FEATURES OF MANAGEMENT OF PITUITARY MICROPROLACTINOMA IN COMBINATION WITH ADENOMYOSIS

2021 ◽  
Vol 2 (1) ◽  
pp. 55-57
Author(s):  
Simonenko A.Yu.
Keyword(s):  
Pituitary Adenoma ◽  
Clinical Case ◽  
Dose Titration ◽  
Optimal Management ◽  
Subsequent Formation ◽  
Pathogenetic Mechanisms ◽  
Mechanisms Of Formation ◽  
The Common ◽  
And Control ◽  
Uterine Body

The purpose of this study was to study a clinical case of hyperpolactinemia caused by pituitary adenoma (microprolactinoma) and subsequent formation of adenimiosis – endometriosis of the uterine body in a patient. This clinical example illustrates the common ethological and pathogenetic mechanisms of formation of microprolactinoma and adenomyosis and justifies the need to choose the optimal management tactics for the patient taking into account these features (cabergoline 0.5 mg with dose titration and control of prolactin levels in dynamics in combination with dienogest 2 mg).

RATIONALE THE EFFECTIVENESS OF TREATMENT OF COMBINED PATHOLOGY OF REPRODUCTIVE SYSTEM CAUSED BY HORMONAL IMBALANCE AND IMMUNE SYSTEM

2021 ◽  
Vol 2 (1) ◽  
pp. 58-61
Author(s):  
Maiorova M.O.
Keyword(s):  
Immune System ◽  
Clinical Case ◽  
Polycystic Ovary ◽  
Pharmacological Properties ◽  
Ovary Syndrome ◽  
Immune Systems ◽  
Hormonal Imbalance ◽  
The Common ◽  
Uterine Body

Based on the study of this clinical case, it is possible to evaluate the effectiveness of using dienogest for the treatment of combined pathology – polycystic ovary syndrome (PCOS) and endometriosis of the uterine body - adenomyosis. Given the common pathogenetic links in the formation of these diseases, the presence of an imbalance of the hormonal and immune systems in these diseases, the pharmacological properties of diengogest, its metabolic neutrality and the possibility of long-term use, the proposed management tactics should be considered effective for the treatment of this combined pathology.

Factors of humoral immunity in the combined course of vibration disease and hypertension

2020 ◽  
pp. 558-559
Author(s):  
R. A. Baraeva ◽  
L. A. Strizhakov ◽  
Y. I. Borzykh
Keyword(s):  
Humoral Immunity ◽  
Clinical Picture ◽  
Pathogenetic Mechanisms ◽  
Vibration Disease ◽  
Mechanisms Of Formation

The study of humoral immunity factors in vibration disease and its combination with hypertension opens up prospects for rehabilitation and treatment of patients with this pathology, as well as complements our knowledge of the pathogenetic mechanisms of formation of the clinical picture of these diseases.

FINANCIAL CONTROLLING IN THE SYSTEM OF FINANCIAL MANAGEMENT

2018 ◽  
Vol 28 (1) ◽  
pp. 137-141
Author(s):  
Petya Yordanova – Dinova
Keyword(s):  
Comparative Analysis ◽  
Financial Management ◽  
Financial Stability ◽  
Business Environment ◽  
Innovative Approach ◽  
Financial Sustainability ◽  
The Common ◽  
The Difference ◽  
Effective Use ◽  
And Control

This paper explores the comparative analysis of the financial controlling, who is a result from the common controlling concept and the financial management. In the specialized literature, financial controlling is seen as an innovative approach to financial management. It is often presented as the most promising instrument of financial diagnostics. Generally speaking, financial controlling is seen as a process of managing the company`s assets which are valued in monetary measures. The difference between the financial management and the financial controlling is that the second covers all functions of management, analysis and control of finances, aiming at maximizing their effective use and increasing the value of the enterprise. Financial controlling is often seen as a function of the common practice of financial management. Its objective is to preserve the financial stability and financial sustainability of enterprises operating in a highly aggressive business environment.

