scholarly journals Effect of prolong consumption of crude Aloe barbadensis (Aloe vera) gel on haematological indices in rats

2014 ◽  
Vol 6 (2) ◽  
pp. 57-61
Author(s):  
C. O. Nku ◽  
O. E. Ofem ◽  
U. A. Okon
Keyword(s):  
Aloe Vera ◽  
Large Family ◽  
Blood Parameters ◽  
Control Group ◽  
Aloe Barbadensis ◽  
Perennial Plant ◽  
Normal Rat ◽  
Group 3 ◽  
Group 2 ◽  
Haematological Indices

Background: Aloe vera is a succulent perennial plant that belongs to the liliaceae family and to a large family called xeroids. It is a magical plant with vast healing properties, but there is paucity in scientific literature on it effects on haematological parameters. The effect of persistent consumption of crude aqueous extract of Aloe vera on haematological indices of albino Wistar rats was investigated in this study.Methods: Twenty four rats were randomly assigned into three groups of eight rats each. Group 1 (control) received 0.26mL of normal saline o.p. Group 2 received 0.26mL of aloe vera extract for 2 weeks while group 3 received 0.26mL of aloe vera extract for 4 weeks p.o. once daily. All animals received drinking water and normal rat chow ad libitum.Results: Results revealed that the control group had a mean PCV of 37.50 ±0.98%; Hb, 11.40 ±0.39g/dL; RBC, 6.91 ±0.35 x106 cells/µL; WBC, 4.36 ±0.54 x103 cells/µL and platelet count, 670.13 ±41.01 x103 cells/µL. These blood parameters were not significantly different in group 2 animals compared with controls, but were significantly higher in group 3 rats compared with controls. Differential WBC counts were as follows for control values: neutrophils, 23.25 ±2.39%; lymphocytes, 72.88 ± 2.55%; monocytes, 0.13 ±0.13%; eosinophils, 3.00 ±0.71% and basophils, 0.13 ±0.12%. Lymphocytes were significantly (p<0.05) higher in group 3 compared with control group.Conclusion: Aloe vera extract contains phytochemicals that boost blood parameters and immunity on prolong consumption. DOI: http://dx.doi.org/10.3126/ajms.v6i2.11106Asian Journal of Medical Sciences Vol.6(2) 2015 58-61

scholarly journals Effect of Solanum gilo leaf extract on some haematological indices of albino Wistar rats

2021 ◽  
Vol 12 (1) ◽  
pp. 108-111
Author(s):  
Nsimah Monday Essien ◽  
Justina Nwadimma Nwangwa ◽  
Charles Cyprian Mfem ◽  
Johnbull Martins Uket ◽  
Efiok Aniekan Archibong
Keyword(s):  
Blood Cell ◽  
Wistar Rats ◽  
Blood Parameters ◽  
Diet Group ◽  
Control Group ◽  
Carbohydrate Consumption ◽  
Group 4 ◽  
Group 3 ◽  
Group 2 ◽  
Haematological Indices

Solanum gilo (eggplant) is an edible vegetable whose leaf is reported to possess numerous medicinal properties due to its rich constituents. Against this backdrop, there is possibility that its consumption may have effect on haematological indices. Therefore this research sought to assess the effect of Solanum gilo leaf diet on some haemotological indices of albino wistar rats. About twenty four (24) albino wistar rats weighing between 120-150mg were randomly assigned into four groups of six animals each. Each rat was allowed to drinking water ad labitum. Control group received normal rodent chow while group 2 was fed 5% Solanum gilo diet. Group 3 was fed 10% Solanum gilo diet and group 4 received 20% Solanum gilo diet. The different diets were prepared by mixing different proportions of ground S. gilo leaves with rodent chow. Automated blood cell analyzer (Model PCE 210, Japan) was used for analysis of haematological parameters. Preliminary study on its proximate composition, showed the appreciable presence of crude fat, protein, fibre and carbohydrate. Consumption of S. gilo caused significant improvement in some blood parameters; notably packed cell volume (PCV), white blood cell (WBC) and platelet counts. Hence, eggplant is a nutritious vegetable with healing, the therapeutic and immunity properties. If exploited in human diet has the potentials of improving quality of life.

scholarly journals Influence of biopreparations on the postnatal period of highly productive cows

