scholarly journals Blood Pressure Variability and Its Relationship with Cognitive Function in Elderly Patients with Essential Hypertension and Type 2 Diabetes

2019 ◽  
Vol 1 (1) ◽  
Author(s):  
Man Xu
Keyword(s):  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Blood Pressure Variability ◽  
The Elderly ◽  
Diabetic Group ◽  
Control Group ◽  
Significant Difference ◽  
The Difference ◽  
Normal Cognition

Objective: To investigate blood pressure variability of Elder hypertensives with type 2 diabetes and its relationship with cognition. Methods: A total of 143 elderly hypertensives were enrolled and divided into diabetic group (59 cases) and non-diabetic group (84 cases). The difference of general clinical characteristics, biochemical parameters, carotid ultrasound, a neuropsychological Scales and 24-hour ambulatory blood pressure (24hABPM) parameters between the two groups of subjects were compared. Then, the two groups (diabetic group and non-diabetic group) were further divided into (Mild cognitive dysfunction) subgroup (MMSE>26) and normal cognition subgroup (MMSE≤26), respectively. On the basis of MMSE scores, the difference of the parameters of ABPM between the two subgroups was analyzed. Results: Compared with the control group, 24hSBP, 24hPP, dSBP, dPP, nSBP, nPP, 24hSSD, dSSD, nSSD, 24hSCV, dSCV and nSCV were significantly higher in the diabetic group (p<0.05). However, cognition was lower in the diabetic group. No significant difference was found in the circadian pattern of blood pressure between the two groups. 24hSSD, dSSD, nSSD, 24hSCV, dSCV, nSCV were significantly higher in the MCI subgroup than normal cognition subgroup in both diabetic and non-diabetic groups(p<0.05), and they were negatively associated with scores of MMSE, the correlation coefficient were -0.235, -0.246, -0.341, -0.158, -0.222, -0.238 (0.001≤P<0.05). Conclusion: The study showed that in the elderly with hypertension, the mean systolic blood pressure and blood pressure variability were both higher in the diabetic group, and the cognition was lower instead. Whether or not with diabetes, blood pressure variability was always higher in the MCI subgroup. Blood pressure variability increased in patients with diabetes, and was associated with cognitive decline.

scholarly journals Blood Pressure Variability and Its Relationship with Cognitive Function in Elderly Patients with Essential Hypertension and Type 2 Diabetes

2019 ◽  
Vol 1 (01) ◽  
Author(s):  
Man Xu
Keyword(s):  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Blood Pressure Variability ◽  
The Elderly ◽  
Diabetic Group ◽  
Control Group ◽  
Significant Difference ◽  
The Difference ◽  
Normal Cognition

Objective: To investigate blood pressure variability of Elder hypertensives with type 2 diabetes and its relationship with cognition. Methods: A total of 143 elderly hypertensives were enrolled and divided into diabetic group (59 cases) and non-diabetic group (84 cases). The difference of general clinical characteristics, biochemical parameters, carotid ultrasound, a neuropsychological Scales and 24-hour ambulatory blood pressure (24hABPM) parameters between the two groups of subjects were compared. Then, the two groups (diabetic group and non-diabetic group) were further divided into (Mild cognitive dysfunction) subgroup (MMSE>26) and normal cognition subgroup (MMSE≤26), respectively. On the basis of MMSE scores, the difference of the parameters of ABPM between the two subgroups was analyzed. Results: Compared with the control group, 24hSBP, 24hPP, dSBP, dPP, nSBP, nPP, 24hSSD, dSSD, nSSD, 24hSCV, dSCV and nSCV were significantly higher in the diabetic group (p<0.05). However, cognition was lower in the diabetic group. No significant difference was found in the circadian pattern of blood pressure between the two groups. 24hSSD, dSSD, nSSD, 24hSCV, dSCV, nSCV were significantly higher in the MCI subgroup than normal cognition subgroup in both diabetic and non-diabetic groups(p<0.05), and they were negatively associated with scores of MMSE, the correlation coefficient were -0.235, -0.246, -0.341, -0.158, -0.222, -0.238 (0.001≤P<0.05). Conclusion: The study showed that in the elderly with hypertension, the mean systolic blood pressure and blood pressure variability were both higher in the diabetic group, and the cognition was lower instead. Whether or not with diabetes, blood pressure variability was always higher in the MCI subgroup. Blood pressure variability increased in patients with diabetes, and was associated with cognitive decline.

