scholarly journals Methodology for application of supramolecular fenbendazole against helminthosis of ruminants

2021 ◽  
Vol 15 (4) ◽  
pp. 57-60
Author(s):  
A. I. Varlamova

The purpose of the research is developing a methodology for application of the supramolecular complex of fenbendazole (SMCF) against helminthosis in ruminants.The SMCF was obtained by the method of mechanochemical technology with polyvinylpyrrolidone (PVP) in a ratio of 1 : 10 in a balling drum. The drug was produced in plastic cans of 2, 4 and 8 kg and stored in its original packaging in dry, nonresidential area. The SMCF was used against gastrointestinal strongylatosis, dictyocaulosis and monieziosis of sheep and goats at a dose of 20 mg/kg (2 mg/kg for the active substance). The methodology provides a brief chemical characteristic of the SMCF, summarizes its mode of action, and describes toxicological properties, which gives an idea of the drug in general. The procedure is described for preparing the drug for use on animals, both individually and in a group. Reasoned recommendations are given on the timing for animal slaughter, and the use of milk after treating cows.

2021 ◽  
Vol 15 (2) ◽  
pp. 101-106
Author(s):  
M. B. Musaev ◽  
V. V. Zashchepkina ◽  
Kh. Kh. Gadayev ◽  
Kh. Kh. Shakhbiyev

The purpose of the research is a commission test of the efficacy of the supramolecular complex of ivermectin at gastrointestinal strongylatoses of horses.Materials and methods. The commission experiment was performed in June 2019 in the North Caucasian Federal District of the Chechen Republic. The efficacy of the supramolecular complex of ivermectin was evaluated on 20 horses of different breeds in the Seradin Equestrian Center. To determine the rate of gastrointestinal nematode infection in horses, we collected fresh feces in the morning, made tissue imprints from perianal folds and examined them by the Fülleborn's method using a saturated solution of sodium chloride.Results and discussion. The coproovoscopic examination determined a 100% infection of horses with Strongylates and 40.0% infection with Oxyuris sp., with 488.7±24.4 strongylates eggs and 16.9±0.84 Oxyuris sp. eggs found in 1 g of feces, respectively. Seven and 15 days after the supramolecular complex of ivermectin administered to the horses from the first test group at a dose of 0.15 mg/kg for the active substance (7.5 mg/kg for the drug) in a mixture with mixed feed, we did not find any Strongylata eggs or Oxyuris sp. eggs in feces or on tissue imprints. Insufficient efficacy was obtained in the horses from the second test group after being treated with the active substance of ivermectin at a dose of 0.15 mg/kg. The strongylate egg number decreased on average by 244.3±12.21, namely, by 50.1%, and no Oxyuris sp. eggs were found. The efficacy against Oxyuris sp. was 100%. The horses consumed the mixture of drugs with feed readily. There were no side effects after the drugs applied. Thus, we established the high efficacy of the supramolecular complex of ivermectin against gastrointestinal strongylatoses, and the convenience of its use in a mixture with feed to untamed herd horses individually and by group feeding. 


2019 ◽  
Author(s):  
N A Kadirov ◽  
M A Eshmuhamedov ◽  
M S Mirzarahimov ◽  
O A Sheralieva ◽  
J K Artikova

The article the results of investigation on obtaining of surface-active substance -SAS on the waste cotton oil for drilling of wells and intensification of the flotation process are presented. The main component of new SAS are waste, cotton oil refinery and chemical plants. SAS have hudrophobization (waterproof) action on easy-swelling rocks (clays, argellites, alevrolits). Direct water emulsions obtained from reagents have low viscosity, high stability and low filtration index. There reagents have influence at drilling tools (that is they increase the life of drilling bits and diamond bits) [1, 2]. The study flotation enrichments of copper-molybdic ore is revealed characteristic foam-former and collector surface-active substances (NA-1) and is simulation one oily provided creation without minerals fields extraction of gold and color metals has been determined. Optimal conditions of the syntheses: ratio of main components, time of reaction, temperature and concentration have been determined. The comparison of new SAS with other foreing analogies was carried out. The main colloidal-chemical characteristic of synthesized SAS: surface activity, adsorption, viscosity, concentration of micelle- formation have been determined. Technology of obtain of anion surfaceactive substances from local organic raw material was elaborated, which by qualitative characteristics is a substitute of the import reagent collector and foam-former [4, 5]. Dependence on obtained product from the temperature of the process, time of reactions, ratio of initial components optimal concentration of NaOH was investigated. The foam forming ability of the new reagents in comparison with standard reagent T-92 was determined and it was shown that by best ability of forms destruction the methyl syloxane’s liquid and mineral oil have possessed.The intensifications of the process of flotation’s enrichment of copper-molybdic ore with using new obtain reagent NA-1 was offered.


