The metabolic effect of fructose on normal rats in a mild dose with glucose and saccharose as control

Aims: To study the metabolic effects of fructose, glucose and saccharose in a moderate dose by analyzing changes of blood indicators, pancreas inflammation, liver fat accumulation and intestinal microbiota in normal Sprague-Dawley (SD) rats. Subjects and methods: Six-week-old rats were assigned to four groups (n = 10), which were gavaged with normalsaline (Con), glucose dissolved in normal saline (Glu), saccharose-glucose dissolved in normal saline (Sac), and fructose dissolved in normal saline (Fru) for 20 weeks. Results: No significant differences in body weight and blood parameters including total cholesterol (TC), total triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), lipase (LPS) and free fatty acid (FFA) among the Con, Glu, Sac and the Fru group. The fructose can significantly (P < 0.05) decrease fasting and postprandial blood glucose increase compared to glucose, and the risk of pancreas inflammation and liver fat accumulation induced by fructose is lower than glucose in rats. We found there were no significant differences in intestinal microbial diversity. At the family level, rats in the Glu group had a relatively higher abundance of Peptostreptococcaceae and rats in the Fru group had a relatively higher abundance of Bacteroidaceae. Moreover, the proportions of Peptostreptococcaceae romboutsia and Staphylococcus lentus in the Glu group were significantly higher than in the Fru group, while the proportions of Lachnospira; Lachnospiraceae blautia, Bacteroides and Cellulosilyticus in the Fru group were significantly higher than in the Glu group. The concentration of isobutyric acid was relatively lower in all the sugar treated groups than in the Con. A significant decrease in isobutyric acid was found on comparing the Fru group to the Con group (P < 0.05). Conclusion: Fructose, glucose and sucrose made no significant changes on rats in body weight, blood indicators, organ index and bacterial diversity. Moreover, fructose can potentially attenuate fasting and postprandial blood-glucose increase, pancreas inflammation and liver-fat accumulation when compared to glucose in mild doses. The relative abundance of six kinds of bacterial genera was found significantly different between rats fed on fructose and glucose.

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Antihyperglycemic and antihyperlipidemic effects of low-molecular-weight carrageenan in rats

Open Life Sciences ◽

10.1515/biol-2018-0046 ◽

2018 ◽

Vol 13 (1) ◽

pp. 379-384 ◽

Cited By ~ 1

Author(s):

Xia Qiu ◽

Wenwen Zhong

Keyword(s):

Molecular Weight ◽

Body Weight ◽

Blood Glucose ◽

High Fat Diet ◽

Density Lipoprotein ◽

Lipoprotein Cholesterol ◽

Postprandial Blood Glucose ◽

Control Group ◽

Low Molecular Weight ◽

High Fat

AbstractThis study investigated the antihyperglycemic and antihyperlipidemic effects of low-molecular-weight carrageenan (LC) on rats fed a high-fat diet. Wistar rats were divided into five groups: normal control group (NC), high-fat diet control group (HC), carrageenan-treated control group (CC), 1% LC group (1% LC), and 3% LC-groups (3% LC). Body weight, food intake, fecal weight, blood glucose, and serum lipid levels were measured. After 30 days, body weight significantly decreased in the LC-treated groups than in the HC group. Moreover, in the LC-treated groups, postprandial blood glucose, total cholesterol, triglyceride, and low-density lipoprotein cholesterol (LDL-C) levels decreased, whereas high-density lipoprotein cholesterol (HDL-C) levels increased. From this study, our data suggest that LC has antihyperglycemic and hypolipidemic effects when compared to carrageenan, likely related to its increased absorption due to its lower molecular weight.

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Effect of Honey & Olive Oil Supplemented Bio-Yoghurt Feeding on Lipid Profile, Blood Glucose and Hematological Parameters in Rats

Current Nutrition & Food Science ◽

10.2174/1573401313666170905160124 ◽

2019 ◽

Vol 15 (2) ◽

pp. 140-147

Author(s):

Magdy M. Ismail ◽

El-Tahra M. Ammar ◽

Abd El-Wahab E. Khalil ◽

Mohamed Z. Eid

Keyword(s):

Body Weight ◽

Weight Gain ◽

Blood Glucose ◽

Olive Oil ◽

Body Weight Gain ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Lipoprotein Cholesterol ◽

