scholarly journals WILSON’S DISEASE

2015 ◽  
Vol 22 (12) ◽  
pp. 1586-1590
Author(s):  
Sunil Kumar ◽  
Awais Bashir ◽  
Raheel Ahmed
Keyword(s):  
Wilson’S Disease ◽  
Tertiary Care ◽  
Care Facility ◽  
Wilson's Disease ◽  
P Value ◽  
Chi Square ◽  
Female Ratio ◽  
Male Predominance ◽  
Tertiary Care Facility ◽  
Chi Square Test

Objectives: To determine the frequency of various neurological manifestationsof Wilson’s disease in patients presenting to tertiary care facility. Study design: Cross sectionalstudy. Setting: Neurology ward, JPMC, Karachi. Period: 14-03-2012 to 13-09-2012. Patientsand Methods: A total of 150 diagnosed patients of Wilson’s disease between the age 15 and55 years were recruited. Structured questionnaire was used to collect the data regardingneurological manifestations of Wilson’s disease along with slit lamp examination for kayser-Fleischer rings. Data were entered and analyzed in SPSS version 17. Chi-Square test was usedas test of significance. Results: Mean age + S.D of patients was 38.7 + 8.23 years. Most of thepatients (42%) belongs to age between 41 to 50 years. Male to female ratio was 2:1. Tremorwas the most common neurological manifestation (88.7%) followed by dysarthria in 77.3%,dystonia was present in 59.3%, chorea in 36%, and Parkinsonism in 28.7%. All patients hadthe Kayser-Fleischer ring positive. Upon stratification of gender, tremor & dysarthria were morecommon in males as compared to females. Only dysarthria was significantly noted to increasewith increasing age up to 5th decade of life and decreased after age of 51 years. (P value< 0.001). Conclusion: Neurologic manifestations are very common in patients of Wilson’sdisease, tremor being the most common with male predominance.

Frequency of Atrial Fibrillation and its Complication

2021 ◽  
Vol 15 (11) ◽  
pp. 2989-2992
Author(s):  
Abdul Haadi ◽  
Sidra Ishfaq ◽  
Munazza Nazir ◽  
Syed M.Sajid Ali Bukhari ◽  
Muhammad Ishraf-Ul-Islam ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
P Value ◽  
Care Hospital ◽  
Chi Square ◽  
Cross Sectional ◽  
Female Ratio ◽  
Hypertensive Patients ◽  
Chi Square Test

Background: Evidence available on atrial fibrillation in Pakistan is not enough. Therefore, present study aims to determine frequency of atrial fibrillation and its associated complications. Place and duration of study: This cross sectional study was conducted at Department of Medicine, at SKBZ/AK CMH Muzaffarabad (Tertiary Care Hospital Muzaffarabad AJK) from July to December, 2019. Methodology: Total 1100 patients included for this study through non-probability consecutive sampling. Ethical approval and consent forms were taken. Patients were examined for atrial fibrillation through ECG. The patients who were confirmed as AF were detail examined and their cause and complications were noted down. Data was analyzed with SPSS version 24. One sample t test was used to predict AF in the population Chi-square test was applied. P value ≤0.05 was considered significant. Results: Out of 1100 patients mean age of patients was 43.4±12.7 years. The male to female ratio was 11:10. The atrial fibrillation was diagnosed in 250 (22.7%). In our population, at least 20% of the patients are having issue of atrial fibrillation with p value 0.016. The percentage of AF was higher in female 40.4% as compared to male 6.9%. Similarly the percentage of AF was higher in hypertensive patients (37.8%) as compared to non-hypertensive patients (12.3%). Conclusion:The prevalence of atrial fibrillation is moderately high in our data. Our sample results support the hypothesis that female are mostly with AF. Hence there is need to take measures to prevent them. Keywords: Atrial fibrillation, Causes of atrial fibrillation, Complications of atrial fibrillation

scholarly journals Accidental childhood poisoning in Paediatrics department of a tertiary care facility: A retrospective review

2020 ◽  
Vol 47 (3) ◽  
Author(s):  
D.C. Obu ◽  
M.C. Orji ◽  
U.V. Muoneke ◽  
U.V. Asiegbu ◽  
G.O. Ezegbe
Keyword(s):  
Tertiary Care ◽  
Care Facility ◽  
Accidental Poisoning ◽  
Female Ratio ◽  
The Public ◽  
Tertiary Care Facility ◽  
Childhood Poisoning ◽  
The Mean ◽  
The Relationship ◽  
Male To Female

