THE ROLE OF MAGNESIUM DEFICIENCY IN THE PATHOGENESIS OF THE FORMATION OF ARTERIAL HYPERTENSION IN WORKERS OF LOCOMOTIVE CREWS. CORRECTION METHODS

2021 ◽  
Author(s):  
V.G. Yarkova ◽  
◽  
V.A. Zhmurov ◽  
E.B. Klester ◽  
Keyword(s):  
Lipid Metabolism ◽  
Arterial Hypertension ◽  
Cardiovascular System ◽  
Magnesium Deficiency ◽  
Clinical Manifestations ◽  
Occupational Disability ◽  
Functional Studies ◽  
Complex Preparation ◽  
Male Patients

Abstract: Purpose of the study: To assess the effects of magnesium deficiency on the indices of lipid metabolism in patients with an arterial hypertension locomotive crews. Purpose of the work: To assess the effect of magnesium deficiency on the pathogenesis of the formation of arterial hypertension in workers of locomotive crews. Correction methods. Materials and methods: This work presents an analysis of the results of clinical observation, special biochemical and functional studies of 136 male patients with arterial hypertension, workers of locomotive crews. Results: In workers of locomotive crews patients with hypertension, increased individual cardiovascular risk according to the SCORE scale, remodeling of the cardiovascular system, as well as the risk of developing occupational disability are interrelated with signs of magnesium deficiency. Conclusion: The inclusion of a complex preparation of magnesium and vitamin B6 in the therapy of arterial hypertension in workers of locomotive crews has a significant effect on the clinical manifestations of chronic stress, magnesium deficiency, improves the dynamics of lipid metabolism, the structural and functional state of the cardiovascular system, and professionally important qualities.

scholarly journals AGGRAVATING EFFECT OF ARTERIAL HYPERTENSION ON THE COURSE OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN PATIENTS WITH COMORBID PATHOLOGY

2021 ◽  
Vol 74 (4) ◽  
pp. 973-976
Author(s):  
Viktoriia V. Rodionova ◽  
Olha O. Boiko
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Arterial Hypertension ◽  
Middle Age ◽  
Clinical Manifestations ◽  
Chronic Obstructive ◽  
Bronchial Obstruction ◽  
Obstructive Pulmonary Disease ◽  
Group I ◽  
Male Patients ◽  
Group Ii

The aim: To study the effect of arterial hypertension on the course of chronic obstructive pulmonary disease in patients with comorbid pathology. Materials and methods: The prospective study included 61 patients with COPD: 32 stable male patients with COPD with comorbid arterial hypertension of stage II 1-3 degrees and 29 stable outpatients of men with COPD of clinical groups A-D with impaired respiratory function II-IV according to GOLD. All patients, in accordance with the goals and objectives of the study, were divided into 2 groups: group I consisted of men with isolated COPD, middle age – 56.0 (8.5) years, average duration of the disease – 16.2 (1.3) years, Group II consisted of male patients with COPD and arterial hypertension (AH), middle age – 59.5 (7.5). The patients underwent a general clinical examination, which included an assessment of complaints, anamnestic data, and a physical examination. The severity of COPD was determined on the basis of the frequency of exacerbations during the year, assessment of dyspnea using the mMRS scale, spirographic data. Statistical materials were processed using the STATISTICA 10.0 program. Results: In group I, 20 patients (69%) complained of dyspnea during exercise, in group II – 25 patients (78%) (p = 0.4), 28 patients (96.5%) complained of cough with vague sputum. group and 30 patients in group II (93.8%) (p = 0.09). When assessing the number of exacerbations over the past year, it was determined that patients with isolated COPD had an average of 1.0 (1.0; 2.0) exacerbations, and patients with COPD and AH – 2.0 (1.0; 3.0 ) (p = 0.06). According to the CAT questionnaire, the following data were obtained: in group I – 9.0 (8.0; 11.0) points, and in group II – 17.5 (10.0; 20.0) points (p = 0.02). When conducting spirographic studies, a statistically significant more expressive bronchial obstruction was found in patients with COPD and comorbid hypertension. Conclusions: The presence of comorbid arterial hypertension leads to the intermittent effect of diseases: according to the results of mMRC and SAT test, ailments for COPD were examined, they have a more severe course of underlying seizure in the presence of concomitant arterial hypertension. Clinical manifestations in patients with COPD and H are more severe compared to clinical manifestations in patients without aggravated diseases of the cardiovascular system. Concomitant arterial hypertension enhances the manifestations of bronchial obstruction, in the same way as with patients with isolated COPD.

