Benign mixed tumour of the upper lip – Report of a rare case

Introduction: Pleomorphic adenomas are the most common non-malignant neoplasms of salivary gland tumours that present mixed histopathological patterns. The purpose of our study was to report an unusual case of a pleomorphic adenoma which was located in the upper lip that had been initially considered as cyst. Case report: The patient was a middle aged man who had a painless, slow-growing swelling in the upper lip. At first, the round-shaped and mobile mass was considered as cystic lesion. However during the operation, it was discovered instead of a cyst, an encapsulated solid tumour that demonstrated both epithelial and mesenchymal cells in histopathology and the diagnosis of pleomorphic adenoma was set. One year postoperatively the patient had no recurrence of tumour. Conclusions: Occurrence of intraoral lip swelling could be attributed, even rarely, to benign mixed tumours. Despite its nonmalignant features, these masses have a relatively low but still existing risk for recurrence or malignant transformation and thus in similar cases a systematic follow-up should be performed even years after surgery.

Download Full-text

Giant Parotid Pleomorphic Adenoma with Atypical Histological Presentation and Long-Term Recurrence-Free Follow-Up after Surgery: A Case Report and Review of the Literature

Case Reports in Dentistry ◽

10.1155/2020/8828775 ◽

2020 ◽

Vol 2020 ◽

pp. 1-18

Author(s):

Mohammed AlKindi ◽

Sundar Ramalingam ◽

Lujain Abdulmajeed Hakeem ◽

Manal A. AlSheddi

Keyword(s):

Pleomorphic Adenoma ◽

Surgical Management ◽

Early Stage ◽

English Literature ◽

Benign Tumors ◽

Adjuvant Radiation ◽

Extracapsular Dissection ◽

Slow Growing

Salivary gland tumors (SGT) comprise 3% of all head and neck tumors, are mostly benign, and arise frequently in the parotid gland. Pleomorphic adenoma (PA) is the commonest SGT, representing 60-70% of all benign parotid tumors. Clinically, parotid PA presents as irregular, lobulated, asymptomatic, slow-growing preauricular mass, involving both superficial and deep lobes, and could grow to gigantic proportions. Histologically, PA has epithelial and mesenchymal elements in chondromyxoid matrix and is managed surgically. Based on a review of 43 cases reported in English literature since 1995, giant parotid PA is reported as large as 35 cm (diameter) and 7.3 kg (resected weight). Although rare, 10 cases of malignant transformation were reported in the review. Surgical management included extracapsular dissection (ECD), superficial parotidectomy, and total parotidectomy for benign tumors, and adjuvant radiation or chemotherapy for malignant tumors. We further present the case of a 36-year-old healthy male with slow-growing and asymptomatic giant parotid PA, of 4-year duration. The patient presented with firm, lobulated preauricular swelling, provisionally diagnosed as PA based on radiographic and cytological findings. The tumor was resected through ECD, and the patient had uneventful postoperative recovery and a 7-year recurrence-free follow-up period. Histological examination revealed epimyoepithelial proliferation punctuated by chondromyxoid areas, with extensive squamous metaplasia and keratin cysts. To the best of knowledge from indexed literature, giant parotid PA is rarely reported in Saudi Arabia. In addition to its rarity, this case is reported for its benign nature despite atypical histological presentation, successful surgical management without complications, and long-term recurrence-free follow-up. Based on this report, clinicians must be aware of atypical histological presentations associated with PA and plan suitable surgical management and follow-up to avoid morbidity. Nevertheless, attempts must be made to diagnose and manage these lesions at an early stage and before they reach gigantic proportions.

Download Full-text

RENAL AMYLOIDOSIS RESULTING FROM A CHRONICALLY INFECTED BURN

PEDIATRICS ◽

10.1542/peds.32.5.888 ◽

1963 ◽

Vol 32 (5) ◽

pp. 888-894

Author(s):

Saul Hoffman ◽

Bernard E. Simon ◽

Robert A. Fischel ◽

Donald Gribetz

Keyword(s):

Nephrotic Syndrome ◽

Renal Biopsy ◽

Clinical Improvement ◽

Short Duration ◽

Unusual Case ◽

White Male ◽

Lower Extremities ◽

Renal Amyloidosis ◽

One Year

An interesting and unusual case of an 11-year-old white male with chronically infected burns of his lower extremities who developed amyloidosis and the nephrotic syndrome is reported. The case is considered from the following aspects: (1) the rarity of amyloidosis in burns, (2) the short duration between the onset of the primary disease and the amyloidosis, (3) the age of the patient, and (4) the striking clinical improvement of the renal manifestations after the treatment of the burn. The treatment of the burns, using homografts, and the importance of renal biopsy in the diagnosis and follow-up are also discussed. Addendum: A third renal biopsy was performed in August, 1963, about one year following the second one. The amount of amyloid seen in the glomeruli did not seem to have diminished.