Low Density ◽

Low Density Lipoprotein Cholesterol

Background and Objective: Yoghurt, especially bio-yoghurt has long been recognized as a product with many health benefits for consumers. Also, honey and olive oil have considerable nutritional and health effects. So, the effect of administration of yoghurt made using ABT culture and fortified with honey (2 and 6%), olive oil (1 and 4%) or honey + olive oil (2+1 and 6+4% respectively) on some biological and hematological properties of rats was investigated.Methods:The body weight gain, serum lipid level, blood glucose level, serum creatinine level, Glutamic Oxaloacetic Transaminase (GOT) activity, Glutamic Pyruvic Transaminase (GPT) activity, leukocytes and lymphocytes counts of rats were evaluated.Results:Blending of bio-yoghurt with rats' diet improved body weight gain. Concentrations of Total plasma Cholesterol (TC), High-Density Lipoprotein cholesterol (HDL), Low-Density Lipoprotein cholesterol (LDL), Very Low-Density Lipoprotein cholesterol (VLDL) and Triglycerides (TG) significantly lowered in plasma of rats fed bio-yoghurt. Levels of TC, LDL, VLDL, and TG also decreased in rat groups feed bio-yoghurt supplemented with honey and olive oil. LDL concentrations were reduced by 10.32, 18.51, 34.17, 22.48, 43.30% in plasma of rats fed classic starter yoghurt, ABT yoghurt, ABT yoghurt contained 6% honey, ABT yoghurt contained 4% olive oil and ABT yoghurt contained 6% honey + 4% olive oil respectively. The blood glucose, serum creatinine, GOT and GPT values of rats decreased while white blood cells and lymphocytes counts increased by feeding bioyoghurt contained honey and olive oil.Conclusion:The findings enhanced the multiple therapeutic effects of bio-yoghurt supplemented with honey and olive oil.

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Liver fat content is independently associated with microalbuminuria in a normotensive, euglycaemic Chinese population: a community-based, cross-sectional study

BMJ Open ◽

10.1136/bmjopen-2020-044237 ◽

2021 ◽

Vol 11 (6) ◽

pp. e044237

Author(s):

Xiaoming Li ◽

Mingfeng Xia ◽

Hui Ma ◽

Yu Hu ◽

Hongmei Yan ◽

...

Keyword(s):

Logistic Regression ◽

Blood Glucose ◽

Density Lipoprotein ◽

Fat Content ◽

Lipoprotein Cholesterol ◽

Liver Fat ◽

Community Based ◽

Liver Fat Content ◽

Cross Sectional ◽

Multivariable Logistic Regression

ObjectiveNon-alcoholic fatty liver disease (NAFLD) is associated with microalbuminuria (MA) in patients with diabetes/pre-diabetes. Whether this association is mediated by blood glucose and blood pressure (BP) remains unclear. This study investigated whether liver fat content (LFC) was associated with MA in a normotensive and non-diabetic population.DesignA cross-sectional substudy.SettingsLFC was determined from the hepatic/renal echogenicity ratio at ultrasound. MA was defined as an albumin-to-creatinine ratio (ACR) of 30–300 µg/mg (early- morning urine sample). Multivariable logistic regression and receiver operating characteristic (ROC) curve analyses were used to evaluate LFC as a predictor of MA.ParticipantsBetween May 2010 and June 2011, this cross-sectional, community-based study enrolled residents from Shanghai (China), aged ≥40 years and with normal glucose tolerance and BP.ResultsA total of 550 residents (median age, 57 years; 174 men) were enrolled and stratified according to LFC quartiles. ACR (p<0.001) and MA prevalence (p=0.012) increased across the LFC quartiles. Multivariable logistic regression showed that the OR for MA (per SD increase in LFC) was 1.840 (95% CI 1.173 to 2.887, p=0.008) after adjustment for potential confounders including age, gender, waist-hip ratio, blood urea nitrogen, systolic and diastolic BP, fasting blood glucose, postprandial glucose, low-density lipoprotein-cholesterol, triglycerides, high-density lipoprotein-cholesterol, total cholesterol, estimated glomerular filtration rate and lipid-lowering drugs. The ROC analysis revealed that the optimal LFC cut-off value for predicting MA was 6.82%.ConclusionLFC is independently associated with MA in normotensive, euglycaemic middle-aged and elderly Chinese individuals. Screening for MA in people with NAFLD might facilitate early intervention to minimise kidney disease risk.

