scholarly journals Formulasi Lotion Esktrak Etanolik Herba Ashitaba (Angelica Keiskei) sebagai Penangkal Radikal Bebas

2019 ◽  
Vol 8 (2) ◽  
pp. 5
Author(s):  
Wahida Hajrin ◽  
Yohanes Juliantoni
Keyword(s):  
Angelica Keiskei

Latar belakang: Senyawa radikal dapat merusak serabut kalogen kulit dan matrik dermis sehingga kulit menjadi kering, keriput, bahkan dapat menjadi penuaan dini. Upaya pencegahan yang dapat dilakukan yaitu dengan penggunaan bahan yang memiliki aktivitas antioksidan. Salah satu tanaman yang memiliki aktivitas antioksidan adalah ashitaba. Metode: Metode yang digunakan pada penelitian ini adalah variasi pengeringan ashitaba untuk melihat pengaruhnya terhadap aktivitas penangkapan radikal DPPH dan kadar fenolik total ekstrak etanoliknya. Sampel dengan metode pengeringan yang lebih baik, digunakan untuk membuat sediaan lotion. Hasil: Hasil penelitian menunjukkan sampel yang dikeringkan dengan oven memiliki rendemen lebih tinggi dari pada dengan sinar matahari. Aktivitas penangkapan radikal DPPH sampel oven dengan IC50 sebesar 350,24 µg/mL lebih baik dari pada sampel matahari yaitu sebesar 3979,46 µg/mL (p0.05). Hasil uji kadar fenolik total sampel oven sebesar 2,9817±0,0935 gEAG/100g lebih tinggi dari pada sampel matahari sebesar 1,7168±0,0142 gEAG/100g sampel. Sampel yang dikeringkan dengan oven kemudian diformulasi dalam bentuk sediaan lotion. Uji acceptabilitas menunjukkan ekstrak etanolik herba ashitaba cocok dibuat sediaan lotion. Kesimpulan: Ekstrak etanolik herba Ashitaba dapat dibuat sediaan lotion namun perlu dilakukan optimasi formula dan uji stabilitas untuk memperoleh sediaan lotion yang baik.

Comparative study on the different extractions of chalcone from the angelica keiskei

2014 ◽  
Author(s):  
Xinhua Chen ◽  
Hongzhen Ning ◽  
Qian Wang ◽  
Yingli Liu ◽  
Nan Liu ◽  
...  
Keyword(s):  
Comparative Study ◽  
Angelica Keiskei

Identification of a new potyvirus isolated from Angelica keiskei

2021 ◽  
Author(s):  
Aya Sakamoto ◽  
Azusa Kanagawa ◽  
Maya Kubota ◽  
Hideo Hoshi ◽  
Keiko T. Natsuaki
Keyword(s):  
Angelica Keiskei

scholarly journals A Chalcone from Ashitaba (Angelica keiskei) Stimulates Myoblast Differentiation and Inhibits Dexamethasone-Induced Muscle Atrophy

Nutrients ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 2419 ◽  
Author(s):  
Minson Kweon ◽  
Hyejin Lee ◽  
Cheol Park ◽  
Yung Hyun Choi ◽  
Jae-Ha Ryu
Keyword(s):  
Muscle Atrophy ◽  
Muscle Protein ◽  
Ethanol Extract ◽  
Mitogen Activated Protein Kinase ◽  
Myoblast Differentiation ◽  
Active Principle ◽  
Mrna Levels ◽  
C2c12 Myoblasts ◽  
E3 Ligases ◽  
Angelica Keiskei

