EXCESSIVE CALCIFICATION OF PLACENTA;

2013 ◽  
Vol 20 (05) ◽  
pp. 743-751
Author(s):  
PUSHPA GOSWAMI ◽  
SAMREEN MEMON ◽  
MUHAMMAD ASLAM CHANNA ◽  
Hemlata Rathi
Keyword(s):  
Placental Abruption ◽  
Histological Study ◽  
Normal Pregnancy ◽  
Fetal Outcome ◽  
University Hospital ◽  
Control Group ◽  
Abruptio Placentae ◽  
New Born ◽  
Study Results ◽  
Induced Hypertension

Objective: To examine the morphological change due to excessive calcification of placenta of pregnancies complicated bypregnancy induced hypertension (PIH) and placental Abruption and its relation with fetal outcome. Study design: Case control type ofstudy. Place and duration: This study was conducted from June 2008 to July 2009 at the department of Anatomy of Liaquat University ofMedical & Health Sciences Jamshoro. Material and Methods: One hundred twenty placentae were collected from labor room andgynecology operation theatre of Liaquat University Hospital. Forty placentae from parturients that had pregnancy induced hypertension(PIH), forty from parturient having placental abruption & forty placentae of normal pregnancy (Control Group). Age of all parturients isbetween 17 to 32 years. Fetal outcome and data was recorded. Weight and diameter of Placentae were measured. Approximately five cmpiece of placenta was taken and processed for histological study. Results: The weight of placenta in control group were 450 to 650 gmwith a mean weight of 526.25± 8.414 gm and their diameter from 19 to 24 cm with a mean of 21.225±0.2148cm. In PIH group weight ofplacenta was from 200 to 550gm with a mean weight of 432.25 ± 11.889gm and their diameter ranges from 10 to 16cms with amean14.208 ± 0.1914cm. In placental abruption group the weight of placenta ranges from 180 to 400 gm with a mean weight of 284.88±9.084 gms and diameter ranges from 10 to 14cms with mean 13.070 ± 0.2504 cm. The difference in weight and diameter of placentain PIH and abruptio placentae was found statistically significant when compared with weight and diameter of normal placentae. Theweight of new born babies in control group was 1.8 kg to 3.6 kg mean weight of 2.790± 0.0689kg. In PIH group, the fetal weight was 1.4kg to 3.0 kg with a mean weight of 2.195 ±0.0703kg. In abruptio placentae group, the weight of new born baby ranges from 1.0 kg to2.8kg with a mean weight of 1.898 ± 0.0660 kg. Conclusions: Fetal outcome in cases of PIH and in abruptio placentae was poor ascompared to control group.

scholarly journals PREGNANCY INDUCED HYPERTENSION;

2014 ◽  
Vol 21 (03) ◽  
Author(s):  
Asghar Khan ◽  
Amin Fahim ◽  
Aneela Qureshi ◽  
Ghulam Shah Nizamani ◽  
Mohammad Ahmed Azmi
Keyword(s):  
University Hospital ◽  
Control Group ◽  
P Value ◽  
Pregnancy Induced Hypertension ◽  
Severity Of Disease ◽  
Induced Hypertension ◽  
Mild Preeclampsia ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Objective: To assess the early detection of thrombocytopenia in womenpresenting with varying degree of pregnancy induced hypertension (PIH). Study Design: A casecontrol study. Place of Study: Hematology laboratory Isra University Hospital Hyderabad.Duration of Study: From July 2009 to December 2010. Materials and Methods: Total 130pregnant women were included in this study. The subjects were divided into three groups asGroup 1 with pre-eclampsia, Group 2 with eclampsia and Group 3 with normotensive pregnantwomen as control group. The Group 1 was further divided into two sub groups such as Subgroup1a with mild preeclampsia and Sub-group 2b with severe pre-eclampsia. Results:Anticoagulated whole blood samples (5cc) from all subjects were analyzed for the detection ofthrombocytopenia for the possible involvement of pregnancy induced hypertension. It was notedthat out of total subjects, 33(25.39%) had mild pre-eclampsia, 17(13.07%) had severe preeclampsia,15(11.54%) had eclampsia and 65 (50.0%) were normotensive pregnant women.Based on the comparative findings, the results showed significant differences between group 3and group 1a (p-value 0.001), group 3 and group 1b (p-value 0.001), group 2 and group 3 alsoshowed same results (p-value 0.001) but the subjects of group 1a and 1b when compared,showed non-significant findings (p value 0.955). Conclusion: The results suggested that earlydetection of platelet count provide significant role for the assessment of severity of disease inwomen with pregnancy induced hypertension when compared with normotensive pregnantwomen.

