Lipid metabolism in primiparous cows with a various state of the reproductive system

2021 ◽  
pp. 33-38
Author(s):  
O. S. Mityashova ◽  
A. A. Solomakhin ◽  
I. Yu. Lebedeva
Keyword(s):  
Lipid Metabolism ◽  
Reproductive System ◽  
Reproductive Function ◽  
Phospholipid Content ◽  
Group I ◽  
Negative Effect ◽  
Group 3 ◽  
Group 2 ◽  
Observation Period ◽  
Group 1

Modified lipid metabolism has a negative effect on the fertility of cows. The aim of the research was to study lipid metabolism in the pre- and postpartum periods in primiparous cows with different signs of the impaired reproductive function. At 8, 6, 4 and 2 weeks before calving and 2 and 7 weeks after calving, the animals were bled to analyze the content of phospholipids and triglycerides. Based on the assessment of the functional state of the ovaries 7 and 9 weeks after calving, the cows were divided into three groups: I - without signs of ovarian hypofunction (n = 31), II - with moderate ovarian hypofunction (n = 13), III - with deep ovarian hypofunction (n = 14). After 12 months of lactation, animals without a diagnosis of deep ovarian hypofunction were divided into 3 groups: 1 - with an open days period of less than 125 days (n = 12), 2 - with an open days period of more than 125 days (n = 21), and 3 - cows that remained infertile (n = 11). The phospholipid concentration increased 1.6-1.9 times (p<0.001-0.05) between the 2nd and 7th weeks after calving in the blood of cows of all studied groups. Meanwhile, in groups II and 3, it decreased 1.4-1.5 times (p<0.05) between the 4th week before calving and the 2nd week of lactation. Seven weeks after calving, the phospholipid content in the blood of group I animals was 1.2-1.4 times higher (p<0.001-0.05) than in animals of groups II and III. In addition, this indicator after 2 and 7 weeks of lactation was 1.4-1.5 times higher (p<0.05) in group 1 than in group 3. The concentration of triglycerides decreased by 1.3 times (p<0.05) between the 2nd week before calving and the 2nd week after calving in the blood of group I cows and by 1.5-1.6 times (p<0.05) between the 6th week before calving and the 7th week after calving in groups II and III. In group 1, it increased 1.6 times (p<0.05) between the 8th and 2nd weeks before calving, and then decreased 1.5 times (p<0.05) by the 2nd week of lactation. This indicator decreased 1.4 times (p<0.01) between the 2nd week before calving and the 7th week of lactation in group 2 and did not change throughout the observation period in group 3. After 7 weeks of lactation, the content of triglycerides in the blood was 1.4 times higher (p <0.05) in group I than in groups II and III and was 1.3 times higher (p <0.05) in group 1 than in group 2. The data obtained suggest that the peculiarities of lipid metabolism during the pre- and postpartum periods are associated with various states of the reproductive system in primiparous cows.

scholarly journals Incidence of Severe Acute Respiratory Syndrome Coronavirus-2 infection among previously infected or vaccinated employees

2021 ◽  
Author(s):  
Noah Kojima ◽  
Arash Roshani ◽  
Matthew Brobeck ◽  
Arthur Baca ◽  
Jeffrey D Klausner
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Clinical Laboratory ◽  
Exact Equation ◽  
Previous Infection ◽  
Group 3 ◽  
Group 2 ◽  
Measure Of Association ◽  
Observation Period ◽  
Group 1

