scholarly journals Placental malarial parasitaemia and pregnancy outcome among parturients in a tertiary hospital in South- South Nigeria

2015 ◽  
Vol 6 (6) ◽  
pp. 53-59
Author(s):  
Godwin J Ibanga ◽  
Aniekan M Abasiattai ◽  
Emem A Bassey ◽  
Michael Ukpe ◽  
Olujimi A Olatunbosun ◽  
...  

Background: Malaria is the most common human parasitic disease and continues to be a complex and overwhelming global health problem, especially in sub-Saharan Africa. Placental malaria, one of the major features of malaria in pregnancy has been associated with serious adverse health consequences to both the mother and her fetus. Objective: This study sought to determine the prevalence of maternal, cord, and placental malarial parasitaemia at parturition, the association between maternal and placental parasitaemia, and also the association between placental parasitaemia and pregnancy outcomes. Materials and Methods: A descriptive cross-sectional design was used to study 330 pregnant women selected by the systematic random sampling technique as they presented in the labour ward of University of Uyo Teaching Hospital, Uyo between April, 2012 and September, 2012. Pre-delivery, maternal peripheral blood was taken for malaria parasite (MP) and packed cell volume (PCV). Post delivery, cord blood was taken for MP and PCV estimation while placental blood was examined for MP. Neonatal demographic and clinical characteristics were also obtained. The data was analyzed using SPSS version 17. Level of statistical significance was set at P less than 0.05 (P < 0.05). Results: The mean age of the respondents was 28.8 ± 4.4 years. The prevalence of maternal, cord, and placental parasitaemia were 30.3%, 14.8% and 18.2% respectively. There was a strong correlation between maternal parasitaemia and placental parasitaemia (rho = 0.75, P< 0.001). Also, a significant linear association between cord parasitaemia and placental malaria (rho = 0.87, p< 0.001) was found. Placental malaria predisposed to low birth weight (OR 1.01{95%CI 1.001 – 1.02}, p = 0.04) and fetal anaemia (OR 1.02{95%CI 1.01 – 1.03}, p < 0.001. Conclusion: There is a relatively high prevalence of placental parasitaemia at parturition. Placental malaria is associated with adverse pregnancy outcomes such as low birth weight, fetal anaemia and cord parasitaemia. Proven strategies to prevent malaria in pregnancy such as use of ITNs and IPT and free antenatal care should be intensified to curb this deadly but preventable disease.DOI: http://dx.doi.org/10.3126/ajms.v6i6.12401Asian Journal of Medical Sciences Vol.6(6) 2015 53-59

2021 ◽  
Author(s):  
Wilson Ndukwe Nwigboji ◽  
John Okafor Egede ◽  
Peace Chinyere Igwe ◽  
Matthew Nwali Igwe ◽  
Gregory Chinedu Nwigwe ◽  
...  

Abstract Background: Malaria in pregnancy is a major public health problem in sub-Saharan Africa and can result in placental malaria with its associated adverse pregnancy outcomes.Method: This was a case control study involving 190 consenting, asymptomatic, booked parturients, recruited consecutively at 36 week. The aim was to determine the effect of placental malaria on pregnancy outcome in asymptomatic women delivering at term. The participants were screened for malaria parasites using peripheral blood film. Based on their results, the participants were grouped into parasitemia positive cases (Group 1) and parasitemia negative controls (Group 2). Both groups were then followed up in the clinic till they presented in labour at term. In labour, participants’ peripheral venous blood sample were collected and used to determine intrapartum haematocrit and peripheral parasitemia. After delivery, cord blood and a section of the placenta were collected for investigation. Data analysis: Collected data were analysed using Statistical Product and service solutions (SPSS) software (version 20). Numerical variables were presented as mean and standard deviation (Mean SD), while categorical variables were presented as numbers and percentages. Chi-square test(X2) was used to compare qualitative variables. Odds ratio (OR) and Confidence interval(CI) were used to observe the odds of outcomes. A p-value 0.05 was considered statistically significant.Results: The prevalence of placental malaria and congenital malaria were 41.05% and 29.47% respectively. Birth weight, APGAR score, NICU admission or congenital malaria were not statistically significant between the two groups. The mean birth weight was 3.16 ± 0.5 kg while 17.89% had low birth weight. There was also no significant difference between the two groups in terms of the association of placental parasitaemia and maternal anaemia or dose of IPT taken. There was no significant association between placental parasitaemia and low parity. Multivariate logistic regression analysis of maternal anaemia and low birth weight showed significant placental parasitaemia in both cases (p = 0.004). Conclusion: Placental parasitaemia is a major complication of malaria in pregnancy and is associated with adverse feto-maternal effects. Early booking and uptake of intermittent preventive therapy with sulphadoxine-pyrimethamine may help reduce the adverse effects.