2021 ◽  
Vol 935 (1) ◽  
pp. 012041
Author(s):  
V G Semenov ◽  
E P Simurzina ◽  
S G Kondruchina ◽  
V G Tyurin ◽  
A F Kuznetsov ◽  
...  
Keyword(s):  
Effective Means ◽  
Blood Parameters ◽  
Postnatal Period ◽  
Control Group ◽  
Milk Productivity ◽  
Service Period ◽  
Group 3 ◽  
Group 2 ◽  
Positive Effect ◽  
Group 1

Abstract The article describes the results of comparative studies on the influence of new immunostimulants on the course of postnatal recovery of the cows under conditions of intensive milk production technology. Injections of PS-2 (group 1) and Prevention-N-E (group 2) at a dose of 10 ml forty, twenty and ten days before calving, and a injection of PDE at a dose of 20 ml with E-Selenium of 10 ml (group 3) twenty days before calving prevent the occurrence of obstetric and gynecological pathology, improve reproductive qualities, as compared to the control group, where no biologicals were injected. This fact impacts the acceleration of the first heat onset by 13.7-21.1 days, the conception rate by 0.5-0.7 times, the service period by 16-29.9 days. A positive effect of the tested agents on metabolic processes, morphological and biochemical blood parameters, nonspecific immunological reactivity of the organism was also established. All these factors led to an increase in milk productivity for 305 days of lactation by 186-478 kg, at the same time, milk quality indicators improved correspondingly. Thus, biological preparations PS-2 and Prevention-N-E are highly effective means of preventing obstetric and gynecological pathology.

scholarly journals Anti-diabetic effect of combined treatment with Aloe vera gel and Metformin on alloxan-induced diabetic rats

2018 ◽  
Vol 4 (1) ◽  
pp. 1-5
Author(s):  
F.O. Atanu ◽  
◽  
O.J. Avwioroko ◽  
S. Momoh ◽  
◽  
...  
Keyword(s):  
Combined Treatment ◽  
Aloe Vera ◽  
Diabetic Rats ◽  
Atherogenic Index ◽  
Control Group ◽  
Diabetic Patients ◽  
Aloe Vera Gel ◽  
Group 3 ◽  
Group 5 ◽  
Group 2

Aim: The present study investigated the effects of intensive glucose regulation with combined treatment of Aloe vera gel (a herbal agent) and Metformin in an alloxan-induced diabetic rat model. Methods: Forty rats were assigned to the following groups and treated for 21 days: Group 1 (normal untreated control), Group 2 (untreated diabetic rats, DR), Group 3 (DR + 300 mg/kg PE of Aloe vera ), Group 4 (DR + 2 mg/kg Metformin) and Group 5 (DR + 300 mg/kg PE of Aloe vera + 2 mg/kg Metformin). The effect of the treatments on fasting blood glucose (FBG) level, lipid profile, renal function, atherogenic index, pancreas and kidney histopathologies were assessed. Results: FBG level in Group 5 rats decreased by 28.4, 38.0 and 69.0% at Day 7, 14 and 21, respectively. Hyperlipidaemia, high atherogenic index, increased plasma creatinine and urea levels observed in the diabetic rats were ameliorated by the single and combined treatments with Aloe vera and Metformin. Reduced level of HDL-cholesterol in the untreated diabetic rats significantly improved by 160.0, 89.8 and 178.7% respectively in Group 3, 4 and 5 animals. The pancreas and kidney histopathologies indicated signs of recovery in Group 5 rats unlike those of Group 2 that had evidence of necrotic cells in both the acini and islet in pancreas and total glomeruli erosion in kidney. Conclusion: Aloe vera in combination with Metformin for treatment of diabetic patients could avert diabetes-associated dyslipidaemia, improve cellular integrity and increase, thereby preventing patients from risk of cardiovascular diseases and kidney failure.

scholarly journals Moringa oleifera Extract Extenuates Echis ocellatus Venom-Induced Toxicities, Histopathological Impairments and Inflammation via Enhancement of Nrf2 Expression in Rats

2021 ◽  
Vol 28 (1) ◽  
pp. 98-115
Author(s):  
Akindele O. Adeyi ◽  
Sodiq O. Adeyemi ◽  
Enoh-Obong P. Effiong ◽  
Babafemi S. Ajisebiola ◽  
Olubisi E. Adeyi ◽  
...  
Keyword(s):  
Moringa Oleifera ◽  
Ethanol Extract ◽  
Male Rats ◽  
Blood Electrolytes ◽  
Tnf Α ◽  
Group 3 ◽  
Group 2 ◽  
Haematological Indices ◽  
Nrf2 Expression ◽  
Potential Remedy