scholarly journals Hyperthyroidism as a Potential Risk Factor for Placental Abruption: A Case Control Study

2021 ◽  
Author(s):  
Tomomi Kotani ◽  
Kenji Imai ◽  
Takafumi Ushida ◽  
Yoshinori Moriyama ◽  
Tomoko Kobayashi ◽  
...  
Keyword(s):  
Pregnancy Outcomes ◽  
Pregnancy Complications ◽  
Case Control Study ◽  
Placental Abruption ◽  
Case Control ◽  
University Hospital ◽  
Control Group ◽  
Multivariable Logistic Regression Analysis ◽  
Increased Risk ◽  
Control Study

Abstract BackgroundOvert hyperthyroidism and hypothyroidism are associated with pregnancy complications; however, most women with these conditions are diagnosed before conception and are under treatment during pregnancy, especially in the developed countries. The purpose of this study was to investigate pregnancy complications among these women.MethodsA retrospective case-control study was conducted, and data on 3824 pregnant women who gave birth at Nagoya University Hospital located in Japan from 2005 to 2014 was collected. The pregnancy outcomes were divided and compared among three groups: the control group (n = 3709), the hyperthyroidism group (n = 52) and the hypothyroidism group (n = 63). Risk factors for placental abruption were also evaluated in singleton pregnancies (n = 3588) by multivariable logistic regression analysis. Moreover, in hyperthyroidism, thyroid function was also compared between successful and failed placentation group, and the latter group included placental abruption and preeclampsia. ResultsThe incidence of placental abruption was significantly higher in hyperthyroidism than in control and hypothyroidism groups (p < 0.01). Hyperthyroidism was independently associated with an increased risk of placental abruption (adjusted odds ratio = 12.52, 95% confidence interval = 2.91–53.88). Thyroid stimulating hormone (TSH) was significantly lower in failed placentation group than in successful placentation group (p < 0.05). ConclusionAccording to the results of our study, pregnancy outcomes in women with treated hypothyroidism were comparable with those in women without thyroid disease. Conversely, women with treated hyperthyroidism showed an independent risk of placental abruption, which might be related with lower TSH level at early gestation. However, further research is required to validate our findings.

scholarly journals Role of cytohormonal study in normal pregnancy and in threatened abortion

2018 ◽  
Vol 7 (5) ◽  
pp. 1735
Author(s):  
Shailesh B. Patil ◽  
Milind B. Patil
Keyword(s):  
Normal Pregnancy ◽  
Fetal Outcome ◽  
Control Group ◽  
Vaginal Smear ◽  
Age Group ◽  
Number Of Patients ◽  
Significant Difference ◽  
Parity Number ◽  
Threatened Abortion

