Case 33. Grasping The Nettle: The Impact Of Lifestyle Change In Metabolic Syndrome

AbstractThe impact of most, but not all, cardiovascular risk factors decline by age. We investigated how the metabolic syndrome (MetS) was related to cardiovascular disease (CVD) during 40 years follow-up in the Uppsala Longitudinal Study of Adult Men (ULSAM, 2,123 men all aged 50 at baseline with reinvestigations at age 60, 70, 77 and 82). The strength of MetS as a risk factor of incident combined end-point of three outcomes (CVD) declined with ageing, as well as for myocardial infarction, ischemic stroke and heart failure when analysed separately. For CVD, the risk ratio declined from 2.77 (95% CI 1.90–4.05) at age 50 to 1.30 (95% CI 1.05–1.60) at age 82. In conclusion, the strength of MetS as a risk factor of incident CVD declined with age. Since MetS was significantly related to incident CVD also at old age, our findings suggest that the occurrence of MetS in the elderly should not be regarded as innocent. However, since our data were derived in an observational study, any impact of MetS in the elderly needs to be verified in a randomized clinical intervention trial.

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Fish Consumption: A Review of Its Effects on Metabolic and Hormonal Health

Nutrition and Metabolic Insights ◽

10.1177/11786388211022378 ◽

2021 ◽

Vol 14 ◽

pp. 117863882110223

Author(s):

Carlos O Mendivil

Keyword(s):

Metabolic Syndrome ◽

Fish Consumption ◽

Dietary Habits ◽

Positive Impact ◽

Polycystic Ovary ◽

Scientific Evidence ◽

Endocrine Disorders ◽

Omega 3 ◽

The Metabolic Syndrome ◽

The Impact

Dietary habits are a major determinant of the risk of chronic disease, particularly metabolic and endocrine disorders. Fish as a food group are a unique source of nutrients with metabolic and hormonal importance including omega-3 fatty acids, iodine, selenium, vitamin D, taurine and carnitine. Fish are also a source of high quality protein and have in general low caloric density. The impact of these nutrients on cardiovascular risk has been extensively reviewed, but the impact of fish on the broader field of endocrine and metabolic health is sometimes not sufficiently appreciated. This article aimed to summarize the impact the effect of regular fish consumption on conditions like the metabolic syndrome, obesity, diabetes, hypothyroidism, polycystic ovary syndrome and the menopausal transition, which are in and of themselves significant causes of morbidity and mortality worldwide. The review revealed that scientific evidence from food science, translational research, epidemiologic studies and interventional trials shows that regular fish consumption has a positive impact on thyroid homeostasis, facilitates maintenance of a healthy body weight, reduces the magnitude of age-associated increases in blood pressure, improves glucose homeostasis helping prevent diabetes and the metabolic syndrome, and has a positive impact on muscle mass preservation among the elderly. These effects are mediated by multiple mechanisms, only some of which have been identified. For most of these effects it holds true that the potential benefits are more substantial when baseline fish consumption is low.

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Impact of the Level of Adherence to Mediterranean Diet on the Parameters of Metabolic Syndrome: A Systematic Review and Meta-Analysis of Observational Studies

Nutrients ◽

10.3390/nu13051514 ◽

2021 ◽

Vol 13 (5) ◽

pp. 1514

Author(s):

Dimitra Rafailia Bakaloudi ◽

Lydia Chrysoula ◽

Evangelia Kotzakioulafi ◽

Xenophon Theodoridis ◽

Michail Chourdakis

Keyword(s):

