scholarly journals Effect of dengue hemorrhagic fever on thrombomodulin level

2009 ◽  
Vol 49 (5) ◽  
pp. 259
Author(s):  
Hendra Widjaja ◽  
Max F. J. Mantik

Background Thrombocyte and endothelial cells play animportant role in dengue hemorrhagic fever pathogenesis.Thrombomodulin is a part of glycoprotein membrane inendothelial cells. Therefore, thrombomodulin level willincrease if endothelial cells disruption occurs.Objective To acknowledge the correlation between thedegree of dengue hemorrhagic fever and thrombomodulinlevel.Methods This was a cross-sectional study. Subjects werehospitalized pediatric patients with age ranging from oneto 13 year old in pediatric ward at Pro£ Dr. R.D. KandouHospital, Manado, who had fever. Three milliliters of bloodwere taken from vein, and were divided for two tests whichwere routine blood analysis and thrombomodulin analysis.Different data resulted from the dengue hemorrhagic fevergroup were processed, and analyzed statistically using F Testand LSD (least significant difference) test. The relationbetween dengue hemorrhagic fever and thrombomodulinwas analyzed with Spearman correlation coefficient.Results There was a significant result in the difference ofthrombomodulin level on four dengue hemorrhagic fevergroups which were classified according to the severity ofdengue hemorrhagic fever. There was a very significantpositive correlation between the severity of denguehemorrhagic fever and thrombomodulin level in detectingendothelial cells impairment.Conclusion Thrombomodulin level can be used as amarker to detect endothelial cells impairment in denguehemorrhagic fever. Higher grade of dengue hemorrhagicfever will have higher thrombomodulin level.

2021 ◽  
Vol 6 (14) ◽  
pp. 1-7
Author(s):  
Emine Serap ÇAĞAN ◽  
Birsen KARACA SAYDAM ◽  
Sinem GÜLÜMSER ATEŞ ◽  
Rabia EKTİ GENÇ ◽  
Esin ÇEBER TURFAN

Introduction: The primary attachment figure is mostly defined as the mother, and studies focus on the mother. However, in many babies, basic attachment is just as good with the father as with the mother. It is seen that there are very few studies in the literature investigating the correlations of father-infant attachment relationships.. The aim of this study is to determine the father-infant attachment status and to determine the factors affecting attachment. Method: The population of the cross-sectional study consisted of the spouses of all puerperant women hospitalized in the Gynecology and Obstetrics Clinic between September 1, 2018 and October 1, 2018. The sample size consisted of 156 fathers who agreed to participate in the study. Father identification form and father-infant attachment scale were used to collect the study data. The analysis of the data obtained from the research was carried out on the computer using the SPSS 16.0 package program. Results: 156 fathers participated in the study. The mean age of the fathers is 33.64±6.49, and 38.5% of them have a bachelor's degree. 91.0% of fathers stated that they felt ready for fatherhood. The fathers' Father-Infant Attachment Scale mean score was 82.60±7.72 In the analysis, the difference between the variables and the total score of the scale was found to be statistically insignificant (p>0.05). Discussion and Conclusion: At the end of the study, the bonding process of fathers participating in the study with their babies and the factors affecting this process were evaluated and it was seen that the father-infant attachment scale mean scores of the fathers participating in the study were high and were similar to other studies. In addition, when the basic factors affecting father-infant attachment were compared with the attachment scale mean score, it was found that there was no statistically significant difference.