Ashitaba, Angelica keiskei Koidzumi (AK), as a traditional medicine in Korea, Japan, and China, has been known as an elixir of life having therapeutic potential. However, there is no scientific evidence to support that Ashitaba can enhance or maintain muscle strength. To find a new therapeutic agent from the medicinal plant, we evaluated the anti-myopathy effect of chalcones from ethanol extract of AK (EAK) in cellular and animal models of muscle atrophy. To examine anti-myopathy activity, EAK was treated into dexamethasone injected rats and muscle thickness and histopathological images were analyzed. Oral administration of EAK (250 or 500 mg/kg) alleviated muscle atrophic damages and down-regulated the mRNA levels of muscle-specific ubiquitin-E3 ligases. Among ten compounds isolated from EAK, 4-hydroxyderricin was the most effective principle in stimulating myogenesis of C2C12 myoblasts via activation of p38 mitogen-activated protein kinase (MAPK). In three cellular muscle atrophy models with C2C12 myoblasts damaged by dexamethasone or cancer cell-conditioned medium, 4-hydroxyderricin protected the myosin heavy chain (MHC) degradation through suppressing expressions of MAFbx, MuRF-1 and myostatin. These results suggest that the ethanol extract and its active principle, 4-hydroxyderricin from AK, can overcome the muscle atrophy through double mechanisms of decreasing muscle protein degradation and activating myoblast differentiation.

Ashitaba (Angelica keiskei) leaves extract cream 8% inhibited the increase of melanin amount as effective as hydroquinone cream 4% and inhibited the increase of tyrosinase enzymes not as effective as hydroquinone cream 4% in the ultraviolet B-exposed Guin

2021 ◽  
Vol 4 (1) ◽  
pp. 22-27
Author(s):  
Chynthia Friama ◽  
Anak Agung Gde Putra Wiraguna ◽  
Wimpie Pangkahila
Keyword(s):  
Guinea Pig ◽  
Sun Exposure ◽  
Ultraviolet B ◽  
Premature Aging ◽  
Control Group ◽  
Cavia Porcellus ◽  
Control Group Design ◽  
Angelica Keiskei ◽  
The Mean ◽  
Tyrosinase Enzyme

Background: Excessive sun exposure results in increased activity of the tyrosinase enzyme and the amount of melanin in the skin which causes hyperpigmentation, a sign of premature aging. The purpose of this study was to prove that Ashitaba (Angelica keiskei) leaves extract cream 8% inhibited the increase of melanin and tyrosinase enzymes as effective as hydroquinone cream 4% in the ultraviolet B-exposed guinea pig (Cavia porcellus) skin. Methods: This study used a randomized post-test only control group design. The subjects were 36 male guinea pigs (Cavia porcellus). Subjects were divided into two groups, the hydroquinone cream 4% group and the Ashitaba leaves extract cream 8% group exposed to UVB light. Skin samples were collected 48 hours after the last exposure to measure the tyrosinase enzyme levels using the ELISA method and the amount of melanin was examined by Masson-Fontana staining. Results: The mean levels of tyrosinase in the hydroquinone cream 4% group was 19.51 ± 5.16 ng/L and the Ashitaba leaves extract cream 8% group was 23.76 ± 3.09 ng/L (p = 0.005). The mean amount of melanin in the  hydroquinone cream 4% group was 2.98 ± 2.27% and the Ashitaba leaves extract cream 8% group was 4.77 ± 3.33% (p = 0.069). Conclusion: The administration of Ashitaba (Angelica keiskei) leaves extract cream 8% inhibited the increase of melanin amount as effective as hydroquinone cream 4% and inhibited the increase of tyrosinase enzymes not as effective as hydroquinone cream 4% in the ultraviolet B-exposed guinea pig (Cavia porcellus) skin.

scholarly journals The Effects of Dietary Fermented Fruit Pomace and Angelica keiskei Koidz Pomace on Shelf Life, Cholesterol and Fatty Acid Composition in Broiler

2010 ◽  
Vol 30 (3) ◽  
pp. 466-471
Author(s):  
Hwan-Ku Kang ◽  
Hee-Chul Choi ◽  
Hyun-Suk Chae ◽  
Jae-Cheon Na ◽  
Han-Tae Bang ◽  
...  
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Shelf Life ◽  
Acid Composition ◽  
Angelica Keiskei ◽  
Fruit Pomace

scholarly journals TEH BUBUK HERBAL DAUN ASHITABA DAN KULIT BUAH NAGA

2019 ◽  
Vol 6 (2) ◽  
pp. 83
Author(s):  
Syirril Ihromi ◽  
Asmawati Asmawati ◽  
Earlyna Sinthia Dewi ◽  
Muliatiningsih Muliatiningsih
Keyword(s):  
Angelica Keiskei

