Correlation of VIT D3 and serum ferritin levels in anemic patients in a hospital based study.

Objectives: To determine the correlation of Vit D3 levels with serum ferritin in patients with anemia. Study Design: Cross Sectional study. Setting: Department of Pathology, Qazi Hussain Ahmed Medical Complex Nowshera. Period: 5th Jan 2019 to 31st Dec 2020. Material & Methods: Data entered in SPSS 25th version. Descriptive statistics was used for numerical variables. Pearson correlation was used for correlation of Vit D3 with gender. Normality of data was checked by Shapiro wilk test. Mann Whitney U test was used to show the difference of Vit D3 and ferritin levels in gender. Results: The total of 192 anemic patients with Hb<10g/dl as per definition of WHO1 were referred for ferritin level estimation with 142(74%) females and 50(26%) males. Out of total, 47 were also advised with Vit D3 level estimation with 29(61.7%) females and 18(38.3%) males. Mean with standard deviation for age was 30+9.6 years. Mean with standard Error of mean of Vit D3 was (Mean-15.5ng/ml, SE 2.19). Mean with standard Error of mean of serum ferritin was (Mean-48.2ng/ml, SE 5.90). We observed 35(74.5%) cases out of 47, as Vit D3 deficient with a count less than 20 ng/ml. We observed that 118 (61.5%) were iron deficient with serum ferritin less than 15ng/ml. Person correlation showed a statistically significant correlation of Vit D3 with ferritin (p= 0.022, r=0.7). Spearman ranked correlation showed a statistically significant correlation between the categories of Vit D3 and ferritin (p=0.022, r=0.7). Mann Whitney U Test showed no significant difference in gender groups for botht the variables (p= 0.86 &p=0.33 respectively) thus retain the null hypotheses. Conclusion: The frequency of deficiency Vit D3<20ng/ml in anemic patients was 74% while that of ferritin<15ng/ml in anemic patients was 61.5%. There is a strong statistically significant correlation of Vit D3 with serum ferritin in anemic patients with Hb<11g/dl.

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Cardiac Dysfunction and Serum Ferritin Level as Early Prognostic Markers in Children with Sepsis: A Cross-Sectional Study

Iranian Journal of Pediatrics ◽

10.5812/ijp.114738 ◽

2021 ◽

Vol In Press (In Press) ◽

Author(s):

Ahlam M. Ismail ◽

Mostafa Ahmed El Sayed Ahmed Abu Elela ◽

Islam Nashaat Roshdy Ahmed ◽

Nagwa Mohamed Sabry Mahmoud

Keyword(s):

Ejection Fraction ◽

Serum Ferritin ◽

Cardiac Dysfunction ◽

Serum Ferritin Level ◽

Ferritin Level ◽

Cross Sectional Study ◽

High Serum ◽

Sectional Study ◽

Cross Sectional ◽

Significant Difference

Background: Sepsis still causes morbidity and mortality in children admitted to the pediatric intensive care unit (PICU). Sepsis induces myocardial dysfunction and causes a reversible decline in ejection fraction (EF) of ventricles. Many biomarkers have been described for diagnosing sepsis, including serum ferritin and C-reactive protein (CRP). Objectives: This study was conducted to assess the relationship of cardiac dysfunction evaluated using echocardiogram, ferritin, and CRP with negative outcomes of sepsis in the PICU. Methods: A cross-sectional study was conducted on 80 patients aged between one month and six years who fulfilled the following criteria: (1) confirmed diagnosis of sepsis according to the American College of Critical Care Medicine; (2) receiving ventilation for 48 h and/or vasoactive medicines. The CRP and ferritin levels were recorded on the first day (D1) and third day (D3) of hospitalization in the PICU. Participants underwent an echocardiography study to investigate the ejection fraction on D1 and D3. All outcomes were evaluated. Results: Our results showed a highly statistically significant difference between D1 and D3 in ejection fraction (P = 0.001). The serum ferritin level and CRP enhanced significantly from D1 to D3 (P < 0.001). Low left ventricular ejection fraction, and high serum ferritin were associated with unfavorable outcomes (P values < 0.001 and 0.021, respectively), but there was no significant difference in the outcomes regarding CRP. Conclusions: Cardiac dysfunction and high serum ferritin were associated with unfavorable outcomes in children with sepsis admitted to the PICU.