Background: It is certain from clinical experience of many that one or more hemorrhages in early pregnancy can still end up in good fetal outcome. So, our study deals with comparison of cytohormonal study in pregnancy and threatened abortion. The study was conducted with the aim of utilizing colpocytogram as a tool in assessing and treating cases of threatened abortion and comparing them with normal pregnant women.Methods: Patients attending antenatal care unit on outdoor basis and labelled as normal pregnancy cases were considered as control group. The patients of threatened abortion were studied when they were admitted in Gynecology department for indoor treatment. Patients were studied taking into consideration their age, parity, number of abortions, complaints (P/V bleeding, pain in abdomen), gestational age, per abdomen and per vaginal findings and also USG findings and vaginal smear pattern.Results: Maximum number of patients was present in the age group of 21-25 years in both the groups. While only 13.33% had normal smear pattern in threatened abortion group. 86.67% patients in threatened abortion group showed abnormal smear pattern. There is statistically significant difference was found (p<0.05). There is statistically significant was found (P<0.01) and indicates good effects of the drug on the vaginal epithelium.Conclusions: The cytohormonal study acts as a simple, reliable, good, noninvasive method for evaluation of hormonal pattern in normal pregnancy and threatened abortion. 

scholarly journals Effects of Preeclampsia on Perinatal Outcome- A Study Done in the Specialized Urban Hospital Set Up in Bangladesh

1970 ◽  
Vol 40 (1) ◽  
pp. 33-36 ◽  
Author(s):  
S Kishwara ◽  
S Tanira ◽  
E Omar ◽  
F Wazed ◽  
S Ara
Keyword(s):  
Normal Pregnancy ◽  
Fetal Outcome ◽  
Control Group ◽  
Urban Hospital ◽  
College Hospital ◽  
Related Disorder ◽  
Group A ◽  
The Mean ◽  
The Difference ◽  
Group B

Preeclampsia is a common pregnancy related disorder in Bangladesh that originates in the placenta and causes variable maternal and fetal problems. A prospective study was designed to see the associated maternal factors and fetal outcome in preeclampsia and to compare with that of normal pregnancy. The study was done in the Department of Obstetrics & Gynaecology, Dhaka Medical College Hospital and Mitford Hospital, Dhaka, from August 2005 to June 2006. Sixty Bangladeshi pregnant women were taken in this study, of which thirty were normal uncomplicated pregnancies (considered as control group or group A) and another thirty having pregnancies complicated by preeclampsia (considered as preeclampsia group or group B), where the patients were normotensive previously. Both the maternal and fetal outcomes were observed and recorded. The mean age of the mother was 26.53±5.26 years and 26.67±5.27 years in group A and group B respectively. The mean gestational age of the mother was 38.27±1.26 weeks and 36.90±1.03 weeks in group A and group B respectively and the difference in between two groups was statistically significant (p<0.001). The mean birth weight of the neonate was 2.80±0.27 kg. and 2.26±0.41 kg. in group A and group B respectively and the difference was significant (p<0.001). The mean APGAR score of the neonate at one minute was 9.00±1.02 and 8.40±0.93 in group A and group B respectively and the difference was significant (p<0.05). DOI: http://dx.doi.org/10.3329/bmj.v40i1.9960 BMJ 2011; 40(1): 33-36

scholarly journals Neurohistological changes in the cerebellar cortex of adult Wistar rats following lead acetate induced cortical damage

2021 ◽  
Vol 15 (3) ◽  
pp. 182-188
Author(s):  
Ajibade AJ ◽  
Ogundero SA
Keyword(s):  
Cerebellar Cortex ◽  
Lead Acetate ◽  
Wistar Rats ◽  
Histological Study ◽  
Control Group ◽  
Hair Dye ◽  
Study Results ◽  
Group A ◽  
The Mean ◽  
The Brain

