scholarly journals Inferring health conditions from fMRI-graph data

2018 ◽  
Author(s):  
PierGianLuca Porta Mana ◽  
Claudia Bachmann ◽  
Abigail Morrison
Keyword(s):  
Binary Classification ◽  
Disease Diagnosis ◽  
Health Condition ◽  
Automated Classification ◽  
Imaging Data ◽  
Data Set ◽  
Sufficient Statistics ◽  
Conjugate Priors ◽  
Healthy Control ◽  
Partial Exchangeability

Automated classification methods for disease diagnosis are currently in the limelight, especially for imaging data. Classification does not fully meet a clinician's needs, however: in order to combine the results of multiple tests and decide on a course of treatment, a clinician needs the likelihood of a given health condition rather than binary classification yielded by such methods. We illustrate how likelihoods can be derived step by step from first principles and approximations, and how they can be assessed and selected, using fMRI data from a publicly available data set containing schizophrenic and healthy control subjects, as a working example. We start from the basic assumption of partial exchangeability, and then the notion of sufficient statistics and the "method of translation" (Edgeworth, 1898) combined with conjugate priors. This method can be used to construct a likelihood that can be used to compare different data-reduction algorithms. Despite the simplifications and possibly unrealistic assumptions used to illustrate the method, we obtain classification results comparable to previous, more realistic studies about schizophrenia, whilst yielding likelihoods that can naturally be combined with the results of other diagnostic tests.

scholarly journals Inferring health conditions from fMRI-graph data

2018 ◽  
Author(s):  
P.G.L. Porta Mana ◽  
C. Bachmann ◽  
A. Morrison
Keyword(s):  
Binary Classification ◽  
Disease Diagnosis ◽  
Health Condition ◽  
Automated Classification ◽  
Imaging Data ◽  
Data Set ◽  
Sufficient Statistics ◽  
Conjugate Priors ◽  
Healthy Control ◽  
Partial Exchangeability

ABSTRACTAutomated classification methods for disease diagnosis are currently in the limelight, especially for imaging data. Classification does not fully meet a clinician’s needs, however: in order to combine the results of multiple tests and decide on a course of treatment, a clinician needs the likelihood of a given health condition rather than binary classification yielded by such methods. We illustrate how likelihoods can be derived step by step from first principles and approximations, and how they can be assessed and selected, using fMRI data from a publicly available data set containing schizophrenic and healthy control subjects, as a working example. We start from the basic assumption of partial exchangeability, and then the notion of sufficient statistics and the “method of translation” (Edgeworth, 1898) combined with conjugate priors. This method can be used to construct a likelihood that can be used to compare different data-reduction algorithms. Despite the simplifications and possibly unrealistic assumptions used to illustrate the method, we obtain classification results comparable to previous, more realistic studies about schizophrenia, whilst yielding likelihoods that can naturally be combined with the results of other diagnostic tests.

A Study on Multi Class Classification from Breast Cancer Images using Ensemble Network and Transfer Learning

2020 ◽  
Vol 14 ◽  
Author(s):  
Lahari Tipirneni ◽  
Rizwan Patan
Keyword(s):  
Breast Cancer ◽  
Neural Network ◽  
Convolutional Neural Network ◽  
Binary Classification ◽  
Disease Diagnosis ◽  
Feature Descriptors ◽  
Histopathological Images ◽  
Viable Approach ◽  
Multi Class Classification

Abstract:: Millions of deaths all over the world are caused by breast cancer every year. It has become the most common type of cancer in women. Early detection will help in better prognosis and increases the chance of survival. Automating the classification using Computer-Aided Diagnosis (CAD) systems can make the diagnosis less prone to errors. Multi class classification and Binary classification of breast cancer is a challenging problem. Convolutional neural network architectures extract specific feature descriptors from images, which cannot represent different types of breast cancer. This leads to false positives in classification, which is undesirable in disease diagnosis. The current paper presents an ensemble Convolutional neural network for multi class classification and Binary classification of breast cancer. The feature descriptors from each network are combined to produce the final classification. In this paper, histopathological images are taken from publicly available BreakHis dataset and classified between 8 classes. The proposed ensemble model can perform better when compared to the methods proposed in the literature. The results showed that the proposed model could be a viable approach for breast cancer classification.

