scholarly journals Correlation Analysis between Ratio of C-Reactive Protein/Albumin and Severity of Dengue Hemorrhagic Fever in Children

2021 ◽  
Vol 9 (3) ◽  
pp. 136
Author(s):  
Agustin Iskandar ◽  
Yuyun Norwahyuni ◽  
Aryati Aryati ◽  
Andrea Aprilia
Keyword(s):  
Dengue Hemorrhagic Fever ◽  
Pearson Correlation ◽  
Dengue Infection ◽  
Dengue Shock Syndrome ◽  
Hemorrhagic Fever ◽  
Bromocresol Green ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Albumin Ratio ◽  
Reactive Protein

Dengue Hemorrhagic Fever (DHF) is a dengue infection which can cause shock and leads to mortality. Hypoalbuminemia is a marker of plasma leakage in DHF and correlated with severity of in fl ammatory response triggered by infection, including DHF. C-Reactive Protein (CRP) is a proin fl ammatory marker that also increases in DHF. This study aims to determine a correlation of CRP/albumin ratio with severity of DHF. Cross sectional study on pediatric patients diagnosed as DHF at Saiful Anwar Malang Hospital was done in July-December 2016. CRP levels were examined using immunoturbidimetry method, while albumin was examined by using Bromocresol Green (BCG) method. Correlation of CRP/albumin ratio with DHF severity was analyzed by using Pearson correlation test.The result showed that there were signi fi cant diff erences in CRP levels and CRP/albumin ratios in the Dengue Shock Syndrome (DSS) and non-DSS group (p = 0.002, p = 0.001, α<0.05). There was no signi fi cant diff erence in albumin level in the same group (p = 0.207, α <0.05). Positive correlation found in CRP and CRP/albumin ratio (r = 0.46, r = 0.49, α <0.01). On the contrary the negative correlation was found in albumin (r = -0.21, α <0.01). This is presumably because albumin is an acute phase protein which will decrease along with the severity of infection. In contrast, CRP will increase during the critical phase of infection. It can be concluded that the CRP/albumin ratio was positively correlated with DHF severity, as well as CRP levels, but not positively correlatedwith albumin. 

scholarly journals Perbedaan Kadar C-Reactive Protein pada Demam Akut karena Infeksi Dengue dan Demam Tifoid

2017 ◽  
Vol 3 (3) ◽  
pp. 138
Author(s):  
Adeputri Tanesha Idhayu ◽  
Lie Khie Chen ◽  
Suhendro Suhendro ◽  
Murdani Abdullah
Keyword(s):  
Typhoid Fever ◽  
Medical Center ◽  
Demographic Data ◽  
Dengue Infection ◽  
Hemorrhagic Fever ◽  
Cross Sectional Study ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Protein Levels ◽  
Reactive Protein

