scholarly journals Evaluation of abortifacient efficacy of Rumex steudelli (Tult) root traditionally used medicinal plant in South West Ethiopia

2015 ◽  
Vol 4 (4) ◽  
pp. 221-223
Author(s):  
Alemu Tadesse Feroche ◽  
Keyword(s):  
Body Weight ◽  
Alcoholic Extract ◽  
Phytochemical Screening ◽  
Albino Rat ◽  
Pregnant Rats ◽  
Plant Medicine ◽  
South West ◽  
Implantation Sites ◽  
South West Ethiopia ◽  
Western Ethiopia

The practice of traditional medicine for the control of fertility in most part of South Western Ethiopia is based on the uses of plant medicine for many years. The present study was carried out in female albino rat to explore the abortifacient activity of the Rumex steudelli roots. Pregnant rats weighing 140- 200 g were randomized into 7 groups. Rats were laprotomised on 10th day of pregnancy and the two horns of uteri were examined to determine the implantation sites. The administration of 400 mg/kg body weight of the aqueous extract of Rumex steudelli resulted in 95% abortion. The 200 and 400 mg/kg body weight alcoholic extract showed 100% fetus abortion. The phytochemical screening of the roots of Rumex steudelli revealed the presence of flavonoids, phenolics, alkaloids, steroids, tannins and saponins.

scholarly journals EVALUATION OF ANTI-ALZHEIMER ACTIVITY OF ALCOHOLIC EXTRACT OF COSTUS PICTUS D. DON LEAVES IN WISTAR ALBINO RATS

2019 ◽  
pp. 36-43
Author(s):  
PASHA KHOOSHBU ◽  
IMTIYAZ ANSARI
Keyword(s):  
Body Weight ◽  
Elevated Plus Maze ◽  
Albino Rats ◽  
Alcoholic Extract ◽  
Object Recognition Test ◽  
Albino Rat ◽  
Y Maze ◽  
Plus Maze ◽  
Wistar Albino Rats ◽  
Phytochemical Studies

Objective: The aim was to assess the effect of anti-Alzheimer’s activity of the alcoholic extract of Costus pictus D. Don Leaves in Alzheimer induce Wistar albino rats. Methods: In the present study, the efficacy of an Extract of Costus pictus D. Don (ECPDD) was evaluated against scopolamine-induced Alzheimer in the Wistar albino rat. Donepezil at a dose of 2.5 mg/kg, ECPDD was given in rat at a dose of 100 mg/kg body weight, 150 mg/kg body weight, and 200 mg/kg body weight. Anti-Alzheimer activity was assessed by victimization novel object recognition test, elevated plus maze, and Y-maze. And by biochemical test like neurotransmitter esterase activity, catalase activity, malonyldialdehyd and glutathione assays. Results: Results showed that extracts treatment prevents Alzheimer and increases the level of acetylcholine, catalase, glutathione peroxidase, and phytochemical studies identified the presence of flavonoid and alkaloid in the ECPDD. Conclusion: According to the results, it was concluded that the leave of C. pictus D. Don has significant anti-Alzheimer activity due to the presence of potent antioxidants such as flavonoid and anticholinesterase enzyme present in alkaloids.

An Amharic manuscript on the mythical history of the Adi kyaz (Dizi, south-west Ethiopia)

1983 ◽  
Vol 46 (2) ◽  
pp. 240-257 ◽  
Author(s):  
Eike Haberland
Keyword(s):  
South West ◽  
History Of ◽  
South West Ethiopia ◽  
Western Ethiopia

The Dizi (as they call themselves) have hitherto been generally known as the Maji, a term derived from the name of their largest chiefdom, in which there also lies the most important Amhara town of this region. They are one of the least studied groups of south-western Ethiopia.

Neuropharmacological Profile and Chemical Analysis of Moroccan Ormenis mixta L.

2018 ◽  
Vol 16 (S1) ◽  
pp. S55-S64
Author(s):  
G. Hajjaj ◽  
A. Bahlouli ◽  
M. Tajani ◽  
K. Alaoui ◽  
Y. Cherrah ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Body Weight ◽  
Traditional Medicine ◽  
Behavioral Tests ◽  
Phytochemical Screening ◽  
Activity Profile ◽  
Acute Toxicity Study ◽  
Pharmacological Studies

Ormenis mixta L. is traditionally used for central nervous system (CNS)-related diseases. Its anti-stress properties have received attention in Moroccan traditional medicine and aromatherapy. However, no pharmacological studies have yet been undertaken on this plant in Morocco. The present study provides a preliminary phytochemical screening and psychopharmacological profile of the essential oil and aqueous extract from Ormenis mixta L. by using behavioral tests in vivo, at graded doses. The result of this research shows that Ormenis mixta L. was safe up to 2 g/kg b.w. (body weight) in the acute toxicity study, possesses potential psychostimulant effect, and has antianxiety and antidepressant-like activity. This activity profile of Ormenis mixta L. was similar to the typical psychostimulant, caffeine. The exact mechanism of action underlying this stimulant-like effect should be clarified with further detailed studies. These results explained the extensive use of Ormenis mixta L. as a traditional medicine in Morocco.

