scholarly journals Hubungan Respon Imun Humoral dengan Derajat Trombositopenia pada Pasien Demam Berdarah Dengue

2017 ◽  
Vol 4 (1) ◽  
pp. 36
Author(s):  
Fatmawati Fatmawati ◽  
Chandra Wijaya
Keyword(s):  
Immune Response ◽  
Dengue Hemorrhagic Fever ◽  
Humoral Immune Response ◽  
Analytical Study ◽  
Dengue Infection ◽  
Hemorrhagic Fever ◽  
Statistical Test ◽  
Cross Sectional ◽  
Humoral Immune ◽  
Fever Patient

The correlation between humoral immune response with the level of of thrombocytopenia on dengue hemorrhagicfever patient The aim of this study was to know the correlation between humoral immune response with the level of ofthrombocytopenia on dengue hemorrhagic fever patient. This is a cross sectional analytical study on internal inpatientsof AwalBros Pekanbaru Hospital in August-November 2008. Population was all internal inpatients of AwalBros PekanbaruHospital with working diagnosis dengue hemorrhagic fever. There were 4 pattern of anti Dengue antibody : IgG-/IgM,IgG-/IgM+, IgG+/IgM-, IgG+/IgM+. Most of patients with IgG+/IgM+ and have secondary dengue infection Thoseresult were analyzed by Friedman statistical test. There isn’t a significant correlation between the level ofthrombocytopenia and anti dengue antibody. It show that there wasn’t a direct correlation between them. It could bedue to a cross reaction between anti dengue antibody with thrombocyte (autoantibody).

Humoral Immune Response of Dengue Hemorrhagic Fever Cases in Children from Tegucigalpa, Honduras

2008 ◽  
Vol 79 (2) ◽  
pp. 262-266 ◽  
Author(s):  
Ivette Lorenzana De Rivera ◽  
Leda Parham ◽  
Walter Moncada ◽  
Wendy Murillo ◽  
Susana Vazquez
Keyword(s):  
Immune Response ◽  
Dengue Hemorrhagic Fever ◽  
Humoral Immune Response ◽  
Hemorrhagic Fever ◽  
Humoral Immune

scholarly journals Impact of Humoral Immune Response and Absorption Effect on Dynamics of Dengue Virus

2017 ◽  
Vol 13 (12) ◽  
pp. 157
Author(s):  
S.D. Perera ◽  
S.S.N. Perera
Keyword(s):  
Immune Response ◽  
Dengue Virus ◽  
Humoral Immune Response ◽  
Dengue Infection ◽  
Endemic Equilibrium ◽  
Absorption Effect ◽  
Globally Asymptotically Stable ◽  
Humoral Immune ◽  
Proposed Model ◽  
Global Threat

Dengue infection represents a global threat causing 50-100 million infections per year and placing half of the world’s population at risk. Even though how infection is controlled and cured rather remains a mystery, antibodies are thought to play a major role in clearing the virus. In this paper, we study the dynamics of dengue virus with humoral immune response and absorption effect. The proposed model incorporates a time delay in production of antibodies. The basic reproduction number R0 is computed and a detailed stability analysis is done. It was found that the model has 3 steady states, namely, infection free equilibrium, no immune equilibrium and the endemic equilibrium. Conditions for R0 were developed for the local stability of these 3 equilibrium states. The global stability was studied using appropriate Lyapunov function and LaSalle’s invariance principle. We then established a condition for which the endemic equilibrium point is globally asymptotically stable. Also it was observed that the virus count goes to negligible levels within 7-14 days after the onset of symptoms.

scholarly journals Retrospective of International Serological Studies on the Formation and Dynamics of the Humoral Immune Response to SARS-CoV-2: from 2020 to 2021

2021 ◽  
Vol 6 (2) ◽  
pp. 47-57
Author(s):  
E. A. Novikova ◽  
A. G. Petrova ◽  
E. V. Moskaleva ◽  
A. S. Vanyarkinа ◽  
L. V. Rychkova
Keyword(s):  
Immune Response ◽  
Humoral Immunity ◽  
Humoral Immune Response ◽  
Herd Immunity ◽  
Clinical Manifestations ◽  
World Population ◽  
Cross Sectional ◽  
Humoral Immune ◽  
Concentration Peak ◽  
Serological Studies