Pendahuluan. Infeksi dengue dan demam tifoid merupakan penyakit endemik di Indonesia. Namun pada awal awitan demam terdapat kesulitan dalam membedakan keduanya. Oleh karena itu dibutuhkan modalitas pemeriksaan penunjang yang sederhana untuk membantu diagnosis infeksi dengue dan demam tifoid. C-Reactive Protein (CRP) merupakan alat bantu diagnostik yang terjangkau, cepat dan murah untuk diagnosis penyebab demam akut. Penelitian ini bertujuan mengetahui perbedaan kadar CRP pada demam akut karena infeksi dengue dengan demam tifoid.Metode. Penelitian ini merupakan studi potong lintang pada pasien demam akut dengan diagnosis demam dengue/ demam berdarah dengue atau demam tifoid yang dirawat di IGD atau ruang rawat RSCM, RS Pluit dan RS Metropolitan Medical Center Jakarta dalam kurun waktu Januari 2010 sampai dengan Desember 2013. Kadar CRP yg diteliti adalah CRP yang diperiksa 2-5 hari setelah awitan demam. Data penyerta yang dikumpulkan adalah data demografis, data klinis, pemberian antibiotik selama perawatan, leukosit, trombosit, neutrofil, LED dan lama perawatan.Hasil. Sebanyak 188 subjek diikutsertakan pada penelitian ini, terdiri dari 102 pasien dengue dan 86 pasien demam tifoid. Median (RIK) CRP pada infeksi dengue 11,65 (16) mg/L dan pada demam tifoid 53 (75) mg/L. Terdapat perbedaan median CRP yang bermakna antara infeksi dengue dan demam tifoid (p <0,001). Pada titik potong persentil 99%, didapatkan hasil kadar CRP infeksi dengue sebesar 45,91 mg/L dan kadar CRP demam tifoid pada level persentil 1% sebesar 8 mg/L.Simpulan. Terdapat perbedaan kadar CRP pada demam akut karena infeksi dengue dengan demam tifoid. Pada titik potong persentil 99%, kadar CRP >45,91 mg/L merupakan diagnostik CRP untuk demam tifoid, kadar CRP <8 mg/L merupakan diagnostik CRP untuk infeksi dengue. kadar CRP 8-45,91 mg/L merupakan area abu-abu dalam membedakan diagnosis keduanya.Kata Kunci: dengue, demam tifoid, protein C-reaktif The Difference of C-Reactive Protein Levels in Acute Fever caused by Dengue and Typhoid InfectionsIntroduction. Dengue infection and typhoid fever are endemic disease in Indonesia. But in the early days of onset sometimes it is difficult to distinguish them. A simple modality test is needed to support the diagnosis. C-Reactive Protein (CRP) is an affordable, fast and relatively less expensive diagnostic tool to diagnose the causes of acute fever. This study was aimed to determine the differences of CRP level in the acute febrile caused by dengue infection or typhoid fever. Methods. A cross sectional study has been conducted among acute febrile patients with diagnosis of dengue fever/ dengue hemorrhagic fever or typhoid fever who admitted to the emergency room or hospitalized in Cipto Mangunkusumo Hospital, Pluit Hospital, and Metropolitan Medical Center Hospital Jakarta between January 2010 and December 2013. Data obtained from medical records. CRP used in this study was examined at 2-5 days after onset of fever. The other collected data were demographic data, clinical data, use of antibiotics, leukocytes, platelets, neutrophils, ESR, and length of stay in hospital. Results. 188 subjects met the inclusion criteria; 102 patients with dengue and 86 patients with typhoid fever. Median CRP levels in dengue infection was 11.65 (16) mg/L and in typhoid fever was 53 (75) mg/L. There were significant differences in median CRP levels between dengue infection and typhoid fever (p < 0.001). At the 99% percentile cut-off point, CRP levels for dengue infection was 45.91 mg/L and CRP levels for typhoid fever at 1% percentile was 8 mg / L. Conclusions. There was significantly different levels of CRP in acute fever due to dengue infection and typhoid fever. At the 99% percentile cut-off point, CRP level >45.91 mg/L was diagnostic for typhoid fever, CRP level <8 mg/L was diagnostic for dengue infection. CRP level between 8 to 45.91 mg/L was a gray area for determining diagnosis of dengue infection and typhoid fever. Keywords: C-reactive protein, dengue, typhoid fever  

scholarly journals Comparison of serial blood lactate level between dengue shock syndrome and dengue hemorrhagic fever (evaluation of prognostic value)

2007 ◽  
Vol 47 (4) ◽  
pp. 150 ◽  
Author(s):  
M. Tatang Puspanjono ◽  
Abdul Latief ◽  
Alan R. Tumbelaka ◽  
Sudigdo Sastroasmoro ◽  
Hartono Gunardi
Keyword(s):  
Oxygen Saturation ◽  
Blood Lactate ◽  
Dengue Hemorrhagic Fever ◽  
Lactate Level ◽  
Venous Blood ◽  
Dengue Shock Syndrome ◽  
Hemorrhagic Fever ◽  
Blood Lactate Level ◽  
Cross Sectional ◽  
The Difference

