scholarly journals Demographic Profile and Extra Intestinal Manifestations of Ulcerative Colitis in Nepalese population: Study from TUTH a Tertiary Care Centre, Kathmandu, Nepal

2015 ◽  
Vol 4 (1) ◽  
pp. 1-5
Author(s):  
Shaneel Harsh ◽  
Ananya Adhikari ◽  
Parmatma Parazuli ◽  
Rahul Pathak ◽  
Prem K Khadga ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Age Of Onset ◽  
Severe Disease ◽  
Tertiary Care ◽  
Data Bank ◽  
Health Care Facilities ◽  
University Teaching ◽  
Cultural Variation ◽  
Tertiary Care Centre ◽  
Demographic Profile

Background and Aims: This study aims at determining the demographic profile and extra-intestinal manifestations of Ulcerative Colitis in the Nepalese patients treated in a tertiary referral centre.Methods: The study was conducted between February 1, 2014 and January 31, 2015 at the Department of Gastroenterology Tribhuvan University Teaching Hospital, Kathmandu, Nepal. The clinical and epidemiologic data from patients diagnosed to have Ulcerative Colitis were obtained and analysed.Results: During the study period, 60 patients were identified as having ulcerative colitis. Mean age at diagnosis was 34.6 years. The mean duration of illness at diagnosis was 3.7 years. Extra-intestinal manifestations (EIM) were seen in 16.6% of the patients. Sacroilitis was the most common EIM seen in11.6% followed by peripheral arthritis in 6.6% of the patients. Episcleritis, Primary Sclerosing Cholangitis and Erythema Nodosum were seen only in 1.6% each. At the time of presentation, 38.3% (n=23) had proctosigmoiditis , 50% (n=30) left sided colitis and pancolitis was seen in 11.7% (n=7).53.3% patients had mild disease, 38.3% and 8.3 % presented with moderate to severe disease respectively.Conclusion: Peak age of onset for UC in the study was third and fourth decade which was similar to the various studies from Asia and West. Musculoskeletal manifestation was the most common extra- intestinal manifestation of UC in Nepalese population. As Nepal is perhaps the most diverse country in terms of ethnicity, cultural variation, socio-economic status and health care facilities, a comprehensive nationwide data bank involving ethnicity and geographical variation is needed for a better definition of the disease characteristics.Journal of Advances in Internal Medicine 2015;04(01):1-5.

scholarly journals Socio-demographic and Clinical Characteristics of Patients with Ulcerative Colitis at a Tertiary Care Centre in Nepal

2019 ◽  
Vol 8 (2) ◽  
pp. 26-29
Author(s):  
Rahul Pathak ◽  
Tshering Wangdi Sherpa ◽  
Anurag Jha ◽  
Rabin Hamal ◽  
Sabin Thapallya
Keyword(s):  
Ulcerative Colitis ◽  
Clinical Characteristics ◽  
Severe Disease ◽  
Descriptive Analysis ◽  
Tertiary Care ◽  
Clinical Manifestations ◽  
Common Symptom ◽  
Tertiary Care Centre ◽  
Cross Sectional ◽  
Colonoscopic Examination

Introduction: The prevalence of ulcerative colitis (UC) has gradually increased in Asia over the last few decades. However, there is a paucity of data regarding UC in Nepal. This study analyzed the socio-demographic and clinical characteristics of patients hospitalized with UC. Methods: This is a hospital based, cross-sectional study. Data was collected among 100 individuals admitted to the hospital with UC from June 2016 to May 2018. A descriptive analysis of the demographic and clinical characteristics was done. Results: Of the 100 patients 51 were male (M:F ratio 1.04:1). Average age at diagnosis was 38}12.53 years. 55% of the patients were Brahmins, 16% Kshetris, 8% Newars, 1% Muslim while the remaining 20% belonged to other indigenous ethnic groups. 79% of the patients were newly diagnosed cases while remaining 21% were admitted for acute flares of the disease. Rectal bleeding (85%) was the most common symptom followed by diarrhea (70%), tenesmus (63%), urgency (61%), pain abdomen (44%), weight loss (14%), fever (7%) and constipation (4%). Clinically, 41% had mild, 46% had moderate and 12% had severe disease activity. Extra intestinal manifestations were seen only in 12% of the patients. On colonoscopic examination, 41% had proctitis, 46% had left sided colitis and 13% had extensive colitis. Conclusion: Our study showed some differences in the demographic variables as well as clinical manifestations in the patients when compared to data from the west and even other Asian countries like India and China. Larger population-based studies are needed to better understand the epidemiology and characteristics of the disease in Nepal.  

scholarly journals Clinical analysis of gynecological diseases in postmenopausal women in tertiary care centre

