scholarly journals Treatment of knee osteoarthritis with traditional Chinese medicine sloughingClinical efficacy study

2020 ◽  
Vol 8 (2) ◽  
Author(s):  
Liang Wen

Objective: To explore the clinical effect of the treatment of knee osteoarthritis with traditional Chinese medicine.Methods: 152 patients with knee osteoarthritis who were treated in our hospital from July 2018 to April 2020 were divided into two groups. Group A (control group) was treated with conventional western medicine, i.e. celecoxib 200 mg capsule +Glucosamine hydrochloride capsule 0.75g, group B (observation group): the treatment of traditional Chinese medicine sloughing using our experience formula, and further comparative evaluation of the treatment effect of the two groups. Results: the effective rate was 75% in the control group and 92% in the observation group. Conclusion: in the treatment of knee osteoarthritis, traditional Chinese medicine is more effective than western medicine.

2021 ◽  
Vol 5 (6) ◽  
pp. 122-124
Author(s):  
Hao Peng ◽  
Yuhong Duan

Objective: Patients with diabetic peripheral neuropathy were treated with integrated traditional Chinese and western medicine, and the final results were observed. Methods: 70 patients with such symptoms were randomly divided into two groups. The number of people is the same, and the treatment methods are different. The control group uses western medicine, while the observation group uses traditional Chinese medicine to evaluate the treatment effect. Results: After treatment, the effective rate of the observation group was (P < 0.05), indicating that the treatment effect was significantly better. Conclusion: Patients with clinical diabetic peripheral neuropathy treated with routine nutrition and nerve repair, and with Chinese medicine, the effect is more satisfactory, and the effect is positive, so as to promote the optimization of their health.


2018 ◽  
Vol 2 (4) ◽  
Author(s):  
Huaide Lin

Objective: To investigate the clinical effect of combination treatment of Chinese medicine Baogan Lishui decoction and western medicine on hepatitis B cirrhosis related refactory ascites.Method: Control group was given conventional western medicine therapy while the observation group was given same conventional western medicine therapy with additional of Chinese medicine Baogan Lishui decoction.Result: The total effective of clinical treatment on hepatitis B cirrhosis related refractory ascites in observation group was higher than that of the control group which was 88.89% compared to 71.11%, respectively and it was significant different (p<0.05).Conclusion: The combination treatment of Chinese medicine Baogao Lishui decoction and conventional western medicine can significantly increased the treatment effect on hepatitis B cirrhosis refractory ascites, and thus increases the quality and safety of life.


2020 ◽  
Vol 12 (3) ◽  
pp. 407-412
Author(s):  
Junheng Bai ◽  
Tingyu Guo ◽  
Wenwen Dong ◽  
Yingming Song ◽  
Tingfang Guo ◽  
...  

To observe the clinical effect of nano-carbon adsorption of 5-fluorouracil (5-FU) on Breast cancer lymph node metastasis in New Zealand rabbits. A breast cancer animal model was established by local injection of a VX2 tumor tissue suspension in thirty New Zealand rabbits. An observation group, control group A, and control group B were established using a random number table, with ten rabbits in each group. Once tumors with a diameter ≥5 mm were identified in the lymph nodes, the animals received the intervention. The observation group had nano-carbon-5-FU suspension subcutaneously injected, control group A had 5-FU subcutaneously injected through the ear margin, and control group B had 5-FU subcutaneously injected; all received a drug dose of 30 mg · kg–1. Half of the animals in the three groups were killed following treatment for thirty minutes, while the rest of the animals were killed following treatment for seven days. Tumors and lymphatic metastases were removed. Tumor and lymphatic metastasis volume were compared. H&E stained sections were used to determine the ND of tumor cells. A dTUP TUNEL assay using Terminal Deoxynucleotidyl Transferase (TdT) was used to assess tumor cell apoptosis. The expression level of casapase-3 mRNA in tumors and lymphoid tissues was determined using RT-PCR. After treatment for 30 mins, the observation group exhibited a significantly higher 5-FU concentration in lymph node metastases, and significantly lower 5-FU concentrations in plasma and tumors. Nano-carbon can increase the 5-FU concentration in tumor tissue, as well as enhance the clinical effect of drugs on lymph node metastases.


