showed zero calcium ct score; however, they scored two in Wilkin's calcium score. Meanwhile, mitral computed tomography calcium score has a weak correlation to the mitral valve area (Correlation −0.294 (Weak correlation), p 0.38 – Statistically not significant). Instead, Wilkin's Calcium Score and Wilkins Score have moderate to strong correlation to the mitral valve area (Correlation −0.609 (Moderate correlation), p 0.047; Correlation −0.722 (Strong correlation), p 0.012). Conclusion Mitral CT calcium score may be incorporated or complement the Wilkin's Score to assess the viability of using percutaneous balloon mitral valvuloplasty (PBMV) as the treatment of choice for mitral stenosis. This is a consideration that Mitral CT calcium score is free from inter-observer variability and thus becomes a gold standard to assess calcium content in the mitral valve. FUNDunding Acknowledgement Type of funding sources: None.

Cultural and Linguistic Adaptation of the Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V) Into Hindi

2020 ◽  
Vol 63 (12) ◽  
pp. 3974-3981
Author(s):  
Ashwini Joshi ◽  
Isha Baheti ◽  
Vrushali Angadi
Keyword(s):  
Strong Correlation ◽  
Concurrent Validity ◽  
Interrater Reliability ◽  
Voice Quality ◽  
Weak Correlation ◽  
Voice Assessment ◽  
Perceptual Evaluation ◽  
Severity Grade ◽  
Normal Voice ◽  
Group A

Aim The purpose of this study was to develop and assess the reliability of a Hindi version of the Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V). Reliability was assessed by comparing Hindi CAPE-V ratings with English CAPE-V ratings and by the Grade, Roughness, Breathiness, Asthenia and Strain (GRBAS) scale. Method Hindi sentences were created to match the phonemic load of the corresponding English CAPE-V sentences. The Hindi sentences were adapted for linguistic content. The original English and adapted Hindi CAPE-V and GRBAS were completed for 33 bilingual individuals with normal voice quality. Additionally, the Hindi CAPE-V and GRBAS were completed for 13 Hindi speakers with disordered voice quality. The agreement of CAPE-V ratings was assessed between language versions, GRBAS ratings, and two rater pairs (three raters in total). Pearson product–moment correlation was completed for all comparisons. Results A strong correlation ( r > .8, p < .01) was found between the Hindi CAPE-V scores and the English CAPE-V scores for most variables in normal voice participants. A weak correlation was found for the variable of strain ( r < .2, p = .400) in the normative group. A strong correlation ( r > .6, p < .01) was found between the overall severity/grade, roughness, and breathiness scores in the GRBAS scale and the CAPE-V scale in normal and disordered voice samples. Significant interrater reliability ( r > .75) was present in overall severity and breathiness. Conclusions The Hindi version of the CAPE-V demonstrates good interrater reliability and concurrent validity with the English CAPE-V and the GRBAS. The Hindi CAPE-V can be used for the auditory-perceptual voice assessment of Hindi speakers.

PREDICTIVE SIGNIFICANCE OF HIGH SERUM FERRITIN LEVELS IN THE DEBUT OF MALIGNANT LYMPHOMA

2020 ◽  
pp. 74-81
Author(s):  
Babaeva T.N. ◽  
Seregina O.B. ◽  
Pospelova T.I.
Keyword(s):  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Prognostic Significance ◽  
Average Concentration ◽  
High Serum ◽  
Control Group ◽  
Malignant Neoplasms ◽  
Significant Prognostic Factor ◽  
Malignant Lymphomas

At present, the serum ferritin level is not included in the list of prognostic factors; however, it is known that its increased serum level in patients with malignant neoplasms relates with the tumor burden, the degree of disease activity and correlates with a worse prognosis in patients with hematologic malignancies.The normalization of serum ferritin level during remission period confirms the involving of hyperferritinemia in mechanisms of tumor progression and may testify for clinical importance of measurement of serum ferritin level in patients, including those with malignant lymphomas. Objective:The aim of this study was to assess of the prognostic significance of high ferritin levels at the onset of the disease in patients with malignant lymphomas. Materials and methods:98 patients with malignant lymphomaswere enrolled in this study, including 72 patients (73.5%) with non-Hodgkins lymphomas (NHL) and 26 patients (26.5%) with Hodgkin’s lymphoma (HL). The increased serum ferritin level (more than 350 ng/ml) was found in 53 (54.2%) patients with malignant lymphomas at the onset of disease and its average concentration was 587,62±131,6 ng/ml (8.3 times higher values of control group, p<0.001).Also the positive statistical correlationsbetween increased ferritin level and increased level of LDH (r=0.47, p<0.001, n=98) and C-reactive protein (r=0.41, p<0.001, n=98) as well as the presence of B-symptomswere found. The median OS was significantly shorter in the group of patients with increased ferritin level (more than 350 ng/ml) at the onset of disease in comparison with group of patients with normal ferritin level, where the median OS was not reach during the observation period. Patients with increased ferritin level before starting chemotherapy also showed worse results of overall survival and increased mortality risk (OR 8.122; 95% CI, 1.764-37.396;р<0.05) compare with a group of patients with ferritin level ˂350 hg/ml at the onset of disease. Conclusion:These results make it possible to include lymphomas’s patients with increased ferritin level at the onset of disease in the group with poor prognosis and lower OS, while the increased ferritin level in patients without previous blood transfusions should be considered as a significant prognostic factor.

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