This study investigated the neurohistological effect of lead acetate on cerebellar cortex of adult wistar rats. Lead is a common industrial poisonous substance that its prevalence in the environment exhibits toxic effect which makes different organs & tissues especially the central nervous system vulnerable to lead exposure. Lead is however, found useful applications in diverse items of daily needs like paints, water pipes, car batteries, leaded gasoline, ammunition, cosmetics, hair dye, airplanes, shielding for x-ray machines. Thirty-six (36) adult wistar rats of both sexes weighing between 120-250 grams were randomly grouped into four groups. Group A, B, C and D each group containing seven (9) rats. Group A rats served as the control, and was maintained on standard feed and water for 28 days, group B, C and D rats were treated orally once daily with 0.09g/kg, 0.18g/kg and 0.2g/kg of lead acetate respectively for 28 days. The weights of the wistar rats were recorded on weekly basis during the treatment. All the wistar rats in group A, B, C and D were sacrificed by cervical dislocation on the 29th day of the treatment. The brain was removed and weighed with a sensitive balance and the cerebellum of each rats was then fixed in 10% formol saline, the tissue was processed and stained with Hematoxylin and Eosin for histological study. Results showed that the mean body weights of the wistar rats significantly decreased in the treated groups when compared with the control group. The mean brain weights of the lead treated groups showed a significant decrease when compared to the control group. Histological study of the brain (cerebellar cortex) of the treated groups demonstrated degenerative changes revealed shrinkage, reduced sized and cellular loss of the Purkinje cells with vacuolations in the Purkinje cell layer compared with normal cerebellar histoarchitecture in the control. The study concluded that lead acetate has a neurotoxic effect on the cerebellar cortex of adult wistar rats which may ultimately impair some cerebellar functions.

scholarly journals A morphology and histological study of placenta in normal and diabetic pregnancies

2018 ◽  
Vol 6 (5) ◽  
pp. 1778
Author(s):  
Ashutosh Tandon ◽  
Durgesh Singh ◽  
Parmatma Prasad Mishra ◽  
Anshu Mishra
Keyword(s):  
Standard Deviation ◽  
Treatment Plan ◽  
Histological Study ◽  
Normal Pregnancy ◽  
Control Group ◽  
Case Group ◽  
Physiological Changes ◽  
Third Trimester ◽  
Random Blood Sugar ◽  
The Mean

Background: The placenta is a vital organ for developing foetus, and it is also the most accessible organ of human body, pregnancy in a diabetogenic state by virtue of various physiological changes which cause insulin resistance. In normal pregnancy, glucose tolerance decreases by third trimester, though plasma levels of insulin increase. Aim was to study comparison of placenta of normal pregnancy with placenta of diabetic pregnancy and it the possible outcome of pregnancy.Methods: The present study was case-control and conducted on cases of 50 Specimens of placenta with intact umbilical cord were collected from the Department of Obstetrics and Gynecology.Results: Variation in the shape and weight of the placenta were observed. The mean placenta weight in control group was found to be 452.80 grams with standard deviation 140.93 grams while in the case group; it was 406.00 grams with standard deviation of 210.31 grams. The random blood sugar of mother in control group was significantly higher than cases (t=2.91, p<0.01).Conclusions: The present study shown that there was a tendency of increase in placental weight and weight of new born in complicated pregnancies as compared to the normal pregnancies. This indicated the earlier diagnosis and strict to treatment plan in diabetic pregnancies.

scholarly journals Diagnostic Efficiency of Adropin As A Preliminary Test To Exclude Acute Pulmonary Embolism

2021 ◽  
Author(s):  
Serhat Orun ◽  
Aliye Celikkol ◽  
Batuhan Ilbey Basol ◽  
Elif Yeniay
Keyword(s):  
Pulmonary Embolism ◽  
Likelihood Ratio ◽  
Acute Pulmonary Embolism ◽  
Preliminary Test ◽  
Pulmonary Angiography ◽  
University Hospital ◽  
Control Group ◽  
Diagnostic Efficiency ◽  
Study Results ◽  
The Mean