Introduction: The protective effect of previous infection versus vaccination is poorly studied. Among a clinical laboratory that has been conducting routine workforce screening since the beginning of the pandemic, we aimed to assess the relative risk of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection among individuals who were SARS-CoV-2 naive, previously infected, or vaccinated. Methods: Using an electronic laboratory information system, employees were divided into three groups: (1) SARS-CoV-2 naive and unvaccinated, (2) previous SARS-CoV-2 infection, and (3) vaccinated. Person-days were measured from the date of the employee first test and truncated at the end of the observation period. SARS-CoV-2 infection was defined as two positive SARS-CoV-2 PCR tests in a 30-day period. Individuals with fewer than 14 days of follow up were excluded. Incidence estimates and the 95% confidence intervals were calculated using the Poisson Exact equation. The incidence rate ratio (IRR) was used as a measure of association between groups. Analyses were performed on StataSE (StataCorp, College Station, TX). Results: We identified 4313, 254 and 739 employee records for groups 1, 2, and 3, respectively. The median age of employees was 29.0 years (interquartile range: 23.6, 39.9). During the observation period, 254, 0, and 4 infections were identified among groups 1, 2, and 3, respectively. Group 1 had an incidence of 25.9 per 100 person-years (95% CI: 22.8-29.3). Group 2 had an incidence of 0 per 100 person-years (95% CI: 0-5.0). Group 3 had an incidence of 1.6 per 100 person-years (95% CI: 0.04-4.2). The IRR of reinfection among those with previous infection compared to SARS-CoV-2 naive was 0 (95% CI: 0-0.19). The IRR of those vaccinated compared to SARS-CoV-2 naive was 0.06 (95% CI: 0.02-0.16). The IRR of those vaccinated compared to prior SARS-CoV-2 was 0 (95% CI: 0-4.98). Conclusion: Previous SARS-CoV-2 infection and vaccination for SARS-CoV-2 were associated with decreased risk for infection or re-infection with SARS-CoV-2 in a routinely screened workforce. The was no difference in the infection incidence between vaccinated individuals and individuals with previous infection. Further research is needed to determine whether our results are consistent with the emergence of new SARS-CoV-2 variants.

Relationships between follicle-stimulating hormone, follicle growth and ovulation rate in sheep

1996 ◽  
Vol 8 (2) ◽  
pp. 279 ◽  
Author(s):  
RC Fry ◽  
MA Driancourt
Keyword(s):  
Follicle Stimulating Hormone ◽  
Follicular Phase ◽  
Oestrous Cycle ◽  
Ovulation Rate ◽  
Follicle Growth ◽  
Group I ◽  
Group 3 ◽  
Group 2 ◽  
Group 1 ◽  
Stimulating Hormone

The changes in follicle-stimulating hormone (FSH) concentration required to affect follicle growth and ovulation rate within individual ewes were examined. Relationships between peripheral FSH concentrations during the late-luteal and follicular phase and subsequent ovulation rates were investigated in 22 ewes from 4 breeds over 3 successive cycles (Experiment 1). Ewes were grouped as follows: Group 1 (n = 6), ewes exhibiting the same ovulation rate at each oestrous cycle: Group 2 (n = 5), ewes with three different ovulation rates at each oestrous cycle; and Group 3 (n = 11), ewes with the same ovulation rate at two oestrous cycles and a different ovulation rate on one occasion. Data from ewes in Group 1 and 3 provided estimates on the variation in FSH concentrations between cycles which were not large enough to alter ovulation rate (range, 0-67% variation in FSH concentration). In Group-2 ewes, there was no consistent association between increases in ovulation rate and the proportional increases in FSH concentrations. Differences in FSH concentrations were often less than those that did not alter ovulation rate in Group-I ewes. Furthermore, only 3 of 11 Group-3 ewes demonstrated high FSH concentrations associated with high ovulation rate (or low FSH concentrations and low ovulation rate) when compared with the concentrations found at the two cycles in which ovulation rate was similar. Hence, there was little evidence that FSH concentrations during the late-luteal and follicular phase are associated with changes in ovulation rate within individual ewes. In Experiment 2, follicles of similar size obtained from the same ewe (FecBFec+ and Romanov) showed markedly different responses in vitro to graded doses of FSH as measured by aromatase activity. It is concluded that, within a ewe, the large variability between gonadotrophin-dependent follicles in their requirement for FSH prevented the expression of any thresholds of ovarian response to FSH.

scholarly journals General Anesthesia in Geriatric Dogs with Propofol-Isoflurane, PropofolSevoflurane, Alphaxalone-Isoflurane, Alphaxalone-Sevoflurane and Their Comparison of Biochemical, Hemodynamic and Cardiopulmonary Effects