Download Full-text

Pleomorphic adenoma of the upper lip: a case report and review of literature

International Journal of Dental Research ◽

10.14419/ijdr.v4i1.5761 ◽

2016 ◽

Vol 4 (1) ◽

pp. 8

Author(s):

Rashmi Metgud ◽

Bhardwaj Tina Neelesh ◽

Saurabh Goel ◽

Smitha Nail ◽

Shrikant Patel ◽

...

Keyword(s):

Salivary Gland ◽

Pleomorphic Adenoma ◽

Unusual Case ◽

Needle Aspiration ◽

Myoepithelial Cells ◽

Upper Lip ◽

Epithelial Tumor ◽

Needle Aspiration Cytology ◽

Benign Mixed Tumor ◽

Morphological Patterns

Pleomorphic Adenoma is a benign epithelial tumor arising from the salivary gland. It is a benign mixed tumor composed of epithelial and myoepithelial cells arranged with various morphological patterns, demarcated from surrounding tissues by fibrous capsule. In this article, we report an unusual case of 30 year, male with a single, nodular swelling evident in the upper lip which was discovered during a routine dental procedure. Fine Needle Aspiration Cytology (FNAC) was planned for the patient, where a of cytological diagnosis of Pleomorphic Adenoma was rendered, which was confirmed by biopsy. Hence, this highlights, FNAC makes up an important diagnosing tool as the first line of investigation to distinguish between benign and malignant salivary gland neoplasms.

Download Full-text

Salivary gland tumours - a three years experience at King Edward Medical College, Lahore

Annals of King Edward Medical University ◽

10.21649/akemu.v10i2.1207 ◽

2016 ◽

Vol 10 (2) ◽

Author(s):

Asmaa Qureshi ◽

Khalilur Rehman ◽

Sohail Husain ◽

Nasirul Hasan Khawaja ◽

Ghulam Rasood Qureshi ◽

...

Keyword(s):

Salivary Gland ◽

Parotid Gland ◽

Salivary Glands ◽

Pleomorphic Adenoma ◽

Single Case ◽

Malignant Neoplasms ◽

Salivary Gland Tumours ◽

Medical College ◽

Common Location ◽

Female Predominance

Salivary gland tumours make an important part of oral & maxillofacial pathology. Only few studies have been done in Pakistani population. The aim of this study was to describe morphological types of salivary gland tumours diagnosed at King Edward Medical College/ Mayo Hospital, Lahore during the years 1999-2001 and to compare their demographic data with those previously published. Material & Methods: This descriptive cross-sectional study was carried out at King Edward Medical College/ Mayo Hospital, Lahore. It reports 117 cases of salivary gland tumours diagnosed at Pathology Department during 1999-2001. Results: Of the 128 specimens of salivary glands, 117(91.4%) were confirmed as salivary neoplasms. Out of them, 62.7% were benign and 37.6% malignant and a slight female predominance (58.1%) was found. The most common location was the parotid gland (65.8%) followed by minor salivary glands (19.6%). Majority oft he t tumours was diagnosed during 3rd to 5 decades of life. Median age for benign tumours was 33 years (range 1-78) and a female predominance (58.9%) was seen again. Median age for malignant neoplasms was 45 years (range 9-70) with a female predilection ( 56.8%). However, 4 out o f 5 patients with Warthin`s tumour were men. Pleomorphic adenoma was the most frequent tumour (51.3%), followed by mucoepidermoid carcinoma (25.6%), adenoid cystic carcinoma (7.7)), Warthin`s tumour (4.3%) and monomorphic adenoma (2.6%). Two cases each of oncytoma & adenocarcinoma were recorded. Rare categories (single case each) of salivary tumours included lipoma, acinic cell carcinoma, basal cell adenoma, capillary haemangioma, metastatic carcinoma and non Hodgkin`s lymphoma. Conclusion: The principal site of salivary tumours was the parotid gland and females were most affected. Pleomorphic adenoma was the most frequent finding. The results of this study are comparable with other studies.

