Study the impact of chronic obstructive pulmonary diseases on bone mineral density of biomass fuel smoke exposed population and its association with hs-CRP in Rural Haryana

Background: Chronic obstructive pulmonary disease (COPD) has deleterious systemic impact due to spillage of inflammatory mediators in the circulation though its association with highly sensitive C-reactive protein (hs-CRP) considers as surrogate marker of inflammation is not much explored hitherto. Aims and Objectives: This study aims to study the impact of COPD on bone mineral density (BMD) and its association with hs-CRP in rural population of Haryana. Materials and Methods: Tertiary care hospital-based case–control multigroup study conducted in the Department of Respiratory Medicine, BPSGMCW, Khanpur Kalan, Sonepat, Haryana, India. A total of 150 female study subjects included and comprise in three groups, G1: Biomass exposed COPD patients; G2: Biomass smoke exposed non-COPD subjects; and G3: Non-biomass exposed healthy control. Bone density measured using dual-energy X-ray absorptiometry, hs-CRP considers as surrogate marker of inflammation. Statistical software SPSS Version 23 used to measure Chi-square/Fisher’s exact test, Student’s t-test, and Pearson/Spearman’s rank correlation as test of significance, P<0.05 considered as statistically significant. Results: Mean total t-score of COPD subjects was −1.81±1.15, significantly lower than healthy control −0.66±1.69 (P=0.000), however, it is near to biomass exposed non-COPD subjects −1.74±1.14 (P=0.625). Odds ratio for the risk of osteoporosis in the lower limb among COPD group (Lt leg: 7.07; Rt leg: 4.51) was significantly high compare to other study subjects. Mean titer of hs-CRP (7.905±9.60; P<0.001) was significantly high in study group (G1), though its correlation with t-score was very weak (r=−0.024; P=0.867). Conclusion: COPD has significant impact on BMD of affected population predominantly on lower limb compare to other study subjects, however, no significant association was found with inflammatory biomarkers in the decrement of bone density despite high mean titer of hs-CRP among COPD patients.

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Enzyme-inducing antiseizure drugs associate with low bone mineral density in men with epilepsy

10.5327/1516-3180.155 ◽

2021 ◽

Author(s):

Aline de Fátima Dias ◽

Lucas Scárdua Silva ◽

Rafael Batista João ◽

Amanda Canal Rigotti ◽

Gabriel Ferri Baltazar ◽

...

Keyword(s):

Bone Mineral Density ◽

Bone Mineral ◽

Age Of Onset ◽

Young Group ◽

Categorical Variables ◽

Mineral Density ◽

Chi Square ◽

T Score ◽

Age Range ◽

The Impact

Introduction: Little is known about the impact of enzyme-inducing antiseizure drugs (EI-ASD) on the reduction of Bone Mineral Density (BMD) in men with epilepsy (MWE). Objectives: To evaluate the BMD in MWE exposed to EI-ASDs (phenytoin, carbamazepine and phenobarbital) and its relationship with the duration of epilepsy. Methods: We evaluated BMD from 74 consecutive MWE (median age (range), 52.5 (25- 74) years) exposed to previous or current EI-ASDs, followed at UNICAMP-Brazil. Individuals were split into two groups (young-group, 31 individuals [25-49 years]; older group, 43 subjects, [50-74 years]). The BMD test evaluated t-score indexes from the femoral neck, whole femur and lumbar spine. Osteopenia was defined with t-score of - 1.0 to -2.4; osteoporosis, with T-scores lower than -2.5. Data were extracted from medical records. We analyzed data with SPSS22, performed chi-square tests for categorical variables and applied a partial correlation test (controlled for age) between BD scores and duration of epilepsy. Results: BMD was reduced in 49/74 men (66.2%). Both groups presented equivalent proportions of BMD abnormalities (p=0.087) (young-group [14/41 normal (45%), 12/31 osteopenia (39%), 5/31 osteoporosis (16%)]; older-group [11/43 normal (26%), 16/43 osteopenia (37%), 16/43 osteoporosis (37%)]. BMD did not correlate with the duration of disease or age of onset. Conclusion: BMD reduction is highly prevalent in MWE exposed to EI-ASD, including young individuals. Data suggest that exposure to EI-ASD may associate with early BMD reduction, which evolve to osteopenia and osteoporosis. BMD evaluation in MWE and appropriate treatment may be necessary to reduce fractures’ risk.

