TO THE QUESTION OF THE CARDIOVASCULAR RISK FACTORS IN MEN UNDER 50 YEARS OLD WITH MYOCARDIAL INFARCTION AND ARTERIAL HYPERTENSION

Author(s):  
Gordienko A.V. ◽  
Davletova A.K.

Relevance. Myocardial infarction and its complications in young and middle-aged men with arterial hypertension remains an important problem of modern cardiology. Aim. To evaluate the cardiovascular risk factors structure features in men under 50 years old with arterial hypertension to improve prevention and outcomes. Material and methods. The study included 209 men aged 19-50 years old with type I myocardial infarction, who underwent a standard diagnostic algorithm in the first 48 hours and at the end of the third week of the disease. The patients were divided into two age-matched groups: with arterial hypertension (121 patients, 88 patients without arterial hypertension). A comparative analysis of the frequency of identifying the main and additional cardiovascular risk factors and their parameters were performed in the selected groups. Results. The study group showed more pronounced glycemia (5.6±1.4 mmol/l) than in the control group (5.2±1.3 mmol/l; p=0.04) at the end of the third week of myocardial infarction. In this group, there was a high incidence of obesity (42.1 and 25.0%, respectively; p=0.01), changes in peripheral arteries (86.0 and 3.5%; p<0.0001) and target organ damage , meteorological dependence (31.4 and 9.1%; p=0.0001), impaired peripheral hemodynamics, as well as hereditary burden of vascular pathology (100 and 56.8%; p=0.03). Conclusions. The data obtained suggest a worse long-term prognosis and a greater degree of resistance to treatment in men with arterial hypertension, which must be considered when implementing preventive programs.

2021 ◽  
Vol 40 (2) ◽  
pp. 49-54
Author(s):  
Al’farabi S. Izmuhanov ◽  
Aleksandr V. Gordienko

AIM: Myocardial rupture currently remains in most cases a fatal complication of myocardial infarction. OBJECTIVE: To study the features of the structure of cardiovascular risk factors in men under 60 years old with complicated myocardial infarction to improve prevention. MATERIALS AND METHODS: The study included men 1960 years old with type I myocardial infarction. The patients were divided into two groups age-comparable: I studied, with myocardial rupture seven patients; II control, without breaks 558 patients. A comparative analysis of the frequency of observation of the main and additional factors of cardiovascular risk in the selected groups was performed. RESULTS OF THE STUDY: In the patients of the study group, frequent (four or more times a year) colds were observed more often than in the control group (42.9 and 14.8%, respectively; p = 0.04), the internal organs foci of infections (85.7 and 40.3%; p = 0.049), bypass surgery (57.1 and 10.2%; p 0.0001) and continuous cardiac pacing (28.6 and 0.5%; p 0.0001) in medical history. The presence of arterial hypertension (28.5 and 67.6%; p = 0.03) and foci of oral cavity infections (0 and 20.3%; p = 0.049) reduced the risk of myocardial rupture. In the study group, the levels of total cholesterol (4.3 0.3 and 5.8 1.2 mmol/l); p = 0.02), low-density lipoproteins (2.7 0.1 and 4.2 1.2 mmol/l); p = 0.04) and triglycerides (0.7 0.1 and 2.6 1.8 mmol/l); p = 0.008) were lower than in the control. CONCLUSION: Combinations of these cardiovascular risk factors indicate an increased risk of myocardial rupture. It is advisable to use them for predictive modeling of this event and the formation of risk groups for the purpose of timely prevention, (bibliography: 18 refs.).


Author(s):  
Gordienko A.V. ◽  
Balabanov A.S. ◽  
Biyaliev E.K.