Download Full-text

Chondroid syringoma of the upper lip: a rare entity

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20204198 ◽

2020 ◽

Vol 6 (10) ◽

pp. 1900

Author(s):

Ashiya Goel ◽

Aman . ◽

Vinny Raheja ◽

Manisha Kumari

Keyword(s):

Differential Diagnosis ◽

Normal Tissue ◽

Neck Region ◽

Rare Entity ◽

Upper Lip ◽

Head And Neck Region ◽

Chondroid Syringoma ◽

The Face ◽

Slow Growing

Chondroid syringomas are uncommon cutaneous neoplasms of sweat gland origin which are slow-growing, nontender, subcutaneous or intracutaneous in location and often occurring in the head and neck region. Chondroid syringoma should be considered in the differential diagnosis of any subcutaneous nodule over the face. The clinician may miss the diagnosis of this lesion and if it is suspected, tumour should be excised with a margin of normal tissue and regular follow up should be done.

Download Full-text

Gingival Lipoma: A Rare Case Report

Journal of Nepalese Society of Periodontology and Oral Implantology ◽

10.3126/jnspoi.v1i1.23537 ◽

2017 ◽

Vol 1 (1) ◽

pp. 37-39

Author(s):

Sweta Shrestha ◽

Shaili Pradhan ◽

Ranjita Shrestha Gorkhali

Keyword(s):

Rare Case ◽

Surgical Excision ◽

Soft Tissue Tumors ◽

Rare Case Report ◽

Postsurgical Complication ◽

Benign Tumours ◽

One Year ◽

Slow Growing ◽

Oral Soft Tissue

Lipomas are benign tumours of mesenchymal origin (mature adipocytes) that are comparatively uncommon in the oral cavity corresponding to less than 4.4% of all benign oral soft tissue tumors. Clinically, they present as slow growing, soft, asymptomatic masses. Histopathologically, they appear as thinly encapsulated lesion composed of mature adipocytes with inconspicuous vascularity. The pathogenetic mechanisms of oral lipomas are still unclear. They are usually treated by surgical excision and bear excellent prognosis. Here we report a case of intraoral lipoma in 54 year old male patient in the left lower lingual alveolar mucosal region that was treated by surgical excision using electrocautery without any postsurgical complication. One-year follow-up showed no evidence of recurrence.

Download Full-text

Unusual mandible fracture caused by metallic spear: case report and literature review

Journal of Oral Medicine and Oral Surgery ◽

10.1051/mbcb/2020014 ◽

2020 ◽

Vol 26 (2) ◽

pp. 20

Author(s):

Samuel Macedo Costa ◽

Bruna Campos Ribeiro ◽

Bernardo Barcelos Greco ◽

Rodolfo César Gual ◽

Alessandro Oliveira de Jesus ◽

...

Keyword(s):

Unusual Case ◽

Mandible Fracture ◽

Operative Care ◽

Surgical Incisions ◽

The Face ◽

Gun Shot ◽

History Of ◽

One Year ◽

Water Sports

Spear gun projectiles injuries are are very rare and are usually related to lack of attention during water- sports or fishing practices. This study aims to describe an unusual case of facial injury associated with a mandibular fracture after a spear gun shot. A 38-years-old man was admitted with a history of penetrating injury on the face caused by an accidental shot from a spear gun. After the initial stabilization and examination, the patient was taken to the surgical room for the removal of the projectile. The post-operative care was uneventful and the patient was discharged with no concerns, being in follow-up for one year with no signs of infection or malocclusion. The surgical procedure should be done as soon as possible and the removal of the spear must be done carefully, under direct vision, with or without surgical incisions. Major complications can occur after spear injuries, therefore, the patient must be observed in the postoperative period and should maintain follow up until the end of the rehabilitative process.

