A Rare Occurrence of Primary Breast Mucormycosis, A Case Report

2021 ◽  
pp. 222
Author(s):  
Keyword(s):  
Soft Tissue ◽  
Antifungal Agents ◽  
Clinical Presentation ◽  
Hematologic Malignancy ◽  
Surgical Excision ◽  
Pulmonary Complications ◽  
Rare Occurrence ◽  
Transplant Recipients ◽  
Immunosuppressed Patients ◽  
Common Clinical Presentation

Zygomycosis occurs primarily in immunosuppressed patients and those with diabetes mellitus. Incidence of zygomycosis has increased among transplant recipients, patients with hematologic malignancy and Covid-19 associated pulmonary complications. Soft tissue zygomycosis may be localized, extend to deep underlying tissues, or may be disseminated. The most common clinical presentation is induration of the skin with surrounding erythema, rapidly progressing to necrosis.Histological examination and culture of soft tissue are important for the diagnosis of cutaneous zygomycosis. Treatment consists of surgical excision or debridement, reversal of predisposing factors and administration of antifungal agents (amphotericin B formulations, Posaconazole/or Isavuconazole).

scholarly journals Subungual Glomus Tumor- Clinical Presentation And Treatment

2014 ◽  
Vol 3 (2) ◽  
pp. 45-48 ◽  
Author(s):  
Shyamal Chandra Debnath ◽  
Suman Kumar Roy ◽  
RR Kairy
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Tumor ◽  
Clinical Presentation ◽  
Glomus Tumor ◽  
Rare Condition ◽  
Surgical Excision ◽  
Tissue Mass ◽  
Delay In Diagnosis ◽  
Nail Deformity

Glomus tumor is a rare condition and constitutes only 1 % of all soft tissue tumor of body. Glomus tumor is familiar for its unusual presentation and long standing symptoms due to delay in diagnosis. Authors have presented the clinical behavior and treatment of 7 patients with subungual soft tissue mass. Following surgical excision, all patients cured of symptoms, at the end of follow up, no recurrence occurred; post operative nail deformity was insignificant. DOI: http://dx.doi.org/10.3329/bdjps.v3i2.18250 Bangladesh Journal of Plastic Surgery July 2012, 3(2): 45-48

scholarly journals Discordance Between Radiologic Findings and Molecular Testing in Patients With Underlying Hematologic Malignancy and Coronavirus Disease 2019

2020 ◽  
Vol 7 (9) ◽  
Author(s):  
Mohammed Raja ◽  
Yoichiro Natori ◽  
Aditya Chandorkar ◽  
Jose F Camargo ◽  
Jacques Simkins ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Clinical Presentation ◽  
Hematologic Malignancy ◽  
Severe Disease ◽  
Molecular Testing ◽  
Radiographic Findings ◽  
X Ray ◽  
Radiologic Findings ◽  
Immunosuppressed Patients ◽  
Chest X Ray

Abstract Severe acute respiratory syndrome coronavirus 2 is associated with severe disease in patients with hematologic malignancy. We report a series of patients with underlying hematologic malignancy and coronavirus disease of 2019 with discrepancy between radiographic findings and molecular testing. Initial chest x-ray findings should raise suspicion in immunosuppressed patients with typical clinical presentation even with negative initial testing.

scholarly journals Mucormycosis and chromoblastomycosis occurring in a patient with leprosy type 2 reaction under prolonged corticosteroid and thalidomide therapy

2012 ◽  
Vol 87 (5) ◽  
pp. 767-771 ◽  
Author(s):  
Flávia Machado Alves Basílio ◽  
Mariana Hammerschmidt ◽  
Maira Mitsue Mukai ◽  
Betina Werner ◽  
Rosângela Lameira Pinheiro ◽  
...  
Keyword(s):  
Risk Factors ◽  
Opportunistic Infections ◽  
Surgical Excision ◽  
Immunosuppressed Patient ◽  
Rare Occurrence ◽  
Work Activities ◽  
Immunosuppressed Patients ◽  
Multibacillary Leprosy ◽  
Neutrophil Dysfunction

Mucormycosis is an uncommon fungal infection caused by Mucorales. It frequently occurs in patients with neutropenia, diabetes, malignancy and on corticoid therapy. However, it is rare in patients with AIDS. Clinical disease can be manifested in several forms. The case reported illustrates the rare occurrence of chromoblastomycosis and mucormycosis in an immunosuppressed patient with multibacillary leprosy, under prolonged corticosteroid and thalidomide therapy to control leprosy type 2 reaction. Neutrophil dysfunction, thalidomide therapy and work activities are some of the risk factors in this case. Chromoblastomycosis was treated by surgical excision and mucormycosis with amphotericin B. Although the prognosis of mucormycosis is generally poor, in the reported case the patient recovered successfully. This case should alert dermatologists to possible opportunistic infections in immunosuppressed patients.