Copper Deficiency Effects on Cardiovascular System and Lipid Metabolism in the Rat; the Role of Dietary Proteins and Excessive Zinc

1985 ◽  
Vol 29 (6) ◽  
pp. 332-347 ◽  
Author(s):  
K.L. Stemmer ◽  
H.G. Petering ◽  
L. Murthy ◽  
V.N. Finelli ◽  
E.E. Menden
Keyword(s):  
Lipid Metabolism ◽  
Cardiovascular System ◽  
Copper Deficiency ◽  
Dietary Proteins

scholarly journals The Role of NLRP3 Inflammasome in Lupus Nephritis

2021 ◽  
Vol 22 (22) ◽  
pp. 12476
Author(s):  
Camila Barbosa Oliveira ◽  
Camilla Albertina Dantas Lima ◽  
Gisele Vajgel ◽  
Paula Sandrin-Garcia
Keyword(s):  
Lupus Nephritis ◽  
Lupus Erythematosus ◽  
Nlrp3 Inflammasome ◽  
Clinical Manifestations ◽  
Systemic Lupus ◽  
Functional Studies ◽  
Pyrin Domain ◽  
Therapeutic Drugs ◽  
Pro Inflammatory Cytokines

Lupus nephritis (LN) is the most frequent and severe of systemic lupus erythematosus (SLE) clinical manifestations and contributes to the increase of morbidity and mortality of patients due to chronic kidney disease. The NLRP3 (NLR pyrin domain containing 3) is a member of the NLR (NOD-like receptors), and its activation results in the production of pro-inflammatory cytokines, which can contribute to the pathogenesis of LN. In this review manuscript, we approach the relation between the NLRP3 inflammasome, SLE, and LN, highlighting the influence of genetic susceptibility of NLRP3 polymorphisms in the disease; the main functional studies using cellular and animal models of NLRP3 activation; and finally, some mechanisms of NLRP3 inhibition for the development of possible therapeutic drugs for LN.

scholarly journals The Role of Magnesium in the Development of Cardiovascular Diseases and the Possibility of their Prevention and Correction with Magnesium Preparations (Part 1)

2019 ◽  
Vol 15 (5) ◽  
pp. 725-735 ◽  
Author(s):  
A. S. Safaryan ◽  
V. S. Sargsyan ◽  
T. V. Kamyshova ◽  
N. M. Akhmedzhanov ◽  
D. V. Nebieridze ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Cardiovascular System ◽  
Magnesium Deficiency ◽  
Magnesium Level ◽  
The Body ◽  
Level Control ◽  
Good Medicine ◽  
Magnesium Salts ◽  
Natural Way

The article is devoted to the influence of magnesium on the homeostasis of the body and, in particular, on the cardiovascular system. It describes the importance of the presence and effects of magnesium on various key processes and functions occurring in the body. The reasons for the lack of magnesium and ways to replenish it both in the natural way (eating, certain foods) and magnesium preparations are considered. The article provides examples of large randomized studies that prove the importance of the influence of normal magnesium levels on human health in general and on the state of the cardiovascular system. These studies show how magnesium deficiency increases the risk of cardiovascular diseases and how it can be reduced. It is also shown which trace elements and vitamins are closely related to magnesium metabolism, and how they (in particular, potassium and vitamin B6) improve and facilitate the normalization of magnesium levels. It is noted how comorbidity decreases with the normalization of magnesium level – the higher the magnesium level in the blood plasma (closer to the upper limit and more), the less comorbidity and longer life expectancy. Magnesium is an absolutely essential ion and a good medicine. Magnesium deficiency and hypomagnesemia are quite common, difficult to diagnose (due to underestimation and rare level control) and accompany many diseases of the cardiovascular system and beyond. The widespread use of organic magnesium salts would improve the situation as a whole, due to their universal multiple effect on many processes in the body. This is an integral part of therapeutic and preventive measures in patients with already existing diseases and in people who do not have diseases, but who are at risk due to existing hypomagnesemia.