2022 ◽  
Vol 2022 ◽  
pp. 1-7
Author(s):  
Qiannan Zhao ◽  
Juanjuan Liu ◽  
Sai Wang ◽  
Xiuqin Wang ◽  
Xiufang Jiang

Background. This study aims to investigate the clinical efficacy of chemotherapy combined with traditional Chinese medicine in patients with cervical cancer and its effect on cellular immunoglobulin, serum sugar chain antigen 125 (CA125), carcinoembryonic antigen (CEA), and tumor necrosis factor-α (TNF-α). Methods. Conventional chemotherapy was performed in control and observation groups. Meantime, the observation group received traditional Chinese medicine. Finally, the clinical efficacy, immunoglobulin, serum tumor markers, and serum TNF-α of the two groups were compared. Results. Compared with the control group, total effective rate in the observation group was increased. After treatment, serum CD8+, TNF-α, CA125, and CEA levels were reduced in the two groups, and the observation group was higher. In the two groups, CD3+ and CD4+ levels were enhanced after treatment, and the observation group was also higher. Compared with the control group, the immunoglobulin IgG, IgA, and IgM levels increased in the observation group. The incidence of adverse reactions in the observation group was reduced compared to the control group. Conclusion. Chemotherapy combined with traditional Chinese can help improve the clinical efficacy and immunity in patients with cervical cancer. Moreover, the safety and feasibility of the treatment method are relatively high.


2018 ◽  
Vol 1 (5) ◽  
Author(s):  
Xiao Zhang ◽  
Pengyi Zhang

Objective External humeral epicondylitis, also known as “tennis elbow”, is a chronic motor inflammation caused by non-normative movement or excessive pressure and torsion of the forearm tendon and bone. The external humeral epicondylitis occursmostly in tennis, badminton, table tennis, fencing, throwing, gymnastics and other sport programs. Because it has the highest incidence in tennis, everyone is used to call it "tennis elbow". Those who have repeatedly used force to do elbow activities in daily life, such as housewives, bricklayers, woodworkers, etc., are also susceptible to this disease. Therefore, the disease affects a large number of occupations and sports. The conventional medical nsurgery leads to a large wound area and a long recovery time, which is easy to shorten the sportlife of the patient. The conservative Chinese medicine ginger moxibustion therapy could clear the meridians and organs by stimulating the acupoint of the human body. This moxibustion therapy has the advantages of small trauma, low cost, comprehensive treatment and small side effects by adjusting the blood, and would not bring inconvenience to patients' daily life and normal exercises. This paper aims to use a conservative treatment-Traditional Chinese medicine ginger moxibustion and its composite therapy to rehabilitate the external humeral epicondylitis systematically and compare the rehabilitation effects of different compound therapy to provide a basis for tennis elbow’s rehabilitation. Methods Eighty-four tennis elbow patients were divided into three treatment groups and one control group randomly, subject and observer-double-blind, third-party evaluation. The treatment groups included a group of ginger moxibustion named A,a group of floating needle combined with ginger moxibustion named B, and a group of Yunnan BaiYao aerosol combined with ginger moxibustion named C, the control group named D, 21 people/group. In the treatment group A, acupuncture points were taken from A’shi, Quchi and Hand Sanli, ginger moxibustion treatment,5 moxibustion columns/time, once every other day, 5 times as a course of treatment, observethe effect after two courses; The group B was first treated with floating needles at three acupoints, and after 2 minutes treated as group A, 5 moxibustion columns each time, once every other day, 5 times as a course of treatment, observe the effect after two courses as well;The group C was first sprayed on Yunnan Baiyaoaeroso in three acupoints,two minutes later, treated as group A, use 5 moxibustion columns each time, once every other day, 5 times as a course of treatment, observe the effect after two courses. The control group was treated with ginger laser treatment at the same acupoints, keep as the same treatment as group A, observethe effect after two courses. The shoulder-arm-hand disability score (DASH) was use for the main observation index, and pain (VAS), painless grip strength (PFGS) and pressure pain threshold (PPT) were meanwhile used as secondary observation indicators. Results  Four sets of experimental data were submitted to Shandong University of Traditional Chinese Medicine. The analysis of results showed that patients in treatment groups improved their function and relieved the pain significantly much better than the ginger-fake laser control group within 3-12 months of treatment completion. In the treatment group, the total effective rate of the group A-- treated with ginger-free moxibustion was 80%, and the total effective rate of the group C --treated with Yunnan Bai Yao aerosol combined with ginger moxibustion was 85%,and the total effective rate of the group B--treatment with floating needle combined with ginger moxibustion was 92%, but the total effective rate of the control group was 10%. Conclusions The clinical recovery evaluation and index assessment results showed that ginger moxibustion and its combination therapy had significant curative effects on patients suffering external humeral epicondylitis. The addition of auxiliary means also promoted the rehabilitation effects, further proving the Traditional Chinese medical effects. The method could significantly improve the rehabilitation of external humeral epicondylitis. The research made a bold exploration for the multi-organizational cooperation mode of TCM compound therapy in the field of sport injury habilitation, and opened a new way for its application ofclinical research.  