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Exertional Desaturation Has Higher Mortality Than Non-Desaturation in COPD

Medicina ◽

10.3390/medicina57101110 ◽

2021 ◽

Vol 57 (10) ◽

pp. 1110

Author(s):

Shih-Feng Liu ◽

Chien-Hung Chin ◽

Ching-Wang Tseng ◽

Yung-Che Chen ◽

Ho-Chang Kuo

Keyword(s):

Cox Regression ◽

Univariate Analysis ◽

Chronic Obstructive ◽

Maximal Heart Rate ◽

Obstructive Pulmonary Disease ◽

Cox Regression Analysis ◽

Copd Patients ◽

Average Survival ◽

Hs Crp ◽

The Impact

Background and objectives: Exertional desaturation (ED) is often overlooked in chronic obstructive pulmonary disease (COPD). We aim to investigate the impact of ED on mortality and the predictors of ED in COPD. Materials andmethods: A cohort of COPD patients with clinically stable, widely ranging severities were enrolled. ED is defined as oxyhemoglobin saturation by pulse oximetry (SpO2) < 90% or a drop of ΔSpO2 ≥ 4% during a six-minute walk test (6MWT). Cox regression analysis is used to estimate the hazard ratio (HR) for three-year mortality. Results: A total of 113 patients were studied, including ED (N = 34) and non-ED (N = 79) groups. FVC (% of predicted value), FEV1/FVC (%), FEV1 (% of predicted value), DLCO (%), maximal inspiratory pressure, SpO2 during the 6MWT, GOLD stage, and COPD severity were significantly different between the ED and non-ED groups in univariate analysis. Low minimal SpO2 (p < 0.001) and high maximal heart rate (p = 0.04) during the 6MWT were significantly related to ED in multivariate analysis. After adjusting for age, gender, body mass index, 6MWD, FEV1, mMRC, GOLD staging, exacerbation, hs-CRP, and fibrinogen, the mortality rate of the ED group was higher than that of the non-ED group (p = 0.012; HR = 4.12; 95% CI 1.37–12.39). For deaths, the average survival time of ED was shorter than that of the non-ED group (856.4 days vs. 933.8 days, p = 0.033). Conclusions: ED has higher mortality than non-ED in COPD. COPD should be assessed for ED, especially in patients with low minimal SpO2 and high maximal HR during the 6MWT.

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Impact of Pharmacist-Led Community Bone Mineral Density Screenings

Annals of Pharmacotherapy ◽

10.1345/aph.1e321 ◽

2005 ◽

Vol 39 (2) ◽

pp. 243-248 ◽

Cited By ~ 19

Author(s):

Kelly M Summers ◽

Tina Penick Brock

Keyword(s):

Bone Mineral Density ◽

At Risk ◽

Bone Mineral ◽

Care Service ◽

Treatment Recommendation ◽

Caffeine Intake ◽

Mineral Density ◽

T Score ◽

Patients At Risk ◽

The Impact

BACKGROUND: Osteoporosis-associated fractures burden both individuals and the overall healthcare system. Bone mineral density (BMD) screening remains the gold standard measure for identifying patients at risk. OBJECTIVE: To determine the impact of convenient, pharmacist-led BMD screening and counseling sessions on identification and education of patients at risk for or with osteoporosis. METHODS: Nonpregnant persons >18 years of age were eligible for enrollment in this descriptive study. At an urban retail pharmacy, participants underwent risk factor assessment, peripheral BMD scanning, and personalized counseling. At 3 and 6 months after screening, subjects were questioned by telephone regarding any subsequent primary care provider (PCP) interactions, as well as any behaviors initiated and/or medications modified. RESULTS: Of the 102 subjects screened, 22.6% and 11.7% were identified as being at medium risk (T score −1.0 to −2.5) and high risk (T score −2.5 or less) for osteoporosis, respectively. By 6 months, 42.5% of the participants reported increasing their dietary intake of calcium, 29.3% began or increased calcium supplements, and 54.9% positively modified smoking status, exercise level, alcohol consumption, or caffeine intake. Additionally, 24 of 52 subjects who had discussed their results with a PCP by 6 months also received a treatment recommendation. Eighty-nine participants reported the community location increased their likelihood of receiving a BMD scan. CONCLUSIONS: Overall, pharmacist-led BMD screenings that include individualized counseling sessions appear convenient, accessible, and beneficial for patients. With the establishment of clinical benefit of and positive reception to such screenings, pharmacists can now look toward securing consistent reimbursement for this vital pharmaceutical care service.