Risk Factor Identification, Classification and Prediction Summary of Chronic Kidney Disease

2020 ◽  
Vol 13 ◽  
Author(s):  
Pramila Arulanthu ◽  
Eswaran Perumal
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Disease Diagnosis ◽  
Medical Data ◽  
Machine Learning Algorithms ◽  
World Health ◽  
Medical Field ◽  
Data Set ◽  
Medical Issues ◽  
Health Organization

: The medical data has an enormous quantity of information. This data set requires effective classification for accurate prediction. Predicting medical issues is an extremely difficult task in which Chronic Kidney Disease (CKD) is one of the major unpredictable diseases in medical field. Perhaps certain medical experts do not have identical awareness and skill to solve the issues of their patients. Most of the medical experts may have underprivileged results on disease diagnosis of their patients. Sometimes patients may lose their life in nature. As per the Global Burden of Disease (GBD-2015) study, death by CKD was ranked 17th place and GBD-2010 report 27th among the causes of death globally. Death by CKD is constituted 2·9% of all death between the year 2010 and 2013 among people from 15 to 69 age. As per World Health Organization (WHO-2005) report, 58 million people expired by CKD. Hence, this article presents the state of art review on Chronic Kidney Disease (CKD) classification and prediction. Normally, advanced data mining techniques, fuzzy and machine learning algorithms are used to classify medical data and disease diagnosis. This study reviews and summarizes many classification techniques and disease diagnosis methods presented earlier. The main intention of this review is to point out and address some of the issues and complications of the existing methods. It is also attempts to discuss the limitations and accuracy level of the existing CKD classification and disease diagnosis methods.

scholarly journals Differential gene expression analysis of ankylosing spondylitis shows deregulation of the HLA-DRB, HLA-DQB, ITM2A, and CTLA4 genes

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Rowan AlEjielat ◽  
Anas Khaleel ◽  
Amneh H. Tarkhan
Keyword(s):  
Gene Expression ◽  
Ankylosing Spondylitis ◽  
Differentially Expressed Genes ◽  
Gene Network ◽  
Disease Diagnosis ◽  
Receptor Activation ◽  
Functional Enrichment ◽  
Differentially Expressed ◽  
Inflammatory Disorder ◽  
Data Set

Abstract Background Ankylosing spondylitis (AS) is a rare inflammatory disorder affecting the spinal joints. Although we know some of the genetic factors that are associated with the disease, the molecular basis of this illness has not yet been fully elucidated, and the genes involved in AS pathogenesis have not been entirely identified. The current study aimed at constructing a gene network that may serve as an AS gene signature and biomarker, both of which will help in disease diagnosis and the identification of therapeutic targets. Previously published gene expression profiles of 16 AS patients and 16 gender- and age-matched controls that were profiled on the Illumina HumanHT-12 V3.0 Expression BeadChip platform were mined. Patients were Portuguese, 21 to 64 years old, were diagnosed based on the modified New York criteria, and had Bath Ankylosing Spondylitis Disease Activity Index scores > 4 and Bath Ankylosing Spondylitis Functional Index scores > 4. All patients were receiving only NSAIDs and/or sulphasalazine. Functional enrichment and pathway analysis were performed to create an interaction network of differentially expressed genes. Results ITM2A, ICOS, VSIG10L, CD59, TRAC, and CTLA-4 were among the significantly differentially expressed genes in AS, but the most significantly downregulated genes were the HLA-DRB6, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, ITM2A, and CTLA-4 genes. The genes in this study were mostly associated with the regulation of the immune system processes, parts of cell membrane, and signaling related to T cell receptor and antigen receptor, in addition to some overlaps related to the IL2 STAT signaling, as well as the androgen response. The most significantly over-represented pathways in the data set were associated with the “RUNX1 and FOXP3 which control the development of regulatory T lymphocytes (Tregs)” and the “GABA receptor activation” pathways. Conclusions Comprehensive gene analysis of differentially expressed genes in AS reveals a significant gene network that is involved in a multitude of important immune and inflammatory pathways. These pathways and networks might serve as biomarkers for AS and can potentially help in diagnosing the disease and identifying future targets for treatment.

scholarly journals ESR white paper: blockchain and medical imaging

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
◽  
Elmar Kotter ◽  
Luis Marti-Bonmati ◽  
Adrian P. Brady ◽  
Nandita M. Desouza
Keyword(s):  
Medical Imaging ◽  
Image Data ◽  
Distributed Database ◽  
Relevant Information ◽  
White Paper ◽  
Imaging Data ◽  
Data Set ◽  
Blockchain Technology ◽  
Potential Applications ◽  
Basic Technology

