scholarly journals PO-263 Clinical rehabilitation of external humeral epicondylitisby ginger moxibustion and its combination therapy

2018 ◽  
Vol 1 (5) ◽  
Author(s):  
Xiao Zhang ◽  
Pengyi Zhang
Keyword(s):  
Chinese Medicine ◽  
Treatment Group ◽  
Total Effective Rate ◽  
Daily Life ◽  
Tennis Elbow ◽  
Effective Rate ◽  
Control Group ◽  
Treatment Groups ◽  
Group A ◽  
Group B

Objective External humeral epicondylitis, also known as “tennis elbow”, is a chronic motor inflammation caused by non-normative movement or excessive pressure and torsion of the forearm tendon and bone. The external humeral epicondylitis occursmostly in tennis, badminton, table tennis, fencing, throwing, gymnastics and other sport programs. Because it has the highest incidence in tennis, everyone is used to call it "tennis elbow". Those who have repeatedly used force to do elbow activities in daily life, such as housewives, bricklayers, woodworkers, etc., are also susceptible to this disease. Therefore, the disease affects a large number of occupations and sports. The conventional medical nsurgery leads to a large wound area and a long recovery time, which is easy to shorten the sportlife of the patient. The conservative Chinese medicine ginger moxibustion therapy could clear the meridians and organs by stimulating the acupoint of the human body. This moxibustion therapy has the advantages of small trauma, low cost, comprehensive treatment and small side effects by adjusting the blood, and would not bring inconvenience to patients' daily life and normal exercises. This paper aims to use a conservative treatment-Traditional Chinese medicine ginger moxibustion and its composite therapy to rehabilitate the external humeral epicondylitis systematically and compare the rehabilitation effects of different compound therapy to provide a basis for tennis elbow’s rehabilitation. Methods Eighty-four tennis elbow patients were divided into three treatment groups and one control group randomly, subject and observer-double-blind, third-party evaluation. The treatment groups included a group of ginger moxibustion named A,a group of floating needle combined with ginger moxibustion named B, and a group of Yunnan BaiYao aerosol combined with ginger moxibustion named C, the control group named D, 21 people/group. In the treatment group A, acupuncture points were taken from A’shi, Quchi and Hand Sanli, ginger moxibustion treatment,5 moxibustion columns/time, once every other day, 5 times as a course of treatment, observethe effect after two courses; The group B was first treated with floating needles at three acupoints, and after 2 minutes treated as group A, 5 moxibustion columns each time, once every other day, 5 times as a course of treatment, observe the effect after two courses as well;The group C was first sprayed on Yunnan Baiyaoaeroso in three acupoints,two minutes later, treated as group A, use 5 moxibustion columns each time, once every other day, 5 times as a course of treatment, observe the effect after two courses. The control group was treated with ginger laser treatment at the same acupoints, keep as the same treatment as group A, observethe effect after two courses. The shoulder-arm-hand disability score (DASH) was use for the main observation index, and pain (VAS), painless grip strength (PFGS) and pressure pain threshold (PPT) were meanwhile used as secondary observation indicators. Results  Four sets of experimental data were submitted to Shandong University of Traditional Chinese Medicine. The analysis of results showed that patients in treatment groups improved their function and relieved the pain significantly much better than the ginger-fake laser control group within 3-12 months of treatment completion. In the treatment group, the total effective rate of the group A-- treated with ginger-free moxibustion was 80%, and the total effective rate of the group C --treated with Yunnan Bai Yao aerosol combined with ginger moxibustion was 85%,and the total effective rate of the group B--treatment with floating needle combined with ginger moxibustion was 92%, but the total effective rate of the control group was 10%. Conclusions The clinical recovery evaluation and index assessment results showed that ginger moxibustion and its combination therapy had significant curative effects on patients suffering external humeral epicondylitis. The addition of auxiliary means also promoted the rehabilitation effects, further proving the Traditional Chinese medical effects. The method could significantly improve the rehabilitation of external humeral epicondylitis. The research made a bold exploration for the multi-organizational cooperation mode of TCM compound therapy in the field of sport injury habilitation, and opened a new way for its application ofclinical research.  