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Perbedaan Rerata Feritin Serum antara Pria Obesitas Sentral dengan Non Obesitas Sentral

e-CliniC ◽

10.35790/ecl.v8i2.29627 ◽

2020 ◽

Vol 8 (2) ◽

Author(s):

Ribka Wowor

Keyword(s):

Serum Ferritin ◽

Central Obesity ◽

Animal Studies ◽

Serum Ferritin Level ◽

Ferritin Level ◽

Cross Sectional Study ◽

Obese People ◽

Cross Sectional ◽

Young Males ◽

Significant Difference

Abstract: Inflammation process that occurs in obese people plays a crucial role for cardiovascular events in the future. Animal studies found an association between macrophage and ferritin as a proinflammatory marker. This study was aimed to determine the difference in serum ferritin level between central obese and non central obese individuals. This was a cross sectional study using consecutive sampling mnethod. Subjects were residents of Medical Faculty, Sam Ratulangi University, consisted of 41 young males divided into two groups: 25 subjects with central obesity and 16 subjects without central obesity. Blood pressure, peripheral blood, serum ferritin, creatinine, and fasting blood sugar tests were performed on all subjects. The results showed that of 25 subjects with central obesity, there were 15 subjects with hyperferritinemia, meanwhile only 3 subjects with hyperferritinemia in non central obesity group. There was a significant difference of mean serum ferritin levels between central obesity and non central obesity groups (303.03±171.53 mcg/dL vs 128.24±66.79 mcg/dL; p=0.000). In conclusion, serum ferritin level in male subjects with central obesity was higher than those without central obesity.Keywords: serum ferritin, central obesity Abstrak: Inflamasi yang terjadi pada obesitas berperan penting terhadap kelainan metabolisme yang menjadi dasar terjadinya kelainan kardiovaskular. Pada hewan coba didapatkan adanya hubungan antara makrofag dengan feritin yang merupakan salah satu protein penanda inflamasi akut dan kronis. Penelitian ini bertujuan untuk mengetahui adanya perbedaan rerata ferritin serum pada individu dengan dan tanpa obesitas sentral. Desain penelitian ialah potong lintang dengan menggunakan konsekutif sampling. Subyek penelitian ialah mahasiswa PPDS Sp1 Fakultas Kedokteran Universitas Sam Ratulangi Manado terdiri dari 41 pria usia dewasa muda berusia kurang dari 40 tahun yang dibagi atas dua kelompok: 25 subyek dengan obesitas sentral dan 16 subyek non obesitas sentral sebagai kontrol. Pemeriksaan tekanan darah, darah perifer lengkap, dan kadar feritin serum dilakukan pada semua subyek. Uji statistik menggunakan uji beda rerata antara kadar feritin pada kedua kelompok. Hasil penelitian mendapatkan pada kelompok obesitas sentral, 15 dari 25 subyek mengalami peningkatan kadar feritin serum, sedangkan pada kelompok non obesitas sentral hanya 3 dari 16 subyek yang mengalami peningkatan kadar feritin serum. Rerata feritin serum pada kelompok obesitas sentral ialah 303,03±171,53 mcg/dL; sedangkan pada kelompok non obesitas sentral ialah 128,24±66,79 mcg/dL (p=0,000). Simpulan penelitian ini ialah terdapat perbedaan rerata feritin serum antara subyek dengan obesitas sentral dibandingkan subyek non obesitas sentral pada pria dewasa muda.Kata kunci: feritin serum, obesitas sentral, dewasa muda

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Determination Of Factors Affecting Father-Baby Attachment

Gevher Nesibe Journal, IESDR ◽

10.46648/gnj.245 ◽

2021 ◽

Vol 6 (14) ◽

pp. 1-7

Author(s):

Emine Serap ÇAĞAN ◽

Birsen KARACA SAYDAM ◽

Sinem GÜLÜMSER ATEŞ ◽

Rabia EKTİ GENÇ ◽

Esin ÇEBER TURFAN

Keyword(s):