AbstractBlockchain can be thought of as a distributed database allowing tracing of the origin of data, and who has manipulated a given data set in the past. Medical applications of blockchain technology are emerging. Blockchain has many potential applications in medical imaging, typically making use of the tracking of radiological or clinical data. Clinical applications of blockchain technology include the documentation of the contribution of different “authors” including AI algorithms to multipart reports, the documentation of the use of AI algorithms towards the diagnosis, the possibility to enhance the accessibility of relevant information in electronic medical records, and a better control of users over their personal health records. Applications of blockchain in research include a better traceability of image data within clinical trials, a better traceability of the contributions of image and annotation data for the training of AI algorithms, thus enhancing privacy and fairness, and potentially make imaging data for AI available in larger quantities. Blockchain also allows for dynamic consenting and has the potential to empower patients and giving them a better control who has accessed their health data. There are also many potential applications of blockchain technology for administrative purposes, like keeping track of learning achievements or the surveillance of medical devices. This article gives a brief introduction in the basic technology and terminology of blockchain technology and concentrates on the potential applications of blockchain in medical imaging.

Internet of things-based cloud computing platform for analyzing the physical health condition

2021 ◽  
pp. 1-15
Author(s):  
Mengyao Cui ◽  
Seung-Soo Baek ◽  
Rubén González Crespo ◽  
R. Premalatha
Keyword(s):  
Cloud Computing ◽  
Internet Of Things ◽  
Health Monitoring ◽  
Tracking System ◽  
Disease Diagnosis ◽  
Health Condition ◽  
Computing Platform ◽  
Concept Model ◽  
Patient Health ◽  
Cloud Servers

BACKGROUND: Health monitoring is important for early disease diagnosis and will reduce the discomfort and treatment expenses, which is very relevant in terms of prevention. The early diagnosis and treatment of multiple conditions will improve solutions to the patient’s healthcare radically. A concept model for the real-time patient tracking system is the primary goal of the method. The Internet of things (IoT) has made health systems accessible for programs based on the value of patient health. OBJECTIVE: In this paper, the IoT-based cloud computing for patient health monitoring framework (IoT-CCPHM), has been proposed for effective monitoring of the patients. METHOD: The emerging connected sensors and IoT devices monitor and test the cardiac speed, oxygen saturation percentage, body temperature, and patient’s eye movement. The collected data are used in the cloud database to evaluate the patient’s health, and the effects of all measures are stored. The IoT-CCPHM maintains that the medical record is processed in the cloud servers. RESULTS: The experimental results show that patient health monitoring is a reliable way to improve health effectively.

Detection of COVID-19 cases through X-ray images using hybrid deep neural network

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Rajit Nair ◽  
Santosh Vishwakarma ◽  
Mukesh Soni ◽  
Tejas Patel ◽  
Shubham Joshi
Keyword(s):  
Real Time ◽  
Binary Classification ◽  
Data Set ◽  
Content Type ◽  
X Ray ◽  
Internal Parameters ◽  
Average Accuracy ◽  
Chest X Ray ◽  
Multi Class Classification