Author(s):  
Swetha Munivenkatappa ◽  
Srinivas M. Govindaraj

Background: There has been a lot of interest in knowing the effects of oral health on adverse pregnancy outcomes like preterm births and low birth weight. Studies have yielded contradicting results and there are lot of confounding issues that blur the picture.  Aim of the study is to determine the prevalence of periodontitis is pregnant population and determine the effect of periodontitis on preterm births and low birth weight.Methods: This was a cross sectional study of singleton pregnant women attending ante-natal checkups with oral interview and clinical examination. Oral examination was done at the beginning of third trimester of pregnancy. They were followed up to delivery to note the duration of gestation, birth weight of babies.Results: The prevalence of periodontitis was 22% with 90.9% having mild and 9.1% having moderate periodontitis. Maternal education (high school and above) was associated with lower prevalence of periodontitis (p=0.042). There was no difference in the birth weights between the group with and without periodontitis (2.9±0.41kgs vs 2.74±0.36kgs, p=0.11). The incidence of low birth weights was also similar (p=0.22). The average gestational age was slightly less in the group with periodontitis (38 weeks 3 days vs 37 weeks 5 days) but the rates of preterm births were similar between the two groups (p=0.61).Conclusions: Mild/moderate periodontitis does not appear to have a significant effect on pre-term births and low birth weight. Maternal education and awareness seem to mitigate development of periodontitis and adverse pregnancy outcomes.


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Prakash Prabhakarrao Doke ◽  
Sonali Hemant Palkar ◽  
Jayashree Sachin Gothankar ◽  
Archana Vasantrao Patil ◽  
Amruta Paresh Chutke ◽  
...  

Abstract Background The preconception phase of women’s life cycle is critical but comparatively ignored. The presence of health risks is judged as hazardous to the wellbeing of women and their offspring. This study aimed to estimate the prevalence of various pregnancy outcomes and assess the association between certain risk factors and adverse outcomes. Methods As a part of a preconception care intervention project, a baseline survey was conducted in four blocks of Nashik District, India. In this population-based cross-sectional analytical study, we compared cases in the study group (randomly selected one tribal and one non-tribal block) with those of the control group (one tribal and one non-tribal block). A comparison was also made between the tribal and non-tribal blocks in each group. All women who had a pregnancy outcome in the preceding 12 months (01 April 2017 to 31 March 2018) were interviewed. Trained Accredited Social Health Activists conducted the survey under the direct supervision of Auxiliary Nurse Midwives and Medical Officers. Multivariate analysis was carried out to find the adjusted prevalence ratio of having a particular adverse outcome because of the prespecified potential risk factors. Results A total of 9307 women participated in the study. The prevalence of adverse pregnancy outcomes was as follows: abortion in 4.1%, stillbirth in 1.7%, preterm birth in 4.1%, low birth weight in 13.2%, and congenital physical defect in 2.8%. Prevalence of parental consanguinity, pre-existing maternal illness at conception, heavy work during the last six months of pregnancy, tobacco consumption, alcohol consumption, direct exposure to pesticides and domestic violence during pregnancy was 18.5, 2.2, 18.7, 5.6, 0.5, 2.3, and 0.8% respectively. Risk factors associated with abortion included pre-existing illness and heavy work in the last six months of the pregnancy. Consanguinity, tobacco consumption during pregnancy and pre-existing illness were identified as risk factors for stillbirth. Significant risk factors of low birth weight were heavy work in the last six months of pregnancy, pre-existing illness and residence in a tribal area. Conclusion There is a need to emphasize on maternal behaviour, including tobacco consumption, and heavy work during pregnancy, as well as on parental consanguinity and pre-existing maternal illnesses, in order to achieve the best possible pregnancy outcomes.