Background Dengue shock syndrome (DSS) mortality is still high.Monitoring of blood lactate level is important to evaluate shock.Objectives The study were to review the difference between bloodlactate level of DSS and that of dengue hemorrhagic fever (DHF),to correlate blood lactate level with hypoxia state as shock riskfactors (PaO 2 , oxygen saturation, and anion gap) and to determinethe cut-off point of blood lactate level to predict shock.Methods The study was carried out at the Department of ChildHealth, Medical School, University of Indonesia, CiptoMangunkusumo Hospital, Jakarta, from January until July 2006.Three mL venous blood specimen was collected from all subjectsfor peripheral blood, blood gasses, serology, and blood lactateexaminations. This study consisted of a retrospective cohort anda cross sectional method. Data were analyzed with Chi-squaretest. Continous data tested using Mann-Whitney method. Toknow the correlation between blood lactate level and shock riskfactors we use logistic regression test.Results In DSS group, 73% shows hyperlactatemia (lactate =2mmol/L). Conversion of lactate means between two groups issignificantly different from day one to day two and three. Therewas a negative correlation between lactate level and pO 2 andoxygen saturation. Oxygen saturation is the only value that hasclinical correlation. Regressions analysis can be applied using Y= 7.05–0.05 X equation. The cut-off point of lactate level asmarker for shock by using ROC curve is 32.015 mmol/L with 70%sensitivity and 83.3% specificity.Conclusions Hyperlactatemia in DSS can be considered as a signfor unappropriate treatment of shock. Blood lactate level can beused as a biochemical marker for tissue hypoxia, to assess severityof the disease, as monitoring of treatment, and has prognosticvalue of DHF cases.

Shock Prognostic Factors in Hospitalized Dengue Hemorrhagic Fever Children

2018 ◽  
Vol 24 (8) ◽  
pp. 6221-6224
Author(s):  
Hindra Irawan Satari ◽  
Rossy Agus Mardani ◽  
Hartono Gunardi
Keyword(s):  
Prognostic Factors ◽  
Dengue Hemorrhagic Fever ◽  
Dengue Infection ◽  
Clinical Manifestations ◽  
Dengue Shock Syndrome ◽  
Hemorrhagic Fever ◽  
Health Department ◽  
Abdominal Tenderness ◽  
Diverse Area ◽  
Plasma Leakage

Various clinical manifestations, complex pathogenesis and different virus serotypes in diverse area make us difficult to predict course of disease, even the child admitted in early. Prognostic factors are very important to predict cases progressing to become DSS. Dengue shock syndrome (DSS) occurs in 15.53% of Dengue hemorrhagic fever (DHF) patients with 7.81% mortality rate. Aim: To explore the prognostic factors of shock in hospitalized DHF children regarding the new 2011 WHO dengue virus infection classification guideline. This was a retrospective study using medical records of children age below 18 years old with WHO fulfilled grade 1 and 2 DHF diagnosis from January 2013–December 2016 in Child Health Department of Dr. Cipto Mangunkusumo Hospital, Jakarta. Independent variables were sex, age, nutritional status, secondary dengue infection, leucopenia, abdominal tenderness, gastrointestinal bleeding, hepatomegaly and plasma leakage. Shock was dependent variable. Multivariate analysis was done by using logistic regresion analysis. There were 98 DHF subjects, 5 subjects became DSS during hospitalization. DSS subject characteristics were age of >5 years old, female, malnutrition, abdominal tenderness, hemoconcentration ≥20%, secondary dengue infection, leucocyte ≥5.000 mm3 and thrombocyte <50.000 mm3. Multivaryate analysis showed malnutrition and hepatomegaly were prognosis factors of DSS. Malnutrition and hepatomegaly were prognotic factors of dengue shock syndrome. Clinicians should be more aware with these factors when managed hospitalized DHF patients.

scholarly journals Participation of Housewives in Prevention of Dengue Hemorrhagic Fever in Sub-District Muara Dua, Lhokseumawe, Aceh, Indonesia

2020 ◽  
Vol 2 (1) ◽  
pp. 222-229
Author(s):  
Wahyu Ajisah ◽  
Irnawati Marsaulina ◽  
R. Kintoko Rochadi
Keyword(s):  
Dengue Fever ◽  
Dengue Hemorrhagic Fever ◽  
Pearson Correlation ◽  
Water Reservoir ◽  
Hemorrhagic Fever ◽  
Cross Sectional ◽  
Dengue Disease ◽  
Prevention Services ◽  
Raising Awareness ◽  
Knowledge And Attitude