scholarly journals Relationship between homocysteine and non-dipper pattern in patients with type 2 diabetes mellitus

2012 ◽  
Vol 56 (5) ◽  
pp. 285-290 ◽  
Author(s):  
Serdal Korkmaz ◽  
Abdulkerim Yilmaz ◽  
Gürsel Yildiz ◽  
Fatih Kiliçli ◽  
Serhat Içağasioğlu
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Control Group ◽  
Diabetic Patients ◽  
Nocturnal Blood Pressure ◽  
Type 2 Dm ◽  
Significant Difference

OBJECTIVE: The rate of reduction of nocturnal blood pressure (NBP) is lesser than normal in patients with type 2 diabetes mellitus (type 2 DM). Hyperhomocysteinemia (HHC) disrupts vascular structure and function, no matter the underlying causes. The risk of development of vascular disease is greater in diabetic patients with hyperhomocysteinemia than in patients with normal homocystein levels. The aim of the study was to investigate whether there are differences of homocystein levels in dipper and non-dippers patients with type 2 DM. SUBJECTS AND METHODS: We compared 50 patients (33 females, 17 males) with type 2 DM and 35 healthy individuals (18 females, 17 males ) in a control group. Ambulatory blood pressure monitoring (ABPM) was performed and homocysteine levels were measured in all patients. RESULTS: We found that the percentage of non-dipper pattern was 72% in patients with type 2 DM and 57% in control group. In diabetic and control individuals, homocystein levels were higher in non-dipper (respectively 13.4 ± 8.1 µmol/L and 11.8 ± 5 µmol/L) than in dipper subjects (respectively, 11.8 ± 5.8 µmol/L and 10.1 ± 4.2 µmol/L), but there was no significant difference between the two groups (respectively, p = 0.545, p = 0.294). CONCLUSION: In both groups, homocystein levels were higher in non-dipper than in dipper participants, but there was no significant difference between the groups. High homocystein levels and the non-dipper pattern increases cardiovascular risk. Therefore, the relationship between nocturnal blood pressure changes and homocystein levels should be investigated in a larger study.

scholarly journals Renal Effects of Sulodexide in Type 2 Diabetic Patients without Nephrotic Range Proteinuria

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Kachonsak Yongwatana ◽  
Ouppatham Supasyndh ◽  
Bancha Satirapoj
Keyword(s):  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Renal Function ◽  
Diabetic Nephropathy ◽  
Control Group ◽  
Diabetic Patients ◽  
Long Term Effects ◽  
Renal Disease Progression ◽  
Significant Difference

Background. Glycosaminoglycan plays an important role in the maintenance of glomerular charge selectivity of diabetic nephropathy. Sulodexide, a mixture of naturally occurring glycosaminoglycan polysaccharide components, has shown a nephroprotective effect in an experimental model of diabetic nephropathy. Although sulodexide reduced albuminuria in patients with type 1 and type 2 diabetes, long-term effects in patients with type 2 diabetes with significant proteinuria have not been established. Objectives. The study was aimed at investigating the effects of sulodexide on proteinuria and renal function in patients with type 2 diabetes and nephropathy. Methods. Fifty-two patients with proteinuria between 500 and 3000 mg/day received sulodexide 200 mg/day for 12 months, while 56 matched patients with type 2 diabetes constituted the control group. All patients received standard metabolic and blood pressure controls. Primary outcome was evaluated as percentage of reduced proteinuria compared with the control group. Renal function was assessed using estimated glomerular filtration rate (GFR). Results. Proteinuria significantly increased in the control group [0.9 (IQR 0.3 to 1.78) to 1.16 (IQR 0.44 to 2.23) g/gCr, P=0.001], whereas it remained stable in the sulodexide group [0.66 (IQR 0.23 to 0.67) to 0.67 (IQR 0.17 to 1.51) g/gCr, P=0.108]. At 12 months, proteinuria was higher by 19.4% (IQR 10.3 to 37.6) in the control group while proteinuria was lower by -17.7% (IQR -53.1 to 3.2) in the sulodexide group with a significant difference between groups (P=0.001). Renal function was noted as a change of estimated GFR, and serum creatinine decreased significantly during the study in both groups but did not significantly differ between groups. No significant changes in the blood pressure, fasting plasma glucose, and hemoglobin A1C were reported. Conclusion. In addition to standard treatment, sulodexide is efficient in maintaining proteinuria in patients with type 2 diabetes with nonnephrotic range proteinuria, but it did not provide an additional benefit concerning renal disease progression.