Purpose The latest 2019 coronavirus (COVID-2019), which first appeared in December 2019 in Wuhan's city in China, rapidly spread around the world and became a pandemic. It has had a devastating impact on daily lives, the public's health and the global economy. The positive cases must be identified as soon as possible to avoid further dissemination of this disease and swift care of patients affected. The need for supportive diagnostic instruments increased, as no specific automated toolkits are available. The latest results from radiology imaging techniques indicate that these photos provide valuable details on the virus COVID-19. User advanced artificial intelligence (AI) technologies and radiological imagery can help diagnose this condition accurately and help resolve the lack of specialist doctors in isolated areas. In this research, a new paradigm for automatic detection of COVID-19 with bare chest X-ray images is displayed. Images are presented. The proposed model DarkCovidNet is designed to provide correct binary classification diagnostics (COVID vs no detection) and multi-class (COVID vs no results vs pneumonia) classification. The implemented model computed the average precision for the binary and multi-class classification of 98.46% and 91.352%, respectively, and an average accuracy of 98.97% and 87.868%. The DarkNet model was used in this research as a classifier for a real-time object detection method only once. A total of 17 convolutionary layers and different filters on each layer have been implemented. This platform can be used by the radiologists to verify their initial application screening and can also be used for screening patients through the cloud. Design/methodology/approach This study also uses the CNN-based model named Darknet-19 model, and this model will act as a platform for the real-time object detection system. The architecture of this system is designed in such a way that they can be able to detect real-time objects. This study has developed the DarkCovidNet model based on Darknet architecture with few layers and filters. So before discussing the DarkCovidNet model, look at the concept of Darknet architecture with their functionality. Typically, the DarkNet architecture consists of 5 pool layers though the max pool and 19 convolution layers. Assume as a convolution layer, and as a pooling layer. Findings The work discussed in this paper is used to diagnose the various radiology images and to develop a model that can accurately predict or classify the disease. The data set used in this work is the images bases on COVID-19 and non-COVID-19 taken from the various sources. The deep learning model named DarkCovidNet is applied to the data set, and these have shown signification performance in the case of binary classification and multi-class classification. During the multi-class classification, the model has shown an average accuracy 98.97% for the detection of COVID-19, whereas in a multi-class classification model has achieved an average accuracy of 87.868% during the classification of COVID-19, no detection and Pneumonia. Research limitations/implications One of the significant limitations of this work is that a limited number of chest X-ray images were used. It is observed that patients related to COVID-19 are increasing rapidly. In the future, the model on the larger data set which can be generated from the local hospitals will be implemented, and how the model is performing on the same will be checked. Originality/value Deep learning technology has made significant changes in the field of AI by generating good results, especially in pattern recognition. A conventional CNN structure includes a convolution layer that extracts characteristics from the input using the filters it applies, a pooling layer that reduces calculation efficiency and the neural network's completely connected layer. A CNN model is created by integrating one or more of these layers, and its internal parameters are modified to accomplish a specific mission, such as classification or object recognition. A typical CNN structure has a convolution layer that extracts features from the input with the filters it applies, a pooling layer to reduce the size for computational performance and a fully connected layer, which is a neural network. A CNN model is created by combining one or more such layers, and its internal parameters are adjusted to accomplish a particular task, such as classification or object recognition.

AEC Classifier: A Tree-Based Classifier with Error Control for Medical Disease Diagnosis and Other Applications

2021 ◽  
Vol 15 (02) ◽  
pp. 241-262
Author(s):  
Wasif Bokhari ◽  
Ajay Bansal
Keyword(s):  
Error Control ◽  
Binary Classification ◽  
False Negative ◽  
Disease Diagnosis ◽  
False Negatives ◽  
Medical Disease ◽  
Unique Nature ◽  
Comparable Accuracy ◽  
The Cost ◽  
Roc Score

In medical disease diagnosis, the cost of a false negative could greatly outweigh the cost of a false positive. This is because the former could cost a life, whereas the latter may only cause medical costs and stress to the patient. The unique nature of this problem highlights the need of asymmetric error control for binary classification applications. In this domain, traditional machine learning classifiers may not be ideal as they do not provide a way to control the number of false negatives below a certain threshold. This paper proposes a novel tree-based binary classification algorithm that can control the number of false negatives with a mathematical guarantee, based on Neyman–Pearson (NP) Lemma. This classifier is evaluated on the data obtained from different heart studies and it predicts the risk of cardiac disease, not only with comparable accuracy and AUC-ROC score but also with full control over the number of false negatives. The methodology used to construct this classifier can be expanded to many more use cases, not only in medical disease diagnosis but also beyond as shown from analysis on different diverse datasets.

scholarly journals Evaluating Word Similarity Measure of Embeddings Through Binary Classification

2019 ◽  
Vol 1 (3) ◽  
Author(s):  
A. Aziz Altowayan ◽  
Lixin Tao
Keyword(s):  
Similarity Measure ◽  
Binary Classification ◽  
General Purpose ◽  
Feature Representation ◽  
Entity Recognition ◽  
Language Models ◽  
Data Set ◽  
Word Similarity ◽  
Domain Specific ◽  
Retrieval Rate

We consider the following problem: given neural language models (embeddings) each of which is trained on an unknown data set, how can we determine which model would provide a better result when used for feature representation in a downstream task such as text classification or entity recognition? In this paper, we assess the word similarity measure through analyzing its impact on word embeddings learned from various datasets and how they perform in a simple classification task. Word representations were learned and assessed under the same conditions. For training word vectors, we used the implementation of Continuous Bag of Words described in [1]. To assess the quality of the vectors, we applied the analogy questions test for word similarity described in the same paper. Further, to measure the retrieval rate of an embedding model, we introduced a new metric (Average Retrieval Error) which measures the percentage of missing words in the model. We observe that scoring a high accuracy of syntactic and semantic similarities between word pairs is not an indicator of better classification results. This observation can be justified by the fact that a domain-specific corpus contributes to the performance better than a general-purpose corpus. For reproducibility, we release our experiments scripts and results.

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