2007 ◽  
Vol 47 (4) ◽  
pp. 150 ◽  
Author(s):  
M. Tatang Puspanjono ◽  
Abdul Latief ◽  
Alan R. Tumbelaka ◽  
Sudigdo Sastroasmoro ◽  
Hartono Gunardi

Background Dengue shock syndrome (DSS) mortality is still high.Monitoring of blood lactate level is important to evaluate shock.Objectives The study were to review the difference between bloodlactate level of DSS and that of dengue hemorrhagic fever (DHF),to correlate blood lactate level with hypoxia state as shock riskfactors (PaO 2 , oxygen saturation, and anion gap) and to determinethe cut-off point of blood lactate level to predict shock.Methods The study was carried out at the Department of ChildHealth, Medical School, University of Indonesia, CiptoMangunkusumo Hospital, Jakarta, from January until July 2006.Three mL venous blood specimen was collected from all subjectsfor peripheral blood, blood gasses, serology, and blood lactateexaminations. This study consisted of a retrospective cohort anda cross sectional method. Data were analyzed with Chi-squaretest. Continous data tested using Mann-Whitney method. Toknow the correlation between blood lactate level and shock riskfactors we use logistic regression test.Results In DSS group, 73% shows hyperlactatemia (lactate =2mmol/L). Conversion of lactate means between two groups issignificantly different from day one to day two and three. Therewas a negative correlation between lactate level and pO 2 andoxygen saturation. Oxygen saturation is the only value that hasclinical correlation. Regressions analysis can be applied using Y= 7.05–0.05 X equation. The cut-off point of lactate level asmarker for shock by using ROC curve is 32.015 mmol/L with 70%sensitivity and 83.3% specificity.Conclusions Hyperlactatemia in DSS can be considered as a signfor unappropriate treatment of shock. Blood lactate level can beused as a biochemical marker for tissue hypoxia, to assess severityof the disease, as monitoring of treatment, and has prognosticvalue of DHF cases.


2020 ◽  
Vol 5 (2) ◽  
pp. 1027-1030
Author(s):  
Shanti Sunuwar Subedi ◽  
Rakina Bhansakarya ◽  
Sajjan Kumar Sharma

Introduction: To evaluate the maternal and perinatal outcome in booked and unbooked cases. Objectives: To assess the maternal and fetal outcomes in unbooked and booked patients. Methodology: This was a cross-sectional comparative study conducted in the Department of Obstetrics and Gynecology from Augustti2019 to January 2020. Using a convenient sampling technique, 204 samples were taken and cross-sectional study was done. Results: There were total 204 cases in this study;102were booked and 102 were unbooked. In this study, 85(83%) of booked cases were educated up to secondary level as compared toti65 (64%) of unbooked cases. There was no significant difference in Apgar score in 1 and 5 minute between booked and unbooked cases. More babies in the unbooked group were transferred to NICU as compared to the booked group and the difference was significant (9.8%vs 1.9%). Greater proportion of booked cases had spontaneous vaginal delivery (81.3% vs 59.8%) and complications like preterm delivery, anemia, preeclampsia/ eclampsia, complicated labor and puerperal sepsis was also less in the booked group. Conclusions: The study showed that unbooked mothers and their newborns had higher chance of having complications.


2019 ◽  
Vol 5 (4) ◽  
pp. 185-189
Author(s):  
Mohammadreza Emamhadi ◽  
◽  
Hamid Behzadnia ◽  
Seifollah Jafari ◽  
Mohammadreza Zamanidoust ◽  
...  

Background: Postoperative pain is a common phenomenon, and its management affects considerably on the recovery process, and patients’ satisfaction. Apotel and pethidine are two conventional medicines used to relieve pain after operation. Objectives: The present study aimed to compare the effect of intravenous injection of Apotel and intramuscular injection of pethidine in relieving pain after hemilaminectomy. Materials & Methods: In the present cross-sectional study, 150 patients who underwent hemilaminectomy were recruited between May 2015 and November 2015. They were taking either Apotel (n=75) or pethidine (n=75) after the operation, which was done at Poursina Hospital affiliated to Guilan University of Medical Sciences, Rasht City, Iran. The patients’ pain levels were measured using visual analog scale (VAS), and the results were compared between the 2 groups. Results: There was no significant difference in the total VAS score between the Apotel and pethidine groups (P=0.189). However, there was a significant reduction in VAS score hours 2 (P=0.03) and 4 (P=0.004) hours after the injection of Apotel in this group, compared with those scores in the pethidine group. Also, VAS scores at other times (8, 12, 20, 28 hours after the injection) were lower than those in the pethidine group, but the difference was not significant. Conclusion: Apotel was better pain-killer in the early hours after the first injection compared to pethidine. But its effect was similar to pethidine at the late hours after the first injection. Therefore it seems that Apotel is better painkiller after laminectomy, especially in the early hours after the operation.


