scholarly journals Talaromikosis Marneffei

2019 ◽  
Vol 12 (2) ◽  
pp. 72
Author(s):  
Sem S. Surja ◽  
Robiatul Adawiyah ◽  
Retno Wahyuningsih
Keyword(s):  
Endemic Area ◽  
Clinical Manifestations ◽  
Its Region ◽  
Clinical Suspicion ◽  
Cross Wall ◽  
Respiratory Disorder ◽  
Fungal Culture ◽  
Talaromyces Marneffei ◽  
Mycotic Disease ◽  
Histopathology Examination

Talaromycosis marneffei is a mycotic disease caused by Talaromyces marneffei which primarily infectimmunocompromised patient. This disease is endemic in Southeast Asia, and Indonesia consider as endemic area dueto a case of tourist who got the infection after visiting Indonesia. Diagnosis was made based on clinical suspicion withlaboratory confirmation. Clinical manifestations are not specific, such as fever, anemia, weight loss, lymphadenopathy,hepatomegaly, splenomegaly, respiratory disorder, and cutaneous manifestation. Histopathology and culture are themost common examination performed for diagnosis. In histopathology examination, fungi appear as fission arthroconidiacells which shape round to oval, with cross wall formation inside or outside macrophage and histiocyte. Thermaldimorphism characteristic can be observed in fungal culture. Fungi grows as mold at 25oC-30oC and as yeast at 37oC.Definitive identification of T. marneffei was done by molecular examination using primers derived from ITS region asprimary marker and beta tubulin region as secondary marker. Talaromyces marneffei is sapronosis, that transmitted viainhalation of conidia from environment.

scholarly journals Lyme Meningoradiculitis: Case Reports and Literature Review

2016 ◽  
Vol 62 (3) ◽  
pp. 373-375
Author(s):  
Maier Smaranda ◽  
Stirbu Nicoleta ◽  
Bajko Zoltan ◽  
Moţăţăianu Anca ◽  
Ţilea Brânduşa ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Endemic Area ◽  
Case Reports ◽  
Correct Diagnosis ◽  
Clinical Manifestations ◽  
Clinical Suspicion ◽  
Neurological Manifestations ◽  
Serological Testing ◽  
Excellent Outcome ◽  
High Degree

AbstractThe clinical manifestations of Lyme disease are protean. The meningoradiculitis is a common and well-recognized complication of neuroborreliosis but can be easily misdiagnosed without a high degree of clinical suspicion, mainly if the tick bite is not present in the medical history. We report two cases of Lyme meningoradiculitis with excellent outcome after appropriate antibiotic therapy. In an endemic area in case of neurological manifestations suggestive for neuroborreliosis the serological testing for B. burgdorferi in serum and cerebrospinal fluid is imperative for the correct diagnosis.

Congenital Malaria: A Rare Cause of Splenomegaly and Anemia in an American Infant

PEDIATRICS ◽  
1977 ◽  
Vol 60 (2) ◽  
pp. 209-212
Author(s):  
D. Thompson ◽  
C. Pegelow ◽  
A. Underman ◽  
D. Powars
Keyword(s):  
Plasmodium Vivax ◽  
Hemolytic Anemia ◽  
Peripheral Blood ◽  
Endemic Area ◽  
Blood Smear ◽  
Clinical Manifestations ◽  
Peripheral Blood Smear ◽  
Pregnancy Malaria ◽  
Congenital Malaria

A 38-day-old infant had fever, jaundice, hepatosplenomegaly, and a hemolytic anemia. A peripheral blood smear demonstrated intraerythrocytic malarial parasites identified as Plasmodium vivax. Maternal and infant sera contained antibodies to this species. A directed history revealed the mother had suffered several febrile illnesses in Mexico during her pregnancy. Malaria had not been diagnosed nor was it considered at the time of her delivery at this hospital. Review of this and six other cases of congenital malaria reported in this country since 1950 indicates clinical manifestations seldom appear before 3 weeks of age. Although these signs are more frequently associated with other transplacental infections, their occurrence in an infant whose mother is from or who has traveled in an endemic area should prompt consideration of the diagnosis of congenital malaria.

scholarly journals Melioidosis in Bihar, India: unearthing the first of many?