Inhibition of IL-13: A New Pathway for Atopic Dermatitis

2020 ◽  
pp. 120347542098255
Author(s):  
Kayadri Ratnarajah ◽  
Michelle Le ◽  
Anastasiya Muntyanu ◽  
Steve Mathieu ◽  
Simon Nigen ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Atopic Dermatitis ◽  
Severity Index ◽  
Severe Atopic Dermatitis ◽  
Treatment Alternative ◽  
Control Groups ◽  
Rapid Improvement ◽  
Common Receptor ◽  
The Common ◽  
And Control

Dupilumab, a monoclonal antibody against the common receptor of interleukin (IL)-4 and IL-13, was the first biologic therapy approved in Canada for treatment of moderate-to-severe atopic dermatitis (AD). While it is considered safe and effective, dupilumab is not universally effective and 8%-38% of patients develop conjunctivitis, while some patients develop head and neck dermatitis. Thus, new therapeutic options are warranted. While both IL-4 and IL-13 play important roles in the pathogenesis of AD, it has been recently demonstrated that IL-13 is the primary upregulated cytokine in AD skin biopsy samples. A placebo-controlled phase 2b clinical trial evaluating the efficacy and safety of lebrikizumab, an IL-13 inhibitor, in AD demonstrated that, at 16 weeks, Eczema Area and Severity Index (EASI) 75 and Investigator’s Global Assessment (IGA) 0/1 were achieved by 60.6% and 44.6% of patients taking lebrikizumab at its highest dose (vs 24.3% and 15.3% of patients taking placebo, respectively). Moreover, treatment with lebrikizumab was associated with rapid improvement of pruritus and low rates of conjunctivitis (1.4%-3.8%). Another IL-13 monoclonal antibody, tralokinumab, was evaluated for safety and efficacy in moderate-to-severe AD. By week 12, among adults receiving 300 mg tralokinumab, 42.5% achieved EASI-75 and 26.7% achieved IGA 0/1 score (vs 15.5% and 11.8% in the placebo group, respectively). Both lebrikizumab and tralokinumab demonstrated acceptable safety profiles in AD (and non-AD) trials with adverse events often being comparable between treatment and control groups. Thus, IL-13 inhibitors may provide a safe and effective treatment alternative for patients with moderate-to-severe AD.

Keeping the Focus on Public Health: The Struggles of a Tobacco Prevention Task Force

2003 ◽  
Vol 30 (6) ◽  
pp. 771-788 ◽  
Author(s):  
Jacquie A. Shillis ◽  
Beverly A. Hall ◽  
Gail G. Sneden ◽  
Nell H. Gottlieb
Keyword(s):  
Public Health ◽  
Task Force ◽  
Tobacco Prevention ◽  
Policy Success ◽  
Public Health Officials ◽  
The Common ◽  
And Control ◽  
Future Program ◽  
Product Sets

This case study examines a nonlegislative task force as it struggled to reach internal consensus despite external-political constraints. The study highlights the convergence of politics and science, revealing complex issues likely to be confronted by advocates and public health officials. Three themes capture participants’experiences: context, sizing up the opportunities and constraints; task force process, tacit strategy to operate outside the political context and play the science card; and aftermath, a glass half full. The task force took advantage of ambiguous parameters, crafting a comprehensive statewide plan to reduce tobacco use and breaking out of the common public health paradigm of allowing budget considerations to drive program design. These internal victories could not sustain a policy success in the legislature. However, the group’s product sets science-based standards for future program development, and the task force’s process provides valuable insights into other states developing tobacco prevention and control policies.

Medical Students’ Professionalism Narratives Reveal That Experiences With Death, Dying, or Palliative Care Are More Positive Than Other Experiences During Their Internal Medicine Clerkship

2016 ◽  
Vol 34 (1) ◽  
pp. 79-84 ◽  
Author(s):  
Larry D. Cripe ◽  
David G. Hedrick ◽  
Kevin L. Rand ◽  
Debra Burns ◽  
Daniella Banno ◽  
...  
Keyword(s):  
Internal Medicine ◽  
Palliative Care ◽  
Medical Students ◽  
Educational Strategies ◽  
Barriers To Learning ◽  
Medicine Clerkship ◽  
Student Preparedness ◽  
Internal Medicine Clerkship ◽  
The Common ◽  
And Control

Purpose: More physicians need to acquire the skills of primary palliative care. Medical students’ clerkship experiences with death, dying, and palliative care (DDPC), however, may create barriers to learning such skills during residency. Whether professional development is differentially affected by DDPC is unknown. This knowledge gap potentially hinders the development of educational strategies to optimize students’ preparedness for primary palliative care. Method: Third-year students submitted professionalism narratives (N = 4062) during their internal medicine clerkship between 2004 and 2011. We identified DDPC-related narratives and then randomly selected control narratives. Narratives were compared by valence (positive or negative) and professionalism-related themes. Results and Conclusion: Less than 10% of the narratives were related to DDPC, but the majority was positive. There was a significant overlap in professionalism themes between DDPC and control narratives. The results suggest student preparedness for primary palliative care may be improved by addressing the common professionalism challenges of clinical clerkships.

