Transcriptomics is a rapidly growing field that generates new data that may be used on its own or in combination with existing clinical data for development of new therapeutics, including gene therapy

2021 ◽  
Author(s):  
Moataz Dowaidar
Keyword(s):  
Gene Therapy ◽  
General Practice ◽  
Clinical Data ◽  
Trial Design ◽  
Therapeutic Options ◽  
Blood Samples ◽  
The Future ◽  
The Creation ◽  
Personalized Medicines

Transcriptomics is a rapidly growing field that generates new data that may be used on its own or in combination with existing clinical data to widen and affect the future of healthcare. While the majority of current applications are limited to research, a growing number of studies suggest that transcriptomics has applications in diagnostics, genomics-driven trial design, and the creation of personalized medicines. Blood samples can be collected in general practice and submitted to a central lab for analysis and interpretation before being provided to the doctor, allowing for greater clinical acceptance of experimental hypotheses. The transcriptome's immense complexity has been revealed by transcriptomics, and we're just beginning to understand how this translates to function, disease, and therapeutic options.

The Management of Corneal Neovascularisation – Update on New Clinical Data and Recommendations of Treatment

2016 ◽  
Vol 10 (02) ◽  
pp. 86 ◽  
Author(s):  
Natasha Spiteri ◽  
Vito Romano ◽  
Matthias Brunner ◽  
Bernhard Steger ◽  
Stephen B Kaye ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Risk Factor ◽  
Clinical Data ◽  
Treatment Options ◽  
Experimental Treatment ◽  
Treatment Modalities ◽  
The Past ◽  
Recent Advances ◽  
The Future ◽  
Subsequent Failure

Vascularisation of the cornea may occur as a sight-threatening response to various insults to the cornea, such as infection, trauma and inflammation, and is a well-recognised risk factor for rejection and subsequent failure of corneal grafts. Various different treatment modalities have been used in the past, with varying levels of success. In this review, we discuss the pathogenesis of corneal neovascularisation, look at recent advances in the assessment of these patients and give an overview of currently available treatment options, both medical and surgical. We also discuss current experimental treatment for corneal neovascularisation, such as gene therapy, which may provide further treatment options in the future.

Molecular imaging of gene therapy. The future in Parkinson's disease therapy?

2005 ◽  
Vol 32 (S 4) ◽  
Author(s):  
A.H Jacobs ◽  
R Hilker ◽  
L Burghaus ◽  
W.D Heiss
Keyword(s):  
Parkinson’S Disease ◽  
Gene Therapy ◽  
Parkinson's Disease ◽  
Molecular Imaging ◽  
Disease Therapy ◽  
The Future

Public Reporting of Cardiovascular Data: Benefits, Pitfalls, and Vision for the Future

2016 ◽  
Vol 10 (1) ◽  
pp. 36
Author(s):  
Gregory J Dehmer ◽  
Keyword(s):  
Clinical Data ◽  
Clinical Status ◽  
Public Reporting ◽  
Professional Organizations ◽  
Healthcare Data ◽  
Outcomes Of Care ◽  
The Future ◽  
Policy Statements ◽  
Quality And Outcomes ◽  
Reporting Programs

Public reporting of healthcare data is not a new concept. This initiative continues to proliferate as consumers and other stakeholders seek information on the quality and outcomes of care. Furthermore, mandates for the development of additional public reporting efforts are included in several new healthcare legislations such as the Affordable Care Act. Many current reporting programs rely heavily on administrative data as a surrogate for true clinical data, but this approach has well-defined limitations. Clinical data are traditionally more difficult and costly to collect, but more accurately reflect the clinical status of the patient, thus enhancing validity of the quality metrics and the reporting program. Several professional organizations have published policy statements articulating the main principles that should establish the foundation for public reporting programs in the future.

SiRNA technology, the gene therapy of the future?