scholarly journals The role of the vegetative part of sympathetic nervous system in development of cardiovascular complications in patients with arterial hypertension: pharmacological aspects

2014 ◽  
Vol 11 (3) ◽  
pp. 88-94
Author(s):  
S R Gilyarevsky
Keyword(s):  
Nervous System ◽  
Sympathetic Nervous System ◽  
Arterial Hypertension ◽  
Cardiovascular System ◽  
Antihypertensive Agents ◽  
Cardiovascular Complications ◽  
Autonomic Regulation ◽  
Sympathetic Nervous ◽  
The Impact

Recently, we have determined new interest in studying the role of sympathetic part of autonomic division of nervous system (SANS) in the pathogenesis of arterial hypertension (AH), as well as in studying the role of agents, suppressing the activity of SANS, using for AH treatment, including the usage of antihypertensive agents and non-pharmacological methods. This article discusses the changes of autonomic regulation of the cardiovascular system in patients with AH. The role of these changes in the development of the functional and structured changes of the heart and systemic vessels can be observing during long-standing AH and will lead to the development of adverse clinical outcomes. We have been showing received data, associated with the impact of non-medicated and pharmacological approaches to the autonomic regulation of the cardiovascular system.

scholarly journals THE ROLE OF GROWTH DIFFERENTIATION FACTOR 11 (GDF11) IN REGULATION OF LIPID METAbOLISM  AND CARDIOHEMODYNAMIC FUNCTIONS IN ESSENTIAL HYPERTENSION PATIENTS IN MODERATE  EFFORT ExERCISES

2018 ◽  
pp. 93-98 ◽  
Author(s):  
E. S. Guseva ◽  
S. O. Davydov ◽  
B. I. Kuznik ◽  
Yu. N. Smolyakov ◽  
A. V. Stepanov ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Lipid Metabolism ◽  
Lipid Profile ◽  
Cardiovascular System ◽  
Enzyme Assay ◽  
Physical Exercises ◽  
Heart Work ◽  
Circulation Condition

Aim. To reveal the role of a “youth protein” GDF11 in regulation of lipid metabolism and cardiovascular system work in essential hypertension (EH) in women taking antihypertension medications and regularly involved in moderate physical exercises (kinesitherapy).Material and methods. In all participants, the level of GDF11 was measured by immune enzyme assay, and levels of lipids; registration was done of blood pressure, echocardiography and circulation condition with a novel sensor of dynamic light scattering (mDLS).Results. In women with AH taking antihypertension medications, the level of GDF11 was lower more than 3 times. In EH patients the deviations found, in a shear flow velocity with significant increase of rapid velocity processes. Correlations found for GDF11 level with the age, blood pressure, condition of the heart work, hemodynamical and oscillatory indexes. In the EH group patients regularly doing exercises (kinesitherapy), the level of GDF11, blood pressure, lipid profile and all parameters of heart work and hemodynamics are close to normal.Conclusion. The “youth protein” CDF11 is a factor of prevention of AH. Kinesitherapy in EH patients normalizes GDF11, lipid profile, and significantly increases the work of cardiovascular system. 

scholarly journals PATHOPHYSIOLOGICAL AND CLINICAL ASPECTS OF MYOCARDIAL BRIDGES

2019 ◽  
pp. 62-70
Author(s):  
T.V. Bogdan ◽  
O.V. Savchenko ◽  
V.V. Bogdan ◽  
D.M. Pryadum ◽  
A.Y. Yakovenko
Keyword(s):  
Coronary Arteries ◽  
Clinical Manifestations ◽  
Vasospastic Angina ◽  
Clinical Aspects ◽  
Myocardial Bridges ◽  
Coronary Syndrome ◽  
Heart Perfusion ◽  
Pathophysiological Role ◽  
Male Patients