scholarly journals Treatment of knee osteoarthritis with traditional Chinese medicine sloughingClinical efficacy study

2020 ◽  
Vol 8 (2) ◽  
Author(s):  
Liang Wen
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Knee Osteoarthritis ◽  
Western Medicine ◽  
Clinical Effect ◽  
Effective Rate ◽  
Control Group ◽  
Observation Group ◽  
Group A ◽  
Group B

Objective: To explore the clinical effect of the treatment of knee osteoarthritis with traditional Chinese medicine.Methods: 152 patients with knee osteoarthritis who were treated in our hospital from July 2018 to April 2020 were divided into two groups. Group A (control group) was treated with conventional western medicine, i.e. celecoxib 200 mg capsule +Glucosamine hydrochloride capsule 0.75g, group B (observation group): the treatment of traditional Chinese medicine sloughing using our experience formula, and further comparative evaluation of the treatment effect of the two groups. Results: the effective rate was 75% in the control group and 92% in the observation group. Conclusion: in the treatment of knee osteoarthritis, traditional Chinese medicine is more effective than western medicine.

scholarly journals Pengaruh pemberian ekstrak biji kakao (Theobroma cacao) terhadap jumlah pigmen melanin kulit tikus Wistar (Rattus novergicus) yang dipapar sinar matahari

2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Koernia H. Yonathan ◽  
Poppy M. Lintong ◽  
Meilany F. Durry
Keyword(s):  
Treatment Group ◽  
Rattus Norvegicus ◽  
Negative Control ◽  
Sunlight Exposure ◽  
Cocoa Bean ◽  
Control Group ◽  
Treatment Groups ◽  
Group A ◽  
Group B ◽  
Group D

Abstract: Excessive exposure of sunlight may cause hyperpigmentation. Cocoa is a beneficial plant to the skin. This study was aimed to reveal the effect of cocoa bean extracts on the number of melanin pigments in rat skin after sun exposure. This was an experimental study using 25 Wistar rats (Rattus norvegicus) divided into one control group and four treatment groups. The treatment consisted of sunlight exposure for one hour/day and application of cocoa bean extract 1600 mg/day that varied among treatment groups. Group A was the negative control group (terminated at day 21). Group B, the treatment group 1, was exposed to sunlight for 30 days (terminated at day 31). Group C, the treatment group 2, was exposed to sunlight for 20 days (terminated at day 31). Group D, the treatment group 3, was divided into group D1 consisted of 2 rats and group D2 consisted of 3 rats. Group D1 was exposed to sunlight 30 minutes after the application of cocoa bean extract for 20 days (terminated at day 21). Group D2 was exposed to sunlight 30 minutes after the application of cocoa bean extract for 30 days (terminated at day 31). Group E was exposed to sunlight for 20 days and continued with the application of cocoa bean extract for the next 10 days (terminated at day 3). The results showed that sunlight exposure increased the number of melanin pigments in group B and C compared to group A. Group D showed fewer melanin pigments than group B and C. Group E showed fewer melanin pigments than group B, C, and D. Conclusion: Cocoa bean extract could reduce the number of skin melanin pigments in rats exposed to sunlight.Keywords: cocoa beans extract, sunlight, melanin pigment, skin Abstrak: Paparan sinar matahari yang berlebihan dapat menyebabkan hiperpigmentasi. Kakao merupakan tanaman yang berkhasiat untuk pemeliharaan kesehatan kulit. Penelitian ini bertujuan untuk mengetahui pengaruh pengolesan ekstrak biji kakao dan pemaparan sinar matahari terhadap jumlah pigmen melanin kulit tikus Wistar. Jenis penelitian ialah eksperimental dengan menggunakan 25 tikus Wistar (Rattus norvegicus) yang dibagi menjadi satu kelompok kontrol dan empat kelompok perlakuan. Perlakuan yang diberikan ialah paparan sinar matahari selama 1 jam/hari dan aplikasi ekstrak biji kakao dosis 1600 mg/hari yang bervariasi untuk masing-masing kelompok perlakuan. Kelompok A merupakan kontrol negatif (diterminasi hari ke-21). Kelompok B ialah kelompok perlakuan 1, diberi paparan sinar matahari selama 30 hari (diterminasi pada hari ke-31). Kelompok C ialah kelompok perlakuan 2, diberi paparan sinar matahari selama 20 hari (diterminasi hari ke-31). Kelompok D ialah kelompok perlakuan 3 yang dibagi menjadi kelompok D1 terdiri dari 2 tikus dan D2 dari 3 tikus. Kelompok D1 diberi paparan sinar matahari setelah diolesi ekstrak biji kakao 30 menit sebelumnya selama 20 hari (diterminasi hari ke-21). Kelompok D2 diberi paparan sinar matahari selama 1 jam setelah diolesi ekstrak biji kakao 30 menit sebelumnya selama 30 hari (diterminasi pada hari ke-31). Kelompok E ialah kelompok perlakuan 4 yang diberi paparan sinar matahari 20 hari dan dilanjutkan dengan pengolesan ekstrak biji kakao untuk 10 hari berikutnya (diterminasi hari ke-31). Hasil penelitian memperlihatkan bahwa kelompok B dan C menunjukkan peningkatan jumlah pigmen melanin dibandingkan kelompok A. Kelompok D menunjukkan jumlah pigmen melanin yang lebih sedikit dibandingkan kelompok B dan C. Kelompok E menunjukkan jumlah pigmen melanin yang lebih sedikit dibandingkan kelompok B, C, dan D. Simpulan: Ekstrak biji kakao dapat mengurangi jumlah pigmen melanin kulit tikus Wistar yang dipapar sinar matahari. Kata kunci: ekstrak biji kakao, sinar matahari, pigmen melanin kulit