Relevance. Mortality in cardiogenic shock remains high. Aim. To evaluate the structure of cardiovascular risk factors features in men under 50 years old with myocardial infarction complicated by cardiogenic shock, in order to improve the prevention of this complication. Material and methods. The study included men 19-50 years old with type I myocardial infarction. The patients were divided into two age-comparable groups: I - the study group, with cardiogenic shock - seven patients; II - control, without it - 202 patients. A comparative analysis of the of cardiovascular risk factors structure in the selected groups and a risk analysis (ANOVA) of the development of cardiogenic shock were performed. Results. In the study group, the predominance of renal dysfunction (100 and 10.3%, respectively; p=0.004), alcohol abuse (71.4 and 35.2%; p=0.049), the presence of atrial fibrillation (57.1 and 5,0%; p˂0.0001), urolithiasis 28.6 and 6.4%; p=0.001), cholelithiasis 14.3 and 5.5%; p=0.001 and gout 14.3 and 0.5%; p=0.001) in history. In the control group, a history of unstable angina pectoris was more often recorded (0 and 38.1%; p=0.04). When assessing the risks, in addition to those listed, smoking 20 cigarettes per day, a decrease in lipid metabolism indicators (very low density lipoproteins 0.36 mmol/l, low density 2.7 mmol/l, cholesterol˂3,8 mmol/l, triglycerides 1.2 mmol/l, cholesterol/high density lipoproteins˂4.63), creatinine≥140 μmol/l in combination with overweight (≥96.0 kg and Quetelet index ≥31,0 kg/m2) and age (≥48 years). Conclusions. The listed factors can be used in the formation of high-risk groups for observation and timely implementation of the necessary treatment as well as for prognostic modeling of cardiogenic shock.


Author(s):  
Epifanov S.Y. ◽  
Tupitsyn V.V. ◽  
Baltabaeva A.M.

Relevance. Recurrent ischemic damages negatively affect the prognosis of myocardial infarction. Aim. To evaluate the peculiarities of cardiovascular risk factors in men younger than 60 years old with myocardial infarction and recurrent ischemic damages to improve prevention, and outcomes. Material and methods. The study included men aged 19-60 years old with type I myocardial infarction. Patients are divided into two age-comparable groups: I - the study group, with recurrent ischemic damages - 95 patients; II - con-trol, without it - 470 patients. A comparative analysis of the frequency of observation of the main and additional car-diovascular risk factors in groups was performed. Results. In patients of the study group, more often than in the control group we observed: hypodynamia (94.7 and 77.7%, respectively; p ˂ 0.05), smoking (86.3 and 72.6%; p ˂ 0.05), myocardial infarction (56.8 and 40.3%; p ˂ 0.05), unstable angina (57.9 and 46.3%; p ˂ 0.05), coronary artery bypass surgery (17.9 and 9, 3%; p ˂ 0.05) in the pa-tient’s medical a history, stress (53.7 and 36.9%; p ˂ 0.05) and changes in meteorological factors (26.4 and 23.0%; p ˂ 0.05) as causes of myocardial infarction , winter (37.9 and 28.1%; p ˂ 0.05) and autumn (28.4 and 18.3%; p ˂ 0.05) periods and impaired renal function (29.2 and 12.1% ; p ˂ 0.05). Conclusions. The use of these factors in prognostic modeling of recurring ischemic damages risk in case of myocardi-al infarction in men under 60 years old, as well as in creating high-risk groups for their development to monitor and conduct preventive measures, will improve the outcome of such patients.


Author(s):  
Tupitsyn V.V. ◽  
Bataev Kh.M. ◽  
Men’shikova A.N. ◽  
Godina Z.N.

Relevance. Information about the cardiovascular diseases risk factors (CVD RF) for in men with chronic lung inflam-matory pathology (CLID) is contradictory and requires clarification. Aim. To evaluate the peculiarities of CVD RF in men under 60 years of age with CLID in myocardial infarction (MI) to improve prevention. Material and methods. The study included men aged 19-60 years old with type I myocardial infarction. Patients are divided into two age-comparable groups: I - the study group, with CLID - 142 patients; II - control, without it - 424 patients. A comparative analysis of the frequency of observation of the main and additional cardiovascular risk fac-tors in groups was performed. Results. In patients of the study group, more often than in the control group we observed: hereditary burden of is-chemic heart disease (40.8 and 31.6%, respectively; p = 0.0461) and arterial hypertension (54.2 and 44.6%; p = 0.0461), frequent colds (24.6 and 12.0%; p = 0.0003), a history of extrasystoles (19.7 and 12.7%; p = 0.04); chronic foci of infections of internal organs (75.4 and 29.5%; p˂0.0001), non-ulcer lesions of the digestive system (26.1 and 14.6%; p = 0.007), smoking (95.1 and 66.3%; p˂0.0001), MI in winter (40.8 and 25.9%; p = 0.006). Less commonly were observed: oral cavity infections (9.2 and 23.6%; p˂0.0001); hypodynamia (74.5 and 82.5%; p = 0.0358), over-weight (44.4 and 55.2%; p = 0.0136), a subjective relationship between the worsening of the course of coronary heart disease and the season of the year (43.7 and 55.2%; p = 0.0173) and MI - in the autumn (14.1 and 21.9%; p = 0.006) period. Conclusions. The structure of CVD RF in men under 60 years of age with CLID with MI is characterized by the pre-dominance of smoking, non-ulcer pathology of the digestive system, frequent pro-student diseases, meteorological dependence, a history of cardiac arrhythmias and foci of internal organ infections. It is advisable to use the listed factors when planning preventive measures in such patients.