2018 ◽  
Vol 7 (4) ◽  
pp. 1394
Author(s):  
Bharti Choudhary Parihar ◽  
Priyanka Tiwari
Keyword(s):  
Pelvic Organ Prolapse ◽  
Age Of Onset ◽  
Tertiary Care ◽  
Pelvic Organ ◽  
Clinical Analysis ◽  
Tertiary Care Centre ◽  
Indian Women ◽  
Urogenital Infections ◽  
Gynecological Diseases ◽  
Study Population

ABSTRACTBackground: Menopause is a natural step in ageing process represents the period end of menstruation after last menstrual period in previous 12 months. Gynaecological disorder in older women differs from those who are younger. Disorders peculiar to ageing are pelvic organ prolapse, urinary incontinence, genital infections and malignancies. Present study is contemplated with a view to assess the magnitude of postmenopausal gynaecological morbidity. The goal of this study was to assess the age of onset of menopause and the spectrum of different gynaecological diseases, their incidence, diagnosis and treatment modality in postmenopausal females.Methods: A Prospective observational study of postmenopausal females attending Gynecology OPD or admitted in Sultania Zanana Hospital, Bhopal was carried out between July 2014 to June 2015. Total 401 postmenopausal females were included. Age of menopause and detail of all gynecological problems were recorded using predesigned proforma.Results: The study population was drawn from both rural (41.4%) and urban (58.8%) areas. Mean age of onset of menopause was 48.01 years in study population. In all, 28.4% had pelvic organ prolapse, 26.6% had genital malignancies, 25.5% had urogenital infections and 17.7% had benign disorder like senile endometritis, fibroid uterus etc.Conclusions: Menopausal health has been one of the neglected area in our country and needs timely vital attention as they are at risk of developing various genital malignancies. This emphasises the need for a screening programme for Indian women in our scenario.

scholarly journals Efficacy and Safety of Rituximab in Immunobullous Diseases: A Retrospective Study from a Tertiary Care Centre of Nepal

2020 ◽  
Author(s):  
Sudip Parajuli ◽  
Jyoti Vidhan ◽  
Dinesh Binod Pokhrel ◽  
Upama Paudel
Keyword(s):  
Retrospective Study ◽  
Adverse Effects ◽  
Tertiary Care ◽  
Data Entry ◽  
Pemphigus Vulgaris ◽  
University Teaching ◽  
Efficacy And Safety ◽  
Tertiary Care Centre ◽  
Cutaneous Lesions

Introduction: Rituximab is effective and safe treatment of immunobullous disorders. There are variations in doses of drugs used in different studies and uncertainties on when to use it along with use of adjuvant therapies. Efficacy and safety of this drug has not been described in Nepalese population till date. Dermatologists have hesitation in starting this drug in immunobullous diseases because of lack of data on efficacy and safety. Aim: To assess the efficacy and side effects of Rituximab therapy in treating immunobullous disorders in Nepalese patients. Materials and Methods: This was a retrospective study of patients with immunobullous diseases treated with Rituximab in Dermatological ward of Tribhuvan University Teaching Hospital, Kathmandu, Nepal from May 2018 to August 2019. Data were analysed for duration of disease and treatment received before Rituximab therapy, duration of steroid used before Rituximab, adverse effects due to prolonged steroid use, time to remission from 1st Rituximab pulse, duration of remission, relapse, duration of steroid and adjuvant drug used post 1st pulse and adverse effects associated with Rituximab. SPSS version 20 was used for data entry and descriptive statistics was used for analysis of the data. Results: Nine patients (Pemphigus Vulgaris-8 (PV-8), Bullous Pemphigoid-1 (BP-1) were treated with Rituximab. Seven were treated for refractory disease not controlled by conventional therapy and two received Rituximab as first-line therapy. The patients were under follow-up for 15-60 weeks (mean 31.89±15.62 weeks). Out of these nine patients, eight were free of lesions in one to eight weeks (mean 5.125±2 weeks) of first pulse. One patient with Oral Pemphigus had persistence of old lesions, however there were no new cutaneous lesions after first pulse. Adverse effects were seen in four patients that included infusion reaction in one and infection in three. There was relapse in one patient at last follow-up. Conclusion: Rituximab is efficacious and is safe in treating immunobullous disorders in Nepalese Population.

scholarly journals Sociocultural Factors That Potentially Affect the Institution of Prevention and Treatment Strategies for Hepatitis B in Chinese Canadians

2009 ◽  
Vol 23 (1) ◽  
pp. 31-36 ◽  
Author(s):  
Harry Wu ◽  
Colina Yim ◽  
Alex Chan ◽  
Michael Ho ◽  
Jenny Heathcote
Keyword(s):  
Health Care ◽  
Hepatitis B ◽  
Access To Health Care ◽  
Severe Disease ◽  
Tertiary Care ◽  
Treatment Strategies ◽  
Chinese Patients ◽  
Medical Attention ◽  
Sociocultural Factors ◽  
Tertiary Care Centre