1965 ◽  
Vol 58 (11P2) ◽  
pp. 943-946 ◽  
Author(s):  
Alastair G MacGregor

The prescribing of mixtures is unfortunately traditional and has a psychological appeal, which is being encouraged by many manufacturers. Doctors must have a sound working knowledge of the mode of action of modern drugs in order to use them effectively and safely, particularly when they are used together. In this context ‘drug’ means any biologically active substance. Interaction between drugs can be inapparent (if equal and opposite), antagonistic or synergistic. This includes summation and potentiation. Interaction between drugs can arise in a variety of ways: directly; in the intestine or other absorptive site; in transit; at the receptor or at another site in the same biological system; by accelerating or slowing drug metabolism; or by influencing excretion. Most of these mechanisms are considered in detail in this Symposium. With greater understanding of underlying mechanisms many of the untoward interactions now being increasingly reported might be foreseen and avoided.


2015 ◽  
Vol 8 (1) ◽  
pp. 94-98 ◽  
Author(s):  
Leonid A. Yakovishin ◽  
Vladimir I. Grishkovets ◽  
Elena N. Korzh ◽  
Elena V. Vetrova ◽  
Nikolay I. Borisenko

Author(s):  
E. A. Elfont ◽  
R. B. Tobin ◽  
D. G. Colton ◽  
M. A. Mehlman

Summary5,-5'-diphenyl-2-thiohydantoin (DPTH) is an effective inhibitor of thyroxine (T4) stimulation of α-glycerophosphate dehydrogenase in rat liver mitochondria. Because this finding indicated a possible tool for future study of the mode of action of thyroxine, the ultrastructural and biochemical effects of DPTH and/or thyroxine on rat liver mere investigated.Rats were fed either standard or DPTH (0.06%) diet for 30 days before T4 (250 ug/kg/day) was injected. Injection of T4 occurred daily for 10 days prior to sacrifice. After removal of the liver and kidneys, part of the tissue was frozen at -50°C for later biocheailcal analyses, while the rest was prefixed in buffered 3.5X glutaraldehyde (390 mOs) and post-fixed in buffered 1Z OsO4 (376 mOs). Tissues were embedded in Araldlte 502 and the sections examined in a Zeiss EM 9S.Hepatocytes from hyperthyroid rats (Fig. 2) demonstrated enlarged and more numerous mitochondria than those of controls (Fig. 1). Glycogen was almost totally absent from the cytoplasm of the T4-treated rats.


Planta Medica ◽  
2007 ◽  
Vol 73 (09) ◽  
Author(s):  
L Moujir ◽  
L de León ◽  
IL Bazzocchi

2020 ◽  
pp. 181-191
Author(s):  
M. Tkachenko ◽  
N. Borys ◽  
Ye. Kovalenko

The research aims to establish the eff ectiveness of granular chalk use produced by «Slavuta-Calcium» Ltd. under growing Poliska–90 winter wheat variety, changing the physicochemical properties of grey forest soil and the wheat productivity. It also aims to establish optimal dosis of «Slavuta-Calcium» granular chalk as the meliorant and mineral fertilizer for grey forest soil in the system of winter wheat fertilization. In the temporary fi eld studies, various doses of nutrients N60–90–120P30–45–60K60–90–120 combined with «Slavuta–Calcium» granular chalk in a dose of Ca230–460–690 kg/ha of the active substance were studied against the background of secondary plowing of rotation products – soybean biomass that averaged 2.34 t/ha. Granular chalk is a modern complex highly eff ective meliorant with the content of Ca – 37.7 and Mg – 0.2 %, the mass fraction of carbonates (CaCO3 + MgCO3) makes at least 95 %. It is characterized by a high level of solubility when interacting with moisture in soil. It has a form of white granules, the mass fraction of 4.0–6.0 mm in size granules makes not less than 90 % and the one of 1.0 mm in size makes less than 5 %. Reactivity – 97 %. The granular chalk is advisable to apply on acidic soils, as a highly concentrated calcium-magnesium fertilizer, with the former as the dominant fertilizer, to optimize the physicochemical properties of the soil, as well as the plant nutrition system, in particular, increasing the availability of an element for assimilation by plants and as long-term ameliorants. The eff ectiveness of the use of mineral fertilizers, in particular acidic nitrogen on highly and medium acidic soils, after chemical reclamation is increased by 30–50 %, and slightly acidic by 15–20 %. The increase in productivity of crops from the combined eff ects of nutrients and chalk granulated is usually higher than when separately applied. The eff ectiveness of the integrated action of these elements is manifested in the growth of plant productivity and the quality of the resulting products, as well as the optimization of physical chemical properties and soil buff ering in the long term. In order to optimize the physicochemical properties of the arable layer of gray forest soil and the productive nutrition of agricultural crops, winter wheat, in particular, biogenic elements should be used in doses N60-90-120P30-45- 60K60-90-120 with granulated chalk «Slavuta-Calcium» in doses of Ca230-460-690 kg/ha of active substance. Granulated chalk obtained as a result of industrial grinding of solid sedimentary carbonate rocks of natural origin, subsequently under the infl uence of the granulation process of the starting material contains Ca and Mg carbonates of at least 95 %, dense granules which facilitates convenient mechanized application, as well as chalk suitable for accurate metered application on the quest map. Key words: granular chalk, gray forest soil, chemical reclamation, crop productivity.


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