Cross Sectional Study ◽

Study Data ◽

Cross Sectional ◽

Infant Attachment ◽

Factors Affecting ◽

Attachment Figure ◽

Gynecology And Obstetrics ◽

Significant Difference ◽

Package Program ◽

The Difference

Introduction: The primary attachment figure is mostly defined as the mother, and studies focus on the mother. However, in many babies, basic attachment is just as good with the father as with the mother. It is seen that there are very few studies in the literature investigating the correlations of father-infant attachment relationships.. The aim of this study is to determine the father-infant attachment status and to determine the factors affecting attachment. Method: The population of the cross-sectional study consisted of the spouses of all puerperant women hospitalized in the Gynecology and Obstetrics Clinic between September 1, 2018 and October 1, 2018. The sample size consisted of 156 fathers who agreed to participate in the study. Father identification form and father-infant attachment scale were used to collect the study data. The analysis of the data obtained from the research was carried out on the computer using the SPSS 16.0 package program. Results: 156 fathers participated in the study. The mean age of the fathers is 33.64±6.49, and 38.5% of them have a bachelor's degree. 91.0% of fathers stated that they felt ready for fatherhood. The fathers' Father-Infant Attachment Scale mean score was 82.60±7.72 In the analysis, the difference between the variables and the total score of the scale was found to be statistically insignificant (p>0.05). Discussion and Conclusion: At the end of the study, the bonding process of fathers participating in the study with their babies and the factors affecting this process were evaluated and it was seen that the father-infant attachment scale mean scores of the fathers participating in the study were high and were similar to other studies. In addition, when the basic factors affecting father-infant attachment were compared with the attachment scale mean score, it was found that there was no statistically significant difference.

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Relationship between Ratio of Second and Fourth Digit and Obesity Traits among Different Ethnic Groups in Ilorin, North Central Nigeria

Notulae Scientia Biologicae ◽

10.15835/nsb849888 ◽

2016 ◽

Vol 8 (4) ◽

pp. 396-400 ◽

Cited By ~ 2

Author(s):

Bolaji Fatai OYEYEMI ◽

John Oluwafemi ADEBAYO ◽

Abass Toba ANIFOWOSHE ◽

Oluyinka Ajibola IYIOLA

Keyword(s):

Ethnic Groups ◽

Pearson Correlation ◽

Standard Procedure ◽

Surrogate Marker ◽

Relative Length ◽

Cross Sectional Study ◽

Digit Ratio ◽

Sectional Study ◽

Cross Sectional ◽

Significant Difference

Digit ratio (2D:4D) denotes the relative length of the second and fourth digits. There are contradicting reports on its relationship with ethnicity/race, whereas convincing studies show it is related to obesity. This cross-sectional study was undertaken to demystify ethnic difference in 2D:4D ratio and to analyze its relationship with obesity among adults in Ilorin Nigeria. The cross-sectional study included 701 individuals. Finger lengths were measured with electronic calipers and other anthropometric traits were measured with standard procedure. Student t test and one-way ANOVA were used to detect differences among groups and relationship was computed with Pearson correlation. The receiver operator characteristic curves were used to detect the diagnostic effect of 2D:4D for obesity. The obtained results showed sexual dimorphism in 2D:4D ratio and other anthropometrics at p < 0.01. Obesity was associated with significantly higher mean of 2D:4D in both genders (female 0.9814 ± 0.012:0.9700 ± 0.012; male 0.9700 ± 0.010:0.9592 ± 0.010 at p < 0.001). The area under the curve was 0.753 (95% CI 0.677-0.829, p < 0.01) and 0.798 (95% CI 0.756-0.804, p < 0.01) in female and male R2D:4D respectively for obesity, implying that 2D:4D might be a surrogate marker for obesity in future. No significant difference was found in 2D:4D among different ethnic groups studied (p >0.05); this result proved that there was no ethnic specificity in 2D:4D ratio among study’ participants. Thus, it can be reported that the digit ratio was related to high 2D:4D, but this cannot be said for different ethnic groups. The results imply that 2D:4D might be a good surrogate indicator for obesity, but not ethnicity.