2021 ◽  
Vol 3 (9) ◽  
Author(s):  
Isra Halim ◽  
Prathyusha Kokkayil ◽  
Ravi Kirti ◽  
Rajeev Nayan Priyadarshi ◽  
Asim Sarfraz ◽  
...  
Keyword(s):  
Clinical Manifestations ◽  
Clinical Suspicion ◽  
Radiological Features ◽  
First Case ◽  
Insidious Onset ◽  
Ankle Joints ◽  
The World ◽  
Resource Poor ◽  
Empirical Antibiotics ◽  
The Right

Melioidosis, a disease with protean clinical manifestations, is prevalent in many parts of India, with established endemic hotspots on the southern coast of the country. However, it is still underdiagnosed in many resource-poor regions of the country. We report what is, to the best of our knowledge, the first case of melioidosis diagnosed and treated in Bihar, an economically underdeveloped state in East India. The patient, a 52-year-old diabetic male, presented to the outpatient department with a fever of insidious onset along with pain and restriction of movement in the right shoulder joint and right knee joint, and swelling and tenderness of bilateral ankle joints. Radiological features were suggestive of multiple joint and organ abscesses. A diagnosis of disseminated septicaemic melioidosis was confirmed microbiologically. The patient improved clinically following aggressive treatment with meropenem and cotrimoxazole. The case highlights the need for increased clinical suspicion of melioidosis and adequate diagnostic facilities, as well as the need for early institution of appropriate empirical antibiotics in suspected cases of melioidosis in this region of the world.

scholarly journals Subcutaneous calcification as a supportive radiologic finding for diagnosis of rhinofacial entomophthoromycosis

2019 ◽  
Vol 9 (2) ◽  
Author(s):  
Navarat Vatcharayothin ◽  
Pornthep Kasemsiri ◽  
Cattleya Thongrong ◽  
Chanticha Laohakittikul ◽  
Surapol Suetrong ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Early Diagnosis ◽  
Clinical Manifestations ◽  
Fungal Culture ◽  
Radiologic Finding ◽  
Radiologic Findings ◽  
Appropriate Treatment ◽  
Sinonasal Mucosa ◽  
Subcutaneous Calcification ◽  
Radiologic Evidence

Rhinofacial entomophthoromycosis is an uncommon chronic fungal infection of the head and neck. The diagnosis is usually based on clinical manifestations; however, diagnosis of this infection based on early manifestations is difficult and occasionally rhinofacial entomophthoromycosis is mistaken for other diseases. Therefore, computed tomography is introduced to support the diagnosis. Radiologic findings were nonspecific with swelling of the sinonasal mucosa and perinasal region. However, subcutaneous calcification, that was observed in all our cases, may be a supportive radiologic evidence for diagnosis. The diagnosis should be confirmed definitively using histopathology or fungal culture. Early diagnosis allows prompt and appropriate treatment that will achieve excellent outcomes. We suggest that subcutaneous calcification radiologic finding may guide the aware physician to an early diagnosis of rhinofacial entomophthoromycosis.

scholarly journals A Case of Cutaneous Purpureocillium lilacinum Infection Looking like Psoriasis

2021 ◽  
pp. 72-76
Author(s):  
Nam Gyoung Ha ◽  
Kyung Duck Park ◽  
Yong Jun Bang ◽  
Jae Bok Jun ◽  
Jong Soo Choi ◽  
...  
Keyword(s):  
Histopathological Examination ◽  
Its Region ◽  
Skin Lesions ◽  
Blue Staining ◽  
Rrna Gene ◽  
Fungal Culture ◽  
Environmental Distribution ◽  
Purpureocillium Lilacinum ◽  
Light Yellow ◽  
Oral Itraconazole

