scholarly journals Positive Effects of Spray-Dried Streptococcus thermophilus on Healing of Second-Degree Burn Wounds in Wistar Rats

2019 ◽  
Vol 13 (2) ◽  
pp. 23-29
Author(s):  
Amir Abbas Barzegari ◽  
Masood Hashemzaei ◽  
Ali Reza ASlihematti ◽  
◽  
◽  
...  
Keyword(s):  
Wistar Rats ◽  
Streptococcus Thermophilus ◽  
Burn Wounds ◽  
Positive Effects ◽  
Degree Burn ◽  
Spray Dried ◽  
Second Degree

scholarly journals THE EFFECTIVENESS OF HYDROLYZED VCO CREAM ON VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) EXPRESSION AND COLLAGEN THICKNESS FOR HEALING 2ND DEGREE BURNS INJURY IN WISTAR RATS

2021 ◽  
Vol 8 (3) ◽  
pp. 273-280
Author(s):  
Fahmi Syarif ◽  
Neni Susilaningsih ◽  
Yuriz Bakhtiar
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Wistar Rats ◽  
Vascular Endothelial ◽  
Vegf Expression ◽  
Burn Wounds ◽  
Degree Burn ◽  
Days Of Therapy ◽  
Endothelial Growth Factor ◽  
Second Degree

ABSTRACT    Burn wounds remain a serious problem in several countries. The presence of burn wounds might trigger local or in severe cases also triggers systemic response. Immediate treatment is required to prevent further tissue damage. Silver sulfadiazine cream is commonly used as a burn therapy. However, long-time usage might cause negative side effects. Several effective alternatives with better safety are opted, including virgin coconut oil (VCO). Originating from Cocos nucifera, commonly known as the coconut plant, VCO is a product that contains a lot of beneficial substances, such as lauric acid, polyphenol, and alpha-tocopherol. Hydrolyzed VCO can be an alternative to topical drugs in second-degree burns as it increases Vascular Endothelial Growth Factor (VEGF) expression and collagen thickness in the burn wound healing phase.    This randomized post-test only with parallel-group experiment was done using Wistar rats induced to a second-degree burn. The effect of 70% and 100% on second-degree burn healing, measured by hydrolyzed VCO on VEGF expression and collagen thickness was observed between 6 and 12 days of therapy. VEGF expression and collagen expression increased higher in groups treated with 70% and 100% hydrolyzed VCO compared with the control group treated with base cream.

673 Effect of Subcutaneous Topical Ozone Therapy on Second Degree Burn Wounds in Rats: An Experimental Study

2021 ◽  
Vol 42 (Supplement_1) ◽  
pp. S193-S193
Author(s):  
Emre Karakaya ◽  
Aydincan Akdur ◽  
H Ebru ◽  
Ayvazoglu Soy ◽  
Alev Ok Atilgan ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Silver Sulfadiazine ◽  
Male Rats ◽  
Control Group ◽  
Ozone Therapy ◽  
Burn Wounds ◽  
Degree Burn ◽  
Significant Difference ◽  
Second Degree

Abstract Introduction Burn is one of the most severe traumas that causes coagulative destruction of the skin. The use of various products that accelerate wound healing in patients with burn may affect the patient’s survival and reduce the complications that may be seen. In the present study we aimed effects of subcutaneous ozone injection on second degree burn wound. Methods A total of 72 Sprague-Dawley male rats included in the study were divided randomly into three groups (control group (CG), silver sulfadiazine group (SG), ozone group (OG)) and each group was divided randomly two subgroups (as sacrificed on d7 and on d14).A deep second degree scald burns were created on the lower back. In CG subcutaneous 0.9% serum saline was injected daily into the burn area. In SG, burns were dressed with silver sulfadiazine daily and in OG subcutaneous ozone was injected daily into the burn area. Tissue hydroxyproline level measurement and histopathological evaluation were done. Results When the groups were compared in terms of weight change, no significant difference was found on the 7th and 14th days. In the evaluation made in terms of tissue hydroxyproline, tissue hydroxyproline level in OG was found to be significantly higher on both the 7th and 14th days (p < 0.001). In histopathological evaluations, it was determined that wound healing in OG was significantly higher than in the other groups. Conclusions According to the results, subcutaneous ozone therapy is more effective than silver sulphadiazine in the healing process of second-degree burn wounds and it can be safely used in the treatment of burn wounds.

scholarly journals Effect of green tea on the second degree burn wounds in rats

2014 ◽  
Vol 47 (03) ◽  
pp. 370-374 ◽  
Author(s):  
Mohammad Javad Fatemi ◽  
Babak Nikoomaram ◽  
Amir Asadollah Khajeh Rahimi ◽  
Donya Talayi ◽  
Shahrzad Taghavi ◽  
...  
Keyword(s):  
Green Tea ◽  
Healing Process ◽  
Digital Camera ◽  
First Aid ◽  
Control Group ◽  
Burn Wounds ◽  
Beneficial Effects ◽  
Pathologic Evaluation ◽  
Degree Burn ◽  
Second Degree

