scholarly journals Nepafenac loaded ophthalmic nanocarriers for treatment of uveitis: A review

2021 ◽  
Vol 15 (3) ◽  
pp. 154-163
Author(s):  
Chetna M Sangode ◽  
Amol A Tatode ◽  
Milind J Umekar

Visual impairment (VI), a worldwide worry that is probably going to raise with delayed futures, has gained increasing attention in the domain of eye care. Now a days, new cases of visual impairment occur in older individuals, some children are born with visual impairments resulting from retinopathy of prematurity, a condition associated with premature birth. Other children experience vision loss because of congenital glaucoma or congenital cataracts, Uveitis and some experience vision loss of unknown etiology. Uveitis is an intraocular inflammation involving primarily the uveal tract. Vision is one of our most cherished senses. There are nearly 45 million people worldwide who are blind and a further 135 million people are visually disabled. Uveitis causes 0.6% - 11% of blindness in various studies. The ophthalmic preparations are available as buffered, sterile and isotonic solution. For the ocular delivery of drugs, several types of dosage forms are prepared and marketed. As drops are easier to administer so the most prescribed dosage form is the eye drop solution. Nepafenac is unique among ophthalmic NSAIDs in that it is a prodrug deaminated to amfenac, a highly effective non-selective cyclooxygenase inhibitor. The compiled data presented in this review will act as a good information resource and reference point for further research in the field of ocular drug delivery aiming non-invasive sustained release of drugs in the anterior and posterior segments of the eye.

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 807-808
Author(s):  
Bonnielin Swenor ◽  
Varshini Varadaraj ◽  
Moon Jeong Lee ◽  
Heather Whitson ◽  
Pradeep Ramulu

Abstract In 2019, the World Health Organization World Report on Vision estimated that that 2.2 billion people have a vision impairment, of which almost half could have been prevented or is yet to be addressed. As the global population ages and the prevalence of visual impairment increases, inequities in eye care and the downstream health and aging consequences of vision loss will become magnified. This session will: (1) provide key information regarding the burden of eye disease and visual impairment among older adults worldwide; (2) outline a framework created to conceptualize the aging and long-term health implications of vision loss, and (3) discuss the global public health challenges to eye care and to maximizing health for older adults with visual impairments.


2021 ◽  
Vol 263 (2) ◽  
pp. 4290-4294
Author(s):  
Mari Ueda

Blind soccer is a sport designed for people with visual impairment. All players (except the goalkeepers) are people with visual impairment but not limited to complete vision loss (i.e. without any ability to see; blind in both eyes) . Considering the various degrees of the disability, all players put on an eye mask for a complete vision blockage so they just rely on their audio sensation for the location of the ball and the goals to drift, shoot, and defend as a game with a high degree of movement. Different from conventional soccer games, the ball makes a sound in which the callers at the back of the shooting goal provide audio guidance in order to make the game highly dependent on audio information. However, the ability to recognize and locate rely solely on training and personal experience of individual players that essential audio information of the game has never been analyzed in a scientific manner and theories about distance positioning is especially inadequate. Hence, this study aims to utilize the audio sensation for better game performance. First, we focus on the distance attenuation feature when the ball spins, which is followed by a description about an audio training system for distance positioning from sounds.


2020 ◽  
Author(s):  
Wendy Andrusjak ◽  
Ana Barbosa ◽  
Gail Mountain

Abstract Background: Hearing and vision loss in older people has proven to affect physical and mental health and increase the speed of cognitive decline. Studies have proven certain practices and aspects of staff knowledge increase the effective care of residents’ ears and eyes, yet it is not known which of these are being implemented in care homes. This study aims to identify the gaps in staff knowledge and underused practices evident in long term care homes when identifying and managing hearing and vision difficulties in older residents. Methods: This study used a cross-sectional survey design. Survey questions were informed by the existing literature and were focused on practices, staff knowledge, and other aspects that have shown to affect residents’ hearing and vision care. The survey was sent to care homes across England between November 2018 and February 2019 both via Email and in paper format for care home staff to complete. Descriptive statistics and Chi-Square analysis was used to assess the factors particularly influencing the current care being provided to care home residents. Results: A total of 400 care home staff responded from 74 care homes. The results revealed that screening tools are rarely used by staff to identify hearing and vision impairments, care homes have limited access to other assistive devices, and audiology services do not regularly assess care home residents. A majority of staff were also not entirely confident in their knowledge of ear and eye care. Responses were also affected by the respondents’ job role, length of time working in care homes and also the care home type and care home capacity revealing a lack of standardised practice and shared communication. Conclusion: This study identifies which practices known to facilitate ear and eye care are currently under used in care homes across England and what particularly staff are not knowledgeable on when it comes to ear and eye care. This can now inform future research of the areas requiring improvement to as effectively address to acknowledged slow identification and poor management of hearing and vision loss in older people residing in care homes.


2021 ◽  
Vol 12 (2) ◽  
pp. 712-716
Author(s):  
Edsel Ing ◽  
Felix Tyndel ◽  
Joyce Tang ◽  
Thomas R. Marotta

A 67-year-old woman had delayed initial diagnosis of her right low flow carotid cavernous fistula (CCF) during the coronavirus disease (COVID-19) pandemic due to difficulty detecting ocular signs via online virtual examinations. Her right eye conjunctival erythema and proptosis with medial rectus enlargement on computed tomography scan was initially misdiagnosed as euthyroid thyroid-associated orbitopathy without lid retraction. She developed vision loss, and increasing episcleral venous congestion and CCF was suspected. Computed tomographic angiography did not show an obvious fistula. Digital subtraction angiography revealed the right-sided low flow CCF, which was fed from vessels from the contralateral side.