Echis ocellatus snakebite causes more fatalities than all other African snake species combined. Moringa oleifera reportedly possesses an antivenom property. Therefore, we evaluated the effectiveness of M. oleifera ethanol extract (MOE) against E. ocellatus venom (EOV) toxicities. Thirty male rats were grouped as follows (n = 5): Group 1 (normal control received saline), groups 2 to 6 were administered intraperitoneally, 0.22 mg/kg (LD50) of EOV. Group 2 was left untreated while group 3 to 6 were treated post-envenoming with 0.2 mL of polyvalent antivenom, 200, 400, and 600 mg/kg of MOE respectively. MOE significantly (p<0.05) normalized the altered haematological indices and blood electrolytes profiles. MOE attenuated venom-induced cellular dysfunctions, characterized by a significant increase in NRF2, and concomitant downregulation of increased antioxidant enzymes (SOD and CAT) activities in the serum and heart of the treated rats. MOE normalized the elevated TNF-α and IL-1β in serum and heart tissues. Furthermore, the IgG titre value was significantly (p<0.5) higher in the envenomed untreated group compared to the MOE-treated groups. Hemorrhagic, hemolytic and coagulant activities of the venom were strongly inhibited by the MOE dose, dependently. Lesions noticed on tissues of vital organs of untreated rats were abolished by MOE. Our findings substantiate the effectiveness of MOE as a potential remedy against EOV toxicities.

Active head movements facilitate compensation for effects of prism displacement on dynamic gait12

2006 ◽  
Vol 16 (1-2) ◽  
pp. 29-33
Author(s):  
Kim R. Gottshall ◽  
Michael E. Hoffer ◽  
Helen S. Cohen ◽  
Robert J. Moore
Keyword(s):  
Head Movement ◽  
Sensory Modality ◽  
Normal Subjects ◽  
The Body ◽  
Head Movements ◽  
Head Motion ◽  
Control Group ◽  
Entire Body ◽  
Group 3 ◽  
Group 2

Study design: Four groups, between-subjects study. Objectives: To investigate the effects of exercise on adaptation of normal subjects who had been artificially spatially disoriented. Background: Many patients referred for rehabilitation experience sensory changes, due to age or disease processes, and these changes affect motor skill. The best way to train patients to adapt to these changes and to improve their sensorimotor skills is unclear. Using normal subjects, we tested the hypothesis that active, planned head movement is needed to adapt to modified visual input. Methods and measures: Eighty male and female subjects who had normal balance on computerized dynamic posturography (CDP) and the dynamic gait index (DGI), were randomly assigned to four groups. All groups donned diagonally shift lenses and were again assessed with CDP and DGI. The four groups were then treated for 20 min. Group 1 (control group) viewed a video, Group 2 performed exercise that involved translating the entire body through space, but without separate, volitional head movement, Group 3 performed exercises which all incorporated volitional, planned head rotations, and Group 4 performed exercises that involved translating the body (as in Group 2) and incorporated volitional, planned head motion (as in Group 3). All subjects were post-tested with CDP and DGI, lenses were removed, and subjects were retested again with CDP and DGI. Results: The groups did not differ significantly on CDP scores but Groups 3 and 4 had significantly better DGI scores than Groups 1 and 2. Conclusions: Active head movement that is specifically planned as part of the exercise is more effective than passive attention or head movements that are not consciously planned, for adapting to sensorimotor change when it incorporates active use of the changed sensory modality, in this case head motion.

scholarly journals Preemptive analgesic effect of lidocaine in a chronic neuropathic pain model

2009 ◽  
Vol 67 (4) ◽  
pp. 1088-1092 ◽  
Author(s):  
Leonardo M. Batista ◽  
Igor M. Batista ◽  
João P. Almeida ◽  
Carlos H. Carvalho ◽  
Samuel B. de Castro-Costa ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Sciatic Nerve ◽  
Control Group ◽  
Thermal Stimulus ◽  
Lidocaine Group ◽  
Local Infiltration ◽  
Neuropathic Pain Model ◽  
Group 3 ◽  
Group 2 ◽  
The Right

Preemptive analgesia inhibits the progression of pain caused by surgical lesions. To analyze the effect of lidocaine on postoperative pain relief, we performed compression of the right sciatic nerve in Wistar rats and observed the differences on behavior between the group that received lidocaine and the group that was not treated with the local anesthetics pre-operatively. Group 1 was not operated (control); group 2 underwent the sciatic nerve ligature without lidocaine; group 3, underwent surgery with previous local infiltration of lidocaine. Group 2 showed significantly longer scratching times with a peak on day 14 post-operative (p=0.0005) and reduction in the latency to both noxious (p=0.003) and non-noxious (p=0.004) thermal stimulus. Group 3 presented significantly shorter scratching times (p=0.004) and longer latency times when compared to Group 2. Preemptive use of lidocaine 2% can potentially reduce the postoperative neuropathic pain associated with sciatic nerve compression.