Background: Accidental childhood poisoning is a recognized preventable cause of morbidity and mortality among children worldwide. This studywas aimed at determining the prevalence, pattern, and outcome of childhood poisoning among children in Abakaliki, Ebonyi State. Material and Methods: Medical records of all cases of accidental childhood poisoning admitted into Children’s emergency room (CHER) of the health facility of study between January 2014 and December 2018 were retrospectively identified and relevant data extracted and analyzed usingSPSS version 22. Results: Out of the 7,700 children that presented to CHER over a 5- year period, 42 were cases of poisoning, giving prevalence rate of 0.5%. Of the 42 cases, only 20 case notes were retrieved. The male to female ratio was 2.3:1 while the ages ranged between 6months and 14 years with the mean age of 3.06±2.88. Kerosene poisoning had the highest proportion of 50.0% (10/20) with the overall mortality rate of 5.0% (1/20).The relationship between age, place of residence and outcome in poisoned children was statistically significant (p = 0.038, 0.045 respectively). Conclusion: Accidental childhood poisoning is common in Abakaliki. Kerosene still remained the major agent while male toddlers were most  vulnerable. There is need to intensify enlightenment campaigns and education of the public about the hazard of improper storage of kerosene and other implicated substances at home. Keywords: Accidental poisoning, Childhood, Kerosene

scholarly journals BILE DUCT INJURIES;

2017 ◽  
Vol 24 (01) ◽  
pp. 64-68
Author(s):  
Muhammad Paryal Tagar ◽  
Khawar Saeed Jamali ◽  
Mujeeb Rehman Abbasi ◽  
Sarang Tagar
Keyword(s):  
Bile Duct ◽  
Open Cholecystectomy ◽  
Thick Wall ◽  
P Value ◽  
Chi Square ◽  
Female Ratio ◽  
Civil Hospital ◽  
Surgical Department ◽  
Bile Duct Injuries ◽  
Chi Square Test

Objectives: Determine the frequency of bile duct injuries during open andlaparoscopic cholecystectomy procedures. Study Design: Prospective Observational Study.Place and Duration of Study: This study was conducted at surgical department of multiplehospitals and compares the results Civil Hospital Naushahro Feroze, Liaquat University HospitalJamshoro and Civil Hospital Karachi and NaushahroFeroze, August 2014 to December 2015.Methods: All 320 patients were equally divided for open cholecystectomy and Laparoscopiccholecystectomy. Demographic profile and detailed Clinical examination were recorded. Allpatients were evaluated for Cholelithiasis underwent preoperative investigations. All patientswere resuscitated and optimized before intervention. Inclusion criteria were diagnosed caseof gallstones, age > 20 years and both gender selected for open cholecystectomy andLaparoscopic cholecystectomy and assessed the frequency of bile duct injury during bothprocedures. Exclusion criteria were of carcinoma of gall bladder, stone in CBD and obstructivejaundice. Chi square test was applied for p-value. Results: 320 cases of gallstone wereundertaken for operative laparoscopic cholecystectomy and open cholecystectomy procedure.Most of the patients were 208(65%) female, male to female ratio were 1:7.2. Gall stonecommonly reported in 3rd and 4th decade 186(58.13%) cases in between 36-50 years. The meanage was 39.8+5.90years. Abdominal ultrasound revealed that multiple stone 253(79.1%) casesas compared to single stone. Other common findings of thick wall gallbladder139 (43.44%)cases while ultrasonologist reported impacted gallbladder stone in 23(7.19%) cases. Commonbile duct injury more occur in open procedure 24(7.5%) cases as compared to laparoscopiccholecystectomy 15 (4.7%) cases and Chi square test was applied for p-value <0.001.Conclusion: The Laparoscopic procedure has decreased rate of complications and bile ductinjury day by day due to improved learning curve.

scholarly journals Anatomical Variations of the Paranasal Sinuses and the Nasal Cavity

2019 ◽  
Vol 21 (1) ◽  
pp. 7-11
Author(s):  
Kundan Kumar Shrestha ◽  
K Acharya ◽  
RR Joshi ◽  
S Maharjan ◽  
D Adhikari
Keyword(s):  
Anatomical Variation ◽  
Anatomical Variations ◽  
P Value ◽  
Deviated Nasal Septum ◽  
Chi Square ◽  
Female Ratio ◽  
Chi Square Test ◽  
The Difference ◽  
The Right ◽  
Sinonasal Symptoms