Author(s):  
Abdul Rauf Awan ◽  
Junaid Jamshed ◽  
Muhammad Mushtaq Khan ◽  
Zahid Latif

<p class="abstract"><strong>Background:</strong> Vision loss<strong> </strong>in childhood has serious implications in all stages of child’s growth and development. It poses social, educational and occupational challenges, with affected children being at greater risk of developing behavioral, psychological and emotional problems, lower self-esteem and poorer social integration. The aim of this study was to assess the prevalence and identify the causes of visual impairment and blindness in school children of UC Gojra, Muzaffarabad, Pakistan so that prevention strategies could be implemented.</p><p class="abstract"><strong>Methods:</strong> This was a<strong> </strong>school-based descriptive cross-sectional study conducted among public and private schools. A multi-stage stratified random sampling technique was used for selecting study participants aged 5-20 years from 24 schools in Muzaffarabad. The vision of school children was examined for visual acuity using standard Snellen chart. Those participants who had visual acuity of &lt;6/18 in either eye underwent a more detailed ophthalmic examination to diagnose the causes of VI. An exploration of demographic variables was conducted using Chi-square test.  </p><p class="abstract"><strong>Results:</strong> The mean age of participants was 10±2.83.<strong> </strong>The prevalence of visual impairment was 19.6% and 2.3% for severe visual impairment. The age group most affected by VI was 11-15 years (74.2%). There were increased chances of developing VI with advancing age of the participants. Males contributed 88.7% of the cases of VI while females contributed only 11.3%. The class category 5-6 had higher percentage of VI cases (32.7%). Public schools contributed 52.8% of the cases of VI while for private schools the corresponding percentage was 47.2%. The leading cause of VI was refractive error (89.3%) followed by amblyopia (5.0%). Other causes of VI included cataract (1.2%), corneal disease (1.8%), strabismus (1.8%) and nystagmus (0.6%).</p><p class="abstract"><strong>Conclusions:</strong> There is a need to implement school health policy on visual screening prior to admissions in schools and annual eye screening program for early detection and prompt treatment of eye problems among school children in Muzaffarabad.</p>


2021 ◽  
Vol 17 (4) ◽  
pp. 343-355
Author(s):  
Lavanya G. Rao ◽  
Dushyanth Sharma ◽  
Sulatha V. Bhandary ◽  
Divya Handa ◽  
Yogish Kamath

Aim: To assess the prevalence of severe visual impairment (SVI) and reasons for not accessing eye care services in a field practice area of a tertiary care hospital. Study design: Cross-sectional observational study. Materials and methods: Through a cross-sectional study using simple random sampling, a total of 1510, individuals above 18 years of age, from six rural and maternity welfare centers (RMCW) within a distance of 20 km from a tertiary hospital were approached. All participants underwent basic assessment of visual acuity, anterior segment evaluation using torch light, and answered a structured questionnaire on eye care. Results: Of 1510 subjects, 267 had SVI (defined as visual acuity < 6/60 either in one or both eyes) with a prevalence of 17.7%. SVI was higher among men and those above 60 years of age (52.8%). Significant association was found between barriers to accessing eye care facilities and lack of knowledge to access health care (p = 0.004), lack of financial support (95% CI, p = 0.006), and social reasons (95% CI, p = 0.028). Prevalence of SVI among diabetics was 32.7% as compared to non-diabetics (OR: 2.630; 95% confidence interval: 1.864–3.712), and among hypertensives was 34.61% as compared to non-hypertensives (OR: 2.836; 95% confidence interval: 1.977–4.068). Conclusion: In spite of being close to a tertiary care center, a prevalence of SVI in 17.7% of this population indicates a lack of knowledge regarding the importance of self-health care in subjects. This emphasizes the need to increase the awareness among the general public to access the ophthalmic health care facilities in order to improve the ocular health of the patients.


Author(s):  
Ricardo Vergaz Benito ◽  
César Vega-Colado ◽  
María Begoña Coco ◽  
Rubén Cuadrado ◽  
Juan Carlos Torres-Zafra ◽  
...  

The aim of the chapter is to review the most recent advances in electro-optical technologies applied to visually disabled people. The World Health Organization (WHO) estimates that the number of people in the world with some kind of visual impairment is 285 million, with 246 million of these persons in a partially sighted or Low Vision (LV) condition. The top three causes of visual impairment are uncorrected refractive errors, cataracts and glaucoma, followed by age-related macular degeneration. On the other hand, Head Mounted Displays or electro-optical materials used in liquid crystal or electrochromic devices can be used in technical aids for LV. In this chapter, the authors review how disabled people receive real world information using these new technologies, how the recently developed electro-optical technical aids can improve visual perception, and how these LV aids do work, from a technological point of view.


Author(s):  
Jacqueline Chua ◽  
Ching-Yu Cheng ◽  
Tien Yin Wong

General physicians have an essential role in preventing vision loss in older people. However, most vision-threatening eye disorders are initially asymptomatic and often go underdiagnosed. Therefore screening, early detection, and timely intervention are important in their management. The most common cause of visual impairment is uncorrected or undercorrected refractive error, followed by cataract, age-related macular degeneration, glaucoma, and diabetic retinopathy. Spectacles and cataract surgery can successfully restore sight for uncorrected refractive error and cataract, respectively. Visual impairment as a result of age-related macular degeneration, glaucoma, and diabetic retinopathy can be prevented with appropriate treatment if they are identified early enough. This chapter provides an overview of common age-related eye disease and visual impairment.


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