scholarly journals Therapeutic Effect of Oral Administration and External Therapy of Traditional Chinese Medicine on Cervical Tuberculous

2019 ◽  
Vol 3 (3) ◽  
Author(s):  
Guoqiang Yang ◽  
Jin Zhang
Keyword(s):  
Statistical Analysis ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Oral Administration ◽  
Total Effective Rate ◽  
Statistical Significance ◽  
Effective Rate ◽  
Control Group ◽  
Treatment Data ◽  
Experimental Group

Objective: To analyze the clinical effect and value of oral administration and external therapy of traditional Chinese medicine for treatment of cervical tuberculous lymphadenopathy. Methods: A total of 56 patients with cervical tuberculous lymphadenopathy admitted to our hospital from January 1 to January 2018 were recruited. By using double-blind method, the patients were divided into control group (n=28) and experimental group (n=28). Control group comprised of patients with conventional anti-tuberculosis treatment, while the experimental group comprised of patients treated with oral administration and external therapy of traditional Chinese medicine. Total effective rate, incidence of complication and level of T lymphocyte subsets were compared between the two groups of cervical tuberculous lymphadenopathy patients. Results: Post-treatment data of total effective rate, complication rate, CD3+, CD4+, CD8+, CD4+/CD8+ of the experimental group were compared with the control group. P<0.05; statistical analysis showed statistical significance. Post-treatment data of CD3+, CD4+, CD8+, CD4+/CD8+ of both control and experimental groups were compared with pre-treatment data. P<0.05; statistical analysis showed statistical significance. Conclusion: Oral administration and external therapy of traditional Chinese medicine possesses significant effect in treatment of cervical tuberculous lymphadenopathy.

scholarly journals EFFECT OF KALO JEERA SEEDS AND PAPAYA LEAF SUPPLEMENTATION ON THE PERFORMANCE OF BROILER

2016 ◽  
Vol 14 (1) ◽  
pp. 37-42 ◽  
Author(s):  
M. G. Sorwar ◽  
M. Mostofa ◽  
M. N. Hasan ◽  
M. Billah ◽  
M. T. Rahman
Keyword(s):  
Body Weight ◽  
Treatment Group ◽  
Nigella Sativa ◽  
Control Group ◽  
Growth Promoter ◽  
Final Body Weight ◽  
Live Body Weight ◽  
Significant Difference ◽  
Group A ◽  
Group B