Purpureocillium lilacinum is a saprophytic fungus with a ubiquitous environmental distribution, and it can be detected in soil samples and decaying materials worldwide. It has been reported as an emerging pathogen in both immunocompromised and immunocompetent patients, showing various cutaneous presentations. Herein, we report a case of a patient with a localized cutaneous P. lilacinum infection, which resembles the skin lesions of psoriasis. A 72-year-old female was presented with a peripherally spreading, well-demarcated, asymptomatic, scaly, erythematous patch on her forehead for several months. Histopathological examination showed pinkish septated fungal elements and mixed inflammatory and granulomatous infiltrates in the dermis. Furthermore, a fungal culture on potato dextrose agar showed gray, velvety colonies with light yellow background after being subcultured. Phialides with chains of oval conidia were observed on lactophenol cotton blue staining. The ITS region of rRNA gene sequence obtained from the colony was identical to that of Purpureocillium lilacinum. The lesion was resolved with oral itraconazole (200 mg/day) after four months of treatment.

scholarly journals Sporotrichosis of Maxillary Sinus

2011 ◽  
Vol 2 (3) ◽  
pp. 269-271 ◽  
Author(s):  
NC Sandeepa ◽  
HP Jaishankar ◽  
B Sharath Chandra ◽  
SN Veena ◽  
T Yeshaswini
Keyword(s):  
Maxillary Sinus ◽  
Rare Case ◽  
Antifungal Agents ◽  
Immunocompetent Patient ◽  
The Body ◽  
Causative Organism ◽  
Fungal Culture ◽  
Mode Of Entry ◽  
Mycotic Disease ◽  
Deep Fungal Infection

ABSTRACT Sporotrichosis or Gardener's disease is a chronic nodular subcutaneous mycotic disease, causative organism being Sporotrichum schenckii. The specific mode of entry of the fungus into the body, being mainly through small cuts and punctures and rarely by inhalation; which usually manifest as cutaneous and subcutaneous infections. Here we report a rare case of sporotrichosis of maxillary sinus in an immunocompetent patient. Our case of sporotrichosis, a deep fungal infection involving maxillary sinus was confirmed by fungal culture and successfully managed by antifungal agents combined with surgical debridement.

scholarly journals Molecular Mechanisms of Curcumin in COVID-19 Treatment and Prevention: A Global Health Perspective

2020 ◽  
Vol 8 (10) ◽  
Author(s):  
Nathan Roberts ◽  
Robert Brown ◽  
L. Buja ◽  
Priya Weerasinghe
Keyword(s):  
Molecular Mechanisms ◽  
Curcuma Longa ◽  
Clinical Manifestations ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Respiratory Disorder ◽  
Therapeutic Effects ◽  
Electron Transfer Mechanism ◽  
Treatment And Prevention ◽  
History Of

Turmeric (Curcuma Longa) has a near 4000-year history of extensive medical use in South Asia. Its main physiologically active phytochemical is curcumin (diferuloylmethane), derived from the rhizome of turmeric. Curcumin is a hydrophobic polyphenol with a diketone moiety connecting two phenoxy rings. It is widely available, and exerts systemic and pleiotropic effects via several key mechanisms. Most famously, it is known to inhibit pro-inflammatory pathways such as PI3k/akt/NF-kB activation. It is also a potent antioxidant and free radical scavenger via a sequential proton loss electron transfer mechanism in ionizing solvents due to its extended conjugating ability across the entire molecule, and its ability to induce NRF-2. It has been implicated in the treatment of diseases ranging from asthma to various cancers, and is also a broad spectrum anti-microbial. COVID-19 is a novel beta-coronavirus that was declared a pandemic by the WHO in March, 2020. It is primarily a respiratory disorder, but it can spread hematogenously and effect many other organs such as the heart, nervous system, and kidneys. There is a significant intersection between the clinical manifestations of COVID-19 and curcumin’s therapeutic effects. In addition, curcumin has been shown to inhibit initial viral infectivity. Thus, there is potential for curcumin to safely both prevent and treat COVID-19 infection across the globe.

scholarly journals Thoracic Endometriosis: a Clinical Review and Update of Current and Evolving Diagnostic and Therapeutic Techniques