2017 ◽  
Vol 6 (1) ◽  
pp. 15-20
Author(s):  
Fatima Bichi ◽  
Dr. Shumaila Hanif

Diastasis Recti (DR) is a common muscular condition often present during and after pregnancy. This cross-sectional correlational study investigated the prevalence of DR among pregnant and postpartum women. A total of 250 pregnant and postpartum women were recruited using convenience sampling technique from obstetrics and gynaecology department, Aminu Kano Teaching Hospital, Kano, Nigeria. Age, body mass, height, BMI, parity, trimester, duration of DR postpartum, location of DR and DR status was recorded for each participant. Presence of DR was confirmed using the finger width method. Descriptive statistics of mean, SD, percentage were used to describe the data and determine the prevalence. Inferential statistics of Pearson’s and Spearman’s correlation were used to analyse the relationship between prevalence of DR and age, parity and duration of DR postpartum. Chi square was computed to determine the difference in prevalence of DR across trimesters. The result of this study indicated high prevalence of DR in post-partum and pregnant women (84% and 64.7% respectively); the most common location of DR was at the umbilicus in both pregnant and postpartum women. Prevalence of DR was high among the multigravida; and a significant relationship was found between prevalence of DR and age and parity of participants. There was a significant difference in prevalence of DR across the trimesters. It can be concluded that prevalence of DR among pregnant and postpartum women is high; age and parity are determinants of DR prevalence. Evaluation of DR should be considered as routine assessment in both pregnant and postpartum women.


2016 ◽  
Vol 17 (6) ◽  
pp. 1052-1065 ◽  
Author(s):  
Joaquim Ramos SILVA ◽  
Mário FRANCO ◽  
André MAGRINHO

This study aims to explore the importance of export barriers and to achieve this by comparing different industry types and firm sizes. We performed a cross-sectional study of 529 Portuguese export firms drawn from the database held by a Portuguese Industrial Association – Business Confederation. From multivariate analysis of variance and the Tukey’s HSD (Honestly Significant Difference) test, we conclude that the more important export barriers mentioned by the firms proved more external than internal. Our results also show that the service and retail trade sectors were the sectors reporting the greatest peculiarities regarding export barriers. Thus, we identify an “industry effect” as regards export barriers even while our findings do not indicate any “size effect”. Knowing the industry-specific export barriers enables companies not only to better coordinate and perform export processes but also to better anticipate the behaviour of their competitors. Other practical and theoretical implications will also be presented.


2014 ◽  
Vol 8 (09) ◽  
pp. 1205-1209 ◽  
Author(s):  
Godwin R Constantine ◽  
Senaka Rajapakse ◽  
Priyanga Ranasinghe ◽  
Balasundaram Parththipan ◽  
Ananda Wijewickrama ◽  
...  