scholarly journals Comparison of the Effectiveness of Metacognitive Therapy and Behavioral Activation on Depression in Elderly with Type 2 Diabetes

2019 ◽  
pp. 9-14
Keyword(s):  
Type 2 Diabetes ◽  
Repeated Measures ◽  
Behavioral Activation ◽  
The Elderly ◽  
Analysis Of Covariance ◽  
Control Group ◽  
Metacognitive Therapy ◽  
Significant Difference ◽  
And Control

Background and Aims: Generalized anxiety and depression are prevalent in patients with type 2 diabetes. Type 2 diabetes is one of the most common chronic diseases leading to many complications. This study aimed to compare the effectiveness of metacognitive therapy and behavioral activation on depression in the elderly with type 2 diabetes. Materials and Methods: This quasi-experimental study was conducted based on a pretest-posttest design using a follow-up and control group. The study population consisted of elderly with type 2 diabetes who referred to five endocrine and metabolism clinics in region 11 of Tehran, Iran, during 2017. A total of 45 males and females were selected by purposive sampling method based on the inclusion criteria. Then they were assigned randomly to one control and two case groups. The Beck Depression Inventory (Second Edition) was utilized to measure the depression scale. In total, eight 90-min group intervention sessions were held weekly. The data were analyzed in SPSS software (version 25) through analysis of covariance and repeated measures ANOVA. Results: The results showed that metacognitive therapy (F=15.07, P<0.001) and behavioral activation (F=7.09, P<0.008) were significantly effective on depression in the elderly with type 2 diabetes, and there was a significant difference between the experimental and control groups in this regard (P<0.001). Conclusions: This study was conducted to compare the effectiveness of metacognitive therapy and behavioral activation on depression in the elderly with type 2 diabetes. The results showed that metacognitive therapy and behavioral activation were significantly effective on depression in this population with type 2 diabetes. Moreover, behavioral activation was more effective than metacognitive therapy on depression reduction.

scholarly journals “CORRELATION OF INTERARM BLOOD PRESSURE DIFFERENCE WITH TYPE 2 DIABETES MELLITUS”

2020 ◽  
pp. 1-3
Author(s):  
Anand Jadhao ◽  
Saumya Naik ◽  
Megha Bhonde ◽  
Saurabh Mishra
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Pressure Difference ◽  
Simple Procedure ◽  
Control Group ◽  
Blood Pressure Difference ◽  
Significant Difference

In type 2 diabetes mellitus (DM-2), cardiovascular diseases are the important cause of mortality and morbidity. Regular monitoring of the diabetic condition is essential for the proper management of diabetes & effective controlling of diabetes-related complications. As the recording of IAD (Interarm blood pressure difference) is a simple procedure and it is also related to the vascular complication, it can be a vital indicator of the severity of diabetes. So, it is very important to study IAD concerning Complicated and Non-Complicated DM-2 which will be helpful for planning a better clinical management. In this cross-sectional study, we compare Interarm blood pressure difference in three groups i.e. Control, Non-Complicated DM-2 and Complicated DM-2 groups. There is a significant increase in systolic IAD in DM-2 group as compared to the control group, but no significant difference found between Non-Complicated and Complicated DM-2 groups.