ABSTRACT Background: Various studies indicate that the green tea has anti-inflammatory and anti-oxidative properties. Moreover, a few studies have been carried out that demonstrate beneficial effects of green tea on burned patients. Materials and Methods: In this study, green tea, Vaseline, and silver sulfadiazine dressings were used as first-aid treatment to deep dermal contact burns in rats, compared with a control of nothing. After creating second-degree burn on the dorsum of rats, the treatments were applied for 15 min in four groups. Wound dressing changes were daily. Macroscopic study was performed on days 1, 3, 7, and 14 by using a digital camera and software processing of photos. Microscopic examination was done by pathologic evaluation of skin specimens on day 14. Results: We observed that green tea usage significantly decreased burn size in comparison to the control group (P = 0.004). Conclusion: Green tea is effective on healing process of second degree burn wounds.

scholarly journals ALOE VERA VS. SILVER SULFADIAZINE FOR TREATING SECOND-DEGREE BURN WOUNDS: EVIDENCE-BASED CASE REPORT

2019 ◽  
pp. 146-148
Author(s):  
CLARA MENNA ◽  
NABILLA CALISTA ◽  
LEORCA AURINO ◽  
ADISTI DWIJAYANTI
Keyword(s):  
Clinical Trials ◽  
Risk Reduction ◽  
Randomized Clinical Trials ◽  
Aloe Vera ◽  
Silver Sulfadiazine ◽  
Number Needed To Treat ◽  
Burn Wounds ◽  
The Third ◽  
Degree Burn ◽  
Second Degree

Objective: Current treatment for second-degree burn wounds, including silver sulfadiazine (SSD) application, may cause side effects such as delayed and incomplete wound healing, leaving a scar. Traditional plants empirically used for burn wounds, such as Aloe vera, seem to be a promising option with good safety profiles. Methods: We therefore compared Aloe vera to SSD for second-degree burn wounds based on a review of clinical trials obtained by an organized search through the Cochrane, PubMed, and DynaMed databases. Three randomized clinical trials studies were selected, two of which were critically appraised. The third study, with a different outcome assessment, was analyzed separately. Results: Two studies showed that Aloe vera was more effective in treating second-degree burn wounds than SSD 1% with an absolute risk reduction of 0.2, relative risk reduction of 0.83–1.0, and number needed to treat five patients. The Aloe vera group showed faster healing, earlier epithelialization, and earlier pain alleviation. The third study combined Aloe vera with other herbs, which showed better healing ability and restored skin hydration than those with SSD. Conclusion: Each of the three articles stated that Aloe vera was more effective than SSD for treating second-degree burn wounds. Nevertheless, each of the studies lacked methodology and comprehensive data reporting.

The effects of Arnebia euchroma ointment on second-degree burn wounds: a randomized clinical trial

2016 ◽  
Vol 189 ◽  
pp. 107-116 ◽  
Author(s):  
Ebrahim Nasiri ◽  
Seyed Jalal Hosseinimehr ◽  
Ahmad Zaghi Hosseinzadeh ◽  
Mohammad Azadbakht ◽  
Jafar Akbari ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Burn Wounds ◽  
Arnebia Euchroma ◽  
Degree Burn ◽  
Second Degree

PATHOGENESIS OF MICROVASCULAR DAMAGE IN SECOND-DEGREE BURN WOUNDS IN THE RAT.

Shock ◽  
1998 ◽  
Vol 9 (Supplement) ◽  
pp. 5
Author(s):  
Z. B. Ravage ◽  
S. A. Watkins ◽  
G. O. Till
Keyword(s):  
Microvascular Damage ◽  
Burn Wounds ◽  
Degree Burn ◽  
Second Degree

scholarly journals The Effect of Honey in Second Degree Burn Healing on Wistar Rats (Overview of Angiogenesis and the Number of Fibroblasts)

Sains Medika ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 27
Author(s):  
Ayyasi Izaz Almaz ◽  
Ratna Dama Purnawati ◽  
Hermawan Istiadi ◽  
Neni Susilaningsih
Keyword(s):  
Hydrogen Peroxide ◽  
Alternative Treatment ◽  
Wistar Rats ◽  
Vegf Expression ◽  
Group Design ◽  
Degree Burn ◽  
Group B ◽  
Post Hoc ◽  
Observation Results ◽  
Second Degree

Introduction: Burn therapy is generally done using a burn ointment. However, honey can also be used as an alternative treatment for burns. Honey contains active flavonoid as an antioxidant and hydrogen peroxide which can stimulate fibroblasts proliferation also angiogenesis on burn healing phase.Objective: to determine the effect of honey in second degree burn healing from angiogenesis and the number of fibroblasts on Wistar rats. Methods: This research used a posttest only controlled group design on 15 rats with random selection and divided into 3 groups: H-G was given honey, B-G was given Bioplacenton�, N-G without any treatment after burn was induced. Rats were given a second degree burn in a size of 2 cm x 2cm on the back area and were treated twice a day for 14 days. Burn healing was measured by calculating the observation results of microscopic VEGF expression, the number of neovascularization, and the number of fibroblasts. Hypothesis analysis used Annova post hoc LSD and Mann-Whitney.Results: The highest mean in VEGF expression and the number of neovascularization was obtained from group B-G followed by group H-G and group N-G. Significant differences in the number of neovascularization between group B-G with group N-G, p<0.05.Conclusion: Honey can provide a healing effect on the second degree of burns in Wistar rats in terms of the number of neovascularization as well as Bioplacenton�

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