Metabolic Syndrome ◽

Mediterranean Diet ◽

Observational Studies ◽

Positive Impact ◽

Fasting Blood Glucose ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

Central Registry ◽

High Adherence ◽

The Impact

High adherence to the Mediterranean diet (MD) has been associated with a lower prevalence of Metabolic Syndrome (MetS). The present study aimed to investigate the impact of MD adherence on parameters of MetS. A systematic literature search was performed in PubMed, Cochrane Central Registry of Clinical Trials (CENTRAL), Scopus, EMBASE, Web of Science and Google Scholar databases. Observational studies that recorded adherence to MD and components/measures of the MetS, such as waist circumference (WC), blood pressure (BP), fasting blood glucose (FBG), high-density lipoprotein (HDL) cholesterol and triglycerides (TG), were included in this study. A total of 58 studies were included in our study. WC and TG were significantly lower in the high adherence MD group (SMD: −0.20, (95%CI: −0.40, −0.01), SMD: −0.27 (95%CI: −0.27, −0.11), respectively), while HDL cholesterol was significantly higher in the same group (SMD: −0.28 (95%CI: 0.07, 0.50). There was no difference in FBG and SBP among the two groups (SMD: −0.21 (95%CI: −0.54, 0.12) & SMD: −0.15 (95%CI: −0.38, 0.07), respectively). MD may have a positive impact on all parameters of MetS. However, further research is needed in this field.

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Obesity and metabolic syndrome associated with systemic inflammation and the impact on the male reproductive system

American Journal of Reproductive Immunology ◽

10.1111/aji.13178 ◽

2019 ◽

Vol 82 (5) ◽

Cited By ~ 10

Author(s):

Kristian Leisegang ◽

Ralf Henkel ◽

Ashok Agarwal

Keyword(s):

Metabolic Syndrome ◽

Systemic Inflammation ◽

Reproductive System ◽

Male Reproductive System ◽

The Impact

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Tu2056 – The Impact of Metabolic Syndrome (MS) in the Stage At Diagnosis of Hepatocellular Carcinoma (HCC)

Gastroenterology ◽

10.1016/s0016-5085(19)39931-7 ◽

2019 ◽

Vol 156 (6) ◽

pp. S-1182-S-1183

Author(s):

Ramiro Tapia-Sosa ◽

Ignacio Garcia-juarez ◽

Yumi Kimura-Sandoval

Keyword(s):

Hepatocellular Carcinoma ◽

Metabolic Syndrome ◽

Stage At Diagnosis ◽

The Impact

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Melatonin and diet-induced metabolic syndrome in rats: impact on the hypophysial-testicular axis

Hormone Molecular Biology and Clinical Investigation ◽

10.1515/hmbci-2013-0005 ◽

2013 ◽

Vol 16 (2) ◽

Cited By ~ 1

Author(s):

Pablo A. Scacchi Bernasconi ◽

Nancy P. Cardoso ◽

Roxana Reynoso ◽

Pablo Scacchi ◽

Daniel P. Cardinali

Keyword(s):

Metabolic Syndrome ◽

Body Weight ◽

Uric Acid ◽

Plasma Levels ◽

Density Lipoprotein ◽

The Body ◽

High Fat ◽

Testosterone Secretion ◽

Diet Manipulation ◽

The Impact

AbstractCombinations of fructose- and fat-rich diets in experimental animals can model the human metabolic syndrome (MS). In rats, the increase in blood pressure (BP) after diet manipulation is sex related and highly dependent on testosterone secretion. However, the extent of the impact of diet on rodent hypophysial-testicular axis remains undefined. In the present study, rats drinking a 10% fructose solution or fed a high-fat (35%) diet for 10 weeks had higher plasma levels of luteinizing hormone (LH) and lower plasma levels of testosterone, without significant changes in circulating follicle-stimulating hormone or the weight of most reproductive organs. Diet manipulation brought about a significant increase in body weight, systolic BP, area under the curve (AUC) of glycemia after an intraperitoneal glucose tolerance test (IPGTT), and plasma low-density lipoprotein cholesterol, cholesterol, triglycerides, and uric acid levels. The concomitant administration of melatonin (25 μg/mL of drinking water) normalized the abnormally high LH levels but did not affect the inhibited testosterone secretion found in fructose- or high-fat-fed rats. Rather, melatonin per se inhibited testosterone secretion. Melatonin significantly blunted the body weight and systolic BP increase, the increase in the AUC of glycemia after an IPGTT, and the changes in circulating lipid profile and uric acid found in both MS models. The results are compatible with a primary inhibition of testicular function in diet-induced MS in rats and with the partial effectiveness of melatonin to counteract the metabolic but not the testicular sequelae of rodent MS.

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