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Glycaemic Control, Lipid Profile, Blood Pressure and Body Weight Status Among Diabetics in Rural Malaysia

IIUM Medical Journal Malaysia ◽

10.31436/imjm.v8i2.753 ◽

2020 ◽

Vol 8 (2) ◽

Author(s):

Hazizi AS ◽

Zaitun Y ◽

Kandiah M ◽

Chan SP

Keyword(s):

Blood Pressure ◽

Body Weight ◽

Blood Glucose ◽

Glycaemic Control ◽

Lipid Profile ◽

Weight Status ◽

Density Lipoprotein ◽

Lipoprotein Cholesterol ◽

Body Weight Status

Introduction: Diabetes is associated with a high risk of cardiovascular disease. The management of blood glucose, dyslipidaemia and other modifiable risk factor, is a key element in the multifactorial approach to prevent complications of type 2 diabetes. Materials and Methods: A cross sectional study was conducted to determine the level of glycaemic control, lipid profile, blood pressure and body weight status among type 2 diabetics in rural Malaysia. A total of 237 diabetic subjects participated in this study. Physical examination was carried out, including measurements of height, weight, waist and hip circumferences, and systolic and diastolic blood pressure. Fasting venous blood samples were collected to determine the glucose level and lipid profile. Results: About 70% of the subjects had a high body mass index (BMI), equal to or above 25 kg/ m2. More than 60% of the subjects had systolic blood pressure ≥ 140 mmHg and/or diastolic ≥ 90 mmHg. Mean fasting blood glucose was 9.84±4.54 mmol/L. Mean total cholesterol was 5.18±1.35 mmol/L. High density lipoprotein cholesterol (HDLC) and triglyceride (TG) and glucose levels were higher in male than in female, but not statistically significant (p>0.05). However, low density lipoprotein cholesterol (LDLC) was higher in females than males (p<0.05). Mean HDLC was below 1.0 mmol/L in all subjects. Conclusion: Glycaemic control, lipid profile, blood pressure and body weight status were not satisfactory and may increase the risk of microvascular and macrovascular complications among these subjects. Appropriate intervention programs should be implemented for better diabetes control among rural subjects.

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Meditative Movements for Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2020/5745013 ◽

2020 ◽

Vol 2020 ◽

pp. 1-12

Author(s):

Tingwei Xia ◽

Yue Yang ◽

Weihong Li ◽

Zhaohui- Tang ◽

Qingsong Huang ◽

...

Keyword(s):

Diabetes Mellitus ◽

Systematic Review ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Blood Glucose ◽

Density Lipoprotein ◽

Lipoprotein Cholesterol ◽

Postprandial Blood Glucose ◽

Meta Analyses

Objective. Physical activity plays a specific role in the fundamental aspect of diabetes care. It is necessary to develop exercise programs for these patients. The aim of this systematic review is to summarize current evidence regarding the effectiveness of meditative movement in patients with type 2 diabetes. Methods. The following databases were searched: PubMed, CENTRAL, Web of Science, Ovid LWW, and EMBASE. Two independent investigators searched and screened the studies by finding duplications, excluding irrelevant titles and abstracts, and then selecting eligible studies by reviewing full texts. 21 studies fulfilled the inclusion criteria. Meta-analyses were performed on glycated hemoglobin (HbA1c), fasting blood glucose (FBG) and postprandial blood glucose (PPBG), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and body mass index (BMI). Results. Meta-analyses showed that meditative movements significantly improved FBG, HbA1c, PPBG, TC, LDL-C, and HDL-C. No improvement was found in BMI. Conclusions. The results demonstrated a favorable effect or tendency of meditative movements to improve blood glucose and blood lipid levels in patients with type 2 diabetes mellitus. The special effects of meditative movements in type 2 diabetes mellitus patients need further research.

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Correlation between Helicobacter pylori Infection and Metabolic Abnormality in General Population: A Cross-Sectional Study

Gastroenterology Research and Practice ◽

10.1155/2018/7410801 ◽

2018 ◽

Vol 2018 ◽

pp. 1-6 ◽

Cited By ~ 10

Author(s):

Li-juan Lu ◽

Ning-Bo Hao ◽

Jian-Jun Liu ◽

Xue Li ◽

Rui-Ling Wang

Keyword(s):

