To study the selective potentiality and anti-tumor activity of CAP in oral cancer treatment
Oral Cancer is one of the leading causes of death in India, specifically in its Northeastern region. India holds about one third cases of the total oral cancer in the world. According to a report (2018), India holds 1,19,992 new cases of oral cancer and 72,616 deaths. Current approaches in cancer treatment mainly include surgery, chemotherapy and radiation therapy. These treatments often give a morbid outcome and reduce survival rate. This is mainly due to their non-selective nature to kill the tumor cells along with the normal cells. Recently the potential of Cold Atmospheric Plasma (CAP) in cancer treatment is gaining great interest among scientists and researchers. This is mainly due to the enhanced selective nature of the CAP in targeting and killing the tumor cells without affecting the surrounding tissue and causing minimal side effects. Reactive Oxygen and Nitrogen species (RONS) are the main contributors of the efficacy of CAP in killing cancer cells. Although many attempts have been made to understand the underlying mechanism of CAP in cancer treatment, there is a lack of detailed studies with respect to different treatment conditions. The use of CAP can be a potential innovative therapy in the upcoming days and more clinical trials should be encouraged to prove its efficacy and relevance in clinical purpose.