This experiment was conducted to determine the effect of papaya leaf (Carica papaya) and kalo jeera (Nigella sativa) seeds powdered supplementation in drinking water as a growth promoter in broiler chickens. A total of 20 Cobb-500 broiler chicks (day-old) were purchased from local hatchery (Nourish Poultry and Hatchery Ltd.) and after seven days of acclimatization chicks were randomly divided into two groups, A (n=10) and B (n=10). The group A was kept as a control and not treated. The group B was supplemented with papaya leaf and kalo jeera powder with feed and water. Weekly observations were recorded for live body weight gain up to 5th weeks and hematological tests were performed at 35th day’s age of broiler to search for hematological changes between control (A) and treatment (B) groups. The initial body weight of groups A and B on 1st were 41.00±0.56 gm and 41.50±0.35 gm, respectively and after 35th day of experiment final body weight were 1470±57.35 gm and 1720±58.56 gm, respectively and economics of production were analyzed and found that net profit per broiler was Tk. 8.91 and Tk. 20.69, respectively. The treatment group B was recorded statistically significant (at 1% level) increased (17.00%) for live body weight than that of control group A. The hematological parameters total erythrocyte count (TEC), erythrocyte sedimentation rate (ESR) and hemoglobin (Hb) estimation value of treatment group shows significant difference, while hemoglobin estimation does not show significant difference from control group. The results suggest that better growth performance could be achieved in broilers supplemented with papaya leaf and kalo jeera seeds.

scholarly journals The Role of Peer- and Self-Assessment in Developing Saudi EFL Learners’ English Writing Skills

2016 ◽  
Vol 8 (3) ◽  
pp. 85
Author(s):  
Manal Obaid Alshammari
Keyword(s):  
Treatment Group ◽  
Writing Skills ◽  
Control Group ◽  
Word Choice ◽  
Self Assessment ◽  
Efl Learners ◽  
English Writing ◽  
Post Test ◽  
Group A ◽  
Group B

<p>The current study focuses on the importance of integrating peer- and self-assessment in<br />teaching English as a second/foreign language in Saudi Arabia. It pays special attention to the<br />mechanisms by which Saudi EFL learners can improve their English writing skills if they<br />engage in peer- and self-assessment regularly. To this end, the researcher administered a<br />writing composition task to measure the participants’ ability to express themselves in good<br />English, focusing on the coherence, cohesion, word choice, spelling, punctuation, and layout<br />of their essays. The researcher utilised the experimental two-groups design of a pre-test and a<br />post-test, in order to evaluate the participants’ performance prior to the application of the<br />treatment (i.e. peer- and self-assessment) and after it. For the purpose of the study, the<br />participants were divided into two groups: students in group A (i.e. the treatment group)<br />engaged in peer- and self-assessment regularly throughout the term, whilst students in group<br />B (i.e. the control group) did not. The results of group A on the pre-test and post-test were<br />compared to those of group B to determine whether the treatment had any impact on their<br />performance. The results reveal that group A outperformed their group B counterparts on the<br />post-test. The statistical analysis demonstrates that the difference between the results of the<br />two groups was statistically significant, suggesting that the treatment contributed positively to<br />the performance of the treatment group. Finally, the study concludes with recommendations<br />for further research.</p>

scholarly journals PENGARUH PEMBERIAN AIR PERASAN JERUK NIPIS (Citrus aurantifolia) TERHADAP JUMLAH PIGMEN MELANIN KULIT MENCIT (Mus musculus) YANG DIPAPARKAN SINAR MATAHARI