Helicobacter Pylori ◽

Uric Acid ◽

Blood Glucose ◽

General Population ◽

Density Lipoprotein ◽

Metabolic Abnormality ◽

Lipoprotein Cholesterol ◽

Postprandial Blood Glucose ◽

H Pylori ◽

Study Participants

Background. Previous studies have suggested a link between Helicobacter pylori (H. pylori) and metabolic abnormality. This study aimed at investigating the correlation between H. pylori infection and metabolic abnormality in a general population. Methods. All enrolled participants underwent a carbon-13 urea breath test (13C-UBT). For each individual, the following data were collected: age, gender, alanine transaminase (ALT), total protein, albumin, cholesterol, triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), urea nitrogen, creatinine, uric acid, fasting plasma glucose, postprandial blood sugar, nonalcoholic fatty liver disease (NAFLD), and bone mineral density (BMD). Results. The study included 1867 (393 females and 1474 males, aged 54.0 ± 9.6 years) people that took a physical examination. There was no significant difference in gender and age between the study participants with and without H. pylori infection. The statistical data are as follows: albumin: P=0.045, uric acid: P=0.025, fasting glucose: P=0.043, and postprandial blood glucose: P=0.035. In terms of the patients with NAFLD, there were significant differences in ALT and HDL-C between the study participants with and without H. pylori infection. TG (P=0.048), HDL-C (P=0.011), and fasting blood glucose (P=0.018) were significantly different in both groups among individuals who got osteopenia. Conclusion. H. pylori infection may be an important factor affecting metabolic abnormality and osteoporosis.

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Comparative Effects of Animal and Vegetable Fats on Lipid Profile and Patho-physiological Changes in Mice

Journal of Scientific Research ◽

10.3329/jsr.v5i2.11909 ◽

2013 ◽

Vol 5 (2) ◽

pp. 353-361

Author(s):

S. Akter ◽

A. Miah ◽

K. Islam ◽

A. H. Khan

Keyword(s):

Body Weight ◽

Blood Glucose ◽

Soybean Oil ◽

Lipid Profile ◽

Total Cholesterol ◽

Control Diet ◽

Density Lipoprotein ◽

Diet Group ◽

Normal Diet ◽

Lipoprotein Cholesterol

Dietary intake of high amounts of animal fats can cause hypercholesterolemia whereas plant fat like soybean oil reduces serum cholesterol and lipoproteins in mice. The effects of animal fat (butter) and plant fat (soybean oil) fortified diet on lipid profile (serum total cholesterol, low density lipoprotein-cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), and triglycerides), body weight, blood glucose and on tissue texture were investigated in mice. 30 Swiss albino mice were divided equally into three groups. Mice were fed a normal diet (untreated control), a high-fat diet (5% butter) (butter group) and an unsaturated fat diet (5% soybean oil) (soybean oil group) for 90 days. Mice of butter group showed significantly increased level of total cholesterol, LDL-C and triglycerides and decreased level of HDL-C in the serum but not found in mice of soybean fed diet group. Body weight and blood glucose were also markedly elevated in mice fed only butter enriched diet. Histological analysis of liver at the end of 90 days showed increased fat deposition in the mice fed with butter diet than those of control diet and plant fat diet group. Mice fed with butter showed an elevation of lipid levels and developed fatty changes in liver.Keywords: Butter; Soybean oil; Lipid profile; Fatty change; Mice.© 2013 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.doi: http://dx.doi.org/10.3329/jsr.v5i2.11909 J. Sci. Res. 5 (2), 353-361 (2013)

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Tolerance to glucose and lipid high metabolic reactions after burns in an obese rat model

Journal of Burn Care & Research ◽

10.1093/jbcr/irab163 ◽

2021 ◽

Author(s):

Huiting Yu ◽

Chan Nie ◽

Yanna Zhou ◽

Xue Wang ◽

Haiyan Wang ◽

...

Keyword(s):

Body Weight ◽

Blood Glucose ◽

Burn Injury ◽

Density Lipoprotein ◽

Normal Weight ◽

Burn Injuries ◽

Lipoprotein Cholesterol ◽

Weight Group ◽

Normal Weight Group ◽

Weight Groups

Abstract The goal of this study was to determine what effect obese body weight and a burn injury can have on the metabolism of glucose and lipids in rats. We used a 3*3 factorial model design to provide basic glucose and lipid metabolic data characterizing the interaction between different weight and burn injury groups. Two hundred Sprague Dawley (SD) rats were categorized into three weight groups (normal, overweight, obese) and then further divided into control, second degree, and third degree burn groups. Our model compared interactions between weight and burn injury factors according to the above groups. Blood glucose and lipid metabolism indicators were monitored on the 1st, 3rd, 7th and 14th days after burn injury occurred, and burned skin and blood samples were collected for testing. Compared with the normal weight group, the overweight group’s fast blood glucose (FBG), fast insulin (FINS) and homeostasis model assessment of insulin resistance (HOMA-IR) were higher (P<0.05), and FBG in the obese group was higher than the normal weight group (P<0.05).Burn injuries combined with obese body weight had an interactive effect on FBG, FINS and HOMA-IR after burn injury (P<0.05). Burn injury combined with obese body weight had an interaction on low density lipoprotein cholesterol (LDL-C) on the 3rd day after burn injury (P<0.05). Burn injury combined with obese weight had no interaction on triglyceride (TRG), total cholesterol (TC) and high density lipoprotein cholesterol (HDL-C) (P>0.05).Rats in the overweight and obese weight groups were observed to develop an adaptation and tolerance to a higher metabolic rate after burn injuries occurred.

