scholarly journals The Relationship between Liver Injury and Serum Levels of C-Reactive Protein and Procalcitonin in Patients with Acute Pancreatitis

2019 ◽  
Vol 29 (3) ◽  
pp. 287-289 ◽  
Author(s):  
Xiujiang Li ◽  
Yuanping Cao ◽  
Zhenyu Liu ◽  
Haiming Chen ◽  
Hongtao Mao
Keyword(s):  
Acute Pancreatitis ◽  
Liver Injury ◽  
Serum Levels ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
The Relationship

Monocyte and neutrophil direct counts correlate with C-reactive protein plasma concentration in patients with acute pancreatitis

Open Medicine ◽  
2007 ◽  
Vol 2 (1) ◽  
pp. 26-36
Author(s):  
Jerzy Naskalski ◽  
Barbara Maziarz ◽  
Beata Kusnierz-Cabala ◽  
Paulina Dumnicka ◽  
Józefa Panek
Keyword(s):  
Acute Pancreatitis ◽  
Plasma Concentration ◽  
Blood Cells ◽  
Regression Equation ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Wbc Count ◽  
The Relationship ◽  
Concentration Levels ◽  
Direct Counts

AbstractAcute pancreatitis (AP) is associated with the intensive inflammatory response in white blood cells (WBC) and C-reactive protein (CRP). This paper presents the relationship between the CRP plasma concentration and the direct counts of peripheral WBC in AP during the initial five days. The study consisted of 56 patients with AP, 36 patients with mild form of AP and 20 patients with severe form of AP. ABX VegaRetic hematological analyzer was used to perform the count of blood cells, and the immunonephelometric method was performed to measure the CRP concentration levels. AP patients presented with WBC count values in the range of 3.2 − 22.4 × 103/µl and CRP concentration levels in the range 3.3 − 599.8 mg/l. The WBC count correlates with CRP levels during the entire observation period. The relationship of CRP and WBC is expressed in the following regression equation: WBC (103/µl) = 3.66 + 1.40 × logeCRP (mg/l). The highest median neutrophil count (8.15 × 103/µl) was observed on the first day. The count decreased to 5.27 × 103/µl on the fifth day. The most substantial finding in this study involved the values found for the monocytes and CRP (r= 0.53; p<0.001). Day two and day three were the highest (r=0.59, p<0.001). On day two, the regression equation for this relationship is: Monocytes (103/µl) = −0.34 + 0.21 × logeCRP(mg/l). The correlation between direct monocyte count and plasma CRP concentration in AP reflect a CRP-dependent stimulation of IL-6 release from activated blood monocytes.

scholarly journals Impact of Fatty Liver on Acute Pancreatitis Severity

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Seung Bae Yoon ◽  
In Seok Lee ◽  
Moon Hyung Choi ◽  
Kyungjin Lee ◽  
Hyoju Ham ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Fatty Liver ◽  
C Reactive Protein ◽  
Prognostic Role ◽  
Hounsfield Units ◽  
Mild Disease ◽  
Reactive Protein ◽  
Unenhanced Ct ◽  
Liver Changes ◽  
The Relationship

Aim. Acute pancreatitis is typically a mild disease, but some patients develop severe courses. Fatty liver changes are seen in patients with acute pancreatitis, but its clinical significance has not been well-studied. We aimed to investigate the relationship between fatty liver and the severity of acute pancreatitis. Methods. Unenhanced CT images of patients with acute pancreatitis were retrospectively reviewed by a radiologist, and mean hepatic and splenic attenuation was measured in Hounsfield units (HU). Fatty liver was defined as mean hepatic/splenic HU<1. Results. Among 200 patients, fatty liver was found in 67 (33.5%) and nonfatty liver in 133 (66.5%). Compared with patients without fatty liver, the severity of pancreatitis and levels of serum C-reactive protein were higher in fatty liver patients. The prevalence of local complications, persistent organ failure, and mortality were also higher in patients with fatty liver. Even after adjusting for age, sex, body mass index, and cause of pancreatitis, fatty liver was significantly associated with moderately severe or severe acute pancreatitis. Conclusions. Fatty liver may play a prognostic role in acute pancreatitis. Fatty liver could be incorporated into future predictive scoring models.

scholarly journals Increased Serum Levels of Cadmium are Associated with an Elevated Risk of Cardiovascular Disease in Adults

2021 ◽  
Author(s):  
Siyu Ma ◽  
Jie Zhang ◽  
Cheng Xu ◽  
Min Da ◽  
Yang Xu ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
White Blood Cells ◽  
Serum Levels ◽  
Blood Levels ◽  
C Reactive Protein ◽  
Epidemiological Evidence ◽  
Reactive Protein ◽  
Health And Nutrition ◽  
The Relationship ◽  
Inflammation Parameters

Abstract Previous studies have determined the effects of exposure to some heavy metals on cardiovascular disease (CVD); however, the association between exposure to cadmium and CVD in adults remains unclear. The relationship between serum levels of cadmium and the risk of CVD was studied by analysing available data from 38,223 participants who participated in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2016. After adjusting for all covariates, we found that higher serum cadmium concentrations were positively related to both the overall risk of CVD (odds ratio (OR): 1.45; 95% confidence interval (CI): 1.22, 1.72; p for trend <0.001) and the risks of its subtypes, including congestive heart failure, coronary heart disease, heart attack and stroke. Elevated levels of cadmium were associated with increased levels of lipids and inflammation parameters, including blood triglycerides, total cholesterol, white blood cells (WBCs) and C-reactive protein (CRP). Our study provided epidemiological evidence that cadmium may increase the risk of CVD by elevating blood lipids and inflammation. CapsuleHigh blood levels of Cd are associated with increased risks of overall CVD and four of the CVD subtypes

scholarly journals The Relationship between Serum Procalcitonin and Dialysis Adequacy in Peritoneal Dialysis Patients