Introduction: Dengue hemorrhagic fever (DHF) is a major cause of morbidity and mortality in tropical regions. Serum free calcium (Ca2+) is known to be important in cardiac and circulatory function. We evaluated association between serum Ca2+ level and severity of dengue. Methodology:A cross-sectional study was carried out at a tertiary care private hospital in Sri Lanka. A probable case of dengue was diagnosed and classified according to World Health Organization criteria and confirmed by either IgM antibody, PCR, or NS1 antigen detection. Socio-demographic details were collected using an interviewer-administered questionnaire. Results: The sample size was 135. The mean age was 26.1 years, and the majority were males (n = 80, 59.3%). DHF was diagnosed in 71 patients (52.6%). Mean serum Ca2+ level of the study population was 1.05 mmol/L (range 0.77–1.24). Mean serum Ca2+ was significantly higher in patients with dengue fever (DF) (1.09 mmol/L) than in those with DHF (1.02 mmol/L) (p < 0.05). A significant difference was observed between mean serum calcium levels of DHF I and DHF II. Prevalence of hypocalcemia in DHF and DF patients was 86.9% (n = 60) and 29.7% (n = 11), respectively (p < 0.05). Conclusions: Serum Ca2+ levels significantly correlated with dengue severity. Serum Ca2+ levels were significantly lower and hypocalcemia was more prevalent in patients with DHF than in patients with DF. Further studies are required to determine whether hypocalcemia can be utilized as a prognostic indicator and to evaluate effectiveness of calcium therapy in prevention of dengue complications.


2020 ◽  
Vol 27 (11) ◽  
pp. 2376-2382
Author(s):  
Hamzullah Khan ◽  
Mohammad Basharat

Objectives: To determine the correlation of Vit D3 levels with serum ferritin in patients with anemia. Study Design: Cross Sectional study. Setting: Department of Pathology, Qazi Hussain Ahmed Medical Complex Nowshera. Period: 5th Jan 2019 to 31st Dec 2020. Material & Methods: Data entered in SPSS 25th version. Descriptive statistics was used for numerical variables. Pearson correlation was used for correlation of Vit D3 with gender. Normality of data was checked by Shapiro wilk test. Mann Whitney U test was used to show the difference of Vit D3 and ferritin levels in gender. Results: The total of 192 anemic patients with Hb<10g/dl as per definition of WHO1 were referred for ferritin level estimation with 142(74%) females and 50(26%) males. Out of total, 47 were also advised with Vit D3 level estimation with 29(61.7%) females and 18(38.3%) males. Mean with standard deviation for age was 30+9.6 years. Mean with standard Error of mean of Vit D3 was (Mean-15.5ng/ml, SE 2.19). Mean with standard Error of mean of serum ferritin was (Mean-48.2ng/ml, SE 5.90). We observed 35(74.5%) cases out of 47, as Vit D3 deficient with a count less than 20 ng/ml. We observed that 118 (61.5%) were iron deficient with serum ferritin less than 15ng/ml. Person correlation showed a statistically significant correlation of Vit D3 with ferritin (p= 0.022, r=0.7). Spearman ranked correlation showed a statistically significant correlation between the categories of Vit D3 and ferritin (p=0.022, r=0.7). Mann Whitney U Test showed no significant difference in gender groups for botht the variables (p= 0.86 &p=0.33 respectively) thus retain the null hypotheses. Conclusion: The frequency of deficiency Vit D3<20ng/ml in anemic patients was 74% while that of ferritin<15ng/ml in anemic patients was 61.5%. There is a strong statistically significant correlation of Vit D3 with serum ferritin in anemic patients with Hb<11g/dl.


