scholarly journals Psychopharmacotherapy of Suicidal Behavior in Schizophrenia and Schizophrenic Spectrum Disorders

2020 ◽  
Vol 5 (1) ◽  
pp. 60-64
Author(s):  
L. A. Ivanova
Keyword(s):  
Mental Disorders ◽  
Suicidal Behavior ◽  
Meaning In Life ◽  
Combined Therapy ◽  
Paranoid Schizophrenia ◽  
Suicidal Thoughts ◽  
Days Of Therapy ◽  
Suicidal Attempts ◽  
Spectrum Disorders ◽  
Schizotypal Disorder

Background. Suicidal behavior in schizophrenia correlates with the severity of productive and negative personality symptoms.Aims. Study of the clinic, the effectiveness of psychopharmacotherapy of paranoid schizophrenia and schizotypal disorder with the presence of suicidal behavior.Material and methods. Patients with paranoid schizophrenia, episodic type of course (n = 19) and schizotypal disorder (n = 15) were studied, in the clinical picture of which various variants of suicidal behavior were revealed. Clinicalpsychopathological, clinical-anamnestic, and psychometric methods were used.Results. Suicidal behavior in patients with an actual attack of paranoid schizophrenia was represented by suicidal intentions to avoid persecution (42.1 %), exposure to “voices” with an order to end their lives (36.8 %), and suicidal attempts (21.1 %). In patients with schizotypal disorder, suicidal thoughts were detected (84.6 %) in the form of loss of meaning in life, and suicidal attempts (15.4 %). Psychopharmacotherapy of suicidal behavior in schizophrenia and schizotypal disorder included the use of antipsychotics (atypical and traditional), antidepressants, tranquilizers, and normotimics. Among patients with paranoid schizophrenia, a decrease in the overall score of the PANSS scale was detected by day 14 of therapy (p < 0.05). The effectiveness of therapy was due to the reduction of delirium, verbal hallucinosis, and deactualization of suicidal behavior. Among patients with schizotypal disorder, a statistically significant decrease in the overall score of the PANSS scale was observed by 21 days of therapy (p < 0.05). The favorable dynamics was characterized by a decrease in manifestations of depression, suicidal thoughts, loss of interests.Conclusion. Combined therapy (antipsychotic, antidepressant, normotimic) helps reduce mental disorders and suicidal tendencies in patients with schizophrenia and schizophrenic spectrum disorders.

scholarly journals ДЕЯКІ ОСОБЛИВОСТІ СУЇЦИДАЛЬНОЇ ПОВЕДІНКИ ХВОРИХ НА ПАРАНОЇДНУ ШИЗОФРЕНІЮ

2018 ◽  
Author(s):  
Ya. Yu. Marunkevych
Keyword(s):  
Clinical Examination ◽  
Suicidal Behavior ◽  
Medical Records ◽  
Suicide Attempts ◽  
Close Association ◽  
Paranoid Schizophrenia ◽  
Medical Documentation ◽  
Suicidal Thoughts ◽  
Clinical Survey ◽  
Gender Factor

Suicidal behavior is one of the most pressing social and medical problems. At the same time, a number of important issues related to the suicidal behavior of schizophrenic patients, in particular gender features, remain insufficiently studied.The aim of the study – to learn the peculiarities of suicidal behavior of patients with paranoid schizophrenia taking into account the gender factor on the basis of a comparative analysis of medical records and direct clinical research.Materials and Methods. To study the peculiarities of suicidal behavior of patients with paranoid schizophrenia, taking into account the gender factor, a study of suicidal behavior was conducted by studying medical records of 407 men and 409 women and a clinical examination of 53 men and 49 women with paranoid schizophrenia.Results and Discussion. A relatively low prevalence of suicidal phenomena before the onset of schizophrenia: a suicidal ideation was found in 1.0 % of men and 1.5 % of women according to medical records and 5.7 % of men and 4.1 % of women according to the clinical examination, suicidal actions – in 1.5 % of women according to medical records. Installed that after the debut of schizophrenia, the suicidal activity of patients sharply increases: according to the analysis of medical documentation suicidal thoughts were found in 17.2 % of men and 18.8 % of women, according to the clinical survey – in 47.2 % of men and 20.4 % of women, suicide attempts were in 9.3% and 15.6%, respectively, and 26.4 %, respectively, versus 10.2 %. The significant severity of psychopathological symptoms of schizophrenia in patients with suicidal tendencies is established. The most closely associated with the presence of suicidal thoughts are negative symptoms and behavioral disorders (97.3 % among all patients, 95.7 % among men, 98.7 % among women according to the documentation analysis, 100.0 % according to the clinical survey). Suicidal actions are characterized by close association with negative symptoms.Conclusions. Patients with paranoid schizophrenia are characterized by high suicidal activity, both at the level of suicidal thoughts and at the level of suicidal actions.