2015 ◽  
Vol 3 (1) ◽  
Author(s):  
Anggun R.P. Layuck ◽  
Poppy M. Lintong ◽  
Lily L. Loho
Keyword(s):  
Treatment Group ◽  
Experimental Research ◽  
Light Exposure ◽  
Skin Pigmentation ◽  
Melanin Pigment ◽  
Control Group ◽  
Group A ◽  
The Subject ◽  
Group B ◽  
Group D

Abstract: Over exposure of light can increase skin pigmentation. The aim of this study is to know the effect of lime and light exposure to the amount of melanin in mice’s skin. This is an experimental research and used mices as the subject research, which was randomly divided into 5 mice of control group and 15 mices of treatment group. Group A (K-) were given pellets for 20 days, Group B (K+) were given pellets and light exposure for 1 hour in 20 days, Group C were given pellets, smeared by lime on the back, then exposed to the light for 1 hour in 20 days, Group D were given pellets and exposed to light for 1 hour in 20 days then smeared by lime the next 10 days. The results showed that light exposure increases melanin pigment in group B compared to group A. For group C and group D, the amount of melanin pigment is less than group B. Conclusions: Lime can reduce the amount of melanin pigment in mice’s skin that had been exposed to the light.Keywords: melanin pigment, sunlight, limeAbstrak: Paparan berlebihan terhadap sinar matahari dapat meningkatkan pigmentasi kulit. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian jeruk nipis dan pemaparan sinar matahari terhadap jumlah pigmen melanin kulit mencit. Metode penelitian yang digunakan adalah metode eksperimental dengan subjek penelitian menggunakan mencit yang dibagi atas 5 ekor kontrol dan 15 ekor perlakuan. Kelompok A (K-) diberikan pelet selama 20 hari, Kelompok B (K+) diberikan pelet dan sinar matahari selama 1 jam dalam waktu 20 hari, kelompok C diberikan pelet, diolesi jeruk nipis di bagian punggung, lalu dipaparkan sinar matahari selama 1 jam dalam waktu 20 hari, kelompok D diberikan pelet, dipaparkan sinar matahari selama 1 jam dalam waktu 20 hari lalu diolesi jeruk nipis 10 hari berikutnya. Hasilnya : paparan sinar matahari menunjukkan peningkatan pigmen melanin pada kelompok B (K+) dibandingkan dengan kelompok A (K-). Sedangkan pada kelompok C dan kelompok D menunjukkan jumlah pigmen melanin yang lebih berkurang dibandingkan kelompok B. Simpulan: Pemberian jeruk nipis menurunkan jumlah pigmen melanin kulit mencit yang dipaparkan sinar matahari.Kata kunci : pigmen melanin, sinar matahari, air perasan jeruk nipis

scholarly journals Acupuncture treatment for acute icteric hepatitis

2021 ◽  
Vol 2021 (2) ◽  
Author(s):  
Xue Mei Wan ◽  
Jing Chen ◽  
Tian Hong Zhang ◽  
Xue Lei Zhou
Keyword(s):  
Treatment Group ◽  
Liver Function ◽  
Clinical Efficacy ◽  
Conventional Therapy ◽  
Liver Enzymes ◽  
Acupuncture Treatment ◽  
Total Effective Rate ◽  
Effective Rate ◽  
Control Group ◽  
Single Use

Objective: To observe the clinical efficacy of acupuncture treatment for acute icteric hepatitis. Method: Forty patients with acute icteric hepatitis were randomized into a treatment group and a control group (20 in each group). Oral liver-protecting medicine was administrated for the control group. In the treatment group, acupuncture with Yinlingquan-SP9, Yanglingquan-GB34, Zhusanli-ST36, Sanyinjiao-SP6, and Taichong-LR3 was added. The clinical efficacies and serum liver enzymes, including (TB, ALT, and GGT) were evaluated. Result: The total effective rate was 94.7% in the treatment group and 85.0% in the control group respectively, which differed significantly different(P<0.05). The liver function indexes decreased significantly in both groups after treatment (P<0.01). The indicators of the treatment group were significantly lower than those of the control group after treatment (P<0.05). Conclusion: Acupuncture combined with hepatoprotective drugs could be an effective method to treat acute jaundice hepatitis and showed better effectiveness than the single use of the conventional therapy.