scholarly journals Using a smartphone video camera to reduce anxiety in speaking activity

2021 ◽  
Vol 12 (1) ◽  
pp. 38-55
Author(s):  
Nur Asma
Keyword(s):  
Smartphone Application ◽  
Video Camera ◽  
New Methods ◽  
Self Confidence ◽  
Significant Difference ◽  
English Speaking ◽  
The Common ◽  
Common Problems ◽  
And Control ◽  
Relevant Factors

The common problems faced by students in English speaking are anxiety and the lack of confidence and ideas. This research was conducted to determine the relevant factors and to provide a solution by using the smartphone video camera. To obtain the data in this research, experimental research was performed inside and outside the classroom with a series of treatments and a questionnaire sheet as the instrument. The data were analyzed using a model proposed by Smeda, Dakich, and Sharda (2014) and a Likert scale questionnaire, which was adapted from Spratt, Humphreys, and Chan (2002). The result from the test showed a significant difference between the experimental and control classes as the carried t-test presented the score of -8.36, which was out of the limit (between -1.96 and 1.96). Another result was the students developed positively which was shown by: the anxiety tends to decrease as they were given time before performing thus prepared better, their self-confidence was increased and challenged by using the smartphone video camera method due to the application of innovation in the speaking class. The conclusion of this research is lecturer needs to apply new methods, one of which is using a smartphone application.

Steroid osteoporosis within the framework of the Itsenko-Cushing drug syndrome: demonstration of a clinical case

2021 ◽  
Vol 7 (2) ◽  
pp. 12-16
Author(s):  
A. Fleyshman ◽  
Elena Belyaeva
Keyword(s):  
Young Patient ◽  
Clinical Case ◽  
Underlying Disease ◽  
Late Diagnosis ◽  
High Dose ◽  
Still’S Disease ◽  
Multiple Fractures ◽  
Medical Supervision ◽  
And Control

A case of severe systemic osteoporosis complicated by multiple fractures of the ribs and vertebrae in a young patient with late diagnosis of Still's disease as a result of independent long-term uncontrolled use of corticosteroids is presented. Lack of medical supervision, taking a high dose (35 mg / day) of prednisolone without recommendation and control of treatment led to untimely recognition and treatment of the underlying disease and the development of irreversible disabling transformations of the skeleton.

Introduction

2007 ◽  
Author(s):  
MICHAEL AYERS
Keyword(s):  
Early Modern ◽  
Common Ground ◽  
Rene Descartes ◽  
Philosophical Theology ◽  
Baruch Spinoza ◽  
René Descartes ◽  
The Common ◽  
And Control

This introductory chapter explains the coverage of this book, which is about the relation between the concepts of rationalism, Platonism, and God. This book is intended as a contribution to the exploration and exposition of the common ground of the great early modern rationalist theories. It examines contemplation and control in Cartesian philosophy and analyses the priority of the perfect in the philosophical theology of the continental rationalists. It also provides commentaries on the relevant theories of philosophers Rene Descartes, Baruch Spinoza, and Gottfried Leibniz.

Investigation of Optimum Conformations and Structure Analysis of RL and LR Nests using Ramachandran Plot

2015 ◽  
pp. 209-224
Author(s):  
Sumukh Deshpande ◽  
Saikat Kumar Basu ◽  
Pooja Purohit
Keyword(s):  
Amino Acids ◽  
Ring Structure ◽  
Ramachandran Plot ◽  
Binding Motifs ◽  
Automated Algorithm ◽  
Automation And Control ◽  
The Common ◽  
And Control ◽  
Common Anion ◽  
Unique Application

We have surveyed polypeptides with the optimal conformations of nests which are the common anion-binding motifs comprising 8% of the amino acids which are characterized by a structural depression or a hole. Using automated bioinformatics algorithm, novel ring structure of the nest has been found. Using automated algorithm, models of polypeptides were made in-silico (computationally) and oxygen atoms are inserted along the extension of the NH groups. These sophisticated algorithms allow insertion of atoms along the NH group at the correct distance which causes extension of the group thus forming hydrogen bond. Optimal conformations of these structures are found from these customized models. This study chapter provides a demonstration of an important discovery of optimum conformations of RL and LR nests by the use of sophisticated bioinformatics automation pipeline and a unique application of automation and control in bioinformatics.

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