The study of suicidal behavior at patients with anhedonia in schizophrenia

2011 ◽  
Vol 26 (S2) ◽  
pp. 1464-1464
Author(s):  
N. Orlova ◽  
M. Shkliar ◽  
E. Khaustova
Keyword(s):  
Risk Factor ◽  
Suicidal Behavior ◽  
Affective Disorders ◽  
Negative Symptoms ◽  
Paranoid Schizophrenia ◽  
Illness Duration ◽  
The Past ◽  
Suicidal Attempts ◽  
Suicidal Ideas ◽  
Suicide Plan

IntroductionThe suicidal behavior at patients with anhedonia in schizophrenia is one of the burn problems in modern psychiatry.ObjectivesAnhedonia belongs to negative symptoms in schizophrenia. The suicidal activity at patients with it consists from 7% tо 43%. At those patients fixed the suicidal ideas - 40%, suicidal attempts - 23% and complete suicide - 6,4%.AimsStudy the methods of suicidal behavior at those patients.MethodsThe Columbia Suicide severity research scale (C-SSRS).Results157 patients with anhedonia. Selected 49 (31, 21%) patients with suicidal behavior on admission or in the past. 23 women and 26 men with a mean age of 34, 37(±1, 92) and mean illness duration of 7, 72(±1, 42). The anhedonia level was 21, 26(±1, 26). 73,48% were the patients with Schizophrenia among them 44,91% with “postpsychotic depression” (295.60), 28, 57% with paranoid schizophrenia (295.30) and 26,52% - patients with affective disorders (296.3×). All patients wished to die. 79,59% (n = 39) had a suicidal attempts and 20,41% (n = 10) had a suicidal ideas. Active suicidal ideas without the suicide plan had 79, 59% patients. The methods of suicidal attempts were poisoning (38, 52%), cutting (25, 64%), hanging (12, 8%), falls (20, 48%), drowning (2, 56%).ConclusionsAnhedonia in schizophrenia is a risk factor of suicidal behavior. The suicidal behavior declared itself with suicidal attempts much more than suicidal ideas. Suicidal attempts were impulsive and dangerous with risk for life. It point to seriousness and danger results of suicidal behavior.

scholarly journals Glutamate Level’s in Blood Serum of Patients with Schisophrenic Spectrum and Bipolar Affective Disorder

Psychiatry ◽  
2020 ◽  
Vol 18 (3) ◽  
pp. 22-31
Author(s):  
A. A. Seregin ◽  
L. P. Smirnova ◽  
E. M. Dmitrieva ◽  
S. N. Vasil’eva ◽  
A. V. Semke ◽  
...  
Keyword(s):  
Blood Serum ◽  
Paranoid Schizophrenia ◽  
Bipolar Affective Disorder ◽  
Glutamate Metabolism ◽  
Healthy Individuals ◽  
Glutamate Concentration ◽  
Episodic Course ◽  
Spectrum Disorders ◽  
Serum Glutamate ◽  
Schizotypal Disorder

The objective: the involvement of glutamatergic neurotransmitter systems in the pathogenesis of schizophrenic spectrum disorders and BD has been repeatedly proven. But today, there are no methods available to evaluate the glutamate metabolism in patients with mental disorders. The paper presents differences in the level of glutamate in the blood serum of patients with a schizophrenic spectrum disorder, bipolar disorder, and healthy individuals.Patients and methods: the study included 224 people. 179 patients were presented with paranoid schizophrenia, simple schizophrenia, schizotypal disorder, acute polymorphic disorder, schizoaffective disorder and BD.Results: in this work shows that the level of glutamate in patients in all studied groups is statistically significantly higher than in healthy individuals, except for acute polymorphic psychotic disorder. Serum glutamate concentration in patients with schizotypal disorder is 1.6 times higher than in healthy individuals. The significant differences in glutamate levels were detected in patients with schizotypal disorder and OCD (p = 0.045), and patients with paranoid schizophrenia (p = 0.012). The concentration of glutamate is also increased in patients with simple schizophrenia compared to patients with paranoid schizophrenia (p = 0.039). In addition, it was observed a glutamate increase in healthy individuals compared in patients with a continuous course of schizophrenia (p = 0.001), in patients with an episodic course with progressive deficit (p = 0.0211) and in patients with a schizophrenia duration of more than 12 years.Conclusions: thus, the concentrations of glutamate in the blood serum of patients are depending on the severity of the course of schizophrenia and maybe an additional paraclinical criterion for the diagnosis of schizotypal disorder.