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Study of Maternal and Fetal Outcome among Booked and Unbooked Patients at tertiary Hospital

Birat Journal of Health Sciences ◽

10.3126/bjhs.v5i2.31376 ◽

2020 ◽

Vol 5 (2) ◽

pp. 1027-1030

Author(s):

Shanti Sunuwar Subedi ◽

Rakina Bhansakarya ◽

Sajjan Kumar Sharma

Keyword(s):

Sampling Technique ◽

Secondary Level ◽

Tertiary Hospital ◽

Fetal Outcome ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Spontaneous Vaginal Delivery ◽

Significant Difference ◽

The Difference

Introduction: To evaluate the maternal and perinatal outcome in booked and unbooked cases. Objectives: To assess the maternal and fetal outcomes in unbooked and booked patients. Methodology: This was a cross-sectional comparative study conducted in the Department of Obstetrics and Gynecology from Augustti2019 to January 2020. Using a convenient sampling technique, 204 samples were taken and cross-sectional study was done. Results: There were total 204 cases in this study;102were booked and 102 were unbooked. In this study, 85(83%) of booked cases were educated up to secondary level as compared toti65 (64%) of unbooked cases. There was no significant difference in Apgar score in 1 and 5 minute between booked and unbooked cases. More babies in the unbooked group were transferred to NICU as compared to the booked group and the difference was significant (9.8%vs 1.9%). Greater proportion of booked cases had spontaneous vaginal delivery (81.3% vs 59.8%) and complications like preterm delivery, anemia, preeclampsia/ eclampsia, complicated labor and puerperal sepsis was also less in the booked group. Conclusions: The study showed that unbooked mothers and their newborns had higher chance of having complications.

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Analgesic Effect of Apotel Versus Pethidine After Hemilaminectomy

Caspian Journal of Neurological Sciences ◽

10.32598/cjns.5.19.185 ◽

2019 ◽

Vol 5 (4) ◽

pp. 185-189

Author(s):

Mohammadreza Emamhadi ◽

◽

Hamid Behzadnia ◽

Seifollah Jafari ◽

Mohammadreza Zamanidoust ◽

...

Keyword(s):

Recovery Process ◽

Cross Sectional Study ◽

Medical Sciences ◽

Cross Sectional ◽

Vas Score ◽

Relieve Pain ◽

Present Cross Sectional Study ◽

Significant Difference ◽

Vas Scores ◽

The Difference

Background: Postoperative pain is a common phenomenon, and its management affects considerably on the recovery process, and patients’ satisfaction. Apotel and pethidine are two conventional medicines used to relieve pain after operation. Objectives: The present study aimed to compare the effect of intravenous injection of Apotel and intramuscular injection of pethidine in relieving pain after hemilaminectomy. Materials & Methods: In the present cross-sectional study, 150 patients who underwent hemilaminectomy were recruited between May 2015 and November 2015. They were taking either Apotel (n=75) or pethidine (n=75) after the operation, which was done at Poursina Hospital affiliated to Guilan University of Medical Sciences, Rasht City, Iran. The patients’ pain levels were measured using visual analog scale (VAS), and the results were compared between the 2 groups. Results: There was no significant difference in the total VAS score between the Apotel and pethidine groups (P=0.189). However, there was a significant reduction in VAS score hours 2 (P=0.03) and 4 (P=0.004) hours after the injection of Apotel in this group, compared with those scores in the pethidine group. Also, VAS scores at other times (8, 12, 20, 28 hours after the injection) were lower than those in the pethidine group, but the difference was not significant. Conclusion: Apotel was better pain-killer in the early hours after the first injection compared to pethidine. But its effect was similar to pethidine at the late hours after the first injection. Therefore it seems that Apotel is better painkiller after laminectomy, especially in the early hours after the operation.

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DIASTASIS RECTI AMONG PREGNANT AND POSTPARTUM WOMEN IN KANO, NIGERIA: A CROSS-SECTIONAL STUDY

Pakistan Journal of Rehabilitation ◽

10.36283/pjr.zu.6.1/003 ◽

2017 ◽

Vol 6 (1) ◽

pp. 15-20

Author(s):

Fatima Bichi ◽

Dr. Shumaila Hanif

Keyword(s):