Computed tomography (CT) of the para-nasal sinuses (PNS) has nowadays become the investigation of choice for the diagnosis of sinonasal diseases. Numerous sinonasal anatomic variants exist and are frequently seen on CT scans. A sound knowledge of these variations is important not only for diagnosis but also for planning surgery in order to avoid complications. The aim of this study is to investigate the frequency of these variations in patients with sinonasal symptoms and also to determine their relation to sinonasal disease if any. A total of 76 patients were included in the study from August 2017 to July 2018 of which 43 (56.6%) were males and while 33 (43.4%) were females with male to female ratio of 1.3:1. The ages of patients ranged from 14 to 72 years with a mean age of 33.2±14.2 years. Out of 76 patients, 68 (89.5%) had at least one type of anatomical variation while 8 (10.5%) had no variation. Only one variation was seen in 39 (51.3%) patients while 29 (38.2%) had two or more variations. The most common variant was deviated nasal septum (DNS), occurring in 49 (64.5%) patients followed by concha bullosa (CB) and agger nasi cell (AN) seen in 15 (19.7%) and 14 (18.4%) patients respectively. Genderwise, anatomical variations were seen more in males but the difference was not statistically significant. Some variations were seen more on the right side while others on the left. Some variations were present bilaterally. The difference was not statistically significant. The presence of DNS was statistically significant in the study population (p value 0.012 in nonparametric chi square test). The age group 14 to 30 years showed maximum variations though not significant statistically. Therefore, during management of patients with sinonasal symptoms, these variations need to be addressed, if required, surgically. Proper knowledge of both common and uncommon sinonasal variations in our community could help in better surgical planning and overall management of sinonasal disorders.

scholarly journals Legal, Social, and Occupational Problems in Persons with Alcohol Use Disorder: An Exploratory Study

2020 ◽  
pp. 025371762095646
Author(s):  
Barikar C Malathesh ◽  
Channaveerachari Naveen Kumar ◽  
Arun Kandasamy ◽  
Sydney Moirangthem ◽  
Suresh Bada Math ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Tertiary Care ◽  
Care Facility ◽  
Cross Sectional Study ◽  
Driving Under The Influence ◽  
Chi Square ◽  
Cross Sectional ◽  
Work Absenteeism ◽  
Targeted Interventions ◽  
Tertiary Care Facility

Background: Very few studies have examined the extent and nature of legal, social, and occupational problems among persons who have SUDs. This study was aimed at studying the prevalence and patterns of the aforementioned problems among individuals with alcohol use disorders (AUDs) and their relationship with the quantity of alcohol consumed and other variables. Methods: We conducted a cross-sectional study of adult patients with a diagnosis of AUDs admitted to the deaddiction unit of a tertiary care facility in India, using a semistructured questionnaire prepared for this study. Results: The mean age (SD) of the 91 subjects (95.6% males) was 40.3 years (8.5). Majority of them (92.3%) had started alcohol consumption before the age of 25 years. Common problems reported were work absenteeism (83.5%), a major altercation with spouse (69.3%), assaulting someone while intoxicated (53.8%), and driving under the influence of alcohol (59.3%). Significant association was found between being unemployed and having a police complaint lodged against them (chi-square = 5.7, P = 0.01). Quantity of alcohol consumed per day was significantly more among those who had a history of work absenteeism ( Z = 2.27, P = 0.01), major altercation with spouse ( Z = 2.25, P = 0.02) and assaulted someone under intoxication ( Z = 2.33, P = 0.02). Conclusion: The quantity of alcohol consumed is significantly more in those who had several legal, social, and occupational problems when compared to those who did not have, highlighting the need for routine assessment of the aforementioned problems among patients of AUDs. Treatment of AUDs should be multidisciplinary, with targeted interventions tailored to the aforementioned problems. Doing so will go a long way in reducing the harm to patients and the community at large.

scholarly journals 219. Is the modified quick SOFA scale superior to quick SOFA in patients with diagnosed septic shock?