2021 ◽  
Author(s):  
Ravi Kanth Velagapudi ◽  
John P. Egan
Keyword(s):  
Multidisciplinary Approach ◽  
Thoracoscopic Surgery ◽  
Clinical Manifestations ◽  
Clinical Suspicion ◽  
Diagnostic Workup ◽  
Medical Thoracoscopy ◽  
High Clinical Suspicion ◽  
Wide Range ◽  
Thoracic Endometriosis ◽  
Video Assisted Thoracoscopic Surgery

Abstract Purpose of Review The goal of this review is to provide a comprehensive understanding of the pathophysiology, clinical presentation, diagnostic workup, and clinical management of thoracic endometriosis (TE), as well as highlight our personal experience with TE workup and management. Recent Findings TE can present in a wide range of clinical manifestations. Without high clinical suspicion, diagnosis can be delayed. Since no specific laboratory testing is available, diagnosis is often based on careful history taking, imaging, and direct visualization of endometrial lesions through video-assisted thoracoscopic surgery (VATS). Medical thoracoscopy (MT) may also be a useful tool in the diagnostic workup of TE. Summary The diagnosis and management of TE require a multidisciplinary approach and a high index of clinical suspicion. While VATS remains the gold standard for diagnosis, we share our experience using MT to diagnose and manage a case of TE-related hemothorax.

Antiphosphatidylserine/Prothrombin Antibodies: An Update on Their Association with Clinical Manifestations of Antiphospholipid Syndrome

2020 ◽  
Vol 120 (04) ◽  
pp. 592-598 ◽  
Author(s):  
Massimo Radin ◽  
Silvia G. Foddai ◽  
Irene Cecchi ◽  
Elena Rubini ◽  
Karen Schreiber ◽  
...  
Keyword(s):  
Antiphospholipid Syndrome ◽  
Antiphospholipid Antibodies ◽  
Odds Ratio ◽  
A Priori ◽  
Strong Association ◽  
Clinical Manifestations ◽  
Clinical Suspicion ◽  
Level Of Evidence ◽  
Robust Test ◽  
Ovid Medline

Abstract Objective The aim of the study is to perform a systematic review on the recent available evidence on antiphosphatidylserine/prothrombin (aPS/PT) antibodies and their association with clinical manifestations of the antiphospholipid syndrome (APS). Methods A detailed literature search was applied a priori to Ovid MEDLINE, In-Process and Other Non-Indexed Citation 2012 to present and to abstract from EULAR and ACR/ARHP Annual Meetings (2012–2019). Results Data from 2,901 patients, 587 diseases controls and 559 healthy controls included in 15 retrieved studies was analyzed. The patient population included 1,219 patients classified as APS according to the Sidney criteria, 285 patients with isolated persistently positive antiphospholipid antibodies (aPL) and 1,397 patients with a clinical suspicion of APS. Twelve studies, including 1,888 patients, analyzed the association between aPS/PT antibodies and thrombosis. We observed a statistically significant association between aPS/PT IgG/IgM positivity and thrombotic events (mean odds ratio [OR]: 6.8 [95% CI: 3.18–16.4], p < 0.05), confirmed when analyzing aPS/PT IgG (mean OR: 6.7 [95% CI: 3.04–21.6], p < 0.05) and aPS/PT IgM (mean OR: 4.35 [95% CI: 1.54–17.77], p < 0.05) separately. Seven studies, including 1,388 patients, evaluated the association between aPS/PT antibodies and PM. When pooled together, we found a statistically significant association between any PM and aPS/PT IgG/IgM positivity (mean OR: 10.6 [95% CI: 3.54–35.38], p < 0.05), particularly aPS/PT IgG positivity (mean OR: 6.7 [95% CI: 3.04–21.6], p < 0.05). Conclusion Our results highlight the strong association between aPS/PT and the clinical manifestations of APS. With the available level of evidence, aPS/PT testing can be considered as a robust test applicable in the investigation of patients suspected for APS, also beyond the research settings.

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