scholarly journals Histological and hormonal studies of calabash chalk on ovarian function in adult female wistar rats

2017 ◽  
Vol 34 (03) ◽  
pp. 173-177
Author(s):  
A. Oyewopo ◽  
K. Obasi ◽  
K. Anumudu ◽  
E. Yawson
Keyword(s):  
Body Weight ◽  
Adult Female ◽  
Wistar Rats ◽  
Ovarian Function ◽  
Female Rats ◽  
Control Group ◽  
Treatment Groups ◽  
Female Wistar Rats ◽  
Group A ◽  
Group B

Abstract Introduction: Calabash chalk is a naturally occurring mineral, chiefly composed of fossilized sea shells. It is prepared from clay and mud mixed with other ingredients, including lead, arsenic, sand and wood ash. Clay consumption is correlated with pregnancy, and also to eliminate morning sickness in women. The aim of this study is to evaluate the effects of calabash chalk on the ovarian function in adult female Wistar rats. Methods: Eighteen (18) adult female Wistar rats. Group A served as the control group, group B received 40 mg/kg body weight of Non-salted calabash chalk while group C received 40 mg/kg body weight of Salted calabash chalk for 14 days. On day 15, the animals were sacrificed for histological and biochemical examination. Results: Results showed a significant (P< 0.05) reduction in follicle stimulating hormone (FSH) levels of the treatment groups when compared with the control group and an increase in luteinizing hormone (LH) levels of the treatment groups when compared with the control group. Histological examination of the ovaries showed severe deterioration of the ovarian follicles, necrosis and follicular atresia. Conclusion: Calabash chalk is toxic to ovarian function. These alterations have been shown to be the leading cause ofinfertility in female rats. Hence, proper monitoring, education, and regulation of the product is needed.

scholarly journals GAMBARAN HISTOPATOLOGI LAMBUNG TIKUS WISTAR (Rattus norvegicus) YANG DIBERIKAN LENGKUAS (Alpinia galanga Willd) SETELAH DIINDUKSI OLEH ASAM MEFENAMAT

2013 ◽  
Vol 1 (1) ◽  
Author(s):  
Juita Pasaribu ◽  
Lily Loho ◽  
Poppy Lintong
Keyword(s):  
Wistar Rats ◽  
Acute Inflammation ◽  
Inflammatory Cells ◽  
Control Group ◽  
Treatment Groups ◽  
Acute Gastritis ◽  
Group A ◽  
Mucosal Lining ◽  
Group B ◽  
Group D