Estimation of vitamin D receptor gene polymorphism in Type 2 Diabetes Mellitus patients in Erbil city

2021 ◽  
Vol 67 (3) ◽  
pp. 76-84
Author(s):  
Kalthum Asaaf Maulood
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus ◽  
Gene Polymorphism ◽  
Vitamin D Receptor ◽  
Diabetic Group ◽  
Control Group

Type 2 diabetes mellitus (T2DM) is a global problem. Recent studies confirmed the association of genes and different single nucleotide polymorphisms with T2DM occurrence and progress. This study was aimed to estimate the vitamin D receptor (VDR) gene polymorphism in Type 2 Diabetes Mellitus patients in Erbil city. The results showed that the Body mass index (BMI), Systolic blood pressure and Diastolic blood pressure were significantly higher in the diabetic group compared to the control group (P<0.05). In addition, the percent of Glycated hemoglobin (HbA1c), Fasting blood glucose (FBG), and Homeostatic model assessment for insulin resistance (HOMA-IR) were significantly higher in the diabetic group compared to the control group (P<0.05). Among different parameters of lipid profile, only Low-density lipoprotein (LDL) was significantly higher in the diabetic group compared to the control group. It was found that FBG value was significantly higher in patients with GA and AA genotypes of BsmI compared with healthy controls. Patients with the GA genotype of BsmI had a higher value of triglyceride compared to healthy individuals. Patients with all ApaI genotypes had higher FBS values than controls. There were not observed any signi?cant associations among the BsmI and ApaI polymorphisms and the risk of T2DM. In conclusion, no evidence was found for the association between two VDR polymorphisms and T2DM patients in Erbil city.

scholarly journals The Effectiveness of Psychoreligius Therapy on Sleep Quality and Anxiety in Diabetes Mellitus Patientstype 2

2021 ◽  
Vol 3 (1) ◽  
pp. 99-107
Author(s):  
Fendy Valentino Fauzan Aftina ◽  
Sri Poeranto ◽  
Yulian Wiji Utami
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Health Education ◽  
Sleep Quality ◽  
Alternative Hypothesis ◽  
Control Group ◽  
Significant Difference ◽  
The Difference

Diabetes mellitus is a chronic degenerative disease characterized by an increase in glucose levels in the blood. Anxiety and sleep quality disturbances are problems that are often experienced by people with diabetes mellitus due to prolonged stressors. The purpose of this study was to determine the effectiveness of psychoreligious therapy on anxiety scores and sleep quality scores in type 2 diabetes mellitus patients in the Junrejo Health Center, Batu City. This study used a queasy experimental design with a pretest and posttest control group design. The number of samples was 36 respondents who were divided into the experimental group (psychoreligious therapy) and the control group (health education) each of 18 respondents. The sample selection used purposive sampling. The results of this study indicate that psychoreligious therapy has ρ value < 0.05, which means that there is a significant difference between the difference in anxiety scores and the difference in sleep quality scores before and after being given psychoreligious therapy, so the alternative hypothesis is accepted and the null hypothesis is rejected. This study concludes that psychoreligious therapy is more effective than health education on anxiety and sleep quality in patients with type 2 diabetes mellitus.

scholarly journals The Effect of Sikkomodo (Combination of Music, Humor, and Prayer) Formulation Toward Blood Pressure of Hypertension Patient on The Elderly Group in Banyumas Regency

2020 ◽  
Vol 86 ◽  
pp. 01002
Author(s):  
S Awaludin ◽  
A Sumeru ◽  
G N Alivian ◽  
D Novitasari
Keyword(s):  
Blood Pressure ◽  
Sampling Technique ◽  
Simple Random Sampling ◽  
The Elderly ◽  
Uncontrolled Hypertension ◽  
Control Group ◽  
Control Group Design ◽  
Significant Difference ◽  
Before And After ◽  
The Difference

Uncontrolled hypertension can lead to heart disease, kidney disease, and stroke. Hence, it needs therapy. There are complementary therapies that can reduce high blood pressure. Music provides a relaxing effect so that blood vessel dilates and blood pressure drops. Humor therapy can provide a relaxation response and decrease blood pressure. Prayer therapy has a positive effect on body physiology that can lower blood pressure. The purpose of this study was to identify the effect of combination of music, humor, and prayertherapy on blood pressure. This study used true experiment pre and post control group design. The number of samples in this study were 131 respondents with primary hypertension on the elderly in Banyumas Regency. The sampling technique used was simple random sampling. Wilcoxon was used to test the difference of blood pressure before and after the intervention in one group, while the difference test among groups employed Mann Whitney test. The result indicated that respondent’s hypertension is categorized into moderate. There is difference on the mean of blood pressure before and after SIKKOMODO therapy and combination of music, humor, and humor therapy. There is a significant difference in term of systolicblood pressure betweentreatment and control group, and there is no difference on the systolic blood pressure between the two groups.