2010 ◽  
Vol 4 (07) ◽  
pp. 448-453 ◽  
Author(s):  
Catherine Olufunke Falade ◽  
Olukemi O Tongo ◽  
Oluwatoyin O Ogunkunle ◽  
Adebola Emmanuel Orimadegun

Background: Malaria in pregnancy remains a major cause of infant mortality through its contribution to preterm delivery, low birth weight and intrauterine death. Methodology: During a cross-sectional study of 983 mothers delivering in a secondary health care facility in Ibadan, southwestern Nigeria, an area of high malaria transmission, the effect of maternal and placental malaria parasitaemia on newborn anthropometry was evaluated. Malaria parasitemia was detected by microscopy of Giemsa stained thick blood smears. Results: Placental, maternal and combined placental and maternal malaria parasitaemia rates at the time of delivery were 13.1%, 12.7% and 11.1% respectively. The geometric mean parasite densities in maternal and placental smears were significantly higher in primigravid mothers than others (p = 0.004 and 0.002 respectively). Low birth weight rate was higher among babies born to mothers with maternal parasitaemia compared to those without (8.0 % versus 6.3%, p < 0.05). The mean birth weight was lower in neonates of mothers with peripheral and placental parasitaemia by 138 g and 122 g (p = 0.01 and 0.02) respectively, while the respective difference was up to 168 g and 151 g among primigravidae (p = 0.03 and 0.04). Neonates of mothers with maternal and placental parasitaemia had a lower mean length than those without parasitaemia (48.2 vs 49.2cm, p = < 0.0001 and 48.5 vs 49.2cm p = 0.02 respectively). Occiptofrontal circumference and ponderal indices were not significantly affected by maternal malaria parasitaemia. Conclusion: Malaria in pregnancy results in symmetric foetal growth restriction and the effect is more marked among primigravid mothers. 


2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Aneth Vedastus Kalinjuma ◽  
Anne Marie Darling ◽  
Ferdinand M. Mugusi ◽  
Ajibola Ibraheem Abioye ◽  
Fredros O. Okumu ◽  
...  

Abstract Background Malaria infection during pregnancy has negative health consequences for both mothers and offspring. Sub-microscopic malaria infection during pregnancy is common in most African countries. We sought to identify factors associated with sub-microscopic placental malaria, and its association with adverse pregnancy outcomes among HIV-negative pregnant women in Dar es Salaam, Tanzania. Methods We recruited a cohort of pregnant women during their first trimester and assessed for the occurrence of placental malaria and pregnancy outcomes. The follow-up was done monthly from recruitment until delivery. Histopathology placental malaria positive results were defined as the presence of malaria pigment or parasitized erythrocytes on the slide (histology-positive (HP)), and the sub-microscopic placental infection was defined as positive Plasmodium falciparum DNA by polymerase chain reaction (DNA PCR) amplification in a negative histopathology test. Adverse pregnancy outcomes investigated included low birth weight (birth weight below 2.5 kg), prematurity (live birth below 37 weeks), and small-for-gestational-age (SGA) (live born with a birth weight below 10th percentile for gestational age and sex). Weighted baseline category logit, log-binomial, and log-Poisson models were used to assess factors associated with placental malaria, and its association with adverse pregnancy outcomes. Results Among 1115 women who had histopathology and DNA PCR performed, 93 (8%) had HP placental infection, and 136 (12%) had the sub-microscopic placental infection. The risk of sub-microscopic placental malaria was greater in women who did not use mosquito prevention methods such as bed nets, fumigation, or mosquito coils (odds ratio (OR) = 1.75; 95% confidence interval (CI): 1.05–2.92; P = 0.03) and in women who were anemic (OR = 1.59; 95% CI: 1.20–2.11; P = 0.001). Women who were underweight had reduced odds of sub-microscopic placental malaria infection (OR = 0.33; 95% CI: 0.17–0.62; P = 0.001). Women who were overweight/obese had 1.48 times higher the odds of HP placental malaria compared to normal weight (OR = 1.48; 95% CI: 1.03–2.11; P = 0.03). HP placental malaria infection was associated with an increased risk of SGA births (RR = 1.30, 95% CI: 0.98–1.72, P = 0.07). In contrast, the sub-microscopic infection was associated with a reduced risk of SGA births (RR = 0.61, 95% CI: 0.43–0.88, P = 0.01). Placental malaria was not associated with low birth weight or prematurity. Conclusion Malaria prevention methods and maternal nutrition status during early pregnancy were important predictors of sub-microscopic placental malaria. More research is needed to understand sub-microscopic placental malaria and the possible mechanisms mediating the association between placental malaria and SGA.


2021 ◽  
Vol 15 (8) ◽  
pp. 2468-2471
Author(s):  
Saadia Yasmeen ◽  
Sumayya . ◽  
Javeria Saleem ◽  
Jawairiah Liaqat ◽  
Nadia Pervaiz ◽  
...  