Post Partum ◽

Sampling Technique ◽

Cross Sectional Study ◽

Postpartum Women ◽

Chi Square ◽

Cross Sectional ◽

Common Location ◽

Diastasis Recti ◽

Significant Difference ◽

The Difference

Diastasis Recti (DR) is a common muscular condition often present during and after pregnancy. This cross-sectional correlational study investigated the prevalence of DR among pregnant and postpartum women. A total of 250 pregnant and postpartum women were recruited using convenience sampling technique from obstetrics and gynaecology department, Aminu Kano Teaching Hospital, Kano, Nigeria. Age, body mass, height, BMI, parity, trimester, duration of DR postpartum, location of DR and DR status was recorded for each participant. Presence of DR was confirmed using the finger width method. Descriptive statistics of mean, SD, percentage were used to describe the data and determine the prevalence. Inferential statistics of Pearson’s and Spearman’s correlation were used to analyse the relationship between prevalence of DR and age, parity and duration of DR postpartum. Chi square was computed to determine the difference in prevalence of DR across trimesters. The result of this study indicated high prevalence of DR in post-partum and pregnant women (84% and 64.7% respectively); the most common location of DR was at the umbilicus in both pregnant and postpartum women. Prevalence of DR was high among the multigravida; and a significant relationship was found between prevalence of DR and age and parity of participants. There was a significant difference in prevalence of DR across the trimesters. It can be concluded that prevalence of DR among pregnant and postpartum women is high; age and parity are determinants of DR prevalence. Evaluation of DR should be considered as routine assessment in both pregnant and postpartum women.

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Effect of dengue hemorrhagic fever on thrombomodulin level

Paediatrica Indonesiana ◽

10.14238/pi49.5.2009.259-63 ◽

2009 ◽

Vol 49 (5) ◽

pp. 259

Author(s):

Hendra Widjaja ◽

Max F. J. Mantik

Keyword(s):

Endothelial Cells ◽

Dengue Hemorrhagic Fever ◽

Pediatric Patients ◽

Hemorrhagic Fever ◽

Cross Sectional Study ◽

Blood Analysis ◽

Cross Sectional ◽

Significant Difference ◽

The Difference ◽

Difference Test

Background Thrombocyte and endothelial cells play animportant role in dengue hemorrhagic fever pathogenesis.Thrombomodulin is a part of glycoprotein membrane inendothelial cells. Therefore, thrombomodulin level willincrease if endothelial cells disruption occurs.Objective To acknowledge the correlation between thedegree of dengue hemorrhagic fever and thrombomodulinlevel.Methods This was a cross-sectional study. Subjects werehospitalized pediatric patients with age ranging from oneto 13 year old in pediatric ward at Pro£ Dr. R.D. KandouHospital, Manado, who had fever. Three milliliters of bloodwere taken from vein, and were divided for two tests whichwere routine blood analysis and thrombomodulin analysis.Different data resulted from the dengue hemorrhagic fevergroup were processed, and analyzed statistically using F Testand LSD (least significant difference) test. The relationbetween dengue hemorrhagic fever and thrombomodulinwas analyzed with Spearman correlation coefficient.Results There was a significant result in the difference ofthrombomodulin level on four dengue hemorrhagic fevergroups which were classified according to the severity ofdengue hemorrhagic fever. There was a very significantpositive correlation between the severity of denguehemorrhagic fever and thrombomodulin level in detectingendothelial cells impairment.Conclusion Thrombomodulin level can be used as amarker to detect endothelial cells impairment in denguehemorrhagic fever. Higher grade of dengue hemorrhagicfever will have higher thrombomodulin level.

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The Role of α-Thalassemia and Iron Deficiency in the Difference between Hemoglobin Levels of African-Americans (AA) and Whites.

Blood ◽

10.1182/blood.v104.11.3706.3706 ◽

2004 ◽

Vol 104 (11) ◽

pp. 3706-3706

Author(s):

Ernest Beutler ◽

Carol West

Keyword(s):