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Influence of a diet and physical activity on the nutritional status of soldiers of the Polish Air Cavalry units

Proceedings of The Nutrition Society ◽

10.1017/s0029665120003638 ◽

2020 ◽

Vol 79 (OCE2) ◽

Author(s):

Jerzy Bertrandt ◽

Anna Anyzewska ◽

Roman Lakomy ◽

Tomasz Lepionka ◽

Ewa Szarska ◽

...

Keyword(s):

Physical Activity ◽

Bone Mineral Density ◽

Nutritional Status ◽

Bone Mineral ◽

Negative Correlation ◽

Dominant Hand ◽

Mineral Density ◽

T Score ◽

Diet And Physical Activity ◽

The Impact

AbstractIntroductionResearch from recent years indicate a problem of excessive body weight among soldiers, who due to the kind of carried out work should reveal the best health and fitness. Moreover, proper nutritional status in case of soldiers is extremely important, as it significantly affects their physical fitness. The aim of the study was to determine impact of the diet and physical activity on selected indicators of protein-energy and mineral nutritional status.Materials and methodsOne hundred and twenty male soldiers (aged: 28 ± 5; years of service: 5 ± 5), serving completed validated for Polish population the Food Frequency Questionnaire and long-form International Physical Activity Questionnaire. Body composition was determined by an electric bioimpedance method (TANITA MC-780) and bone mineral density of forearm bone of the non-dominant hand was assessed by the DEXA densitometric method, using apparatus EXA 3000.Results and discussionThis study confirmed the impact of both the diet and physical activity on selected measures of soldiers’ nutritional status, i.e. fat mass index and bone mineral density. Out of selected 61 products negative correlation between FMI and frequency of apples and pears consumption (r = -0.23, p = 0,023), and positive correlation with frequency of beer (r = 0.20, p = 0.049) and vodka and spirits drinking (r = 0.26, p = 0.010) consumption were found. While the T-score value positively correlated with frequency of tropical fruits (r = 0.23, p = 0.024), avocado (r = 0.25, p = 0.014), fine-grained not refined groats (r = 0.22, p = 0.030) and eggs (r = 0.29, p = 0.004) consumption. A negative correlation was found for frequency of refined bread (r = -0.24, p = 0.019), sausages(r = -0.35, p < 0.023), high-quality cold cuts (r = -0.25, p = 0.014, sugar to sweeten beverages (r = -0.31, p = 0.002), biscuits and cakes (r = -0.23, p = 0.016), salty snacks (r = -0.23, p = 0.023), fruit juices and nectars (r = -0.28, p = 0.005) and sugar-sweetened beverages (r = -0.34, p = 0.001). A negative correlation with FMI (r = -0.22, p = 0.036) for weekly physical activity expressed in MET-minutes/week was found. Positive correlations were found between T-score value and physical activity expressed in MET-minutes per week in total, housework, house maintenance and caring for family (r = 0.22; p = 0.040), and recreation, sport and physical activity in leisure time (r = 0.25, p = 0.019), as well as moderate physical activity (r = 0.28, p = 0.008) and intense one (r = 0.21, p = 0.046). The founded abnormalities in nutritional status, as well as numerous nutritional errors indicate a need for further monitoring of this group of soldiers, not only in terms of accuracy of nutritional status, their diet and physical activity, but also wider understood health behavior

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Impact of hypogonadism on bone mineral density and vertebral fractures in HIV-infected men

Journal of Endocrinological Investigation ◽

10.1007/s40618-021-01665-7 ◽

2021 ◽

Author(s):

L. C. Pezzaioli ◽

T. Porcelli ◽

A. Delbarba ◽

F. Maffezzoni ◽

E. Focà ◽

...

Keyword(s):