2008 ◽  
Vol 149 (4) ◽  
pp. 153-159 ◽  
Author(s):  
Zsuzsanna Rácz ◽  
Péter Hamar
Keyword(s):  
Gene Therapy ◽  
Short Interfering Rna ◽  
The Future ◽  
Interfering Rna

A genetikában új korszak kezdődött 17 éve, amikor a petúniában felfedezték a koszuppressziót. Később a koszuppressziót azonosították a növényekben és alacsonyabb rendű eukariótákban megfigyelt RNS-interferenciával (RNSi). Bár a növényekben ez ősi vírusellenes gazdaszervezeti védekezőmechanizmus, emlősökben az RNSi élettani szerepe még nincs teljesen tisztázva. Az RNSi-t rövid kettős szálú interferáló RNS-ek (short interfering RNA, siRNS) irányítják. A jelen cikkben összefoglaljuk az RNSi történetét és mechanizmusát, az siRNS-ek szerkezete és hatékonysága közötti összefüggéseket, a célsejtbe való bejuttatás virális és nem virális módjait. Az siRNS-ek klinikai alkalmazásának legfontosabb akadálya az in vivo alkalmazás. Bár a hidrodinamikus kezelés állatokban hatékony, embereknél nem alkalmazható. Lehetőséget jelent viszont a szervspecifikus katéterezés. A szintetizált siRNS-ek ismert mellékhatásait szintén tárgyaljuk. Bár a génterápia ezen új területén számos problémával kell szembenézni, a sikeres in vitro és in vivo kísérletek reményt jelentenek emberi betegségek siRNS-sel történő kezelésére.

ASO GUMBALO SEBAGAI INSPIRAS DALAM PENCIPTAAN SENI LUKIS

2018 ◽  
Vol 7 (2) ◽  
pp. 178
Author(s):  
Satri Yadi ◽  
Yuniarti Munaf ◽  
Dhasono Dhasono
Keyword(s):  
Design Phase ◽  
Symbolic Expression ◽  
Ethical Research ◽  
Process Stage ◽  
Form Processing ◽  
The Future ◽  
The Creation ◽  
Visual Strategies ◽  
Work Done ◽  
Exploration Phase

AbstrakAso Gumbalo dalam penciptaan karya seni lukis diilhami dari kehidupan pengembala yang menjadi inspirasi pencipta yang diungkap melalui media seni lukis dengan mengambil ide “Harapan Pengembala” (Aso Gumbalo). Harapan Gembala dapat diartikan sebagai keinginan, kecendrungan dan dorongan hati yang kuat terhadap sesuatu hal yang ingin direalisasikan untuk menjadikan seorang lebih baik dimasa depan. Pengekspresian ide cipta berangkat dari fenomena Aso Gumbalo yang pencipta ungkap dengan ekspresi simbolik kedalam penciptaan karya seni lukis. Metode penciptaan karya ini melalui tahapan yaitu; 1) Tahap eksplorasi adalah tahap pencarian ide-ide dengan melakukan riset emik dan etik untuk pembuatan karya, 2) Tahap perancangan yaitu tahap pembuatan purwarupa yang akan diwujudkan kedalam bentuk karya seni lukis, 3) Tahap proses garapan karya. Konsep dari penciptaan karya merupakan ekspresi simbolik dengan memanfaatkan idiom tradisi, ekspresi tersebut digambarkan pada perwujudan karya menggunakan strategi media dan strategi visual dengan menggunakan konsep pengolahan bentuk, yaitu disformasi dan transformasi dengan melakukan penggabungan beberapa teknik antara lain, teknik plakat, transparan, tekstur semu dan tekstur nyata. Aso Gumbalo sebagai inspirasi yang diungkapkan dalam bentuk karya seni lukis ekspresi simbolik. Karya-karya yang diciptakan pengkarya disajikan dalam bentukpameran.           Kata Kunci:aso gumbalo, ekspresi simbolik, seni lukis.   AbstractAsoGumbalo in the creation of painting works was inspired from the life of the shepherd who became the inspiration of the creator which revealed through the medium of painting by taking the idea of "Hope of the Shepherd" (AsoGumbalo). Shepherd Hope can be interpreted as a strong desire, inclination and encouragement towards something that wants to be realized to make someone better in the future. The expression of copyrighted ideas departs from the phenomenon of AsoGumbalo, which the creator expressed with a symbolic expression into the creation of painting. This method of creating works through several stages, namely; 1) The exploration phase is the stage of searching for ideas by conducting emic and ethical research for the production of works, 2) the design phase that is the prototype-making stage which will be realized in the form of painting, 3) the process stage of the work done. The concept of creation of works is a symbolic expression by utilizing traditional idioms, these expressions are depicted in the realization of the work using media strategies and visual strategies by using the concept of form processing, namely deformation and transformation by combining several techniques, such as plaque, transparent, pseudo-texture and real texture. AsoGumbalo as an inspiration expressed in the form of paintings of symbolic expression. works created by artists are presented in the form of exhibitions.  Keywords:asogumbalo, symbolic expression, painting.  