Iron Deficiency ◽

Serum Ferritin ◽

Gene Frequency ◽

Ferritin Level ◽

Transferrin Saturation ◽

Hemoglobin Concentration ◽

Iron Deficient ◽

High Prevalence ◽

Hardy Weinberg Equilibrium ◽

The Difference

Abstract The fact that the average hemoglobin concentration (Hb) of AA is lower than that of whites has been documented extensively. Several investigations have shown that this difference of approximately 0.8 g/dL is due neither to iron deficiency nor to socioeconomic status. Its cause remains unknown. We compared the Hb of 1,493 AA and 31,029 white anonymized patients attending a Health Appraisal Clinic and confirmed the known difference in Hb, both for females and males (0.79 and 0.47 g/dL) respectively. The difference persisted when a subset of the subjects were paired by age and narrowed slightly in females when those with serum ferritin levels of <10 ng/ml or transferrin saturations of <16% were excluded (difference in females 0.59 g/dL; males 0.47). We determined the α-thalassemia −3.7 genotype of 298 AA. The gene frequency was found to be 0.17, and the distribution of genotypes fit the Hardy-Weinberg equilibrium. However, in a sample of 155 white subjects only one α-thalassemia allele was found (gene frequency=0.003). Among the AA subjects, the Hb and MCV values were lower in homozygotes (−a/−a) and heterozygotes (aa/−a) for α-thalassemia than in the aa/aa subjects. The table presents data for AA and white subjects after excluding all who did not have a documented serum ferritin level of >9 ng/ml and a transferrin saturation of >16%. Excluding subjects with sickle trait had no effect. Ethnic Group Genotype n Mean Hb SE Hb Mean MCV SE MCV −a/−a 3 11.87 0.418 72.23 2.32 F AA aa/−a 20 12.69 0.202 85.22 0.86 aa/aa 65 13.17 0.127 90.43 0.61 White 2917 13.60 0.016 90.85 0.07 −a/−a 2 13.85 0.550 83.05 1.65 M AA aa/−a 36 14.37 0.161 85.81 0.78 aa/aa 86 14.75 0.123 89.78 0.53 White 5335 15.09 0.013 90.35 0.06 As shown in the table, the average Hb of non-iron deficient AA females and males who had 4 normal α loci (aa/aa) was 0.43 and 0.34 g/dL lower respectively than those of whites, the difference being significant with p<0.01. We conclude that one cause of the lower Hb of AA compared to white subjects is the high prevalence of α-thalassemia in the AA population, but that it accounts for only about one-quarter of the difference after iron deficiency has been excluded. There are other, as yet undefined, causes that play a role. These may include the lower ATP (Biochem. Genet.1:25, 1967) and higher 2,3 BPG (Transfusion18:108, 1978) levels that have been documented in the red cells of AA subjects.

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Serum Ferritin Is Inversely Correlated with Serum Adiponectin Level: Population-Based Cross-Sectional Study

Disease Markers ◽

10.1155/2009/931082 ◽

2009 ◽

Vol 27 (6) ◽

pp. 303-310 ◽

Cited By ~ 14

Author(s):

Bon-Jeong Ku ◽

Seul-Young Kim ◽

Tae-Yong Lee ◽

Kang-Seo Park

Keyword(s):

Multivariate Analysis ◽

Serum Ferritin ◽

Adiponectin Level ◽

Ferritin Level ◽

Hdl Cholesterol ◽

Population Based ◽

Cross Sectional Study ◽

Serum Adiponectin ◽

Cross Sectional ◽

Hs Crp

Background: The serum concentrations of ferritin and adiponectin are associated with several metabolic disorders and have been used as predictors of insulin resistance and metabolic syndrome. But there have been no reports demonstrating a direct correlation between serum ferritin and adiponectin levels. We performed this study to evaluate the association between serum ferritin and adiponectin concentrations.Subjects and methods: We evaluated a total of 995 subjects from the Korea Rural Genomic Cohort Study in a population-based cross-sectional study. Extensive clinical and laboratory measurements, including adiponectin and ferritin concentrations, were recorded.Results: Univariate analysis revealed that the serum adiponectin level was correlated with age, sex, BMI, diastolic blood pressure, triglyceride, HDL-cholesterol, fasting blood glucose, fasting insulin, HOMA-IR, hs-CRP, and ferritin. Multivariate analysis demonstrated that the adiponectin concentration was correlated with age, BMI, fasting glucose, hs-CRP, and ferritin. The ferritin concentration was the most powerfully associated with serum adiponectin. In non-diabetic subgroups, the adiponectin level was correlated with BMI, triglyceride, HDL-cholesterol, fasting glucose, and ferritin level in multivariate analysis. In diabetic subgroups, the adiponectin level was correlated with BMI, triglyceride, hs-CRP, and ferritin level in multivariate analysis.Conclusions: The serum adiponectin concentration was correlated with conventional clinical variables, but the most powerfully associated factor was the serum ferritin level.

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