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S128-S128
Author(s):  
Deniz Akyol ◽  
Ayşe Uyan Önal ◽  
Uğur Önal ◽  
Damla Akdağ ◽  
Cansu Bulut Avşar ◽  
...  
Keyword(s):  
Septic Shock ◽  
Survival Rate ◽  
Tertiary Care ◽  
University Hospital ◽  
P Value ◽  
Chi Square ◽  
Number Of Patients ◽  
Significant Difference ◽  
Chi Square Test ◽  
Qsofa Score

Abstract Background In this study it was aimed to compare the effects of qSOFA (Quick Sequential Organ Failure Assessment) score with modified qSOFA score (PLoS One. 2018 Sep 26;13(9):e0204608) for predicting one month survival in patients with diagnosed septic shock (SS) in a tertiary-care educational university hospital in a developing country. Methods Modified qSOFA was created by adding age factor (>50 years=1 point) to patients with qSOFA scale 1 or 2 or 3 who had SS (sepsis+hypotension+adrenergic agent) and consulted by Infectious Diseases consultants between December 2013-December 2018. Arterial lactate level of >2 mmol/L criterion was added as an including criteria for SS according to 3rd International Sepsis and Septic Shock Consensus Statement after 23rd February 2016. Statistical analysis was performed via Chi-square test and a p-value <0.05 was considered significant. Results The number of patients with qSOFA score of 1 or 2 or 3 from 527 patients are in Table1 [some of the cases were diagnosed as septic shock according to elder definition (without lactate criterion) and there was a subgroup with qSOFA score 1]. Among the >50-year aged group, the 30-day survival rate was lower in patients with qSOFA3 vs. qSOFA 2 vs. qSOFA 1 (Table1, 3x2 Chi Square test, P = 0.0057). Among the <50 years group, the qSOFA one month survival rate was lower in patients with qSOFA 3 vs. qSOFA 2 vs. qSOFA 1 (Table, 3x2 Chi Square Test, P = 0.0052). According to modified qSOFA, there was a significant difference for one month survival among SS cases with scores of 1, 2, 3 and 4 (12/21 57% vs. Fifty/126 40% vs. 78/269 29% vs. 22/111 20%, 4x2 Chi-square test, P = 0.0003). On the other hand, there was no significant difference in terms of one month survival when we performed subgroup analysis in qSOFA score 1, 2, or 3 subgroups, as ≤50 years vs. >50 years (table, Chi-square test, 12/21 vs. 39/97 P = 0.224, 11/29 vs. 75/244 P = 0.526, 3/25 vs. 22/111 P = 0.572). Conclusion In terms of survival at one month, there was a significant difference between qSOFA score 1, 2, 3 and 4 subgroups. In patients with qSOFA score of 1 or 2 or 3, being under 50 years did not have a significant effect on one-month survival. Modified qSOFA may be beneficial to foresee the probable mortality but these findings need to be validated in larger cohorts Disclosures All authors: No reported disclosures.

scholarly journals Association of Acute Otitis Media with Breast Feeding Position Among Infants in a Tertiary Care Hospital of Pakistan

2020 ◽  
Vol 2 (6) ◽  
Author(s):  
Samia Tul Rasool ◽  
Sana Mansoor ◽  
Tayyab Mumtaz Khan ◽  
Ashar Alamgir ◽  
Maida Meer ◽  
...  
Keyword(s):  
Otitis Media ◽  
Breast Feeding ◽  
Tertiary Care ◽  
Acute Otitis Media ◽  
P Value ◽  
Care Hospital ◽  
Chi Square ◽  
Educational Levels ◽  
Breastfed Infants ◽  
Chi Square Test

Acute otitis media (AOM) is the commonest disease of childhood. High incidence of AOM might be due to immature Eustachian Tube and immaturity of immune system. Exclusive breast feeding is protective against acute otitis media, however, improper breastfeeding  position can increase AOM occurrence in infants. This study aims to assess the association of improper breastfeeding position with occurrence of Acute otitis media in infants and to assess association of Maternal educational levels with feeding positions. 220 breastfed infants satisfying inclusion criteria with diagnosed AOM were enrolled. Study was conducted over a period of 6 months from August 2019 to January 2020. Demographic details and Detailed history regarding feeding positions and maternal educational levels were obtained through a Self-structured proforma from parents. Data analysis was done through descriptive statistics and chi square test and p value less than 0.5 was set significant. Out of 220 infants, 123(55.90%) were male and 97(44.10%) were females. AOM was more common in male infants than female infants, however it was not statistically significant(p=0.169). The mean age for enrolled infants(1-12months) was 6.90(±3.413). Statistically significant association between increase incidence of AOM and breastfeeding position was found(p=0.032). We also found a statistically significant association between maternal educational levels and breastfeeding position (p= 0.000). In this study, we have noted that Breastfeeding in supine position is associated significantly with increase in incidence of AOM. Feeding positions are statistically associated with Maternal Educational levels.