Abstract Background This study aimed to investigate the efficiency of adropin as a biomarker to exclude the diagnosis of acute pulmonary embolism (PE). Methods Patients presenting to the emergency department (ED) of a tertiary health center (a university hospital) between August 2019 and August 2020 and diagnosed with PE were included in this prospective cohort study. The amount of serum adropin was determined in patients with PE (who were diagnosed using computerized tomography pulmonary angiography) and compared with healthy volunteers. Results There were 57 participants in the study (28 controls and 29 PE patients). The mean adropin level of the PE group was 187.33 ± 62.40 pg/ml and significantly lower than the control group (524.06 ± 421.68 pg/ml) (p = 0.000). When the optimal adropin cut-off value was 213.78 pg/ml, the likelihood ratio of the adropin test was 3.4, and the sensitivity of the adropin test at this value was 82% with specificity of 75% (95% CI; AUC: 0.821). Further, the highest likelihood ratio obtained was 13.5, where the cut-off value was 304 pg/ml, the sensitivity of the test was 46%, and the specificity of the test was 96% (95% CI, AUC: 0.821). Conclusion The adropin test can be used to exclude the diagnosis of acute pulmonary embolism in the ED. However, more research is required to verify and support the generalizability of our study results.

scholarly journals Shoulder Tip Pain in Laparoscopic Cholecystectomy with Active vs Passive Evacuation of Pneumoperitoneum

Esculapio ◽  
2021 ◽  
Vol 16 (4 (oct 2020 - dec 2020)) ◽  
Author(s):  
Anum Arif ◽  
Sabih Nofal ◽  
Muhammad Atif Khan ◽  
Abdul Waheed Khan ◽  
Ahsin M Bhatti ◽  
...  
Keyword(s):  
Laparoscopic Cholecystectomy ◽  
Abdominal Cavity ◽  
Intervention Group ◽  
University Hospital ◽  
Control Group ◽  
Key Words Laparoscopic Cholecystectomy ◽  
Pain Scores ◽  
Study Results ◽  
Surgery Department ◽  
Negative Suction

Objective: The objective of the study was to compare the frequency of severity of shoulder tip pain after active (gas suctioning) and passive removal of pneumoperitoneum among patient undergoing laparoscopic cholecystectomy. Methods: This Observational comparative study was directed in general surgery department of DOW university hospital beginning from February 2016 to February 2017. Two hundred and six patients undergoing standard 4 port laparoscopic cholecystectomy were enrolled equally in either groups. The surgeon evacuated the abdomen by using a multiporous suction tube limiting the negative suction pressure to - 40 mmHg for 2-5 minutes under direct vision in active aspiration group, while in control group, CO2 was removed passively. Pain scores were recorded using visual analog score at 16 hours post-operatively by residents of surgery blinded to the study. Results: Mean VAS pain score at 16 hours in intervention group was much inferior than control group 1.00 ±2.09 vs. 3.06 ± 2.58 ( p < 0.001). Conclusion: Active aspiration of CO2 is an effective method that removes most if not all gas from the abdominal cavity. This will cause statistically significant decrease post-operative discomfort, pain and decrease need of rescue analgesics. Key Words: Laparoscopic cholecystectomy, Pneumoperitoneum, Active Aspiration, shoulder tip pain, post- laproscopic cholecystectomy pain How to Cite: Arif A, Nofal S, Khan MA, Khan AW, Bhatti AM, Ishaq SH. Shoulder tip pain in laparoscopic cholecystectomy with active vs passive evacuation of pneumoperitoneum. Esculapio. 2020;16(04):116-119.

Enhancement of plasma corticotropin-releasing hormone in pregnancy-induced hypertension

1990 ◽  
Vol 122 (6) ◽  
pp. 711-714 ◽  
Author(s):  
W. Jeske ◽  
P. Soszyński ◽  
E. Lukaszewicz ◽  
R. Dȩbski ◽  
W. Latoszewska ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Gestational Age ◽  
Placental Tissue ◽  
Normal Pregnancy ◽  
Placental Lactogen ◽  
Control Group ◽  
Pregnancy Induced Hypertension ◽  
Human Placental Lactogen ◽  
Induced Hypertension ◽  
In Pregnancy