Bone Mineral Density ◽

Bone Mineral ◽

Vertebral Fractures ◽

Bone Health ◽

Sex Hormone Binding Globulin ◽

Gonadal Function ◽

Mineral Density ◽

T Score ◽

Normal Bone Mineral Density ◽

The Impact

Abstract Purpose Hypogonadism and osteoporosis are frequently reported in HIV-infected men and, besides multifactorial pathogenesis, they might be directly linked because of testicular involvement in bone health. We evaluated the prevalence of osteoporosis and vertebral fractures (VFs) in HIV-infected men, and assessed their relationship with gonadal function. Methods We enrolled 168 HIV-infected men (median age 53). Osteoporosis and osteopenia were defined with T-score ≤ – 2.5SD and T-score between – 1 and – 2.5SD, respectively. VFs were assessed by quantitative morphometric analysis. Total testosterone (TT), calculated free testosterone (cFT), Sex Hormone Binding Globulin (SHBG), Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH) were obtained; overt hypogonadism was defined on symptoms and low TT or cFT, and classified into primary and secondary according to gonadotropins; compensated hypogonadism was defined as normal TT and cFT with high LH levels. Results Overall, osteoporosis and osteopenia were found in 87.5% of patients, and VFs were detected in 25% of them; hypogonadism was identified in 26.2% of cases. Osteoporotic patients had higher SHBG vs those with normal bone mineral density (BMD). Fractured patients were more frequently hypogonadal and with higher SHBG. SHBG showed negative correlation with both spine and femoral BMD, and positive correlation with VFs. In multivariate models, FSH showed negative impact only on femoral BMD, whereas older age and higher SHBG predicted VFs. Conclusion We found a high burden of bone disease and hypogonadism in HIV-infected men, and we showed that the impact of gonadal function on bone health is more evident on VFs than on BMD.

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AB0908 ASSESSMENT OF THE IMPACT OF THE LEAN MASS WITH BODY COMPOSITION BY DUAL-ENERGY X-RAY ABSORPTIOMETRY ON THE BONE MINERAL DENSITY

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2020-eular.4525 ◽

2020 ◽

Vol 79 (Suppl 1) ◽

pp. 1756.3-1756

Author(s):

M. Nikolov ◽

N. Nikolov

Keyword(s):

Bone Mineral Density ◽

Body Composition ◽

Bone Mineral ◽

Lean Mass ◽

Dual Energy ◽

Mineral Density ◽

X Ray ◽

T Score ◽

The Impact

Background:Lean mass, mainly composed of muscle, has been correlated to bone mineral density (BMD) [4]. Studies reported that lean mass has an important impact on BMD not only in young women but also in postmenopausal women [1]. High lean mass is more favorable for the BMD than low lean mass. Some studies suggested that genetic factors responsible for both lean mass and BMD are shared [3]. Low muscle mass and low BMD could impair the quality of the patient’s life [2, 5].Objectives:The aim of this study is to assess the impact of the lean mass with body composition by dual-energy X-ray absorptiometry on the bone mineral density.Methods:107 women underwent body composition analysis by dual-energy X-ray absorptiometry (DXA). Lean mass in kg and BMD in kg/cm2 were analyzed. Normal BMD was defined as T-score > -1.0 standard deviation (SD). Osteopenia was defined as T-score between -1.0 SDs and -2.5 SDs and osteoporosis was defined as T-score ≤ - 2.5 SDs.Results:The mean age of the women was 57 years (yrs.) ± 11 yrs. (range 41 yrs. – 80 yrs.). Subjects had mean weight of 75 kg ± 12 kg (range 50 kg – 110 kg) and mean height of 156 cm ± 9 cm (range 151 cm – 172 cm). 73/107 women (68.2%) were with normal BMD, 24/107 women (22.4%) were with osteopenia and 10/107 women (9.4%) were with osteoporosis. Lean mass differed significantly between the groups (p = 0.000). Women with normal BMD had the highest mean lean mass (58.47 kg) and the mean lean mass of the women with osteopenia and osteoporosis decreased as follow: 47.56 kg for women with osteopenia and 36.22 kg for women with osteoporosis.Conclusion:Women with osteoporosis have the lowest lean mass compared to the women with osteopenia and osteoporosis.References:[1]Ilesanmi-Oyelere BL, Coad J, Roy N, Kruger MC. Lean Body Mass in the Prediction of Bone Mineral Density in Postmenopausal Women. Biores Open Access. 2018;7(1):150–158. Published 2018 Oct 10. doi:10.1089/biores.2018.0025.[2]Kirilov N., Vladeva SG, Kirilova E. Assessment on the Improvement of the Quality of Life after One Year of Regular Physical Activity and Treatment in Patients with Postmenopausal OsteoporosisCOR 2017: 19th International Conference on Orthopedics and Rheumatology Miami, USA March 9 - 10, 2017, WASET, Paper Code 17US030051.[3]Nguyen TV, Howard GM, Kelly PJ, Eisman JA. Bone mass, lean mass, and fat mass: same genes or same environments? Am J Epidemiol. 1998 Jan 1;147(1):3-16.[4]Patel HP, Dawson A, Westbury LD, et al. Muscle Mass, Muscle Morphology and Bone Health Among Community-Dwelling Older Men: Findings from the Hertfordshire Sarcopenia Study (HSS). Calcif Tissue Int. 2018;103(1):35–43. doi:10.1007/s00223-018-0388-2.[5]Kirilova E, Kirilov N, Vladeva S. A study on the physical activity in women with decreased bone mineral density. Abstract book 13thscience conference MC, PlevenDisclosure of Interests:None declared