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The Effects of Postprandial Resistance Exercise on Blood Glucose and Lipids in Prediabetic, Beta-Thalassemia Major Patients

Sports ◽

10.3390/sports8050057 ◽

2020 ◽

Vol 8 (5) ◽

pp. 57

Author(s):

Kalliopi Georgakouli ◽

Alexandra Stamperna ◽

Chariklia K. Deli ◽

Niki Syrou ◽

Dimitrios Draganidis ◽

...

Keyword(s):

Blood Glucose ◽

Resistance Exercise ◽

Density Lipoprotein ◽

Thalassemia Major ◽

Lipoprotein Cholesterol ◽

Postprandial Blood Glucose ◽

Beta Thalassemia ◽

Post Exercise ◽

Breakfast Consumption ◽

Beta Thalassemia Major

Insulin resistance and diabetes mellitus are common consequences of iron overload in the pancreas of beta-thalassemia major (BTM) patients. Moreover, postprandial blood glucose elevations are linked to major vascular complications. The purpose of this study was to investigate the effects of a bout of acute resistance exercise following breakfast consumption of glucose and fat on the metabolism in prediabetic, BTM patients. Six patients underwent two trials (exercise and control) following breakfast consumption (consisting of approximately 50% carbohydrates, 15% proteins, 35% fat), in a counterbalanced order, separated by at least three days. In an exercise trial, patients performed chest and leg presses (3 sets of 10 repetitions maximum/exercise), while in the control trial they rested. Blood samples were obtained in both trials at: pre-meal, 45 min post-meal (pre-exercise/control), post-exercise/control, 1 h post-exercise/control, 2 h post-exercise/control and 24 h post-exercise/control. Blood was analysed for glucose and lipids (total cholesterol, High Density Lipoprotein-cholesterol, Low Density Lipoprotein-cholesterol, triglycerides). Blood glucose levels increased significantly 45 min following breakfast consumption. Blood glucose and lipids did not differ between trials at the same time points. It seems that a single bout of resistance training is not sufficient to improve blood glucose and fat levels for the subsequent 24-h post-exercise period in prediabetic, BTM patients.

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Analysis of the Effect of Miglitol in the Treatment of Diabetes Mellitus Based on Ag+ Disinfectant Sampling Needle

Nanoscience and Nanotechnology Letters ◽

10.1166/nnl.2020.3132 ◽

2020 ◽

Vol 12 (4) ◽

pp. 550-555

Author(s):

Ling Zhao ◽

Liping Tan ◽

Guoliang Cheng ◽

Yuanyuan Miao ◽

Xiangming Zhou ◽

...

Keyword(s):

Blood Glucose ◽

Adverse Reactions ◽

Fasting Blood Glucose ◽

Density Lipoprotein ◽

Insulin Level ◽

Lipoprotein Cholesterol ◽

Postprandial Blood Glucose ◽

Control Group ◽

Diabetic Patients ◽

Study Group

The present work selected 120 patients, affected by diabetes, as control subjects in the Affiliated Hospital of Kunming Medical University. According to the principle of random distribution, two groups were established, miglitol study group (65 cases) and metformin control group (55 cases). The Ag + disinfectant sampling needle is a rapid detection tool to evaluate the efficacy of diabetes in both groups. The related biochemical indexes of the patients were measured before and after treatment at the 3rd, 6th, and 12th weeks. The test results showed that there were significant differences in fasting blood glucose value (FBG) and postprandial blood glucose value (2hFBG) among the two groups after 3-, 6-, and 12-month treatment. With the extension of treatment, the blood glucose level of diabetic patients gradually stabilized. Fasting insulin level (FINS) and postprandial two-hour insulin level (2hINS) increased gradually. At the 12th week, by measuring the HbA1c level of the patients, it was found decreasing significantly. In detail, the study group decreased more significantly than the control group, and the incidence of adverse reactions during treatment was 10.8% and 23.6%, respectively, with a significant statistical significance (P < 0 05). Meanwhile, we measured other biochemical indexes of patients from both groups after drug treatment. At the 6th week, the levels of glycosylated glycoprotein (HbA1c), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) in the study group decreased more than in the control group. Therefore, miglitol shows a better hypoglycemic effect on type 2 diabetes, and the gastrointestinal adverse reactions are lesser than metformin, which is more worthy in clinical application.

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