Author(s):  
Scarlett Olejnik-Brzusek ◽  
Michal Seweryn Karbownik

Introduction: Patient adherence to medications is a constant concern. Some barriers to adherence are that the patient may believe that medications are overused or feel that the medications they take are not necessary for their well-being.  Materials and Methods: A written paper survey was given to general outpatient clinics, pharmacies and senior living homes. The original English version as well as the recently validated Polish version of the Beliefs about Medicines Questionnaire (BMQ) was used together with the Adherence to Refills and Medications Scale (ARMS). Additionally, patients were asked to answer demographic questions regarding sex, age, place of residence and socioeconomic status.  Results: The extent of general beliefs that medicines are harmful and overused as well as the specific beliefs of concerns did not significantly differ between the studied populations (p>0.05).  However, beliefs about the necessity of prescribed medications were significantly higher in the group of Polish patients as compared to the American and the difference remained significant after adjusting for sociodemographic covariates (18.3, 95%CI 17.2-19.5 vs. 16.2, 95%CI 14.9-17.5, p=0.02). Necessity-minus-Concern beliefs significantly predicted self-reported medication adherence also after adjusting for sociodemographic covariates (r=0.41, 95%CI 0.25-0.55, p<0.0001), with no significant difference existing between the studied groups (p=0.65). Conclusions: Polish cardiovascular patients seem to believe that their medications are more necessary than American patients, however, the results may be biased due to the possible effect of unmeasured covariates. The Necessity Concerns Framework appears equally useful in predicting self-reported adherence to cardiovascular medications in both populations.  


2021 ◽  
Vol 13 (1) ◽  
pp. 27-34
Author(s):  
Retno Hestiningsih ◽  
Govinda Restu Syahputra ◽  
Martini Martini ◽  
Sri Yuliawati ◽  
M. Arie Wuryanto ◽  
...  

Sendangmulyo Village is one of the DHF (Dengue Hemorrhagic Fever) endemic areas in Semarang City. Previous studies reported that Aedes spp. active biting at night (nocturnal biting activity) in some areas in Indonesia. This indicates that changes in the blood-sucking behavior of Aedes spp mosquitoes can have an impact on dengue transmission. This research is a descriptive study with a cross-sectional study design. The study was conducted in 64 houses. The mosquito field collection was carried out using the resting mosquito collection method at 18.00-06.00 WIB. Observations of environmental parameters were also carried out to determine the temperature and humidity of the environment around the breeding grounds of Aedes spp. The results showed that there was a change in Aedes spp's blood-sucking activity from 16.00-17.00 WIB to 18.00-20.00 WIB. The distribution of Aedes albopictus in Sendangmulyo Village was 18% of the total Aedes spp. mosquitoes collected with a Resting Rate (RR) value of 0.98%. The average temperature and humidity in the area were 28.6 °C and 77.2%, respectively. This change in blood-sucking activity in Aedes spp has the potential to increase the risk of spreading DHF in Sendangmulyo Village. Dengue Hemorrhagic Fever vector control efforts need to be improved. Abstrak Kelurahan Sendangmulyo merupakan salah satu daerah endemis DBD (Demam Berdarah Dengue) di Kota Semarang. Studi-studi sebelumnya melaporkan bahwa Aedes spp. aktif menggigit pada malam hari (aktivitas menggigit nokturnal) di beberapa daerah di Indonesia. Hal ini mengindikasikan adanya perubahan perilaku menghisap darah nyamuk Aedes spp. dapat berdampak pada penularan dengue. Penelitian ini merupakan penelitian deskriptif dengan desain studi cross sectional. Penelitian dilakukan pada 64 rumah. Koleksi lapangan nyamuk dilakukan dengan metode  koleksi nyamuk istirahat  pada pukul 18.00-06.00 WIB. Pengamatan parameter lingkungan juga dilakukan untuk mengetahui suhu dan kelembaban lingkungan disekitar tempat perkembangbiakan Aedes spp. Hasil penelitian menunjukkan adanya perubahan aktivitas menghisap darah Aedes spp dari pukul 16.00-17.00 WIB menjadi pukul 18.00-20.00 WIB. Sebaran Aedes albopictus di Kelurahan Sendangmulyo adalah  18% dari total nyamuk Aedes spp yang terkoleksi dengan nilai Resting Rate (RR) sebesar 0,98%. Rata-rata suhu dan kelembaban di daerah tersebut masing-masing adalah 28,6 °C dan 77,2%. Perubahan aktivitas menghisap darah pada Aedes spp ini berpotensi meningkatkan risiko penyebaran DBD  di  Kelurahan Sendangmulyo. Upaya pengendalian vektor DBD perlu ditingkatkan.  


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