scholarly journals Surgical Excision of Mycosis Fungoides Using Thumb-Sparing Reconstruction

Hand ◽  
2016 ◽  
Vol 12 (2) ◽  
pp. NP22-NP26 ◽  
Author(s):  
Giancarlo McEvenue ◽  
Ashley Kim ◽  
Paul Binhammer
Keyword(s):  
Soft Tissue ◽  
Mycosis Fungoides ◽  
Hematologic Malignancy ◽  
Surgical Excision ◽  
Soft Tissue Tumors ◽  
Careful Consideration ◽  
Cutaneous Manifestations ◽  
Radial Forearm ◽  
History Of ◽  
Tumors Of The Hand

Background: The differential for soft tissue tumors of the hand and upper limb is broad. Hematologic malignancy remains quite low on the differential for soft tissue tumors involving the hand, and there is little in the literature describing surgical management of such cutaneous manifestations. When the tumor is large or involves the thumb, careful consideration of reconstructive options is required. Methods: We present a rare case of an aggressively enlarging mycosis fungoides, a cutaneous T-cell lymphoma tumor, involving the thumb. This tumor had a history of multiple failed treatment attempts, including radiation and chemotherapy. Results: Our surgical plan was a reverse radial forearm osteocutaneous flap. Conclusion: A reverse radial osteocutaneous forearm flap was successfully used to avoid thumb amputation and preserve thumb function.

scholarly journals Nodular Fasciitis: A Tumor with Misnomer!

2020 ◽  
Vol 5 (6) ◽  
Keyword(s):  
Soft Tissue ◽  
Benign Tumor ◽  
Clinical Presentation ◽  
Malignant Lesion ◽  
Benign Neoplasm ◽  
Surgical Excision ◽  
Needle Aspiration ◽  
Nodular Fasciitis ◽  
Reactive Process ◽  
Complete Surgical Excision

Nodular fasciitis is a peculiar a tumor in its clinical presentation and cytological appearance, owing to its similarity with soft tissue sarcoma. It is a rare benign neoplasm most commonly occurring in the upper extremity. Meanwhile it is selflimiting reactive process mimicking malignant lesion composed of Fibroblasts and Myoblasts. Here we are reporting two cases in the hand, with varied clinical presentation, were treated with complete surgical excision and pathologically confirmed to be Nodular Fasciitis. The term Nodular Fasciitis although pathologically is indicative of an inflammatory process, clinically it seems to be misleading since “Fasciitis” usually denotes an acute serious soft tissue infection. As per literature, this benign tumor is often described as pseudo-sarcomatous, yet its title gives no hint of such a concern. After dealing with the presented cases and the literature review it is evident that, diagnosing this specific lesion on basis of clinical picture, MRI or fine needle aspiration is very unlikely. Most cases will end up having surgical excision due to its frequently alarming presentation.

scholarly journals Axillary fibromatosis with radiological-pathological correlation: a case report and literature review

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Flávia Sprenger ◽  
Sofia Tokars Kluppel ◽  
Valmir Vicente Filho ◽  
Ana Carolina Staats ◽  
Raul Alberto Anselmi Junior ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Color Doppler ◽  
Young Patients ◽  
Microscopic Analysis ◽  
Surgical Excision ◽  
Soft Tissue Tumors ◽  
Histopathological Study ◽  
Diagnosis Delay ◽  
Beta Catenin ◽  
Clear Cytoplasm

Abstract Background The term fibromatosis refers to a spectrum of soft tissue tumors resulting from the unbridled proliferation of fibroblasts, with high infiltrative power. It is a rare neoplasm, with an incidence of about 3 cases per million. Most common sites include the abdominal wall and cavity, chest wall, scapular area, and the limbs, rarely affecting the axilla. Imaging plays a major role in surgical planning and clinical follow-up. Differential diagnosis with other soft tissue tumors may be arduous, but a correct evaluation is fundamental. Case presentation A 33-year-old case is reported for the evaluation of a palpable hardened and immobile left axillary nodule. The ultrasound reveals a solid, elongated, heterogeneous, poorly delimited, infiltrative lesion observed in the left axillary hollow, with no detectable flow in the color Doppler mode. At magnetic resonance imaging, the same elongated and expansive lesion was better defined, revealing its irregular contours, alternating areas of hypo- and hyperintense on T2, heterogeneous enhancement, and no signs of signal decay on in- and out-of-phase sequences. Due to its growth and local invasion potential, surgical excision was performed. The microscopic analysis showed long and uniform spindle cell fascicles, with clear cytoplasm and wavy nuclei, arranged in different directions, included in collagen stroma. Immunohistochemistry was positive for nuclear beta-catenin, confirming the diagnosis of fibromatosis. Conclusion Imaging methods reflect the heterogeneous nature of the lesion. This study demonstrates the importance of using a multidisciplinary approach in addition to imaging tests and histopathological study for better diagnosis and therapeutic planning. The high infiltrative power always must be reminded of, since it affects young patients and diagnosis delay can lead to mutilating surgeries.