scholarly journals Clinical profile of pulmonary tuberculosis and MDR TB in children at tertiary medical institute

2019 ◽  
Vol 6 (6) ◽  
pp. 2571
Author(s):  
Anupama Vinayak Mauskar ◽  
Amrit Gopan
Keyword(s):  
Risk Factor ◽  
Pulmonary Tuberculosis ◽  
Tertiary Care ◽  
Admission Rate ◽  
P Value ◽  
Chi Square ◽  
Pulmonary Tb ◽  
Medical College ◽  
Mdr Tb ◽  
Chi Square Test

Background: India is the country with highest burden of TB. There is paucity of data as far as Pediatric TB is concern. TB in children directly reflects intensity of on-going transmission of TB in a given community. This study was done including indoor cases of Pediatric pulmonary TB in a medical college hospital, a tertiary care institute in the city of Mumbai. The aim and objectives of this study the clinical profile and outcome of Pediatric pulmonary tuberculosis/MDR TB in an indoor setting of a tertiary care center. It was a clinical observational study in a setting of medical college hospital.Methods: All admitted children with newly diagnosed pulmonary TB were included in study. A detailed clinical analysis was done. Statistical Analysis Association between two qualitative data was assessed by Chi-Square test, Fisher's exact test for all 2 X 2 tables where Chi-Square test was not valid due to small counts. Comparison of quantitative data measured between two outcomes was done using unpaired t-test. PSPP version 0.8.5 was used for statistical analysis.Results: Total of 41 patients with pulmonary TB were included in the study, making admission rate of 0.7% of total admission. Three out of 41 children had MDRTB making incidence 7% of total TB patients. Severe acute malnutrition was a major risk factor for dissemination of disease and mortality (p value 0.031and 0.0017).Conclusions: The study estimates 0.7% admission rate and 7% as incidence of MDRTB in indoor patients. Severe malnutrition was found to be risk factor for dissemination of disease [p value 0.031].

scholarly journals Characteristic of COVID-19 infection in pediatric patients: early findings from a tertiary care center, Nagercoil, Tamil Nadu, India

2020 ◽  
Vol 7 (10) ◽  
pp. 2048
Author(s):  
Babitha Rexlin G. ◽  
Suresh P. M.
Keyword(s):  
Tamil Nadu ◽  
Care Center ◽  
Tertiary Care ◽  
Care Facility ◽  
Retrospective Chart Review ◽  
Respiratory Illness ◽  
Family Welfare ◽  
P Value ◽  
Mild Disease ◽  
Tertiary Care Facility

Background: The planet faces a new challenge with COVID-19 disease caused by novel SARS-CoV2. Pediatric COVID-19 is considered to be mild. Methods: The study aim was to describe the clinical presentation, diagnostic findings and outcome of a cohort of paediatric patients according to Ministry of health and family welfare (MOHFW) criteria, at KKGMCH a tertiary care facility in Kanyakumari district. It’s a retrospective chart review including data of children aged 0 to 12 years with COVID-19 from 20 March to 19 July 2020. Results: Of the 137 children with COVID-19, 17 (12.45%) were infants, 65 (35%) were 1-5 years and 72 (52.55%) were 6-12 years. Age didn’t have influence on acquiring the illness as p value is 0.125. Age had no influence on severity too as p value is 0.28. 46.7% were female and 53.3% were male. There was an apparent male preponderance with (OR 1.63, 95% CI 1.00 to 2.21) but a non-significant p value of 0.54. of the 34 (24.8%) mild symptomatic, 22 (64.7%) were males and 12 (35.2%) were females. The p value is 0.086 stating gender non-influential on severity. 129 (94.1%) children had contact history. The contacts were parents or close relatives. No child with comorbidity presented during this period. Most common clinical features were fever (8.76%), cough (6.6%), rhinorrhoea (2.2%), vomiting (2.9%) and diarrhoea (1.5%). Children never progressed to severe respiratory illness requiring intensive care as per MOHFW criteria. 1 (0.7%) presented with focal consolidation in chest x-ray. All 137 (100%) children got cured.Conclusion: Study concludes pediatric COVID-19 is a mild disease without mortality at beginning of pandemic in Kanyakumari district. Factors like age and gender neither influenced the occurrence of the disease nor the severity.

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