2018 ◽  
Vol 46 (1) ◽  
pp. 9
Author(s):  
Zeynep Bilgen Şen ◽  
Nuh Kiliç
Keyword(s):  
Blood Collection ◽  
Anesthesia Induction ◽  
Isoflurane Anesthesia ◽  
Group 4 ◽  
Anesthetic Drugs ◽  
Group I ◽  
Organ Systems ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Background: Geriatric is defined as the life-cycle in which the physical state, organ functions, sensory functions, mental function and immunity progressively regress. Aging causes progressive and irreversible changes in the functional capacities of organ systems, which in turn alter the response to stress and anesthetic drugs. Propofol is an anesthetic agent with sedative and hypnotic effects. Anesthesia induction with propofol is fast and smooth. Alphaxalone (3α-hydroxy-5α-pregnane11,20-dione) is a central nervous system depressant in the form of synthetic neuroactive steroids. This allows anesthesia and muscle relaxation by increasing the inhibition of gamma amino butyric acid type A (GABA) receptors. The aim of this study is to compare effects of propofol-isoflurane and propofol-sevoflurane with relatively a new anesthetic combination alphaxalone-isoflurane and alphaxalone-sevoflurane on hematological, biochemical and physiological parameters.Materials, Methods & Results: Dogs were randomly divided into 4 groups and anesthesia protocols were applied. After induction of anesthesia with 6 mg/kg propofol in groups 1 and 2, isoflurane anesthesia was continued in group 1 and sevoflurane in group 2. After induction of 3 mg/kg alphaxalone anesthesia in groups 3 and 4, isoflurane anesthesia was continued in group 3 whereas sevoflurane in group 4. Vena cephalica was catheterized for blood collection. At the preanesthetic period, 15, 30, 45, 60 min and 60 min after the anesthesia, complete blood counts were performed. Serum ALT, AST, urea, creatinine values were measured during preanesthesia, perianesthesia 15-30 min and 60 min after anesthesia. Cardiopulmonary parameters and reflexes were evaluated before anesthesia and recorded at perianesthetic 5, 10, 15, 30, 45, 60 min and 60 min after full recovery. Patients were monitored during anesthesia. The average age of the dogs in the study was 10.83. All of the dogs were anesthetized in a few seconds with intravenous injection of propofol or alphaxalone. During anesthesia the respiratory rate (fR) was recorded by counting the movements of the reservoir bag. A pulse oximeter was used to monitor pulse rate (fH) and haemoglobin oxygen saturation (SpO2). Body temperature was measured from rectum with a thermometer. Geriatric dogs were anesthetized for a variety of clinical reasons, concerning laparatomy (12.5%), orthopedic (7.5%), soft tissue (60%),  dental (10%) and ophthalmologic surgery (10%). Duration of anesthesia was 94.44 (± 12.6) for group I, 81(± 10.54) for group II, 93.88 (± 11.6) for group III and 64.5 (± 3.97) min for group IV. Serum urea and creatinine concentrations were not significantly different in the four groups.Discussion: The mean duration of anesthesia recovery was 6.0 ± 2.0 in group 1, 4.6 ± 1.45 in group 2, 3.7 ± 1.23 in group 3 and 9.7 ± 3.09 min in group 4. In group 4 recovery was longer than other groups and statistically significant (P < 0.05). In our research, the recovery is shorter in the isoflurane treated groups than in the sevoflurane treated groups. When the effect of different groups on heart rate was examined, the difference between them was not significant.  Duration and depth of the anesthesia with propofol-isoflurane, propofol-sevoflurane, alphaxalone–isoflurane and alphaxalone-sevoflurane were found to be satisfactory for surgery. Four anesthetic agents applied in geriatric dogs did not adversely affected the hematological and biochemical parameters. In conclusion anesthesia on geriatric dogs after induction of propofol and alphaxalone maintained with isoflurane or sevoflurane found to be safe. However, they did not provide analgesia in painful operations, so it would be appropriate to use analgesics in the pre or intraoperative period.

scholarly journals Remineralization potential of GC Tooth Mousse and GC Tooth Mousse plus on initial caries like lesion of primary Teeth – An in-vitro comparative evaluation