2021 ◽  
Author(s):  
Benyong WANG ◽  
Chan GAO ◽  
Qi CHEN ◽  
Ming WANG ◽  
Xiao FEI ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
High Sensitivity ◽  
Serum Levels ◽  
Control Group ◽  
C Reactive Protein ◽  
Dialysis Patients ◽  
Roc Curve Analysis ◽  
Dialysis Adequacy ◽  
Reactive Protein ◽  
The Relationship

Background: To detect the serum procalcitonin (PCT) levels of peritoneal dialysis (PD) patients. Methods: We analyzed the relationship between the PCT Level and dialysis adequacy. We studied 120 peritoneal dialysis patients without signs of infection in Affiliated Hangzhou First People's Hospital and 120 controls from Jan 2014 to Apr 2016. PCT and high sensitivity C-reactive protein (hs-CRP) were detected. 120 PD patients were divided into two groups according to the dialysis adequacy. A correlation analysis was processed between the PCT level and the total solute clearance (Kt/V). The value of PCT for identifying the dialysis adequacy in PD patients was assessed by ROC curve analysis. Results: PCT level in serum of PD group (0.29±0.24 ng/ml) was higher than that of the control group (0.02±0.01 ng/ml) (P<0.01). Compared with the inadequate dialysis group (0.5±0.37 ng/ml), the PCT Level of the adequate dialysis group (0.23±0.15 ng/ml) was lower (P<0.01). There were negative correlations between PCT and Kt/v(r=- 0.451), Prealbumin (PA) (r=-0.258), Glomerular Filtration Rate (eGFR; r=-0.280), while there was positive correlation between PCT and Hypersensitive c-reactive protein (r=0.458) (P<0.01). At a serum PCT cut-off value of 0.283 ng/ml, the sensitivity and specificity for identifying the dialysis adequacy in PD patients were 0.913 and 0.805 respectively. The serum levels of PCT in peritoneal dialysis patients were significantly higher than the levels in healthy controls. Conclusion: The serum level of PCT can be used as an indirect maker to evaluate the adequacy of dialysis.

scholarly journals The Relationship Between CRP Gene Polymorphism and the Serum Concentrations of C-Reactive Protein, Total Cholesterol and HDL Cholesterol in Suckling Piglets / Związek polimorfizmu genu CRP z koncentracją kodowanego białka C-reaktywnego, cholesterolu całkowitego i HDL-ch w surowicy krwi ssących prosiąt

2013 ◽  
Vol 13 (3) ◽  
pp. 503-512 ◽  
Author(s):  
Marek Łaszyn ◽  
Hanna Sielawa ◽  
Krystyna Życzko
Keyword(s):  
Total Cholesterol ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Serum Levels ◽  
Serum Concentrations ◽  
C Reactive Protein ◽  
Large White ◽  
Reactive Protein ◽  
Suckling Piglets ◽  
The Relationship

AbstractThe relationship between CRP gene (1271 G/A, 3’UTR) polymorphism and the serum levels of C-reactive protein (CRP), total cholesterol (Ch-T) and high density lipoprotein cholesterol (HDL-ch) was analysed in suckling crossbred [Polish Large White × Polish Landrace (♀) × × Duroc × Pietrain (♂)] piglets. CRP genotypes were identified by PCR-RFLP with Hinfi restriction enzyme. The levels of CRP, Ch-T, HDL-ch and white blood cell (WBC) counts were determined in blood samples collected from younger (21±3 days of age) and older piglets (35±3 days of age). There was a relationship between CRP gene (1271 G/A, 3’UTR) polymorphism and variations in the serum levels of CRP in piglets with normal WBC counts. The above relationship did not manifest itself in piglets with elevated WBC counts. The studied genotypes differed in their response to elevated WBC counts, and the noted differences were more pronounced in older piglets. The response of genotypes with weak CRP expression caused an increase in CRP levels and a decrease in the serum concentrations of Ch-T and HDL-ch. Such a response was not observed in the genotype with strong CRP expression.

scholarly journals C-Reactive Protein and Cognition Are Unrelated to Leukoaraiosis

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Liara Rizzi ◽  
Fabricio Correia Marques ◽  
Idiane Rosset ◽  
Emilio Hideyuki Moriguchi ◽  
Paulo Dornelles Picon ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Elevated Serum ◽  
Serum Levels ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Increased Risk ◽  
Coronary Patients ◽  
The Relationship

Elevated serum levels of C-reactive protein (CRP) have been associated with leukoaraiosis in elderly brain. However, several studies indicate that leukoaraiosis is associated with an increased risk of cognitive impairment. It is unknown how the effect of CRP on cognition is mediated by leukoaraiosis. The purpose of this study is to assess the relationship between serum levels of CRP, the presence of leukoaraiosis, and cognitive impairment in a population of coronary patients over 50 years old. CRP levels explained 7.18% (P: 0.002) of the variance of the MMSE. The adjustment for the presence of leukoaraiosis little changed this variance (5.98%,P: 0.005), indicating that only a small portion of the CRP influence on cognition was mediated via leukoaraiosis. Patients with CRP levels ≥5.0 had 2.9 (95% CI: 1.26–6.44) times more chance to present cognitive impairment (P: 0.012). We found that elevated serum levels of CRP were associated with increased risk of cognitive impairment in elderly and it was not mediated by presence of leukoaraiosis.

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