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Osteoporosis in Chronic Obstructive Pulmonary Disease: More than just a Comorbidity

Journal of Advanced Research in Medicine ◽

10.24321/2349.7181.202011 ◽

2020 ◽

Vol 07 (03) ◽

pp. 7-21

Author(s):

Mradul Kumar Daga ◽

Keyword(s):

Bone Mineral Density ◽

Chronic Obstructive Pulmonary Disease ◽

Vitamin D ◽

Pulmonary Disease ◽

Bone Mineral ◽

Chronic Obstructive ◽

Mineral Density ◽

Obstructive Pulmonary Disease ◽

Copd Patients ◽

Life Years

Chronic Obstructive Pulmonary Disease (COPD) is one of the leading causes of mortality and loss of Disability-Adjusted Life-Years (DALYs) worldwide. It often is accompanied by the presence of various systemic comorbidities including osteoporosis which may have an impact on the course of the disease. Osteopenia and osteoporosis are the consequences of loss of Bone Mineral Density (BMD) and have been widely known major comorbidities in COPD patients. Female sex, age, and smoking are common pathogenic factors for both COPD and osteoporosis, other factors such as reduced daily physical activity, malnutrition, low body mass index, hypogonadism, vitamin D deficiency, chronic renal insufficiency, chronic hypoxemia, and drugs like corticosteroids, have been invoked to explain such a frequent association between them. Osteoporosis in COPD is however often undertreated. It has been shown in recent studies that both decreased Bone Mineral Density (BMD) and impaired bone quality contribute to bone fragility, causing fractures in COPD patients. Pulmonary function and activities of the daily life of COPD patients may be further deteriorated by osteoporosis-associated fractures. Calcium and vitamin D, hormone replacement when indicated, calcitonin, and bisphosphonate administration are few effective strategies to tackle bone loss and osteoporosis. Awareness about this high prevalence of osteoporosis in COPD patients is critically important and physicians should look for such fracture risks. Routine screening and early diagnosis of osteoporosis will enable physicians to provide the appropriate treatment to prevent fracture, which leads to improved quality of life as well as better long-term prognosis.

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Relationship Between Bone Mineral Density and Syndrome Types Described in Traditional Chinese Medicine in Chronic Obstructive Pulmonary Disease: A Preliminary Clinical Observation

The American Journal of Chinese Medicine ◽

10.1142/s0192415x0500351x ◽

2005 ◽

Vol 33 (06) ◽

pp. 867-877 ◽

Cited By ~ 6

Author(s):

Gang Wang ◽

Ting-Qian Li ◽

Bing Mao ◽

Lei Wang ◽

Lin Wang ◽

...

Keyword(s):

Bone Mineral Density ◽

Chronic Obstructive Pulmonary Disease ◽

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Bone Mineral ◽

Healthy Subjects ◽

Chronic Obstructive ◽

Mineral Density ◽

Obstructive Pulmonary Disease ◽

Copd Patients

Osteoporosis is a common finding following chronic obstructive pulmonary disease (COPD), but there are few reports on the relationship between bone mineral density (BMD) and the syndrome types described in traditional Chinese medicine (TCM) in patients with COPD. A cross-sectional medical survey was used in this study. Twenty-six male patients with COPD and 26 age-matched male healthy subjects were recruited. The symptom questionnaire survey of TCM was implemented, and thereafter the COPD patients were divided into two subgroups: type of deficiency of the lung and spleen (TDLS) and type of deficiency of the lung, spleen and kidney (TDLSK). BMD of lumbar spine (L2-4), non-dominant femoral neck (Neck), Ward's triangle (Ward's), and great trochanter (Troch) were measured by dual-energy x-ray absorptiometry. In addition, the other bone turnover markers were also examined. The results showed that BMD was much more decreased in TDLSK than that in TDLS patients ( p < 0.05), and BMD in the patients of the TDLS subgroup without symptoms of kidney-vacuity has showed the decreased trend from healthy subjects to TDLS patients. Furthermore, there was a higher incidence of osteoporosis in patients with TDLSK compared with that in TDLS ( p < 0.05, OR > 2.0). Therefore, the data suggest that: (1) BMD might be a marker more sensitive than the symptom for the diagnosis of kidney-vacuity in COPD patients; (2) the deficiency of kidney would be the key factor of bone mineral loss; and (3) that invigorating the kidney should be performed in the phase of TDLS in COPD patients in advance.