BACKGROUND: Despite the availability of screening for chronic hepatitis B (CHB) infection and effective treatments now available, many at-risk individuals fail to seek appropriate medical attention.OBJECTIVE: To identify the barriers to care for CHB infection in a Chinese Canadian community.METHODS: A survey conducted in English or Chinese collected information from individuals with CHB infection that evaluated the level of understanding and identified the barriers that may prevent Chinese patients from undergoing monitoring, screening and/or treatment for CHB infection.RESULTS: Among the 204 patients enrolled, common misconceptions were that sharing food transmits hepatitis B and that patients with severe disease are always symptomatic. Patients with a better understanding of hepatitis B were better educated, younger and were being followed at a tertiary care centre (P<0.01 for all). Prominent barriers to health care were time, inconvenience and language difficulties. Patients under the care of family physicians who had extended office hours were less likely to cite time (P=0.06) and distance (P=0.05) as barriers.CONCLUSION: Patient misconceptions that severe liver disease due to hepatitis B infection is symptomatic may factor into the unwillingness to spare the time and undergo the inconvenience associated with regular medical follow-up. Implementation of programs that increase awareness of the silent progression of CHB infection and provide culturally responsive clinics, better able to work within patients’ time constraints may improve Chinese patients’ access to health care.

scholarly journals Outcome following emergency surgery for refractory severe ulcerative colitis in a tertiary care centre in India

2005 ◽  
Vol 5 (1) ◽  
Author(s):  
Sujoy Pal ◽  
Peush Sahni ◽  
Girish K Pande ◽  
Subrat K Acharya ◽  
Tushar K Chattopadhyay
Keyword(s):  
Ulcerative Colitis ◽  
Emergency Surgery ◽  
Tertiary Care ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Severe Ulcerative Colitis

scholarly journals Clinico-hematological manifestations of malaria in children in Western Uttar Pradesh, India

2018 ◽  
Vol 5 (5) ◽  
pp. 1904
Author(s):  
Najia Hassan ◽  
Sonam Chalotra ◽  
Satinder Aneja
Keyword(s):  
Severe Malaria ◽  
Severe Disease ◽  
Tertiary Care ◽  
Case Fatality ◽  
Pediatric Intensive Care ◽  
Febrile Illness ◽  
Control Programme ◽  
Age Group ◽  
Tertiary Care Centre ◽  
Hematological Manifestations

Background: Globally, malaria is one of the important causes of mortality in pediatric age group.  We describe here the clinico-hematological manifestations of malaria in children in Western Uttar Pradesh.Methods: A Retrospective study was done over 8 months in pediatric ward and pediatric intensive care unit of a tertiary care centre in Greater Noida. Children below 18 years admitted with acute febrile illness with peripheral smear and / or rapid malaria antigen test positive were included in the study.  Detailed clinical, biochemical and hematological characteristics of children hospitalized with severe malaria were recorded and patients were managed according to National Vector Born Disease Control Programme Guidelines for malaria treatment.Results: Out of 115 children admitted with malaria, majority of cases were due to P. vivax (88.7%) compared to P. falciparum (5%) and Mixed infection (6%). Malaria was more common in males and in 1 to 5 years age group. Out of 115 patients, severe malaria was present in 27 (23.4%) patients, all infected with P. vivax. Among them, bleeding was present in 13.04 %, shock in 9.56%, acidosis in 9.56%, jaundice in 5.21%, seizures in 3.47%, severe anemia in 5.21%, renal impairment in 3.47%, impaired sensorium in 1.73% and pulmonary edema was present in 0.86% patients respectively.  Case fatality Rate was 1.73%, all due to severe vivax malaria.Conclusions: The study highlights that P. vivax is a common  cause of malaria in Western UP and can result in a severe disease with potential mortality.

scholarly journals A profile of heart failure patients in a tertiary care centre in Eastern India

2016 ◽  
Vol 5 (1) ◽  
pp. 216
Author(s):  
Biswajit Majumder ◽  
Yatindra Mohan Bahuguna ◽  
Sharmistha Chatterjee
Keyword(s):  
Heart Failure ◽  
Age Of Onset ◽  
Tertiary Care ◽  
Epidemiological Data ◽  
Western Country ◽  
Eastern India ◽  
Tertiary Care Centre ◽  
Heart Failure Patients ◽  
Epidemiological Profile ◽  
Symptoms And Signs

Background: Epidemiological data regarding profile of heart failure in India is lacking. So this study was done to assess the epidemiological profile of heart failure patients in eastern India. Aim of the study was to assess the epidemiological profile of heart failure patients in this part of country.Methods: Total 1000 outdoor and indoor patients presented with symptoms and signs of heart failure according to Framingham criteria were studied.Results: Age of onset of HF is lower than western country. IHD is the commonest cause of HF. Diabetes and hypertensions are important risk factors.Conclusions: Earlier detection and treatment of hypertension and diabetes mellitus might have greater impact in reducing the burden of HF in this part of country.

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