2008 ◽  
Vol 99 (06) ◽  
pp. 1085-1089 ◽  
Author(s):  
Marianna Politou ◽  
Christoforos Komporozos ◽  
Demosthenes Panagiotakos ◽  
Chrisoula Belessi ◽  
Anthi Travlou ◽  
...  

SummaryThere are limited and controversial data regarding the impact of factor XIII (FXIII) Val34Leu polymorphism in the pathogenesis of premature myocardial infarction (MI). We examined whether FXIII Val34Leu polymorphism is associated with the development of early MI.We recruited 159 consecutive patients who had survived their first acute MI under the age of 36 years (mean age=32.1 ± 3.6 years, 138 were men). The control group consisted of 121 healthy individuals matched with cases for age and sex, without a family history of premature coronary heart disease (CHD). FXIII Val34Leu polymorphism was tested with polymerase chain reaction and reverse hybridization. There was a lower prevalence of carriers of the Leu34 allele in patients than in controls (30.2 vs. 47.1%, p=0.006). FXIII Val34Leu polymorphism was associated with lower risk for acute MI after adjusting for major cardiovascular risk factors (odds ratio [OR] = 0.51, 95% confidence interval [CI] 0.27–0.95, p=0.03). Subgroup analysis according to angiographic findings (“normal” coronary arteries [n=29] or significant CHD [n=130]) showed that only patients with MI and significant CHD had lower prevalence of carriers of the Leu34 allele compared to controls after adjusting for major cardiovascular risk factors (OR = 0.42, 95% CI 0.22–0.83, p=0.01). Our data indicate that FXIII Val34Leu polymorphism has a protective effect against the development of MI under the age of 36 years, particularly in the setting of significant CHD.


2018 ◽  
Vol 15 (3) ◽  
pp. 27-31
Author(s):  
T A Mulerova ◽  
S A Maksimov ◽  
A N Chigisova ◽  
M Yu Ogarkov

Objective - to evaluate the association of genetic markers and cardiovascular risk factors with thickening of the intima-media complex among patients with arterial hypertension in the indigenous and non-indigenous population of Mountain Shoriya. Material and methods. The population of Mountain Shoriya in the number of 1409 people was surveyed by a single method (901 people are of indigenous nationality, Shorians, 508 people are non-indigenous 90% of them are Caucasians). Shors are a small Turkic-speaking people. Lipid blood spectrum, fasting plasma glucose, Quetelet index, waist circumference, genetic markers [ACE (I/D, rs4340), AGT (c.803T>C, rs699), AGTR1 (A1166C, rs5186), ADRB1 (p.145A>G, Ser49Gly, rs1801252), ADRA2B (I/D, rs28365031), MTHFR (c.677C>T, Ala222Val, rs1801133) and NOS3 (VNTR, 4b/4a)]. Carotid ultrasound was performed. Hypertension was diagnosed according to the National Guidelines of the Russian Society of Cardiology/the Russian Medical Society on Arterial Hypertension (2010). The study included 226 Shorians and 124 non-indigenous people with arterial hypertension and an increased thickness of the intima-media complex. The control group consisted of individuals with high blood pressure without atherosclerosis of carotid arteries (81 and 66 people, respectively). Results. It was revealed that such risk factors as gender and age are significantly associated with the thickness of the intima-media complex in the shorthand cohort (OR 1.93; 95% CI 1.03-3.62 and OR 20.01; 95% CI 4.79-83.65) and age - in the cohort of representatives of non-indigenous nationality (OR 3.20; 95% CI 1.39-7.36). An important role in the formation of atherosclerosis of carotid arteries in patients with arterial hypertension has a duration of the course of the disease in both ethnic groups, respectively - OR 2.78; 95% CI (1.45-5.33) and OR 4.22; 95% CI (1.97-9.01). A significantly smaller contribution is made by the genetic component: the rs699 polymorphism of the AGT gene, as in the Shorts (OR 3.51; 95% CI 1.10-11.25), and in non-indigenous residents (OR 4.90; 95% CI 1.15-20.92) and polymorphism rs1801133 of the MTHFR gene only in persons of indigenous nationality (OR 10.80; 95% CI 2.35-49.70). Conclusion. Timely establishment of risk factors for subclinical atherosclerosis in hypertension and their correction depending on the national trait will help prevent the progression of the process, reverse it, and reduce the risk of complications, premature disability and mortality.