Abstract. The role of a high CRH level in normal pregnancy remains unknown. Therefore we evaluated the concentrations of CRH and the related hormones in patients with pregnancy-induced hypertension. Fourteen women with pregnancy-induced hypertension, aged 20-39, at 30-39 gestational week, were investigated. The control group consisted of 20 healthy pregnant women matched according to gestational age. Plasma CRH, β-endorphin-like immunoreactivity, cortisol, and human placental lactogen were measured by radioimmunoassay, ACTH by an immunoradiometric method. It was found that in hypertensive patients the mean CRH concentration was significantly higher (4257±840 (sem) ng/l) than that in healthy pregnant women (1083±227 ng/l, p<0.001). The concentration of ACTH, however, was only slightly higher 65.0±6.0 vs 50.7±2.5 ng/l, p<0.025, whereas the differences in β-endorphin, cortisol and human placental lactogen were not significant. In both groups there was no correlation between the CRH level and those of the related hormones. In healthy pregnant women the CRH level closely correlated with gestational age (r=0.76, p<0.001), whereas in patients with hypertension no such correlation was present (r=0.29). We assume that the marked enhancement of plasma CRH in pregnancy-induced hypertension is probably caused by its decreased breakdown in ischemic placental tissue, but its increased synthesis in the placenta and its indirect counterregulatory hypotensive role must also be considered.

scholarly journals Fetoplacental Weight Relationship in Normal Pregnancy and Pregnancy Complicated by Pregnancy-Induced Hypertension and Abruption of Placenta among Mothers Who Gave Birth in Southern Ethiopia, 2018

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Tsegaye Mehare ◽  
Daniel Kebede
Keyword(s):  
Normal Pregnancy ◽  
Fetal Outcome ◽  
Cross Sectional Study ◽  
Normal Group ◽  
Southern Ethiopia ◽  
Pregnancy Induced Hypertension ◽  
Cross Sectional ◽  
Weight Relationship ◽  
Induced Hypertension ◽  
In Pregnancy

Introduction. Placenta is a complex multifunctional organ that maintains pregnancy and promotes normal fetal development. The fetal outcome is adversely influenced by pathological changes in the placenta because it is a mirror that reflects the intrauterine status of the fetus. Placental abnormalities are considered a leading cause of maternal and prenatal mortality. This study aimed to assess the fetoplacental weight relationship in pregnancy-induced hypertension and abruption placenta and compare with the normal one. Objective. This study designed to assess fetoplacental weight relationships in normal pregnancy and pregnancy complicated by pregnancy-induced hypertension and abruption of placenta among mothers who gave birth in Dilla University Referral Hospital, southern Ethiopia, 2018. Materials and Methods. Institution-based comparative cross-sectional study was used on 50 placentas from mothers with pregnancy-induced hypertension, 50 placentas from mothers with abruption of placenta, and 50 placentas from mothers with normal pregnancy (control) with an age range of 19–34 years. The weight of the placenta and newborn were taken and the fetoplacental ratio was calculated. Results. Placental index as well as the weight of the newborn shows statistically significant (p<0.001) difference in pregnancy-induced hypertension and abruption placenta group compared with the normal group. The mean of the fetoplacental ratio in the normal group was 5.52 ± 0.07, in pregnancy-induced hypertension was 5.15 ± 0.11, whereas the abruption placenta was 4.99 ± 0.82. Conclusion. Both PIH and abruption placenta were associated with remarkable changes in the placenta index such as small placental weight and diameter and results in different kinds of congenital anomalies and low birth weight of the baby. Hence, fetoplacental ratio was altered. The lowest fetoplacental ratio was 4.99 for abruption placenta, and the highest was for a normal group of the placenta which was 5.52. Therefore, an examination of the placenta before and after birth guarantees for feto-maternal health.

Sign in / Sign up

Export Citation Format

Share Document