Download Full-text

An Unusual Case of Carcinoma Ex-pleomorphic Adenoma of the Parotid Gland: A Comprehensive Clinicopathological Review

The Journal of Medical Sciences ◽

10.5005/jp-journals-10045-0013 ◽

2015 ◽

Vol 1 (2) ◽

pp. 44-46

Author(s):

K Harish ◽

PS Sharmila ◽

K Shashikala ◽

Padmini Jeychandran

Keyword(s):

Salivary Gland ◽

Parotid Gland ◽

Pleomorphic Adenoma ◽

Unusual Case ◽

Minor Salivary Gland ◽

Sudden Onset ◽

Carcinoma Ex Pleomorphic Adenoma ◽

Malignant Neoplasms ◽

Diagnostic Challenge ◽

Histologic Subtype

ABSTRACT Carcinoma ex-pleomorphic adenoma (CaxPA) is a carcinoma arising from a primary or recurrent benign pleomorphic adenoma (PA). It presents approximately 11.6% of all malignant neoplasms of salivary gland and mostly originates from major salivary glands. It is a common histologic subtype of primary parotid malignancy. Location in the minor salivary gland is uncommon and occurs in less than 7% of all cases. The majority of CaxPA develops from epithelial component of PA. Salivary gland tumors are known to have a benign clinical behavior with unrecognized metastatic potential. It often poses a diagnostic challenge to clinicians and pathologists. The entity is difficult to diagnose preoperatively. Pathologic assessment is the gold standard for making the diagnosis. We present a case of a 55-year-old female patient who had a right preauricular mass of 10 years duration, with sudden onset of pain of duration of 1 month. How to cite this article Sharmila PS, Shashikala K, Harish K, Jeychandran P. An Unusual Case of Carcinoma Expleomorphic Adenoma of the Parotid Gland: A Comprehensive Clinicopathological Review. J Med Sci 2015;1(2):44-46.

Download Full-text

Coblator-Assisted Endoscopic Transnasal Resection of a Large Nasopharyngeal Pleomorphic Adenoma

Case Reports in Otolaryngology ◽

10.1155/2019/4654357 ◽

2019 ◽

Vol 2019 ◽

pp. 1-5

Author(s):

Jonathan Bowman ◽

Anu Daudia ◽

Neil Sahasrabudhe ◽

Antonio Belloso

Keyword(s):

Pleomorphic Adenoma ◽

English Language ◽

Nasal Congestion ◽

Invasive Technique ◽

Transnasal Approach ◽

Complete Excision ◽

Benign Pathology ◽

Endoscopic Transnasal Approach ◽

One Year

Background. Pleomorphic adenomas occurring in the adult nasopharynx are rare, with our literature search identifying only 11 previous English-language reports. We document the unusual case of a large nasopharyngeal pleomorphic adenoma that was resected using radiofrequency coblation via an endoscopic transnasal approach. Methods. A 39-year-old male presented with worsening nasal congestion, intermittent otalgia, and a progressive change in voice. Flexible nasendoscopy showed a large homogeneous mass occupying the postnasal space, and computed tomography confirmed a 28 × 31 × 22 mm nasopharyngeal tumour. The biopsy-proven benign tumour was locally dissected using a coblator-assisted transnasal approach. Results. Histology confirmed complete excision of a myoepithelial-rich pleomorphic adenoma. The patient was symptom-free postoperatively, and no signs of recurrence were seen at one-year follow-up. Conclusions. This is a useful addition to the existing literature on surgical procedures used to treat benign pathology in the nasopharynx. The minimally invasive technique was well tolerated and had favourable patient outcomes.

Download Full-text

Pleomorphic adenoma of the palate

Journal of Clinical Images and Medical Case Reports ◽

10.52768/2766-7820/1316 ◽

2021 ◽

Vol 2 (5) ◽

Author(s):

Naourez Kolsi ◽

◽

Emna Bergaoui ◽

Rachida Bouatay ◽

Jamel Koubaa ◽

...

Keyword(s):

Ct Scan ◽

General Anesthesia ◽

Pleomorphic Adenoma ◽

Soft Palate ◽

Smooth Surface ◽

Surgical Excision ◽

Radiographic Evidence ◽

History Of ◽

Slow Growing

A woman 43 years, presented with 9 years history of a painless swelling in the palatal region, slow-growing. Her medical history was not significant. On intraoral examination, a median ovoid mass measuring 4 cm diameter was found at the junction of hard and soft palate. The mass was firm, with smooth surface. No radiographic evidence of bone involvement was seen on the CT scan (Figure A). Surgical excision under general anesthesia: excision of the mass was carried out, the overlying mucosa was healthy, so conserved (Figure B,C&D). Histopathologic report confirmed the lesion to be “pleomorphic adenoma”. The lesion has not recurred after four years follow-up.

Download Full-text