Last year the COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has started. The new coronavirus is highly contagious and causes severe complications. The mechanisms of humoral immunity and kinetics of SARS-CoV-2 specific antibodies in a population are not well understood. Therefore, we aimed to summarize and analyze numerous global and Russian serological studies for understanding dynamics of the SARSCoV-2 humoral immune response and getting an accurate picture of the seroprevalence to SARS-CoV-2 in the world population. The PubMed and e-library databases were searched from February 2020 to March 2021 using terms “SARSCoV-2”, “antibodies”, “humoral immunity”. At the beginning of the pandemic first studies were cross-sectional by design and were responsible for determination of the seropositivity and for understanding the fundamental humoral immunity parameters of SARS-CoV-2. Since then, longitudinal seroepidemiological studies have been studying antibody kinetics. Seroconversion time for IgM, IgG antibodies varies, but most researchers report the seroconversion of IgM from the 1st to 14th days after the onset of clinical manifestations, and the seroconversion for IgG is around the 14th day with a concentration peak by the 21st day. Regarding seroprevalence we may say about low herd immunity at the COVID-19 pandemic. Thus, global seroprevalence is about 10 %, and more than 20 % for regions with high incidence and among healthcare workers. Seroprevalence studies have to be continued for more accurate monitoring of long-term humoral immunity to SARS-CoV-2, because the majority of the world’s population is still susceptible to SARS-CoV-2 infection. 

scholarly journals Persistence of humoral immune response to SARS-CoV-2 up to 7 months post-infection: Cross-sectional study, South India, 2020-21

2021 ◽  
Author(s):  
Jeromie Wesley Vivian Thangaraj ◽  
Muthusamy Santhosh Kumar ◽  
CP Girish Kumar ◽  
V Saravana Kumar ◽  
Nathella Pavan Kumar ◽  
...  
Keyword(s):  
Immune Response ◽  
Humoral Immune Response ◽  
Post Infection ◽  
South India ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Humoral Immune

scholarly journals EXPOSURE OF INFORMATION, FAMILY KNOWLEDGE OF DENGUE HEMORRHAGIC FEVER, AND BEHAVIORS IN IMPLEMENTING ERADICATION OF MOSQUITO NESTS IN SIDOARJO

2020 ◽  
Vol 9 (2) ◽  
pp. 219-225
Author(s):  
Meli Diana ◽  
Riesmiyatiningdyah Riesmiyatiningdyah
Keyword(s):  
Dengue Hemorrhagic Fever ◽  
Sampling Technique ◽  
Hemorrhagic Fever ◽  
Statistical Test ◽  
P Value ◽  
Test Results ◽  
Residential Areas ◽  
Cross Sectional ◽  
And Behavior ◽  
The Relationship

Dengue Hemorrhagic Fever is an infectious disease caused by one of four dengue viruses that is transmitted by mosquitoes, especially aedes aegypti and aedes albopyctus. The occurrence of outbreaks in Indonesia caused by various factors, including an environment that is still conducive to the breeding of Aedes mosquitoes, expansion of endemic areas due to the emergence of new residential areas, minimal eradication of mosquito nests, and increased population mobilization.This correlational study uses cross sectional method where the data collection is by distributing questionnaire. The number of samples in this study were three hundred (300) respondents who were drawn using stratified random sampling technique. After the data is collected then tabulated and processed using the Spearman Rho Test with p ≤ 0.05.The statistical test results of the relationship between the level of knowledge and behavior in mosquito nests eradication using the Spearmen rho test showed that p-value = 0.882> α so that it was concluded that there was no relationship between them. While the statistical test results of the relationship between information exposure and behavior mosquito nests eradication using the Spearmen rho test found that there was no relationship between the two variables p value = 0.229> α so it was concluded that there was no relationship between them.The community must be active in seeking information about dengue hemorrhagic fever and increase their participation in eradicating mosquito nests on an ongoing basis both at home and in the surrounding environment. Keywords: Information, Knowledge, DHF, PSN Behavior

scholarly journals Correlation Analysis between Ratio of C-Reactive Protein/Albumin and Severity of Dengue Hemorrhagic Fever in Children