2020 ◽  
Vol 6 (2) ◽  
pp. 3-10
Author(s):  
Anshul ◽  
Kaushal Kishor Jha
Keyword(s):  
Group Iii ◽  
Initial Caries ◽  
Anterior Teeth ◽  
Group I ◽  
Group 3 ◽  
Group Ii ◽  
Group 2 ◽  
Tooth Mousse ◽  
Group 1

Aim: Teeth are constantly going through cycles of demineralization and remineralization. The ultimate goal of clinical intervention is the preservation of tooth structure and the prevention of lesion progression to the point where restoration is required. Thus promoting remineralization is the ultimate goal of clinical prevention of caries lesion. The present in vitro study aimed to investigate the efficacy of GC Tooth Mousse (CPP-ACP) and GC Tooth Mousse Plus (CPP-ACP)F  on artificial enamel caries in primary human teeth.   Methods and Material:    Sixty freshly extracted human primary anterior teeth were used in this study.      The root portion of 60 primary anterior teeth was separated from the crown portion at the cemento-enamel junction (CEJ)      Teeth samples were divided into 3 Groups (n=20 each). Group 1 as a control group, Group 2  GC Tooth Mousse, and Group 3 Tooth Mousse Plus containing dentifrices were used. Samples were subjected to 10 days of pH cycling protocol. The changes were analyzed using Vickers Hardness Testing Machine and SEM.    Pre and post groups were compared by paired t-test.  Independent groups were compared by one-way analysis of variance.   Result: Micro-morphological observations of the enamel surfaces with SEM :      Group 1 the enamel scanning showed shallow depressions and fine porosities within these depressions, Group 2 showed numerous granular particles and amorphous crystals which were arranged on the enamel surface. Smooth, homogeneous surface, and no irregularities were seen in Group 3. Surface Microhardness Evaluation   After treatment, the mean hardness Group III was the highest followed by  Group II and Group I (i.e. Group I < Group II < Group III).   Conclusion:  GC Tooth Mousse Plus showed a statistically significant amount of remineralization.

scholarly journals Influence of Chromium and Cadmium Addition on Quality of Japanese Quail Eggs

2008 ◽  
Vol 77 (4) ◽  
pp. 503-508 ◽  
Author(s):  
M. Skalická ◽  
B. Koréneková ◽  
P. Naď ◽  
J. Šály
Keyword(s):  
Japanese Quail ◽  
Egg Yolk ◽  
Control Group ◽  
Egg Mass ◽  
Negative Effect ◽  
Group 3 ◽  
Group 2 ◽  
Positive Effect ◽  
Group 1

The experiment was conducted to evaluate the effect of chromium (Cr) and cadmium (Cd) on the quality of Japanese quail eggs. The birds (n = 60) were divided into 3 groups of 20 animals each. Group 1 was the control group. Group 2 was administered 0.12 mg Cr/day (Cr group) per quail in drinking water, whereas Group 3 was given a combination of 0.12 mg Cd and 0.12 mg Cr/ day (Cd-Cr group). The distribution of Cd in eggs, the egg mass, and the strength and thickness of shells was determined after after Day 35 and 58 of administration. Addition of Cr had a positive effect on the weight of eggs. A significant decrease of eggshell strength (p < 0.05) and thickness was found after Day 35 and 58 of the experiment in the Cd-Cr group (3) in comparison to the Cr-only group (2) and the control group (1). The content of Cd was significantly lower (p < 0.05) in eggshells and in the egg yolk from the Cr-only group (2) in comparison to the Cd-Cr group (3) and the control group (1). The data show that addition of Cr can improve quality indicators of quail eggs and eliminate the negative effect of Cd.

scholarly journals The effect of uncooked and roll-dried maize starch, alone and mixed in equal quantity with sucrose, on dental caries in the albino rat

1967 ◽  
Vol 21 (1) ◽  
pp. 225-230 ◽  
Author(s):  
R. M. Green ◽  
R. L. Hartles
Keyword(s):  
Dental Caries ◽  
Maize Starch ◽  
Albino Rat ◽  
Group 4 ◽  
Group I ◽  
Weanling Rats ◽  
Group 3 ◽  
Group 5 ◽  
Group 2 ◽  
Group 1