2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Shisheng Zhou ◽  
Xia Fan ◽  
Xiaojie Du ◽  
Shuang Liu ◽  
Hongmei Sun ◽  
...  

Objective. To observe the clinical effect of Xiaozheng Decoction combined with bladder perfusion with hydroxycamptothecin in the treatment of bladder cancer. Methods. A total of 92 bladder cancer patients admitted to our hospital from January to December 2018 were selected and divided into an observation group and a control group according to the random number table method, with 46 cases in each group. The observation group was given Xiaozheng Decoction combined with bladder perfusion with hydroxycamptothecin, and the control group was given hydroxycamptothecin. The levels of serum-related factors (intercellular adhesion molecule-1 (ICAM-1), E-cadherin, cell adhesion molecules (CAM), fibroblast growth factor (FGF), and vascular endothelial growth factor (VEGF)), white blood cell (WBC) level, immune function indexes, short-term total response rate, and incidence of adverse reactions were compared between the two groups before and after treatment. Results. After 2 years of postoperative treatment, the levels of ICAM-1, E-cadherin, CAM-1, FGF, and VEGF (a, b, c) in both groups were improved compared with those before treatment and the observation group was better than the control group p < 0.01 . The number of WBCs was significantly higher than in the control group after Traditional Chinese Medicine (TCM) treatment. The observation group was better than the control group in increasing CD3+ and CD4+ levels and decreasing CD8+ level p < 0.05 , indicating that this prescription could improve the immune function of patients. The recurrence rate in the observation group was 6.52% after 2 years of treatment, lower than 17.39% in the control group. Color ultrasound parameters showed that there were no statistically significant differences in arrive time (AT) and time to peak (TTP) between patients with and without recurrence and peak intensity (PI) and washout time (WT) were higher in patients with recurrence than in patients without recurrence p < 0.01 . The incidence of adverse reactions was significantly lower than that of the control group p < 0.01 . Conclusion. The clinical effect of Xiaozheng Decoction combined with hydroxycamptothecin on the treatment of bladder cancer was clear and superior to that of hydroxycamptothecin, which could effectively improve the serological indicators of patients with a low incidence of adverse reactions and prolong the survival cycle of patients. Therefore, it is worthy of promotion and application.


2020 ◽  
Author(s):  
Li Lin ◽  
Yuan Wang ◽  
Sennan Shao ◽  
Wen Lin ◽  
Dan Huang ◽  
...  