Coronary arteries are normally located on the epicardial surface of the heart (surrounded by adipose and loose connective tissue), can "plunge" into the thickness of the myocardium at different depths, and then again "appear" on the surface of the heart. The muscle that covers the intramural segment of the epicardial coronary artery is called the myocardial "bridge" (MB), and the artery extending into the thickness of the myocardium is called the tunnel. MB is the most common congenital pathology of the coronary arteries. MB occurs in about 1/3 of the entire population, but it does not always manifest itself in violation of heart perfusion and related symptoms: angina pectoris, vasospastic angina (Prinzmetalla), acute coronary syndrome, loss of consciousness, ventricular tachycardia, sudden death. This pathology is found in both women and men, but the target group remains in men 25–35 years of age, who experience clinical manifestations mainly during physical activity. According to autopsies, MB is found in 87 %, up to 5 % of them are hemodynamically significant. Among those who died suddenly, 25 % had MB. This topic is relevant because previously diagnosed with MB can prevent the development of the above pathological conditions and save the life of the patient. The article presents data on morphology, pathogenesis, clinical manifestations, diagnosis and treatment of myocardial bridges (MB). The role of this coronary vessel pathology in the emergence of vasospastic angina (Prinzmetal) and sudden cardiac death in young, mainly male patients has been revealed. The pathophysiological role of CO2 levels in the blood and its relationship to the clinical manifestations of the muscular bridges were also analyzed.

scholarly journals The use of potassium and magnesium supplements for cardiovascular diseases

2021 ◽  
pp. 27-33
Author(s):  
D. Motruk
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cardiovascular Diseases ◽  
Chronic Heart Failure ◽  
Arterial Hypertension ◽  
Magnesium Deficiency ◽  
Complex Therapy

The article substantiates the role of potassium and magnesium deficiency in the pathogenesis of cardiovascular diseases and the effectiveness of the use of combined preparations of these electrolytes, which has been confirmed in numerous clinical studies. The combination of potassium and magnesium aspartate has proven itself best in the complex therapy of arrhythmias, coronary heart disease (in particular, post-myocardial infarction), chronic heart failure, and arterial hypertension.

scholarly journals Neurotic disorder, headache, and stress: experience of managing a comorbid patient and the role of magnesium drugs

2021 ◽  
pp. 94-100
Author(s):  
V. A. Golovacheva ◽  
G. R. Tabeeva
Keyword(s):  
Magnesium Deficiency ◽  
Clinical Manifestations ◽  
Cardiac Activity ◽  
The Body ◽  
Reproductive Age ◽  
Primary Headaches ◽  
Neurotic Disorder ◽  
Adequate Treatment ◽  
Neurotic Disorders

In the practice of neurologists and therapists, patients with complaints of headache, increased fatigue, and irritability are common. The most frequent causes of headaches in ambulatory patients are primary headaches (migraine and tension headaches). Lack of sleep, stress, symptoms of anxiety and depression, and abuse of analgesic drugs are the most common factors that contribute to the frequency of headaches. Magnesium deficiency is another factor, the role of which has been discussed in the frequency of primary headaches, in the development of neurotic disorders and depression. Clinical manifestations of magnesium deficiency itself usually include such nonspecific symptoms as fatigue, anxiety, irritability, numbness in the extremities, leg cramps, sleep disorders, etc.Magnesium deficiency is widespread among the population of developed countries, especially among women of reproductive age, often occurs during pregnancy, while taking oral contraceptives. Magnesium is involved in the regulation of the nervous system, neuromuscular transmission, cardiac activity, regulation of vascular tone, blood clotting and bone tissue metabolism. Magnesium deficiency is associated with diseases such as coronary heart disease, hypertension, type 2 diabetes, Alzheimer’s disease, migraine, osteoporosis, depression, neurotic disorders (panic disorder, generalized anxiety, various phobias), and fibromyalgia syndrome. Stress can lead to a decrease in magnesium levels in the body, and magnesium deficiency, in turn, reduces tolerance to stressful situations. Timely diagnosis and adequate treatment of magnesium deficiency and associated conditions represent important clinical challenges.The clinical case of a patient with neurotic disorder, headache and magnesium deficiency is presented, and the effectiveness of an interdisciplinary approach including an educational talk, adequate therapy for headache management, magnesium drug therapy and psychological methods is demonstrated. The role of magnesium deficiency in the development of various neurologic diseases is reviewed. The most effective magnesium compounds for therapy are discussed. Principles of diagnosis and treatment of patients with magnesium deficiency are presented.

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