Indonesia is a dengue endemic area and it has an epidemic once in 4-5 years. Until now it tends to increase in number of cases as well as its widespread. Researchers investigated that socio-demography, knowledge and attitudes related to dengue disease affecting the participation of housewives in prevention of dengue fever dengue mosquito through questionnaires and interviews. This research was conducted descriptively with cross sectional approach to 72 housewives in sub-district Muara Dua, Lhokseumawe, Aceh, Indonesia using sample purposive sampling process. The relationship between the characteristics of housewives with their involvement in prevention of Dengue Hemorrhagic Fever (DHF) was analyzed using Pearson correlation analysis. More than 75% of respondents live in endemic areas and over 68% of respondents knew that dengue is transmitted through mosquitoes. 50% of respondents knew that 3M (draining the water reservoir, closing the water reservoir and burying the garbage) Plus as DHF prevention but only 37.5% of respondents have applied 3M Plus even though they know that it needs to be continuously done throughout the year especially in the rainy season. The respondents' participation in prevention of DHF disease in moderate category was 50 respondents (69.44%), 9 respondents (12.5%) were categorized as low in participation and only 13 respondents (18.06%) were categorized as very good in participation in the effort to eliminate DHF. There was a highly significant correlation between knowledge and attitude (p <0.01) and there was a significant correlation in education (p <0.05) of housewives with their actions in the prevention of dengue hemorrhagic fever. This reflects the urgent need for advocacy programs in raising awareness of DHF in the community. The nearest inter-sector collaborates with the medical, veterinary, community and local authority sectors to ensure the availability of DHF prevention services besides 3M Plus, also a monitoring officer/home and public health service to undertake health promotion programs of DHF prevention. This is a key element to eliminate deaths from dengue fever which occur every year.

scholarly journals Hubungan Respon Imun Humoral dengan Derajat Trombositopenia pada Pasien Demam Berdarah Dengue

2017 ◽  
Vol 4 (1) ◽  
pp. 36
Author(s):  
Fatmawati Fatmawati ◽  
Chandra Wijaya
Keyword(s):  
Immune Response ◽  
Dengue Hemorrhagic Fever ◽  
Humoral Immune Response ◽  
Analytical Study ◽  
Dengue Infection ◽  
Hemorrhagic Fever ◽  
Statistical Test ◽  
Cross Sectional ◽  
Humoral Immune ◽  
Fever Patient

The correlation between humoral immune response with the level of of thrombocytopenia on dengue hemorrhagicfever patient The aim of this study was to know the correlation between humoral immune response with the level of ofthrombocytopenia on dengue hemorrhagic fever patient. This is a cross sectional analytical study on internal inpatientsof AwalBros Pekanbaru Hospital in August-November 2008. Population was all internal inpatients of AwalBros PekanbaruHospital with working diagnosis dengue hemorrhagic fever. There were 4 pattern of anti Dengue antibody : IgG-/IgM,IgG-/IgM+, IgG+/IgM-, IgG+/IgM+. Most of patients with IgG+/IgM+ and have secondary dengue infection Thoseresult were analyzed by Friedman statistical test. There isn’t a significant correlation between the level ofthrombocytopenia and anti dengue antibody. It show that there wasn’t a direct correlation between them. It could bedue to a cross reaction between anti dengue antibody with thrombocyte (autoantibody).

scholarly journals Is there any relationship between C-reactive protein/albumin ratio and clinical severity of childhood community-acquired pneumonia

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Hayrunnisa Bekis Bozkurt
Keyword(s):  
Severe Pneumonia ◽  
Multivariate Regression Analysis ◽  
Blood Parameters ◽  
Community Acquired Pneumonia ◽  
Clinical Severity ◽  
Control Group ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Albumin Ratio ◽  
Reactive Protein