1. One hundred and ten weanling rats were distributed between five dietary groups in randomized blocks. Each block was constructed from within a litter and each member of the block received a different diet.2. The main features of the diets were: group I (twenty-six rats) 72% sucrose, group 2 (sixteen rats) 72% uncooked maize starch, group 3 (sixteen rats) 72% roll-dried maize starch, group 4 (twenty-six rats) 36% sucrose and 36% uncooked starch, group 5 (twenty-six rats) 36% sucrose and 36% roll-dried starch.3. The animals were killed after 20 days on the diets and assessed for dental caries. The rats of group 1 (sucrose) had significantly more caries than all other groups, the rats of group 2 (uncooked starch) had significantly less caries than any of the other groups. Roll-dried starch (group 3) produced significantly more caries than uncooked starch (group 2). The mixture of uncooked starch and sucrose (group 4) was significantly more cariogenic than the mixture of roll-dried starch and sucrose (group 5).

scholarly journals Posttreatment and physiologic occlusal changes comparison

2012 ◽  
Vol 83 (2) ◽  
pp. 239-245 ◽  
Author(s):  
Karina Maria S. Freitas ◽  
Guilherme Janson ◽  
Bryan Tompson ◽  
Marcos Roberto de Freitas ◽  
Tassiana Mesquita Simão ◽  
...  
Keyword(s):  
Peer Assessment ◽  
Untreated Group ◽  
Anterior Crowding ◽  
Irregularity Index ◽  
Intergroup Comparison ◽  
Group 3 ◽  
The Mean ◽  
Group 2 ◽  
Observation Period ◽  
Group 1

ABSTRACT Objective: To compare posttreatment and postretention occlusal changes with the physiologic occlusal changes caused by natural development of untreated subjects. Materials and Methods: The sample was divided into three groups. Group 1 comprised 97 subjects treated with four premolar extractions at a mean pretreatment (T0) age of 13.03 years, a mean posttreatment (T1, first observation) age of 15.12 years, and a mean postretention (T2, second observation) age of 20.52 years. The mean observation period (T2-T1) was 5.39 years. Group 2 comprised 58 subjects treated nonextraction at a mean pretreatment age of 12.83 years, a mean posttreatment age of 14.99 years, a mean postretention age of 20.22 years, and a mean observation period of 5.22 years. Group 3 comprised 114 untreated subjects at a mean age at T1 of 14.91 years and at T2 of 20.48 years. The mean observation period was 5.56 years. Dental casts were evaluated using the Peer Assessment Rating (PAR) index and the Little irregularity index in maxillary and mandibular arches. Changes in PAR and Little indexes were compared among the three groups by analysis of variance and Tukey tests. Results: Intergroup comparison showed that at T1 and T2 the treated groups presented smaller PAR and Little indexes than the untreated group. In the observation period, the treated groups showed greater increase in PAR and Little maxillary indexes than the untreated group. The extraction group showed a greater increase of the Little mandibular index than the untreated group. Conclusions: The treated groups showed more changes according to PAR and Little maxillary indexes than the untreated group. The posttreatment change of the mandibular anterior crowding of the treated extraction group was greater than the mandibular crowding caused by physiologic changes in the untreated group.

scholarly journals Dry eye syndrome and the fundus periphery. Correlations in diagnosis and treatment

The Eye ◽  
2019 ◽  
Vol 127 (2019-3) ◽  
pp. 28-33
Author(s):  
Alexander Kravchenko ◽  
Olga Shilova
Keyword(s):  
Dry Eye ◽  
Dry Eye Syndrome ◽  
Peripheral Retina ◽  
Initial Correlation ◽  
Tear Production ◽  
Comparison Results ◽  
Group 3 ◽  
Group 2 ◽  
Observation Period ◽  
Group 1