Ashitaba (Angelica keiskei) merupakan salah satu tanaman introduksi yang berpotensi meningkatkan produksi sel darah merah, produksi hormon pertumbuhan serta meningkatkan pertahanan tubuh untuk melawan infeksi, kanker dan  juga sebagai sumber antioksidan. Selain daun ashitaba bahan potensial untuk dikembangkan menjadi teh herbal adalah kulit buah naga yang kaya polyphenol dan sumber antioksidan. Penelitian ini bertujuan untuk mengetahui formulasi daun ashitaba dan kulit buah naga merah yang tepat  dan mengetahui pengaruh formulasi daun ashitaba dan kulit buah naga merah terhadap sifat kimia dan organoleptik teh bubuk herbal. Adapun formulasi perlakuan yaitu; perlakuan 1 (daun ashitaba 0%:kulit buah naga merah100%), 2 (daun ashitaba 25% : kulit buah naga merah 75%), 3 (daun ashitaba 50% : kulit buah naga merah 50%), 4 (daun ashitaba 75% : kulit buah naga merah 25%) dan 5 (daun ashitaba 100% : kulit buah naga merah 0%). Hasil penelitian menunjukkan formulasi daun ashitaba dengan kulit buah naga berpengaruh secara nyata terhadap kadar abu, antioksidan, skor nilai rasa, warna bubuk dan warna seduhan tetapi tidak berpengaruh pada kadar air da skor aroma teh herbal. Perlakuan terbaik didapatkan pada perlakuan  P2 (formulasi daun ashitaba 25% dengan kulit buah naga 75%) karena menghasilkan teh herbal yang memenuhi standar SNI.

scholarly journals AKTIVITAS ANTIINFLAMASI EKSTRAK ETANOL 70% DAUN ASHITABA (Angelica keiskei) SECARA IN VIVO DENGAN PENGINDUKSI KARAGENAN

2019 ◽  
Author(s):  
Haka As'ada ◽  
Yardi Saibi ◽  
Hendri Aldrat
Keyword(s):  
Dose Range ◽  
White Male ◽  
Ethanol Extract ◽  
Negative Control ◽  
Inflammatory Activity ◽  
Male Rat ◽  
Control Group ◽  
Angelica Keiskei ◽  
Anti Inflammatory

Ashitaba leaves (Angelica keiskei) or also known as tommorow's leaf is plant that known to have various health benefit, one of them is as an anti-inflammatory activity. The anti-inflammatory activity of ashitaba leaves has been known through in vitro assays. This study aims to determine the anti-inflammatory activity of 70% ethanol extract of ashitaba leaves through in vivo assay. Anti-inflammatory activity was performed on white male rat of Sprague dawley strain with induction method of edema on rat's foot using 1% carrageenan 0.2 ml. Rats were divided into 5 groups. The negative control group was given a 0.5% Na-CMC suspension, a positive control group was given sodium diclofenac suspension of 5.14 mg / kgBW, and the test group was given 70% ethanol extract of ashitaba leaves at a dose of 1000; 2000; and 4000 mg / kgBW suspended in 0.5% Na-CMC. The results showed that in that dose range the 70% ethanol extract of ashitaba leaves had anti-inflammatory activity that did not depend on the dose. Percentage of edema of 70% ethanol extract of ashitaba leaves dose 1000; 2000; 4000 mg / kgBB was significantly different with negative control (p ≤ 0,05) and had percentage of edema inhibition respectively 83,95%, 79,01%, and 80,25%. The results of this study showed that 70% ethanol extract of ashitaba leaves have anti-inflammatory activity. Keywords: Ashitaba, Angelica keiskei, tommorow's leaf, anti-inflammatory, carrageenan.

scholarly journals Inhibitory Effect of Angelica keiskei Extract in an Atopic Dermatitis Animal Model

2012 ◽  
Vol 19 (5) ◽  
pp. 792-798 ◽  
Author(s):  
Min-A Kim ◽  
Hyeong-U Son ◽  
Dong-Yoon Nam ◽  
Yong-Su Cha ◽  
Yong-Kyu Shin ◽  
...  
Keyword(s):  
Animal Model ◽  
Atopic Dermatitis ◽  
Inhibitory Effect ◽  
Angelica Keiskei
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