Incarcerated Adolescents' Distress and Suicidality in Relation to Parental Bonding Styles

Crisis ◽  
1999 ◽  
Vol 20 (4) ◽  
pp. 164-170 ◽  
Author(s):  
Elizabeth L McGarvey ◽  
Ludmila A Kryzhanovskaya ◽  
Cheryl Koopman ◽  
Dennis Waite ◽  
Randolph J Canterbury
Keyword(s):  
At Risk ◽  
Attachment Theory ◽  
Suicidal Behavior ◽  
Parental Bonding ◽  
Psychosocial Problems ◽  
Self Esteem ◽  
Suicidal Thoughts ◽  
Parental Bonding Instrument ◽  
Significant Relationships ◽  
Incarcerated Adolescents

This study examines the relationships between the bonding style of an incarcerated adolescent with parents and his/her current feelings of self-esteem, hopelessness, and suicidal thoughts and attempts. It also investigates differences between bonding to mother and bonding to father. Some 296 incarcerated adolescents were interviewed using the Parental Bonding Instrument. Significant relationships were found between youths' self-esteem, hopelessness, and suicidal behavior and their bonding style. Youths whose parent(s) had a parental bonding style of affectionless control reported the greatest distress, and youths whose parent(s) had an optimal bonding style reported the least distress. Differences were found between bonding styles with the mother and with the father. Attachment theory may be useful in targeting incarcerated youths who have affectionless control bonding with parent(s) for special interventions since these youths are most at risk for psychosocial problems.

Trombodynamics Method in the Assessment of Coagulation Parameters in Psychopharmacotherapy of Endogenous Mental Disorders

Psychiatry ◽  
2020 ◽  
Vol 18 (4) ◽  
pp. 16-25
Author(s):  
N. S. Karpova ◽  
O. S. Brusov ◽  
I. V. Oleichik ◽  
M. I. Faktor ◽  
N. S. Levchenko ◽  
...  
Keyword(s):  
Mental Disorders ◽  
Response To Therapy ◽  
Procoagulant Activity ◽  
Coagulation Activity ◽  
Continuous Type ◽  
Chronic Neuroinflammation ◽  
Psychopharmacological Treatment ◽  
Before And After ◽  
First Time ◽  
Schizotypal Disorder

Background: currently, it has been proven that the pathogenesis of endogenous mental disorders is associated with the process of neuroinflammation in the brain of patients. It is also known that chronic neuroinflammation, accompanied by a violation the permeability of the blood-brain barrier. It is accompanied by the activation of platelets that generate procoagulant microparticles, which leads to a disturbance of the hemostasis system, causing an increase in blood clotting in patients. Objective: to investigate the dynamics of procoagulant activity of blood in patients with endogenous mental disorders before and after psychopharmacotherapy.Patients and methods: the study included 185 patients aged 16 to 64 years with the following mental disorders: schizophrenia with attack-like/attack-progressive/continuous type of course (F20.00–2), affective disease (F31.1–5; F32.0–3; F33.0–3), schizotypal disorder with affective fluctuations (F21.3–4). The thrombodynamic test (TD) was performed on T-2 Trombodynamis device according to the manufacturer’s instructions (Hemacore LLC, Moscow, Russia). All patients received standard pharmacotherapy according to their condition.Results: a significant decrease of procoagulant activity of spontaneous clots in the patients’ blood after psychopharmacological treatment is observed. Our data on the positive dynamics of changes in the values of TD test’s indicators in most of the examined patients suggest that a decrease in the coagulation activity of the patients’ blood as a result of treatment may be associated with the anti- inflammatory effect of antipsychotics and antidepressants.Conclusion: for the first time, it was shown that there is a positive dynamic in changing the values of the main parameters of the TD test in most patients with endogenous mental diseases. The results of TD tests can be the basis for monitoring the response to therapy.

Suicide attempt in alcohol use disorder and Wernicke encephalopathy: A case report

2016 ◽  
Vol 33 (S1) ◽  
pp. S599-S599
Author(s):  
L. Espinosa ◽  
A. Fortea ◽  
G. Oriolo ◽  
M. Balcells ◽  
C. Oliveras
Keyword(s):  
Risk Factor ◽  
Alcohol Use ◽  
Suicidal Behavior ◽  
Alcohol Use Disorder ◽  
Blood Analysis ◽  
Wernicke Encephalopathy ◽  
Suicidal Attempts ◽  
Competing Interest ◽  
Concomitant Condition ◽  
Image Volume