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STUDY OF HS-CRP AND TNF-A LEVELS IN COPD PATIENTS ACCOMPANIED WITH CORONARY ARTERY DISEASE

Journal of Medicine and Pharmacy ◽

10.34071/jmp.2014.4_5.6 ◽

2014 ◽

pp. 48-56

Author(s):

Van Thi Tran ◽

Van Bang Le ◽

Thị Thu Huong Hoang

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Systemic Inflammation ◽

Chronic Obstructive ◽

Low Grade ◽

Cross Sectional ◽

Copd Patients ◽

Coronary Artery Angiography ◽

Hs Crp ◽

Artery Disease

Aim: Some studies have linked the present of chronic obstructive oulmonary disease (COPD) to coronary artery disease (CAD). Low grade systemic inflammation occurs in patients with COPD as well as patients with CAD. This study was designed to find out the concentration differences of hs-CRP and TNF-a in patients having both chronic obstructive pulmonary and coronary artery diseases with those having either. Methods: A cross - sectional descriptive study was conducted in 200 patients undergoing a coronary artery angiography in the Heart Institute, Thong Nhat Hospital and 115 People Hospital. COPD was diagnosed using GOLD classification. Result: Our study had shown that the levels of hs-CRP and TNF-a were statistically increased in patients with COPD, CAD as well as in patients who had COPD with CAD (p<0,05). The levels of hs-CRP were higher in CAD than in COPD nad the levels of TNF-a were higher in COPD than in CAD. In patients with COPD and CAD, there were increased the levels of both hs-CRP and TNF-a in serum. Conclusion: Systemic inflammation presents in both COPD and CAD. Key words: hs-CRP, TNF-a, coronary artery disease (CAD).

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Bone mineral density assessment by DXA in rheumatic patients with end-stage osteoarthritis undergoing total joint arthroplasty

BMC Musculoskeletal Disorders ◽

10.1186/s12891-021-04039-5 ◽

2021 ◽

Vol 22 (1) ◽

Author(s):

Moritz Mühlenfeld ◽

André Strahl ◽

Ulrich Bechler ◽

Nico Maximilian Jandl ◽

Jan Hubert ◽

...

Keyword(s):

Bone Mineral Density ◽

Bone Mineral ◽

Rheumatic Diseases ◽

Total Joint Arthroplasty ◽

Joint Destruction ◽

Joint Arthroplasty ◽

Mineral Density ◽

T Score ◽

End Stage ◽

Rheumatic Patients

Abstract Background Patients with rheumatic diseases have a high risk for joint destruction and secondary osteoarthritis (OA) as well as low bone mineral density (BMD, i.e., osteoporosis). While several factors may lead to low BMD in these patients, the value of BMD measurements in rheumatic patients with end-stage OA scheduled for total joint arthroplasty is unknown. Methods In this retrospective cross-sectional study of 50 adults with secondary OA due to rheumatic diseases, we evaluated dual energy X-ray absorptiometry (DXA) measurements of both hips and the spine performed within 3 months prior to arthroplasty (n = 25 total hip arthroplasty, THA; n = 25 total knee arthroplasty, TKA). We analyzed various demographic and disease-specific characteristics and their effect on DXA results by using group comparisons and multivariate linear regression models. Results Although patients undergoing TKA were younger (63.2 ± 14.2 vs. 71.0 ± 10.8 yr., p = 0.035), osteoporosis was observed more frequently in patients scheduled for TKA than THA (32% vs. 12%). Osteopenia was detected in 13/25 patients (52%) in both the THA and TKA cohort. In the THA cohort, female sex, lower BMI and prednisolone use were associated with lower T-score in the hip. In TKA patients, higher OA grade determined by Kellgren-Lawrence score was associated with lower T-score in the hip of the affected side. Conclusions Osteoporosis is present in a considerable frequency of rheumatic patients with end-stage OA, and THA and TKA patients show distinct frequencies and risk factors of low BMD. Our findings point to a potential value of DXA regarding preoperative evaluation of bone status.

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