Abstract Objectives To investigate the relationship between the ratios of C-reactive protein (CRP)/albumin, neutrophil/lymphocyte (NLR), monocyte/lymphocyte (MLR), mean platelet volume (MPV)/platelet and erythrocyte sedimentation rate (ESR)/albumin in pediatric patients diagnosed with community-acquired pneumonia based on the severity of the disease. Methods This retrospective cross-sectional study included 52 patients with mild pneumonia, 30 with severe pneumonia, and 46 healthy controls. Whole blood parameters, CRP, ESR, and albumin values and ratios were recorded at the time of admission. The multivariate regression analysis, Pearson’s correlation and ROC curve analyses were performed. Results The CRP/albumin, ESR/albumin, NLR and CRP values were significantly higher in the severe pneumonia group compared to both the other pneumonia group and the control group (p<0.005). According to the regression and correlation analyses, these values were positively correlated (p<0.001). For CRP/Albumin ratio, ESR/albumin ratio calculated OR were 2.103 (CI: 1.675–2.639); 1.907 (CI: 1.552–2.344); respectively. Conclusions The data presented can be a guide in the follow-up and treatment of this patient group.

scholarly journals Deranged liver among Sudanese Patients with Dengue Virus Infection in Port Sudan Teaching Hospital

2017 ◽  
Vol 12 (3) ◽  
pp. 187
Author(s):  
Bashir Abdrhman Bashir Mohamed
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Teaching Hospital ◽  
Hepatic Dysfunction ◽  
Dengue Infection ◽  
Moderate Increase ◽  
C Reactive Protein ◽  
Dengue Virus Infection ◽  
Cross Sectional ◽  
Reactive Protein

Background Deranged liver is a well-recognized feature of dengue infection, often demonstrated by coagulopathy and mild to moderate increase in transaminase levels although jaundice and fulminant hepatic failure are generally uncommon. Objective This study aimed to evaluate the hepatic effect of dengue fever amongst Sudanese patients.Materials and Methods A cross-sectional descriptive study recruited in Port Sudan teaching hospital in the period from February 2013 to June 2014.  334 cases of dengue along with 101 cases of control were enrolled. Rapid immune chromatographic test was used to confirm positive dengue cases and WHO criteria were used for classifying the dengue severity. Prothrombin time (PT), partial thromboplastin time (PTT), fibrinogen level (FB), platelet count (PLT), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and C-reactive protein (CRP) were all measured. Results PT, PTT, and FB were found to be significantly higher in the infected cohort when compared to the controls (P< 0.0001). PT was prolonged in 9%, PTT was prolonged in 12.6% and shortened by 5.4% of the patients, whereas hypofibrinogenemia in 18.3% and hyperfibrinogenemia in 67.4% of the patients. Bleeding was seen in 10.5% of patients and thrombocytopenia was detected in 83.5% of patients. Out of 334 patients, 101 (30.2%) had abnormal coagulation results. Of 101 patients, 72 were subjected mixing studies for PT and PTT that revealed deficiencies in factors VIII (35%), IX (10%), V (10%), X (19%), and XII (14%). 43.6% patients had elevated AST and 21.8% had elevated ALT.ConclusionThis study demonstrated that hepatic dysfunction may be attributed to dengue virus infection which evident by prolongation in PT and PTT as well as hypofibrinogenemia and factor deficiencies.    

scholarly journals Importance of Platelet Count and Hematocrit in Dengue Fever in Children

2021 ◽  
Vol 44 (2) ◽  
pp. 74-77
Author(s):  
Farhana Rahat ◽  
Morsheda Khanam ◽  
Kazi Iman ◽  
UK Ghosh ◽  
NK Ghosh
Keyword(s):  
Platelet Count ◽  
Dengue Fever ◽  
Dengue Hemorrhagic Fever ◽  
Dengue Infection ◽  
Tertiary Care ◽  
Dengue Shock Syndrome ◽  
Hemorrhagic Fever ◽  
Warning Signs ◽  
Care Hospital ◽  
Pediatric Age Group