Purpose: Comparison of dry eye syndrome stages with intensity of changes in peripheral retina in patients undergoing medical therapy. Material and methods. The clinical study involved 94 patients with mild and moderate dry eye syndrome (DES). Group 1 and Group 2 were both comprised of 25 patients; group 3 was comprised of 44 patients. The observation period was 6 months. Parameters of the anterior eye surface and intensity of changes in the peripheral retina were subjected to evaluation and comparison. Results. The study has shown, that the radius of the tear meniscus, surface tension coefficient and the number of areas stained with fluorescein significantly correlate with the probability of changes in the peripheral retina. The interrelation between the probable formation of changes in the peripheral parts of the retina and the indicators of tear production was revealed in all patients. After 3 months the performed treatment led to the disappearance of the initial correlation between the factors: on visits 3 and 4 logit-models appeared to be unreliable, that meant the absence of interrelation between the probability of formation of changes in the peripheral retina and indicators characterizing the condition of the anterior ocular surface or tear production. Conclusion. The correlation between changes in the peripheral parts of the retina and tear production was described.

scholarly journals Hematology of 2, 4 (Dinitrophenyl Hydrazine) Induced Anaemic Rat Administered with Ficus capensis Fruits and Leave Extract

2020 ◽  
pp. 41-49
Author(s):  
N. N. Umerah ◽  
J. I. Okoye ◽  
A. I. Asouzu
Keyword(s):  
Body Weight ◽  
Blood Cell ◽  
Blood Parameters ◽  
Haematological Parameters ◽  
Group 4 ◽  
Group I ◽  
Group 3 ◽  
The Mean ◽  
Group 2 ◽  
Group 1

Background: Anemia is regarded as public health challenge and is predominant in developing countries due to nutritional deficiencies. Aim/Objectives: The study was carried out to evaluate the biological properties of Ficus capensis fruits and vegetables on some haematological parameters in 2, 4 (dinitrophenyl hydrazine) induced anemic rat. Materials and Methods: Ficus capensis leaves and fruits were separately plucked, sorted cleaned. Twenty male adult rats were purchased from the Department of Veterinary Pathology, University of Nigeria, Nsukka. The animals were divided into 4 groups of 5 rats each on the basis of body weight. The rats in all the groups received 2, 4-DNPH (20 mg/kg body weight) once daily for 7 days to induce anaemia. Group I were fed rat chow alone, group 2 were fed rat chow with ferrous sulphate, group 3 were fed rat chow with Ficus capensis leaves extract and group 4 were fed rat chow with Ficus capensis seed extract. The aqueous extracts of the leaves and fruits were tested for haematinic effects in albino rats. Blood parameters such as Packed Cell Volume (PCV), Red Blood Cell (RBC) count, White Blood Cell (WBC) count and Haemoglobin concentration (Hb) were measured. Results: The result showed that the mean PCV baseline of the rats were (38.72-39.24%), mean PCV of anemic rats (33.01- 34.60%) and the mean PCV of the rats after test of recovery were group 1 (34.10%), group 2 (51.81%), group 3 (40.20%) and group 4 (38.20%).The result showed that the mean HB baseline of the rats were (9.67-10.47 g/dl), mean HB of anemic rats (6.50- 7.10 g/dl) and the mean HB of the rats after test of recovery were group 1 (6.51 g/dl), group 2 (12.32 g/dl), group 3 (9.73 g/dl) and group 4 (9.69 g/dl). The results of the effect of the extracts on the haematological parameters indicated that oral administration of the aqueous extract of Ficus capensis leaves and fruits after 22 days exhibited a significant (P < 0.05) increase in haematinic activity by increasing the blood parameters Hb, PCV, WBC and RBC.

Influence of viscersal obesity and adipokin status on the rsenal function in hyperstensive patients with obesity and chrsonic hearst failurse

2021 ◽  
Vol 25 (6) ◽  
pp. 39-48
Author(s):  
M. E. Statsenko ◽  
M. V. Derevyanchenko ◽  
S. V. Fabritskaya ◽  
Yu. A. Ryndina
Keyword(s):  
Correlation Analysis ◽  
Functional State ◽  
Visceral Obesity ◽  
Multivariate Regression Analysis ◽  
Regression Equations ◽  
Group 4 ◽  
Negative Effect ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