Unusual childhood extramedullary hematologic malignancy with natural killer cell properties that contains tropomyosin 4–anaplastic lymphoma kinase gene fusion

Blood ◽  
2001 ◽  
Vol 98 (4) ◽  
pp. 1209-1216 ◽  
Author(s):  
Sandra J. Meech ◽  
Loris McGavran ◽  
Lorrie F. Odom ◽  
Xiayuan Liang ◽  
Lynne Meltesen ◽  
...  
Keyword(s):  
Nk Cells ◽  
Natural Killer ◽  
Tumor Cells ◽  
Functional Properties ◽  
Anaplastic Lymphoma Kinase ◽  
Clinical Presentation ◽  
Hematologic Malignancy ◽  
Malignant Cells ◽  
Neoplastic Cells ◽  
Anaplastic Lymphoma

This report describes an unusual extramedullary hematologic malignancy in an 18-month-old child who presented with a capillary leak syndrome that evolved into hyperleukocytosis with malignant cells. The circulating tumor cells did not express an antigen profile typical of any subtype of leukemia commonly observed in children. Tumor cells were CD3−/CD56+; had germline TCRgenes; and strongly expressed CD30, epithelial membrane antigen, and anaplastic lymphoma kinase (ALK) consistent with a null cell anaplastic large cell lymphoma (ALCL). The malignant cells contained a t(2;19)(p23;p13.1) that interrupted ALK and translocated it to the der(19). Reverse transcriptase-polymerase chain reaction and nucleotide sequence analysis revealed fusion of ALK to tropomyosin 4, an ALK fusion partner not described previously in hematologic malignancies. The clinical presentation and phenotypic features of this malignancy were not typical for ALCL because tumor cells expressed both myeloid (CD13, CD33, HLA-DR) and natural killer (NK) cell antigens. The neoplastic cells most resembled NK cells because in addition to being CD3−/CD56+ with germline TCR genes, these cells were CD25+/CD122+/granzyme B+ and possessed the functional properties of immature NK cells. The unusual clinical presentation, immunophenotype, and functional properties of these neoplastic cells suggest that this malignancy may be derived from the putative myeloid-NK precursor cell. Furthermore co-expression of NK and ALCL features supports the concept that a minority of null-ALCL may be derived from NK cells and expands the spectrum of phenotypes that can be seen in tumors produced by ALK fusion proteins.

A Case of Multiple Chemical Sensitivities: Cognitive Therapy for Somatization Disorder and Metaworry

2003 ◽  
Vol 17 (3) ◽  
pp. 267-277 ◽  
Author(s):  
Scott Temple
Keyword(s):  
Cognitive Therapy ◽  
Unusual Case ◽  
Clinical Presentation ◽  
Somatization Disorder ◽  
Case Conceptualization ◽  
Marital Problems ◽  
Multiple Chemical Sensitivities ◽  
Common Clinical Presentation ◽  
History Of ◽  
Multiple Chemical

“Multiple chemical sensitivities” has become an increasingly common clinical presentation to physicians, though it is infrequently seen by psychotherapists. This case report describes a 61-year-old woman who presents with a long history of chemical sensitivities, that led to a somatization disorder with debilitating agoraphobia, depression, and marital problems. Features of a variety of anxiety disorders are present, as are metacognitions that required an unusual case conceptualization. A cognitive therapy case conceptualization and treatment are described, which address the highly idiosyncratic clinical presentation of this patient.

Rare Facial Clefts

2015 ◽  
Vol 87 (8) ◽  
Author(s):  
Marta Fijałkowska ◽  
Bogusław Antoszewski
Keyword(s):  
Surgical Treatment ◽  
Soft Tissue ◽  
Clinical Presentation ◽  
Treatment Plan ◽  
General Rule ◽  
Common Type ◽  
Facilitated Communication ◽  
Facial Clefts ◽  
Therapeutic Problem ◽  
Variable Clinical Presentation

AbstractIn 1976 Dr. Paul Tessier described numeric classification for rare craniofacial clefts. He first emphasized that a fissure of the soft tissue corresponds, as a general rule, to a cleft of the bony structure. The classification, easy to understand, became widely accepted because the recording of the malformations was simple and facilitated communication between observers.was to present our own experience with treatment of patients with rare facial clefts.Our Department has 11 patients with rare craniofacial clefts under its care. This group includes 8 boys and 3 girls. The patients aged from 2 months to 18 years at the time of the first consultation.In two patients the cleft was median, in seven patients it was one-sided and in two – bilateral. The most common type of cleft was number 6, and the rarest were 2, 3, and 7. All patients underwent surgical treatment.Atypical facial clefts are rare congenital anomalies, however because of functional and aesthetic disturbances they constitute a serious medical and therapeutic problem. Facial clefts are characterized by variable clinical presentation and require individualized treatment plan.

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