Abstract Background: The combination of traditional Chinese medicine and western medicine is commonly accepted in clinics in China. Shaoyao-Gancao-Fuzi decoction (SGFD) has been extensively used to dispel wind, eliminate dampness and treat paralysis. Tofacitinib is approved for the treatment of rheumatoid arthritis. SGFD and tofacitinib could be used together for the treatment of rheumatoid arthritis.Methods: A cocktail approach was employed to assess the effects of SGFD on the activities of CYP450s. After pretreatment for 2 weeks with SGFD, a cocktail solution was given to rats 24 h after the last dose of saline or SGFD. Additionally, the pharmacokinetic profiles of oral administration of tofacitinib in rats, with or without SGFD pre-treatment were investigated.Results: The results showed that SGFD could induce the activity of CYP1A2 and inhibit the activity of CYP3A4. Furthermore, SGFD could significantly affect the pharmacokinetics of tofacitinib. Compared with control group, the AUC0-∞ of tofacitinib was increased from 13669.53 ± 4986.83 to 28706.69 ± 9563.13 ng/mL*h (p < 0.01), and the Cmax was increased from 8359.66 ± 1512.22 to 11332.51 ± 2791.90 ng/mL (p < 0.05).Conclusions: The system exposure of tofacitinib was increased by SGFD. The mechanism might be through inhibiting the activity of CYP3A4 and reducing the metabolism of tofacitinib in rats. The study will provide better guidance for the safe clinical use of SGFD and tofacitinib.


2020 ◽  
Vol 4 (3) ◽  
Author(s):  
Yu Zhu ◽  
Lu Shi

Objective: To analyze the clinical treatment effect of traditional Chinese medicine five-color therapy on chronic urticaria in children. Methods: The income data target of this article is 80 children with chronic urticaria. The grouping method is a randomized method with 40 children in each group. The experimental group was treated with five-color treatment of traditional Chinese medicine, and the control group was treated with western medicine. The incidence, treatment and recurrence of adverse reactions in children with chronic urticaria were compared between the two groups. Results: Showed total effective rate of children with chronic urticaria in the experimental group was compared with the control group, P<0.05, the data showed statistical significance. Conclusion: Stated use of TCM five-color therapy in the treatment of children with chronic urticaria can significantly improve safety.


2019 ◽  
Vol 3 (3) ◽  
Author(s):  
Guoqiang Yang ◽  
Jin Zhang

Objective: To analyze the clinical effect and value of oral administration and external therapy of traditional Chinese medicine for treatment of cervical tuberculous lymphadenopathy. Methods: A total of 56 patients with cervical tuberculous lymphadenopathy admitted to our hospital from January 1 to January 2018 were recruited. By using double-blind method, the patients were divided into control group (n=28) and experimental group (n=28). Control group comprised of patients with conventional anti-tuberculosis treatment, while the experimental group comprised of patients treated with oral administration and external therapy of traditional Chinese medicine. Total effective rate, incidence of complication and level of T lymphocyte subsets were compared between the two groups of cervical tuberculous lymphadenopathy patients. Results: Post-treatment data of total effective rate, complication rate, CD3+, CD4+, CD8+, CD4+/CD8+ of the experimental group were compared with the control group. P<0.05; statistical analysis showed statistical significance. Post-treatment data of CD3+, CD4+, CD8+, CD4+/CD8+ of both control and experimental groups were compared with pre-treatment data. P<0.05; statistical analysis showed statistical significance. Conclusion: Oral administration and external therapy of traditional Chinese medicine possesses significant effect in treatment of cervical tuberculous lymphadenopathy.


2021 ◽  
Vol 7 (5) ◽  
pp. 3384-3388
Author(s):  
Wei Sun ◽  
Wenjie Yu ◽  
Yanhua Wang ◽  
Guangliang Hu

Objective: The clinical effect of arthroscopic debridement combined with rehabilitation training in the treatment of knee arthritis was studied and analyzed. Methods: A total of 90 patients with knee osteoarthritis treated in our hospital from August 2017 to August 2018 were selected as the research objects. All patients were divided into the observation group and the control group by using the random number method. The control group was treated by arthroscopic cleaning operation, and the observation group was treated by combined rehabilitation training on the basis of the treatment in the control group. The total effective rate and simple McGill pain of the two groups were compared Score and lyshoim score. Result: The total effective rate of the observation group was significantly higher than that of the control group (P < 0.05), the difference was statistically significant; after treatment, the simple McGill pain score of the observation group was significantly lower than that of the control group (P < 0.05), the difference was statistically significant, the lyshoim score of the observation group was significantly better than that of the control group (P < 0.05), the difference was statistically significant. Conclusion: In the treatment of knee osteoarthritis, arthroscopic debridement combined with rehabilitation training has a significant effect, which can significantly reduce the pain and improve the prognosis of patients. It is worth popularizing in clinical treatment.


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