PENGARUH TERAPI TERTAWA TERHADAP PENURUNAN TEKANAN DARAH LANSIA DI UPT PANTI WREDHA BUDHI DHARMA YOGYAKARTA

2019 ◽  
Vol 13 (1) ◽  
Author(s):  
Niken Setyaningrum ◽  
Andri Setyorini ◽  
Fachruddin Tri Fitrianta
Keyword(s):  
Blood Pressure ◽  
Data Analysis ◽  
The Elderly ◽  
Control Group ◽  
Group Comparison ◽  
Control Blood Pressure ◽  
Men And Women ◽  
Treatment Of Hypertension ◽  
Before And After ◽  
The Difference

ABSTRACTBackground: Hypertension is one of the most common diseases, because this disease is suffered byboth men and women, as well as adults and young people. Treatment of hypertension does not onlyrely on medications from the doctor or regulate diet alone, but it is also important to make our bodyalways relaxed. Laughter can help to control blood pressure by reducing endocrine stress andcreating a relaxed condition to deal with relaxation.Objective: The general objective of the study was to determine the effect of laughter therapy ondecreasing elderly blood pressure in UPT Panti Wredha Budhi Dharma Yogyakarta.Methods: The design used in this study is a pre-experimental design study with one group pre-posttestresearch design where there is no control group (comparison). The population in this study wereelderly aged over> 60 years at 55 UPT Panti Wredha Budhi Dharma Yogyakarta. The method oftaking in this study uses total sampling. The sample in this study were 55 elderly. Data analysis wasused to determine the difference in blood pressure before and after laughing therapy with a ratio datascale that was using Pairs T-TestResult: There is an effect of laughing therapy on blood pressure in the elderly at UPT Panti WredhaBudhi Dharma Yogyakarta marked with a significant value of 0.000 (P <0.05)

Effects of epigallocatechin-3-gallate of Camellia sinensis leaves on blood pressure, lipid profile, atherogenic index of plasma and some inflammatory and antioxidant markers in type 2 diabetes mellitus patients: a clinical trial

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Hadi Bazyar ◽  
Seyed Ahmad Hosseini ◽  
Sirous Saradar ◽  
Delsa Mombaini ◽  
Mohammad Allivand ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Lipid Profile ◽  
Atherogenic Index ◽  
Control Group ◽  
Atherogenic Index Of Plasma ◽  
The Mean

Abstract Background In patients with type 2 diabetes mellitus (T2DM) the inflammatory and metabolic responses to epigallocatechin-3-gallate (EGCG) are unknown. Objectives Evaluate the impacts of EGCG on metabolic factors and some biomarkers of stress oxidative in patients with T2DM. Methods In this randomized, double-blind, placebo-controlled trial, 50 patients with T2DM consumed either 2 tablets (300 mg) EGCG (n=25) or wheat flour as placebo (n=25) for 2 months. The total antioxidant capacity (TAC), interleukin-6 (IL-6), lipid profile, mean arterial pressure (MAP), atherogenic index of plasma (AIP) were evaluated before and after the intervention. Results The finding of present study exhibited a significant increase in the serum levels of TAC after the EGCG supplementation (p=0.001). Also, in compare with control group, the mean changes of TAC were significantly higher in supplement group (p=0.01). In intervention group, a significant decrease was observed in the mean levels of triglyceride, total cholesterol, diastolic blood pressure (DBP), AIP, and MAP (p<0.05). Taking EGCG resulted in the mean changes of total cholesterol, MAP and DBP were significantly lower in compare with control group (p<0.05). Conclusions This study recommended that EGCG supplementation may be improved blood pressure, lipid profile, AIP, and oxidative status in patients with T2DM.

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