2021 ◽  
Vol 9 (3) ◽  
pp. 136
Author(s):  
Agustin Iskandar ◽  
Yuyun Norwahyuni ◽  
Aryati Aryati ◽  
Andrea Aprilia
Keyword(s):  
Dengue Hemorrhagic Fever ◽  
Pearson Correlation ◽  
Dengue Infection ◽  
Dengue Shock Syndrome ◽  
Hemorrhagic Fever ◽  
Bromocresol Green ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Albumin Ratio ◽  
Reactive Protein

Dengue Hemorrhagic Fever (DHF) is a dengue infection which can cause shock and leads to mortality. Hypoalbuminemia is a marker of plasma leakage in DHF and correlated with severity of in fl ammatory response triggered by infection, including DHF. C-Reactive Protein (CRP) is a proin fl ammatory marker that also increases in DHF. This study aims to determine a correlation of CRP/albumin ratio with severity of DHF. Cross sectional study on pediatric patients diagnosed as DHF at Saiful Anwar Malang Hospital was done in July-December 2016. CRP levels were examined using immunoturbidimetry method, while albumin was examined by using Bromocresol Green (BCG) method. Correlation of CRP/albumin ratio with DHF severity was analyzed by using Pearson correlation test.The result showed that there were signi fi cant diff erences in CRP levels and CRP/albumin ratios in the Dengue Shock Syndrome (DSS) and non-DSS group (p = 0.002, p = 0.001, α<0.05). There was no signi fi cant diff erence in albumin level in the same group (p = 0.207, α <0.05). Positive correlation found in CRP and CRP/albumin ratio (r = 0.46, r = 0.49, α <0.01). On the contrary the negative correlation was found in albumin (r = -0.21, α <0.01). This is presumably because albumin is an acute phase protein which will decrease along with the severity of infection. In contrast, CRP will increase during the critical phase of infection. It can be concluded that the CRP/albumin ratio was positively correlated with DHF severity, as well as CRP levels, but not positively correlatedwith albumin. 

scholarly journals Reactogenicity and Immunogenicity of the Pfizer and AstraZeneca COVID-19 Vaccines

2021 ◽  
Vol 12 ◽  
Author(s):  
Waleed H. Mahallawi ◽  
Walaa A. Mumena
Keyword(s):  
Immune Response ◽  
Humoral Immune Response ◽  
Weight Status ◽  
Age Groups ◽  
Vaccine Dose ◽  
Cross Sectional Study ◽  
Enzyme Linked Immunosorbent Assay ◽  
Cross Sectional ◽  
Humoral Immune ◽  
Related Symptom

BackgroundThe relationships of the coronavirus disease 2019 (COVID-19) vaccination with reactogenicity and the humoral immune response are important to study. The current study aimed to assess the reactogenicity and immunogenicity of the Pfizer and AstraZeneca COVID-19 vaccines among adults in Madinah, Saudi Arabia.MethodsA cross-sectional study, including 365 randomly selected adult Pfizer or AstraZeneca vaccine recipients who received a homologous prime-boost vaccination between February 1st and June 30th, 2021. Data of height and weight were collected to assess the weight status of percipients. An evaluation of seropositivity for anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies was assessed using enzyme-linked immunosorbent assay (ELISA).ResultsAmong the participants, 69% (n = 250) reported at least one vaccine-related symptom. Pain at the injection site was the most frequently reported vaccine-related symptom. The mean total score for vaccine-related symptoms was significantly higher among participants who received the AstraZeneca vaccine, women, and participants with no previous COVID-19 infection (p &lt; 0.05). Spike-specific IgG antibodies were detected in 98.9% of participants after the receipt of two vaccine doses, including 99.5% of Pfizer vaccine recipients and 98.3% of AstraZeneca vaccine recipients. Significantly, higher proportions of participants in the &lt;35-year age group developed a humoral immune response after the first vaccine dose compared with the participants in other age groups.ConclusionParticipants who received the Pfizer COVID-19 vaccine reported fewer vaccine-related complications compared with those who received the AstraZeneca COVID-19 vaccine, but no serious side effects were reported in response to either vaccine. Health status and age were factors that may influence COVID-19 vaccine effectiveness for the generation of antibodies against the SARS-CoV-2 spike protein.

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