scholarly journals Quantifying the real-life impacts of vaccination on critical COVID-19

2021 ◽  
Author(s):  
Mircea T Sofonea ◽  
Corentin Boennec ◽  
Anne Fontalirant ◽  
Marjolaine Regnat ◽  
Jean-Yves Lefrant ◽  
...  
Keyword(s):  
Critical Care ◽  
Confidence Interval ◽  
Vaccine Coverage ◽  
Vaccination Campaign ◽  
Real Life ◽  
Epidemiological Model ◽  
Simultaneous Reduction ◽  
The Real ◽  
Hospital Deaths ◽  
Vaccine Impact

The effectiveness of individual prophylaxis of symptomatic or severe COVID-19 by anti-SARS-CoV-2 vaccination is now well established. However, real-life quantification of the vaccine impact on critical COVID-19 forms -- which require critical care and may lead to death -- is still lacking, especially because simultaneous reduction in community spread has to be accounted for. In this study, we use an epidemiological model tailored to capture hospital dynamics in France to investigate counterfactual scenarios, including purely collective and purely individual vaccines. The model estimates the transmissibility reduction from breakthrough infections to 43% ([32 -- 55]% 95%-likelihood interval) and that 39,100 critical care stays ([26,100 -- 57,100] 95% confidence interval) and 47,400 ([36,200-62,800]) hospital deaths have been prevented by the French vaccination campaign by August 20 2021 -- respectively corresponding to 46% and 57% relative preventions of these outcomes. Furthermore, we show that most of the critical COVID-19 forms have been prevented by the collective component of the vaccine rather than individual prophylaxis, despite its greater effectiveness. These results are in line with the accelerating decrease in fatality ratio with vaccine coverage we highlight in worldwide data.

scholarly journals Patterns of COVID-19 pandemic dynamics following deployment of a broad national immunization program

2021 ◽  
Author(s):  
Hagai Rossman ◽  
Smadar Shilo ◽  
Tomer Meir ◽  
Malka Gorfine ◽  
Uri Shalit ◽  
...  
Keyword(s):  
Temporal Dynamics ◽  
Vaccination Campaign ◽  
Descriptive Analysis ◽  
Age Groups ◽  
Real Life ◽  
Population Level ◽  
Older Individuals ◽  
The Real ◽  
Younger Age ◽  
Life Impact

AbstractStudies on the real-life impact of the BNT162b2 vaccine, recently authorized for the prevention of coronavirus disease 2019 (COVID-19), are urgently needed. Here, we analysed the temporal dynamics of the number of new COVID-19 cases and hospitalization in Israel following a rapid vaccination campaign initiated on December 20th, 2020. We conducted a retrospective descriptive analysis of data originating from the Israeli Ministry of Health (MOH) from March 2020 to February 2021. In order to distill the possible effect of the vaccinations from other factors, including a third lockdown imposed in Israel on January 2021, we compared the time-dependent changes in number of COVID-19 cases and hospitalizations between (1) individuals aged 60 years and older, eligible to receive the vaccine earlier, and younger age groups; (2) the latest lockdown (which was imposed in parallel to the vaccine rollout) versus the previous lockdown, imposed on September 2020; (3) early-vaccinated cities compared to late-vaccinated cities; and (4) early-vaccinated geographical statistical areas (GSAs) compared to late-vaccinated GSAs. In mid-January, the number of COVID-19 cases and hospitalization started to decline, with a larger and earlier decrease among older individuals, followed by younger age groups, by the order in which they were prioritized for vaccination. This fast and early decline in older individuals was more evident in early-vaccinated compared to late-vaccinated cities. Such a pattern was not observed in the previous lockdown. Our analysis demonstrates evidence for the real-life impact of a national vaccination campaign in Israel on the pandemic dynamics. We believe that our findings have major public health implications in the struggle against the COVID-19 pandemic, including the public ’s perception of the need for and benefit of nationwide vaccination campaigns. More studies aimed at assessing the effectiveness and impact of vaccination both on the individual and on the population level, with longer followup, are needed.

Exploring Citizenship: Unit 4 My Heritage

EDIS ◽  
2019 ◽  
Vol 2019 (5) ◽  
pp. 14
Author(s):  
John Rutledge ◽  
Joy C. Jordan ◽  
Dale W. Pracht
Keyword(s):  
Youth Development ◽  
Real Life ◽  
Development Program ◽  
The Real ◽  
Volunteer Leaders ◽  
Youth Development Program ◽  
Major Revision ◽  
The World ◽  
Individual Needs

 The 4-H Citizenship Project offers the opportunity to help 4-H members relate all of their 4-H projects and experiences to the world around them. The 4-H Citizenship manuals will serve as a guide for 4-H Citizenship experiences. To be truly meaningful to the real-life needs and interests of your group, the contribution of volunteer leaders is essential. Each person, neighborhood, and community has individual needs that you can help your group identify. This 14-page major revision of Unit IV covers the heritage project. Written by John Rutledge, Joy C. Jordan, and Dale Pracht and published by the UF/IFAS Extension 4-H Youth Development program. https://edis.ifas.ufl.edu/4h019

L'esperienza clinica con Levometadone nel trattamento del disturbo da uso di oppiacei