Postoperative Morphine Use and Hyperalgesia Are Reduced by Preoperative but Not Intraoperative Epidural Analgesia

2003 ◽  
Vol 98 (6) ◽  
pp. 1449-1460 ◽  
Author(s):  
Joel Katz ◽  
Lorenzo Cohen ◽  
Roger Schmid ◽  
Vincent W.S. Chan ◽  
Adarose Wowk
Keyword(s):  
Morphine Consumption ◽  
Gynecologic Surgery ◽  
Control Group ◽  
Epidural Administration ◽  
Blinded Manner ◽  
Group 3 ◽  
Group 2 ◽  
Double Blinded ◽  
Postoperative Morphine ◽  
Group 1

Background The aim of this study was to evaluate the postoperative morphine-sparing effects and reduction in pain and secondary mechanical hyperalgesia after preincisional or postincisional epidural administration of a local anesthetic and an opioid compared with a sham epidural control. Methods Patients undergoing major gynecologic surgery by laparotomy were randomly assigned to three groups and studied in a double-blinded manner. Group 1 received epidural lidocaine and fentanyl before incision and epidural saline 40 min after incision. Group 2 received epidural saline before incision and epidural lidocaine and fentanyl 40 min after incision. Group 3 received a sham epidural control (with saline injected into a catheter taped to the back) before and 40 min after incision. All patients underwent surgery with general anesthesia. Results One hundred forty-one patients completed the study (group 1, n = 45; group 2, n = 49; group 3, n = 47). Cumulative patient-controlled analgesia morphine consumption at 48 h was significantly lower (P = 0.04) in group 1 (89.8 +/- 43.3 mg) than group 3 (112.5 +/- 71.5 mg) but not group 2 (95.4 +/- 60.2 mg), although the hourly rate of morphine consumption between 24 and 48 h after surgery was significantly lower (P &lt; 0.0009) in group 1 (1.25 +/- 0.02 mg/h) than group 2 (1.41 +/- 0.02 mg/h). Twenty-four hours after surgery, the visual analog scale pain score on movement was significantly less intense (P = 0.005) in group 1 (4.9 +/- 2.2 cm) than group 3 (6.0 +/- 2.6 cm) but not group 2 (5.3 +/- 2.5 cm), and the von Frey pain threshold near the wound was significantly higher (P = 0.03) in group 1 (6.4 +/- 0.6 log mg) than in group 3 (6.1 +/- 0.8 log mg) but not group 2 (6.2 +/- 0.7 log mg). Conclusions Preincisional administration of epidural lidocaine and fentanyl was associated with a significantly lower rate of morphine use, lower cumulative morphine consumption, and reduced hyperalgesia compared with a sham epidural condition. These results highlight the importance of including a standard treatment control group to avoid the problems of interpretation that arise when two-group studies of preemptive analgesia (preincisional vs. postsurgery) fail to find the anticipated effects.

scholarly journals Antioxidant Effect of MnTE-2-PyP on Lung in Asthma Mice Model

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Lyudmil Terziev ◽  
Violeta Dancheva ◽  
Veneta Shopova ◽  
Galya Stavreva
Keyword(s):  
Superoxide Dismutase ◽  
Glutathione Peroxidase ◽  
Control Group ◽  
Mice Model ◽  
Antioxidant Defence ◽  
Group 4 ◽  
Antioxidant Defence System ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Aim. To investigate the effects of MnTE-2-PyP on some markers of antioxidant defence system in asthma mice model.Material and Methods. The animals were divided into four groups: group 1, controls; group 2, injected with ovalbumin, group 3, treated with MnTE-2-PyP, and group 4, treated with ovalbumin and MnTE-2-PyP. The activities of superoxide dismutase, catalase, glutathione peroxidase and nonprotein sulfhydryl groups content (NPSH) were determined in lung homogenate.Results. The activities of superoxide dismutase and catalase in group 2 decreased significantly as compared to control group. The decrease of the same enzymes in group 4 was lower and significant as compared to group 2. Changes in the glutathione peroxidase activity showed a similar dynamics. The NPSH groups content decreased in group 2. In group 4 this decrease was relatively lower as compared to group 2.Conclusions. The application of MnTE-2-PyP mitigated the effects of oxidative stress in asthma mice model.