2021 ◽  
pp. 26-31
Author(s):  
І. P. Vakaliuk ◽  
K. V. Levandovska ◽  
N. B. Tymochko

Cardiovascular diseases (CVD) are known to account for one-third of all deaths worldwide. According to the American Heart Association, 18% of men and 35% of women with prior acute myocardial infarction (AMI) developed recurrent AMI within 6 years after initial MI; 22% of men and 46% of women were disabled due to the development of chronic heart failure (CHF). The purpose of the research: to analyse clinical features of recovering period after myocardial infarction taking into account cardiovascular risk factors. Materials and methods of the research. 175 persons with myocardial infarction and related risk factors were examined. Study groups were homogenous by age, gender, disease severity, clinical signs of decompensation, that served as a basis for inclusion of the patients in the research. All patients underwent the general-clinical examination (pain syndrome analysis, medical history, objective signs), clinical and instrumental (electrocardiography, echocardioscopy, 6-minute walk test, in a quiet 30-50-m long hospital corridor in the morning) and laboratory tests (lipidogram, leptin level). Study groups were homogenous by age, gender, disease severity, duration of the post-infarction period, clinical signs of decompensation. All patients were divided into groups according to the presence of risk factors: group 1 of MI with HF (74 patients), group 2 – MI with AH (76 patients), group 3 – MI and obesity (72 patients); group 4 consisted of patients with all risk factors (78 patients) together. The obtained results were statistically processed on the personal computer by means of an advanced analytics software package STATISTICA-7 and a statistical software package “Microsoft-Excel” using the statistical variation analysis. Research results and their discussion. The most important cardiovascular risk factors, which aggravate the post infarction period are age, arterial hypertension, diabetes mellitus, heart failure, congenital and acquired valvular defects, obesity. In patients with heart failure, recovering period is characterized by stabile heartbeat, reduced exercise tolerance combined with progressing dilatation of left ventricular chambers in 83.78% of patients. Patients with arterial hypertension have stable anginal pain syndrome and reduced exercise tolerance (89.47% of cases). In obese patients, consistent fatigue, general weakness, dyspnoea, high levels of total cholesterol and leptin in blood serum (81.94% of patients) are mostly observed. In patients with combined heart failure, arterial hypertension, obesity, the recovery period clinics after myocardial infarction is characterized by significantly reduce of exercise tolerance (92.30% of patients). Shortness of breath, which was accompanied by heart palpitations, was prevalent in the group of patients with HF (89.1%) and was the least manifested in the group of patients with obesity (52.7%). Conclusions. Changes in cardiac hemodynamics in patients who had undergone the myocardial infarction with concomitant heart failure and with a combination of risk factors were accompanied by the eccentric hypertrophy onset, characterized by a combination of the left venricle cavities dilation with hypertrophy of its walls and the decreased contractility. The presence of decompensated heart failure significantly degrades the performance of six-minute walk test.


Author(s):  
Gordienko A.V. ◽  
Reiza V.A. ◽  
Izmuhanov A.S. ◽  
Golikov A.V.