THE AIM: to evaluate the effect of visceral obesity, adipokine status on the functional state of the kidneys in patients with arterial hypertension (AH), obesity, and chronic heart failure (CHF).PATIENTS AND METHODS. 383 AH patients aged 45-70 years were divided into four groups: group 1 - persons with AH without obesity and CHF, group 2 - AH + obesity without CHF, group 3 - AH + obesity + CHF, group 4 - AH + CHF without obesity. A clinical examination was carried out, the indicators of visceral obesity, adipokine status, and functional state of the kidneys were assessed. In addition to descriptive statistics, comparison of groups with each other, and correlation analysis, multivariate regression analysis was used with the construction of regression equations.RESULTS. Revealed statistically significant differences between 1 and 2, 1 and 3, 2 and 4, 3 and 4 groups not only in body mass index (BMI) - 23.9 [22.4; 24.3] vs 32.8 [31.1; 36.3], 23.9 [22.4; 24.3] vs 33.6 [30.8; 35.6], 32.8 [31.1; 36.3] vs 24.1 [23.1; 24.5], 33.6 [30.8; 35.6] vs 24.1 [23.1; 24.5] kg / m2, respectively, but also by the percentage of visceral fat (7.0 [6.0; 8.0] vs 14.0 [11.0; 16.0] vs 18.0 [14.3; 22.0] vs 8.0 [5.0; 10.0] % in groups 1,2, 3 and 4, respectively - p1-2, p1-3, p2-3, p2-4, p3-4 less than 0,0001, p1-4 = 0.022. The level of leptin in blood serum was significantly lower in group 1 in comparison with 2, 3, 4, and in group 4 in comparison with 3 (6.9 [6.6; 22.7] vs 64.8 [59.3; 70.3], 63.6 [42.0; 86.1], 58.7 [18.9; 73.5] and 58.7 [18.9; 73, 5] vs 63.6 [42.0; 86.1] ng / ml, respectively) The serum adiponectin concentration was statistically significantly higher in group 1 compared with group 2, 3 and in group 4 compared with group 3 (36.6 [29.2; 44.1] vs 18.9 [17.1; 20.6] vs 26.9 [22.2; 32.2] and 36.8 [20.2; 62.8] vs 26,9 [22.2; 32.2] ng / ml, respectively) Visceral obesity index (VAI) was 1.49 [1.24; 2.07] vs 2.58 [2.03; 3.37] vs 3.08 [2.59; 3.84] vs 2.36 [1.81; 3.13] c.u. in groups 1,2, 3, 4, respectively, p1-2 = 0.0007, p1 -4 = 0.0001, p2-3 = 0.017, p1-3 and p3-4 less than 0.00001. There was a significant decrease in the glomerular filtration rate (GFR) in groups 3 and 4 in comparison with group 1 (59.0 [53.0; 67.8] and 69.0 [62.0; 83.0] vs 75.0 [68.0; 96.0] ml / min / 1.73 m2, respectively), as well as in group 3 in comparison with 2 and 4 (59.0 [53.0; 67.8] vs 71.0 [60.0; 86, 5] and 69.0 [62.0; 83.0] ml / min / 1.73 m2, respectively). The level of albuminuria increased with adherence to hypertension of obesity and / or CHF (14.2 [3.7; 44.4] vs 36.9 [13.6; 118.2] vs 149.8 [92.2; 247, 6] vs 72.0 [36.2; 104.7] mg / g in groups 1,2, 3 and 4, respectively, the differences are statistically significant between 1 and 2, 1 and 3, 1 and 4, 2 and 3, 3 and 4 groups). The concentration of p2-microglobulins in urine was significantly lower in group 1 compared with groups 3 and 4 (0.10 [0.05; 0.42] vs 0.25 [0.20; 0.31] vs 0.27 [0,19; 0.31] pg / ml). Correlation analysis revealed the peculiarities of the influence of visceral obesity, adipokine status on the functional state of the kidneys in each of the studied groups.CONCLUSION. The study confirmed the negative effect of visceral obesity, hyperleptinemia, and hypoadiponectinemia on the progressive deterioration of the renal function in hypertensive patients with adherence to obesity and/or CHF.

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