scholarly journals Palmitoylethanolamide: Prenatal Developmental Toxicity Study in Rats

2021 ◽  
pp. 109158182098607
Author(s):  
Narendra S. Deshmukh ◽  
Shailesh Gumaste ◽  
Silma Subah ◽  
Nathasha Omal Bogoda
Keyword(s):  
Body Weight ◽  
Developmental Toxicity ◽  
Reproductive Toxicity ◽  
Toxicity Study ◽  
High Dose ◽  
Pregnant Rats ◽  
Human Dose ◽  
Adverse Effect Level ◽  
Female Wistar Rats ◽  
Effect Level

Palmitoylethanolamide (PEA) is an endogenous ethanolamine playing a protective and homeodynamic role in animals and plants. Prenatal developmental toxicity of PEA was tested following oral administration to pregnant female Wistar rats, from days 0 to 19 of gestation, at dosage of 250, 500, or 1,000 mg/kg body weight, according to Organisation for Economic Co-operation and Development Test Guideline No. 414. On gestation day 20, cesarean sections were performed on the dams, followed by examination of their ovaries and uterine contents. The fetuses were further examined for external, visceral, and skeletal abnormalities. Palmitoylethanolamide did not cause any alterations at any of the given dosages in the measured maternal parameters of systemic toxicity (body weight, food consumption, survival, thyroid functions, organ weight, histopathology), reproductive toxicity (preimplantation and postimplantation losses, uterus weight, number of live/dead implants and early/late resorptions, litter size and weights, number of fetuses, their sex ratio), and fetal external, visceral, or skeletal observations. Any alterations that were recorded were “normal variations” or “minor anomalies,” which were unrelated to treatment with PEA. Under the condition of this prenatal study, the no-observed-adverse-effect level of PEA for maternal toxicity, embryotoxicity, fetotoxicity, and teratogenicity in rats was found to be >1,000 mg/kg body weight/d. It indicates that PEA is well tolerated by and is safe to pregnant rats even at a high dose of 1,000 mg/kg body weight/d, equivalent to a human dose of greater than 9.7 g/d. This prenatal developmental toxicity study contributes greatly in building a robust safety profile for PEA.

The effect of production decline of Qoltso on food security in Gamo Highlands, South-west Ethiopia

GeoJournal ◽  
2019 ◽  
Author(s):  
Abera Uncha Utallo ◽  
Tarekegne Shado Shano ◽  
Degefa Tolosa Degaga
Keyword(s):  
Food Security ◽  
South West ◽  
South West Ethiopia

scholarly journals Effect of nitrofen in the final stages of development of the diaphragm muscle in rats

2013 ◽  
Vol 28 (suppl 1) ◽  
pp. 13-18 ◽  
Author(s):  
Frances Lilian Lanhellas Gonçalves ◽  
Fábio Santana de Oliveira ◽  
Augusto Frederico Schmidt ◽  
Luís Antônio Violin Dias Pereira ◽  
Rodrigo Melo Gallindo ◽  
...  
Keyword(s):  
Body Weight ◽  
Congenital Diaphragmatic Hernia ◽  
Olive Oil ◽  
Diaphragmatic Hernia ◽  
Muscle Fibers ◽  
Diaphragm Muscle ◽  
External Control ◽  
Stages Of Development ◽  
Pregnant Rats ◽  
Histological Staining

PURPOSE: To evaluate the expression of myosin in muscle fibers of the diaphragm in experimental congenital diaphragmatic hernia (CDH). METHODS: Fetuses of pregnant rats were divided into four groups: External Control (EC), composed of non-manipulated rats; Nitrofen, composed of pregnant rats that received 100 mg of nitrofen (2,4-dichloro-4'nitrodiphenyl ether) diluted in olive oil on gestational day (GD) 9.5, whose fetuses developed CDH (N+) or not (N-), and Olive Oil Placebo (OO), composed of pregnant rats that received the oil on the same GD. The fetuses were collected on GD 18.5, 19.5, 20.5 and 21.5 (term = 22 days). We obtained body weight (BW) and photographed the diaphragm area (DA), hernia area (HA) and subsequent calculated the HA/DA ratio in N+ group. Samples of Diaphragm muscle were processed for histological staining with H/E and immunohistochemistry (IHQ) for myosin.} RESULTS: The fetuses of N- and N+ groups had decreased BW and DA compared to EC and OO groups (p <0.001). HA was decreased on GD 18.5 compared to 21.5 (p <0.001) and the HA/DA ratio showed no difference. IHQ showed decreased expression of myosin in nitrofen groups. CONCLUSION: CDH induced by nitrofen model contributes to the understanding of muscularization in the formation of the diaphragm where the myosin expression is decreased.

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