Background and Aim: Advanced maternal age pregnancy could be referred to as pregnancy after 35 years or older. The prevalence of postponing pregnancies is increasing day by day worldwide. However, limited evidence was found on advanced maternal age pregnancy association with fetal adverse outcomes. The present study aimed to evaluate the frequency of advanced maternal age selected fetal adverse pregnancy outcomes. Place and Duration: Obstetrics & Gynaecology department of Alkhidmat Hospital Kohat and Qazi Hussain Ahmad Medical Complex, Nowshera for duration of six months from November 2020 to April 2021. Materials and Methods: This single-centered retrospective study was conducted on 220 postpartum women in the study group (≥35 years) and 170 control group postpartum women (20-34 years) who delivered at Obstetrics & Gynaecology department of Alkhidmat Hospital Kohat and Qazi Hussain Ahmad Medical Complex, Nowshera after 28 gestational weeks. Individuals who met the inclusion criteria were enrolled and sampled based on randomized control sampling technique for both control and study groups. Data extraction checklist and pretested questionnaire were used for data collection from the maternal charts. Adverse pregnancy outcome and advanced maternal age was correlated adjusted relative risks and strength with a 95% confidence interval. SPSS version 20 was used for data analysis and considered p-value >0.05 as a statistical standard. Results: The adverse neonatal outcomes include low birth weight, preterm birth, and stillbirth with a prevalence 38 (17.4%), 46 (20.8%), and 31 (14.2%) respectively in the study group. In the control group, the incidence of low birth weight, preterm birth, and stillbirth was 21 (12.6%), 15 (14.6%) and 6 (3.5%) respectively. The stillbirth (ARR=3.16 95% CI (1.29–6.03) and preterm deliveries (ARR=2.71 95% CI (1.79–3.86) risk had significantly higher prevalence compared to control group advanced age pregnancy. Insignificance association was found between low birth weight and advanced maternal age. Conclusion: Stillbirth and preterm birth was the adverse fetal outcome significantly related with advanced maternal age pregnancy. There was no significant association between low birth weight and advanced maternal age. Keywords: Maternal age, Fetal Adverse Pregnancy Outcomes


2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Farideh Kazemi ◽  
Seyedeh Zahra Masoumi ◽  
Arezoo Shayan ◽  
Seyedeh Zahra Shahidi Yasaghi

Abstract Background The results of some studies have indicated the association between food insecurity and certain adverse pregnancy outcomes. The present study aimed to investigate the prevalence of food insecurity in pregnant women and its association with pregnancy outcomes and complications. Methods The present cross-sectional study was conducted on 772 mothers who visited comprehensive health service centers during the first 10 days after delivery in 2018. The tools included the demographic and midwifery information questionnaire and an 18-item questionnaire devised by the U.S. Department of Agriculture. The significance level was considered to be 0.05. Results 67.5% of pregnant women had food insecurity. The multivariate analysis showed that birth weight decreased with the increase in the severity of food insecurity, but the reduction was not statistically significant. Based on the results, food insecurity had no statistically significant impact on the mothers’ weight gain pattern (p = 0.13). The risk of hypertension/preeclampsia and anemia was not related to food insecurity. Compared with the food-secure group, the probability of gestational diabetes was 56% lower in the food-insecure group without hunger and 61% lower in the food-insecure group with moderate hunger; however, in the food-insecure group with severe hunger, this probability was 1.5 times more than the food-secure group, which is not statistically significant. Conclusions The prevalence of food insecurity was high in pregnant women. Maternal weight gains during pregnancy and birth weight (despite being statistically insignificant) were affected by this condition; therefore, it is necessary to identify women with food insecurity on their first pregnancy visit; it is also crucial to take steps towards improving their health through allocating a family food basket and nutritional support for these women at least during pregnancy. Due to the limited sample size and inability to control the potential confounders, the association between food insecurity during pregnancy and the incidence of pregnancy complications could not be reached, hence the need for more studies.