A Rapture of the Nerds? A Comparison between Transhumanist Eschatology and Christian Parousia

2019 ◽  
Vol 24 (2) ◽  
pp. 343-367
Author(s):  
Roberto Paura
Keyword(s):  
Human Brain ◽  
Point Theory ◽  
The Body ◽  
Christian Theology ◽  
Human Beings ◽  
Human Species ◽  
The Future ◽  
The Creation ◽  
The Universe

Transhumanism is one of the main “ideologies of the future” that has emerged in recent decades. Its program for the enhancement of the human species during this century pursues the ultimate goal of immortality, through the creation of human brain emulations. Therefore, transhumanism offers its fol- lowers an explicit eschatology, a vision of the ultimate future of our civilization that in some cases coincides with the ultimate future of the universe, as in Frank Tipler’s Omega Point theory. The essay aims to analyze the points of comparison and opposition between transhumanist and Christian eschatologies, in particular considering the “incarnationist” view of Parousia. After an introduction concern- ing the problems posed by new scientific and cosmological theories to traditional Christian eschatology, causing the debate between “incarnationists” and “escha- tologists,” the article analyzes the transhumanist idea of mind-uploading through the possibility of making emulations of the human brain and perfect simulations of the reality we live in. In the last section the problems raised by these theories are analyzed from the point of Christian theology, in particular the proposal of a transhuman species through the emulation of the body and mind of human beings. The possibility of a transhumanist eschatology in line with the incarnationist view of Parousia is refused.

The (future) doctor will see you now: Piloting a longitudinal virtual patient in medical education, simulating general practice

2020 ◽  
pp. 1-5
Author(s):  
Thomas Dale MacLaine ◽  
Cornelia Juengst ◽  
David Harris ◽  
Catherine Fenn ◽  
Helen Gabathuler ◽  
...  
Keyword(s):  
Medical Education ◽  
General Practice ◽  
Virtual Patient ◽  
The Future ◽  
Future Doctor

Ethical trial design for the future

2021 ◽  
Vol 8 (4) ◽  
pp. e181
Author(s):  
The Lancet HIV
Keyword(s):  
Trial Design ◽  
The Future

scholarly journals Telehealth consultations in general practice during a pandemic lockdown: survey and interviews on patient experiences and preferences

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Fiona Imlach ◽  
Eileen McKinlay ◽  
Lesley Middleton ◽  
Jonathan Kennedy ◽  
Megan Pledger ◽  
...  
Keyword(s):  
Health Care ◽  
General Practice ◽  
Access To Health Care ◽  
Online Survey ◽  
Sudden Change ◽  
High Satisfaction ◽  
The Future ◽  
Clinical Relationship ◽  
General Practices ◽  
Key Aspects

Abstract Background During the first COVID-19 pandemic ‘lockdown’ in Aotearoa/New Zealand (March–May 2020, in which strict ‘stay at home’ measures were introduced), general practices were advised to use telephone and video consultations (telehealth) wherever possible instead of the usual in-person visits. This was a sudden change for most practices and patients. This research aimed to explore how patients accessed general practice during lockdown and evaluate their experiences with telehealth, to inform how telehealth could be most effectively used in the future. Methods Using a mixed-method approach, we undertook an online survey and in-depth interviews with adults (> 18 years) who had contact with practices during lockdown, recruited through social media and email lists. We present descriptive statistics from the survey data (n = 1010) and qualitative analysis of interview data (n = 38) and open-ended survey questions, using a framework of access to health care, from the patient’s perspective. Results In general, patients reported high satisfaction with telehealth in general practice during lockdown. Telehealth was convenient and allowed patients to safely access health care without having to weigh-up the fear of COVID-19 infection against the need to be seen. Telehealth worked best for routine and familiar health issues and when rapport was established between patients and clinicians. This was easier with a pre-existing clinical relationship, but not impossible without one. Telehealth was less suitable when a physical examination was needed, when the diagnosis was unknown or for patients who had a strong preference to be seen in-person. Conclusions Even in this disruptive lockdown period, that prompted an unexpected and rapid implementation of telehealth services in general practices, most patients had positive experiences with telehealth. In the future, patients want the choice of consultation type to match their needs, circumstances, and preferences. Technological issues and funding barriers may need to be addressed, and clear communication for both patients and clinicians is needed about key aspects of telehealth (e.g. cost, appropriateness, privacy). Maintaining telehealth as an option post-lockdown has the potential to increase timely and safe access to primary health care for many patients.

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