BackgroundThe relation between alcohol dependence and suicidal behavior is well known and alcohol consumption is a risk factor to take in consideration in order to prevent suicidal attempts. Wernicke encephalopathy (WE) is a common acute neurological disorder caused by thiamine deficiency frequently associated with alcohol use disorder and often infra-diagnosed. Just few cases are reported about the possible correlation between suicidal behaviour and Wernicke encephalopathy.ObjectiveTo describe the possible association between suicidal attempts and Wernicke encephalopathy.MethodsWe report the case of a 57 year old man, with past diagnosis of disthymia and amphetamine abuse disorder, and a history of bariatric surgery, who was hospitalized in the intensive care unit (ICU) of hospital clinic for a suicidal attempt by mean of metro railway precipitation. He presented two episodes of psychomotor agitation in the context of an abstinence syndrome that reverted with midazolam continuous perfusion and clonazepam 8 mg per day. Consequently to medical improvement, he was moved to Psychiatry Unit of Addictive Behavior and finally diagnosed with alcohol use disorder.ResultsIn the physical exam, bilateral nystagmus and cerebellar ataxia were observed. Signs of malnutrition were detected in the blood analysis. In a brain magnetic resonance image, volume deficits in the mammillary bodies, thalamus, cortex and corpus callosum, as well as peri-aqueductal altered signal were observed, all signs compatible with Wernicke encephalopathy diagnoses.ConclusionsWernicke encephalopathy is a frequent concomitant condition in patients with alcohol use disorder. The consequent cognitive decline could represent an independent added risk factor for suicidal behavior.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Depression and tobacco smoking (analytical review). Part 2

2021 ◽  
pp. 44-56
Author(s):  
Sergey Zinovievich Savin ◽  
Evgeniya Valerievna Solodkaya
Keyword(s):  
Risk Factors ◽  
Suicidal Behavior ◽  
Tobacco Smoking ◽  
Depressive Disorders ◽  
Effective Means ◽  
Scientific Publications ◽  
Analytical Review ◽  
The Central Nervous System ◽  
Spectrum Disorders ◽  
Causes And Risk Factors

In the pathogenesis of depressive disorders and the consequent suicidal behavior, an important role belongs to the neurochemical processes and structures of the central nervous system. An analytical study of Russian and foreign literature was carried out to obtain information about the relationship between neurochemical factors in the development of depressive disorders and to elucidate the causes and risk factors of suicidal behavior due to depression and an unhealthy habit common among young people, i.e. tobacco smoking. A systematic search of scientific publications on the neurobiological aspects of the research into the causes and risk factors of depressive spectrum disorders was carried out. The analysis of the results of relevant neurobiological studies in the field of etiology and formation of depressive disorders with suicidal behavior contributes to the development of effective means of prevention and treatment of depressive spectrum disorders.

The comparative analysis of clinical and social characteristics of patients with schizophrenia and organic mental disorders receiving care in partial inpatient units

2021 ◽  
pp. 394-403
Author(s):  
George Petrovich Kostyuk ◽  
Burygina Larisa Andreevna Burygina Larisa Andreevna ◽  
Andrey Yurevich Berezantsev ◽  
Valeriya Vasilyevna Surikova
Keyword(s):  
Comparative Analysis ◽  
Mental Disorders ◽  
Psychiatric Care ◽  
Psychiatric Inpatient ◽  
Inpatient Unit ◽  
Social Characteristics ◽  
Organic Mental Disorders ◽  
Spectrum Disorders ◽  
Day Hospitals ◽  
Inpatient Units

The article presents the results of a comparative analysis of the clinical and social characteristics of patients with schizophrenic spectrum disorders (SSD) and organic mental disorders (OMD) who received care in day hospitals and intensive psychiatric care units (Moscow). During the study, a random sample of 487 discharge epicrises was studied, of which 392 (80,49%) were patients with SSD and OMD, who were subjected to further analysis. The study revealed gender differences and low rates of labor and family adaptation in both nosological groups of patients. The highest percentage of patients observed on a long-term basis in neuropsychiatric dispensaries and the rate of hospitalization in a round-the-clock inpatient unit were among the patients with diagnoses of schizophrenic spectrum disorders who were treated in intensive psychiatric care units. There were significant differences in the routing of patients depending on the pathology: district psychiatrists more often refer patients with a diagnosis of schizophrenia to the intensive psychiatric care unit in order to prevent hospitalization and patients with organic mental disorders - to day hospitals for therapy selection and medical and social rehabilitation, while doctors of the round-theclock hospital – vice versa (in order to continue treatment or follow up in out-of-hospital conditions). There was also a circulation of patients between the intensive psychiatric care unit and the day hospitals. Isolated episodes of compliance violations were noted. Indicative indicators such as hospitalization in a round-the-clock psychiatric inpatient unit within a year after the discharge from partial inpatient units was low and was usually due to severe continuous forms of the disease and the formation of therapy resistance in patients. Day hospitals and departments (offices) of intensive psychiatric care in general effectively perform the functions of inpatient unit substitution.

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