MISSION ◽  
2019 ◽  
pp. 54-57
Author(s):  
Marco Riglietta ◽  
Paolo Donadoni ◽  
Grazia Carbone ◽  
Caterina Pisoni ◽  
Franca Colombi ◽  
...  
Keyword(s):  
Adverse Events ◽  
Real Life ◽  
Opioid Use Disorder ◽  
Racemic Mixture ◽  
Opioid Use ◽  
The Real ◽  
New Formulation

In Italy, at the end of the 1970s, methadone hydrochloride was introduced for the treatment of opioid use disorder, in the form of a racemic mixture consisting of levomethadone and dextromethadone.In 2015 Levometadone was introduced, a new formulation marketed in Italy for the treatment of opioid use disorder in 2015.The article aims to bring the experience of an Italian Addiction Centre back to the use of this new formulation in the "real life" analyzing the efficacy, the trend of adverse events and pharmacological iterations in a context in which the treated population often uses besides the opiates, cocaine and alcohol, are burdened by a relevant physical and psychic comorbidity and frequently have a prescribed polypharmacy.

Efficacy and safety of long-acting pasireotide in acromegalic patients in the real life: The reappraisal of the first-dose follow-up visit

2020 ◽  
Author(s):  
Claudio Urbani ◽  
Francesca Dassie ◽  
Benedetta Zampetti ◽  
Di Certo Agostino Maria ◽  
Renato Cozzi ◽  
...  
Keyword(s):  
Real Life ◽  
Efficacy And Safety ◽  
The Real ◽  
Long Acting

Experiential Learning in Graduate Archival Education at the University of Botswana

Mousaion ◽  
2019 ◽  
Vol 37 (1) ◽  
Author(s):  
Olefhile Mosweu
Keyword(s):  
Experiential Learning ◽  
Work Experience ◽  
Real Life ◽  
Opportunity To Learn ◽  
Theory And Practice ◽  
Records Management ◽  
Archival Theory ◽  
Snowball Sampling ◽  
The Real ◽  
The University

Most curriculum components of archival graduate programmes consist of contextual knowledge, archival knowledge, complementary knowledge, practicum, and scholarly research. The practicum, now commonly known as experiential learning in the global hub, is now widely accepted in library and information studies (LIS) education as necessary and important. It is through experiential learning that, over and above the theoretical aspects of a profession, students are provided with the opportunity to learn by doing in a workplace environment. The University of Botswana’s Master’s in Archives and Records Management (MARM) programme has a six weeks experiential learning programme whose purpose is to expose prospective archivists and/or records managers to the real archival world in terms of practice as informed by archival theory. The main objective of the study was to determine the extent to which the University of Botswana’s experiential learning component exposes students to real-life archival work to put into practice theoretical aspects learnt in the classroom as intended by the university guidelines. This study adopted a qualitative research design and collected data through interviews from participants selected through purposive and snowball sampling strategies. Documentary review supplemented the interviews. The data collected were analysed thematically in line with research objectives. The study determined that experiential learning does indeed expose students to the real world of work. It thus helps to bridge the gap between archival theory and practice for students without archives and records management work experience. For those with prior archival experience, experiential learning does not add value. This study recommends that students with prior archives and records management experience should rather, as an alternative to experiential learning, undertake supervised research, and write a research essay in a chosen thematic area in archives and records management.

ANALISIS STRUKTUR SOSIAL CERITA DALAM CERITA PENDEK ANAK “ANGGREK RARA” (SEBUAH KAJIAN SOSIOLOGI SASTRA TERHADAP SASTRA ANAK)

2017 ◽  
Vol 3 (2) ◽  
pp. 184
Author(s):  
Sari Herleni
Keyword(s):  
Social Structure ◽  
Short Story ◽  
Real Life ◽  
Central Character ◽  
The Real ◽  
Social Fact ◽  
The Social ◽  
Family Home

This article describes about the figure of children world in a short story “Anggrek Rara” written by Ina Inong, by connecting the social structure in the text and in the real life. After analyzing the social structure in the story, it is found that the plot of this story was the progressive plot, the background was from the social fact that came from inner house and outer house, otherwise the central character were Rara and Bunda. By analyzing social structure of text, it was found that a family (home) is the serious and formal environment while outer house is free and non formal. The result of the research showed that the children short story “ Anggrek Rara” was expected to give the figure outlines of the children world.AbstrakPenelitian ini membahas tentang gambaran dunia anak dalam cerita pendek anak “Anggrek Rara” karya Ina Inong dengan menghubungkan struktur sosial teks dalam karya dan struktur sosial teks dengan realitas. Melalui analisis struktur sosial dalam karya terungkap bahwa alur cerita ini merupakan alur lurus, latar terdiri dari fakta sosial yang bersumber dari rumah dan di luar rumah, sedangkan tokoh Rara dan Bunda adalah tokoh sentral. Melalui analisis struktur sosial teks dengan realitas terungkap bahwa keluarga (rumah) merupakan lingkungan yang sifatnya serius dan formal, sedangkan di luar rumah bahkan bersifat bebas dan non formal. Hasil yang diperoleh dari analisis ini menunjukkan bahwa cerita pendek anak “Anggrek Rara” dianggap mampu memberikan garis-garis besar gambaran kehidupan dunia anak.

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