scholarly journals Effectiveness of medical treatment in overcoming the ureteral double-J stent related symptoms

2012 ◽  
Vol 6 (6) ◽  
pp. 234 ◽  
Author(s):  
Ugur Kuyumcuoglu ◽  
Bilal Eryildirim ◽  
Murat Tuncer ◽  
Gokhan Faydaci ◽  
Fatih Tarhan ◽  
...  
Keyword(s):  
The Body ◽  
Control Group ◽  
Group 4 ◽  
Double J Stent ◽  
Urinary Tract Symptoms ◽  
Stone Treatment ◽  
Group 3 ◽  
Group 5 ◽  
Group 2

Background: We investigated whether the frequency of lower urinary tract symptoms (LUTS) increased in patients in whom double-J stents were applied. We also evaluated several medical therapy protocols to treat symptoms related with ureteral stents.Materials and Methods: A total of 108 patients, in whom unilateral double-j stent was applied during ureteral stone treatment, were included. Before the double-J stent was applied, all patients completed storage components of the “International Prostate Symptom Score” (IPSSs), quality of life components of the IPSS (IPSS-QOL) and “Overactive Bladder Questionnaire” (OABq) forms and scores were calculated. After the procedure, cases were randomized into 5 groups, an antiinflammatory was given to Group 1, spasmolytic to Group 2, anticholinergic to Group 3 and α-blocker to Group 4. No additional drug was given to Group 5 as this control group. During the fourth week of the procedure, IPSSs, IPSS-QOL and OABq forms were again completed and scores were compared with the previous ones.Results: When all the cases were evaluated, the IPSSs, IPSS-QOLand OABq scores of patients in whom the double-J stent was applied were statistically significantly higher the procedure. Compared to the control group, the cases where the double-J stent was applied showed a higher IPSSs, IPSS-QOL and OABq scores and none of the medical therapies could prevent this increase.Interpretation: The frequency of LUTS increased in cases where the ureteral stent was applied and discomfort continued as long as the stent stayed in the body.

scholarly journals Hibiscus sabdariffa Aqueous Leaf Extract Reverses Hematological Alterations in Phenylhydrazine Anemic Wistar Rats

2020 ◽  
pp. 30-38
Author(s):  
E. B. Umoren ◽  
T. A. Kolawole ◽  
I. Wopara ◽  
O. G. Adebayo ◽  
B. Ben-Azu ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Leaf Extract ◽  
Hemoglobin Concentration ◽  
Control Group ◽  
Mean Corpuscular Hemoglobin ◽  
Hibiscus Sabdariffa ◽  
Aqueous Leaf Extract ◽  
Group 3 ◽  
Group 2 ◽  
Hb Concentration

Background: The extract of Hibiscus sabdariffa commonly known as Sobo is widely consumed for its nutritional and health benefits. This study investigated the effect of aqueous leaf extract of  H. sabdariffa on anemic condition caused by phenylhydrazine in rats. Materials and Methods: Thirty (30) rats used for this study were divided into three groups of 10 rats each. Group 1 received distilled water and served as control. Group 2 received phenylhydrazine (40 mg/kg, i.p.). Group 3 was treated with phenylhydrazine (40 mg/kg, i.p.) 30 minutes prior to administration of (200 mg/kg, p.o.) aqueous extract of H. sabdariffa (Sobo) once daily for 14 days. At the end, 2 ml blood samples were collected through cardiac puncture into clean sample bottles containing ethylenediamine tetra acetic acid (EDTA) for hematological analyses. Results: Sobo significantly increased (P<0.05) hemoglobin (Hb) concentration and packed cell volume (PCV) in the phenylhdrazine-treated rats. Also, Sobo significantly (P<0.05) increased total white blood cell (TWBC) in phenylhydrazine administered rats. However, the extract did not produce any significant effect on mean corpuscular hemoglobin concentration (MCHC) relative to control and anemic groups. Conclusion: The findings from this study revealed that the aqueous extract of H. sabdariffa demonstrates anti-anemic effect in rats treated with phenylhydrazine, suggesting its ethno-pharmacological beneficial effect in anemic conditions.

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