Background: Dengue fever has become one of the most important public health concerns now a day due to increasing complications and fatal outcomes. Dengue hemorrhagic fever and dengue shock syndrome are life threatening but reversible complications of dengue fever. Objectives: This study was performed to evaluate the relationship between platelet count and hematocrit with the severity of dengue infection in pediatric age group. Materials & Methods: This was a prospective observational study which included 280 dengue seropositive children of 1 month to 15 years, conducted during 1st June to 30th November, 2018 in a tertiary care hospital of Dhaka. Results: Out of 280 dengue cases, 187(66.78%) had thrombocytopenia and 88(47%) had raised hematocrit. Among the thrombocytopenic patients 44% had dengue fever, 47% had dengue hemorrhagic fever and 9% dengue shock syndrome. A significant co-relation was observed between the severities of thrombocytopenia and raised hematocrit with the appearance of dengue warning signs in case of dengue hemorrhagic fever. Conclusion: Thrombocytopenia and raised hematocrit were related to the severity of dengue hemorrhagic fever. Bangladesh J Child Health 2020; VOL 44 (2) :74-77

scholarly journals HUBUNGAN JUMLAH TROMBOSIT DAN JUMLAH LEUKOSIT PADA PASIEN ANAK DEMAM BERDARAH DENGUE

2013 ◽  
Vol 1 (1) ◽  
Author(s):  
Jilly J. G. Masihor ◽  
Max F. J. Mantik ◽  
Maya Memah ◽  
Arthur E. Mongan
Keyword(s):  
Dengue Hemorrhagic Fever ◽  
Pearson Correlation ◽  
Hemorrhagic Fever ◽  
P Value ◽  
Inclusion Criteria ◽  
Laboratory Findings ◽  
Cross Sectional ◽  
Pearson’S Correlation ◽  
Correlation Test ◽  
Pearson's Correlation

Abstract: Dengue hemorrhagic fever (DHF) is an acute fever disease with high mortality and morbidity in many regions of the world. Leucopenia and thrombocytopenia are two of several laboratory findings that could be found in the course of DHF. This was an analytical retrospective study with a cross sectional design. Samples were patients diagnosed with DHF in Prof. Dr. R.D Kandou General Hospital Manado during the period of 2012. The inclusion criteria were patients <15 years, were diagnosed as DHF according to WHO 1997 criteria, and were examined for platelet and white blood cell count. This study used the medical record data which were analyzed statistically by using the Pearson's correlation test. There were 137 children with DHF during the period of 2012. Samples were 56 children that fulfiled the inclusion criteria. The Pearson correlation test showed a P value 0.801 and correlation coefficient r = -0.034 that indicated that there was a negative correlation which was not significant. Conclusion: There was no significant correlation between the number of thrombocytes and leukocytes in children with dengue hemorrhagic fever.Keywords: dengue hemorrhagic fever, leukocyte, thrombocyteAbstrak: Demam berdarah dengue (DBD) merupakan penyakit demam akut dengan morbiditas dan mortalitas yang tinggi di banyak daerah di dunia. Leukopenia dan trombositopenia merupakan dua temuan laboratorik yang sering ditemukan pada DBD. Penelitian ini bersifat analitik retrospektif dengan pendekatan potong lintang. Sampel penelitian ialah pasien anak yang terdiagnosis DBD di RSUP Prof. Dr. R.D. Kandou Manado selama periode tahun 2012. Pasien yang masuk dalam kriteria inklusi ialah pasien < 15 tahun, telah terdiagnosis menurut kriteria WHO 1997, serta melakukan pemeriksaan laboratorium trombosit dan leukosit. Penelitian ini menggunakan catatan rekam medik, dan untuk analisis statistik digunakan Pearson’s correlation test. Terdapat 137 anak dengan demam berdarah dengue pada periode 2012 dan 56 anak menjadi sampel dalam penelitian ini. Hasil penelitian melalui uji korelasi Pearson mendapatkan nilai P = 0,801 dan koefisien korelasi r = -0,034 yang berarti bahwa korelasi tidak bermakna, dengan kekuatan korelasi lemah dan arah korelasi negatif. Simpulan: Tidak terdapat hubungan yang bermakna antara jumlah trombosit dan leukosit pada pasien anak demam berdarah dengue.Kata kunci: demam berdarah dengue, leukosit, trombosit

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