2021 ◽  
Vol 21 (2) ◽  
pp. e00511-e00511
Author(s):  
Shondra Loggins Clay ◽  
Markisha J. Woodson ◽  
Renique Kersh

Background: Numerous studies have been conducted to seek a better understanding of disparities in adverse pregnancy outcomes. The present study aimed to explore racial differences in influential socio-demographic, economic, and environmental factors in women who have had a low birth weight (LBW) infant (outcome variable). Study Design: A cross-sectional study. Methods: This study used data from the Fragile Families and Child Wellbeing Study (FFCWS). Univariate and multivariate analyses were performed. Results: The obtained results pointed to statistical racial differences between Non-Hispanic (NH) Black and NH White women in the socio-demographic variable of marital status (P<0.001). Regarding the assessed economic stability variables, employment status (P=0.032), poverty level (P<0.001), earnings (P=0.038), and federal government assistance paying for rent (P=0.007) were statistically significant across the two racial groups. The environmental factors that were statistically significant across racial groups were living in public housing projects (P=0.018), car ownership (P<0.001), and neighborhood safety (P=0.010). The results of the multivariate models revealed that NH Black race and government assistance to pay rent were associated with an increased likelihood of LBW, while being married, having health care coverage, and living in public housing were associated with a decreased likelihood. Conclusion: As evidenced by the obtained results, there were statistically significant racial differences in sociodemographic, economic, and environmental/physical characteristics associated with adverse pregnancy outcomes.


2020 ◽  
Vol 5 (3) ◽  
pp. 1201-1205
Author(s):  
Vibha Mahato ◽  
Pravin Shrestha

Introduction: Anemia is one of the most common disorders affecting the pregnant women in the developing countries like Nepal. Anemia during pregnancy is commonly associated with adverse pregnancy outcomes. Identifying anemia in pregnancy and knowing its common complications will help improve maternal quality care. Objectives: The objective - was to  assess the effects of anemia on pregnancy outcome at Manipal Teaching Hospital Methodology: This cross sectional study was conducted in Manipal Teaching Hospital from September 2019 to April 2020. A total of 200 anemic pregnantladies  attending obstetrics Out Patient Department were selected.Hemoglobinlevel was taken as criteria for deciding anemia and  to classify  severity of anemia.Anemia in pregnancy is defined by World Health Organization as hemoglobin level less than 11 gm/dl, and hemoglobin concentration of 10–10.9 g/dl, 7–9.9 g/dl, and <7 g/ dl was considered as mild, moderate, and severe anemia, respectively . All were treated depending on severity of anemia and followed up for maternal and perinatal outcome.Data was collected in Microsoft Excel and analyzed by using SPSS version 16. Result: We found moderate anemia in 129 (64.5%) cases followed by mild in 61(30.5%) and severe in 10(5%) cases. Common maternal complications in anemic patients werepremature rupture of membranein 30 (15%) cases and Urinary Tract Infection in 30(15%) cases.During puerperiumPostpartum Hemorrhage was observed in 12(6%) and wound infection in 9 (4.5%) cases of anemic patient. High incidence of adverse fetal outcome in the form of preterm in 39 (19.5%), Intrauterine growth restrictionin 23(11.5%), Intensive Care Unitadmission in28(14%),low birth weight in41(20.5%) and Intrauterine Death in4(2%) cases of anemic patients were seen. Conclusion: Maternal infection and adverse perinatal outcome in form of intrauterine growth restriction, Intensive Care Unitadmission, low birth weight and perinatal death were significantly associated with anemia in pregnancy.


2021 ◽  
Vol 9 (1) ◽  
pp. 109-115
Author(s):  
Dyah Ponco Sudarmaningsih ◽  
◽  
Febrial Hikmah ◽  
N Sri Widada ◽  
Rustiana Tasya Ariningpraja

Physiological changes in pregnant women have an impact on reducing the hemoglobin (Hb) level so that they can experience anemia. Anemia in pregnant women is still a high case and be one of the factors of low birth weight (LBW). Iron (Fe) is consumed routinely is thought to help reduce the risk of anemia, but it's still not known yet between the relation of Fe consumed to LBW incidents. Data were taken by cross sectional as many as 150 samples of pregnant women. The results obtained that 56% of pregnant women had anemia. After Fe therapy doses 60-120 mg/day, Hb levels increased by 0.3 g/dL. Although there were significant differences before and after Fe therapy in pregnant women with anemia, about 74% of pregnant women still had experience anemia despite Fe therapy. Provision of Fe therapy for pregnant women either with a dose of 60-120 mg/day, had not been effective enough in increasing Hb levels. LBW cases were also found in this study, which is around 9.3%. Pregnant women with anemia have a higher risk of LBW. This indicates that offering Fe to pregnant women has not been effective.


Sign in / Sign up

Export Citation Format

Share Document