Abstrak: Gastritis akut merupakan proses inflamasi yang bersifat akut dan biasanya terjadi pada bagian permukaan mukosa lambung. Penyakit ini biasanya disebabkan karena banyak faktor salah satunya yaitu penggunaan asam mefenamat dalam dosis yang berlebihan. Pada penelitian yang telah dilakukan sebelumnya didapatkan bahwa lengkuas dapat mengurangi terjadinya radang akut. Tujuan penelitian ini adalah untuk mengetahui gambaran histopatologi lambung tikus wistar yang diberikan lengkuas setelah diinduksi dengan asam mefenamat. Penelitian ini menggunakan metode eksperimental dengan sampel 11 ekor tikus wistar yang dibagi dalam 4 kelompok perlakuan. Kelompok A tidak diberikan perlakuan. Kelompok B diberikan asam mefenamat 10 mg selama 7 hari. Kelompok C diberikan asam mefenamat 10 mg selama 7 hari kemudian diberikan perasan lengkuas selama 7 hari. Kelompok D diberikan asam mefenamat 10 mg kemudian tidak diberikan perlakuan selama 7 hari. Hasil penelitian ini menunjukkan bahwa gambaran mikroskopik lambung tikus wistar pada kelompok C terdapat sel-sel radang PMN yang lebih sedikit dibandingkan dengan kelompok B dan D. Simpulan: lengkuas dapat mengurangi sel-sel radang PMN pada mukosa lambung yang diberikan dengan asam mefenamat. Kata kunci: Lengkuas, Asam Mefenamat, Gastritis akut.   Abstract : acute gastritis is an acute inflammatory process normally occurring in the mucosal lining of the stomach. This disease is caused by a variety of factors, one of which is the use of mefenamat acid in large doses. Previous research has revealed that galangal can be used to reduce acute inflammation. The objective of this research was to reveal the histopathological pictures of stomach of wistar rats that treatment with galangal after induce by mefenamat acid. This study is an experimental, employing 11 wistar rats which were assigned for four treatment groups. Group A was the control group in which the rats received no treatment. Rats in group B were administered mefenamat acid 10 mg for 7 days. In group C, the rats were also administered mefenamat acid 10 mg for 7 days and then received galangal distillation for 7 days. In group D, rats were administered mefenamat acid 10 mg for 7 days and then for 7 days without receiving anymore mefenamat acid or galangal distillation. Results showed that microscopic pictures of stomach of wistar rats in group C were presented with PMN inflammatory cells fewer than rats in group B and D. Conclusion: galangal can reduce PMN inflammatory cells in mucosal lining of the stomach exposed to mefenamat acid. Key words: galangal, mefenamat acid,  acute gastritis.

scholarly journals Mild Cerebral Hypothermia during and after Cardiac Arrest Improves Neurologic Outcome in Dogs

1990 ◽  
Vol 10 (1) ◽  
pp. 57-70 ◽  
Author(s):  
Yuval Leonov ◽  
Fritz Sterz ◽  
Peter Safar ◽  
Ann Radovsky ◽  
Ken-Ichi Oku ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Treatment Group ◽  
Mild Hypothermia ◽  
Myocardial Damage ◽  
Neurologic Outcome ◽  
Control Group ◽  
Significant Group ◽  
Head Cooling ◽  
Group A ◽  
Group B

We previously found mild hypothermia (34–36°C), induced before cardiac arrest, to improve neurologic outcome. In this study we used a reproducible dog model to evaluate mild hypothermia by head cooling during arrest, continued with systemic cooling (34°C) during recirculation and for 1 h after arrest. In four groups of dogs, ventricular fibrillation (no flow) of 12.5 min at 37.5°C was reversed with cardiopulmonary bypass and defibrillation in ≤5 min, and followed by controlled ventilation to 20 h and intensive care to 96 h. In Study A we resuscitated with normotension and normal hematocrit; Control Group A-I (n = 12) was maintained normothermic, while Treatment Group A-II (n = 10) was treated with hypothermia. In Study B we resuscitated with hypertension and hemodilution. Control Group B-I (n = 12) was maintained no rmo thermic (6 of 12 were not hemodiluted), while Treatment Group B-II (n = 10) was treated with hypothermia. Best overall performance categories (OPCs) achieved between 24 and 96 h postarrest were in Group A-I: OPC 1 (normal) in 0 of 12 dogs, OPC 2 (moderate disability) in 2, OPC 3 (severe disability) in 7, and OPC 4 (coma) in 3 dogs. In Group A-II, OPC 1 was achieved in 5 of 10 dogs (p < 0.01), OPC 2 in 4 (p < 0.001), OPC 3 in 1, and OPC 4 in 0 dogs. In Group B-I, OPC 1 was achieved in 0 of 12 dogs, OPC 2 in 6, OPC 3 in 5, and OPC 4 in 1 dog. In Group B-II, OPC 1 was achieved in 6 of 10 dogs (p < 0.01), OPC 2 in 4 (p < 0.05), and OPC 3 or 4 in 0 dogs. Mean neurologic deficit and brain histopathologic damage scores showed similar significant group differences. Morphologic myocardial damage scores were the same in all four groups. We conclude that mild brain cooling during and after insult improves neurologic outcome after cardiac arrest.

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