Relevance. The cardiovascular risk factors structure features in myocardial infarction, complicated by urinary disorders, in young and middle-aged men have been insufficiently studied. Aim. To evaluate the cardiovascular risk factors structure features in men under 60 years old with myocardial infarction, complicated by urinary disorders, to improve prevention and outcomes. Material and methods. The study included men 19-60 years old with type I myocardial infarction. The patients were divided into two age-comparable groups: I - study group, with acute kidney injury - 15 patients; II - control, without it - 496 patients. A comparative analysis of the main and additional cardiovascular risk factors frequency, analysis of their influence on the risk of urinary disorders in myocardial infarction (ANOVA) were performed. Results. The study group differed from the control group in the greater frequency of coronary artery bypass surgery (in the study group: 31.8%; in the control group: 8.4%; p = 0.0002), pacing (9.1 and 0.5%; respectively); p < 0.0001), history of atrial fibrillation and/or flutter (27.3 and 9.2%; p = 0.005), chronic cerebrovascular insufficiency (77.3 and 51.3%; p = 0,02), alcohol abuse (63.6 and 25.2%; p < 0.0001), frequent (four or more per year) colds (27.3 and 12.6%; p = 0,04), cardiac arrhythmias and conduction disturbances in the onset of coronary artery disease (61.9 and 24.9%; p = 0.0007), smoking for 20 years or more (36.4 and 16.8%; p = 0.003) , chronic kidney disease (46.7 and 16.2%; p = 0.02), chronic foci of internal organs infections (77.3 and 39.4%; p = 0.002), urine (27.3 and 8.6%; p = 0.006) and gallstone diseases (13.6 and 5.4%; p = 0.006). These indicators were the markers of the urinary disorders development in myocardial infarction. Conclusions. Men under 60 years old with urinary disorders in myocardial infarction are characterized by smoking, metabolic disorders, chronic kidney disease, heart rhythm and conduction disorders, alcohol abuse, frequent colds and chronic foci of internal organ infections. The data listed above should be used in the formation of high-risk groups for the development of urinary disorders, as well as for prognostic modeling.


Medicina ◽  
2021 ◽  
Vol 57 (10) ◽  
pp. 1103
Author(s):  
Egidija Rinkūnienė ◽  
Silvija Gimžauskaitė ◽  
Jolita Badarienė ◽  
Vilma Dženkevičiūtė ◽  
Milda Kovaitė ◽  
...  

Background and Objectives: This study estimates the prevalence and severity of erectile dysfunction and its association with cardiovascular risk factors in patients after a myocardial infarction. Materials and Methods: This study included men aged 35–80 years, diagnosed with myocardial infarction and examined in the Department of Preventive Cardiology of Vilnius University Hospital Santaros Klinikos between 2016 and 2020. Anthropometric characteristics, blood pressure, lipid profile, blood glucose levels and prevalence of cardiovascular risk factors were evaluated. The International Index of Erectile Function-5 was used to assess patients’ erectile function. Results: A total of 171 patients were analysed. The mean age was 57.6 ± 8.8 years. Of the patients, 42.1, 25.1 and 11.7% had three, four and five established cardiovascular risk factors, respectively. Of the patients, 100% were diagnosed with dyslipidaemia, 90.0%—arterial hypertension, 14.6%—diabetes, 23.3%—smoking, 43.7%—positive familial history and 54.5%—insufficient physical activity. The overall prevalence of erectile dysfunction was 62%. It was scored mild in 37.4%, mild-to-moderate—15.2%, moderate—5.3% and severe in 4.1% of the patients. The mean age was significantly different between severity groups (p < 0.001). The study demonstrated a negative correlation between age and total score of the questionnaire (r = −0.308, p < 0.001). Arterial hypertension was more frequent in the patients with erectile dysfunction (p = 0.02). Other cardiovascular risk factors were distributed similarly. Conclusions: Erectile dysfunction is common in patients after a myocardial infarction and its severity is age dependent. The prevalence of cardiovascular risk factors is high, with arterial hypertension significantly more frequent in patients with erectile dysfunction.


2014 ◽  
Vol 21 (4) ◽  
pp. 327-333
Author(s):  
George Razvan Maxim ◽  
Elena Dumea ◽  
Andreea Bosneagu ◽  
Mihaela Ciucea ◽  
Irinel Raluca Parepa ◽  
...  

AbstractBackground and Aims: Acute myocardial infarction is one of the main causes of mortality worldwide, atherosclerosis being the most common mechanism of coronary artery obstruction. Many cardiovascular (CV) risk factors are associated with these pathogenic processes. The aim of our study was to investigate a group of patients with ST-segment elevation acute myocardial infarction in terms of the prevalence of cardiovascular risk factors. Materials and Methods: We investigated 97 patients with acute myocardial infarction (AMI) and 30 persons without AMI (control group) for CV risk parameters (metabolic syndrome, diabetes, sedentary, dyslipidemia, glycosylated hemoglobin- HbA1c), and the risk of developing AMI. Results: We found statistically significant differences (p<0.05) for the patients with metabolic syndrome, diabetes, sedentary lifestyle, high level of total cholesterol, LDLc, HbA1c, low level of HDLc for the risk to develop AMI. Conclusion: This study emphasizes the need to implement measures of primary and secondary prevention, and carry out a strict control of cardiovascular risk factors as well as implicitly improve the therapeutic conduct.


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