scholarly journals Socio-demographic and Clinical Characteristics of Patients with Ulcerative Colitis at a Tertiary Care Centre in Nepal

2019 ◽  
Vol 8 (2) ◽  
pp. 26-29
Author(s):  
Rahul Pathak ◽  
Tshering Wangdi Sherpa ◽  
Anurag Jha ◽  
Rabin Hamal ◽  
Sabin Thapallya
Keyword(s):  
Ulcerative Colitis ◽  
Clinical Characteristics ◽  
Severe Disease ◽  
Descriptive Analysis ◽  
Tertiary Care ◽  
Clinical Manifestations ◽  
Common Symptom ◽  
Tertiary Care Centre ◽  
Cross Sectional ◽  
Colonoscopic Examination

Introduction: The prevalence of ulcerative colitis (UC) has gradually increased in Asia over the last few decades. However, there is a paucity of data regarding UC in Nepal. This study analyzed the socio-demographic and clinical characteristics of patients hospitalized with UC. Methods: This is a hospital based, cross-sectional study. Data was collected among 100 individuals admitted to the hospital with UC from June 2016 to May 2018. A descriptive analysis of the demographic and clinical characteristics was done. Results: Of the 100 patients 51 were male (M:F ratio 1.04:1). Average age at diagnosis was 38}12.53 years. 55% of the patients were Brahmins, 16% Kshetris, 8% Newars, 1% Muslim while the remaining 20% belonged to other indigenous ethnic groups. 79% of the patients were newly diagnosed cases while remaining 21% were admitted for acute flares of the disease. Rectal bleeding (85%) was the most common symptom followed by diarrhea (70%), tenesmus (63%), urgency (61%), pain abdomen (44%), weight loss (14%), fever (7%) and constipation (4%). Clinically, 41% had mild, 46% had moderate and 12% had severe disease activity. Extra intestinal manifestations were seen only in 12% of the patients. On colonoscopic examination, 41% had proctitis, 46% had left sided colitis and 13% had extensive colitis. Conclusion: Our study showed some differences in the demographic variables as well as clinical manifestations in the patients when compared to data from the west and even other Asian countries like India and China. Larger population-based studies are needed to better understand the epidemiology and characteristics of the disease in Nepal.  

scholarly journals Clinico-demographic profile of deceased patients with coronavirus disease in a tertiary care centre of central India

2021 ◽  
Vol 8 (5) ◽  
pp. 2474
Author(s):  
Rupali A. Patle ◽  
Ashok R. Jadhao ◽  
Priya B. Dhengre ◽  
Manjusha A. Dhoble
Keyword(s):  
Clinical Characteristics ◽  
Tertiary Care ◽  
Case Fatality ◽  
Central India ◽  
Cross Sectional Study ◽  
Common Symptom ◽  
Care Hospital ◽  
Tertiary Care Centre ◽  
Cross Sectional ◽  
The Difference

Background: The covid pandemic started from Hubei, Wuhan in December 2020 then covered many other countries including India. Understanding the demographic and clinical characteristics of deceased COVID-19 patients could inform public health interventions focusing on preventing mortality due to COVID-19. The present study was done with the objective of studying the socio-demographic and clinical profile of deceased patients with coronavirus disease.Methods: This is a hospital based cross-sectional study on 1190 deceased patients of coronavirus disease in a tertiary care hospital of central India which is a dedicated covid hospital from 11 March 2020 to 28 February 2021. Socio-demographic and clinical characteristics of deceased patients were recorded.Results: Overall case fatality rate was 13.24%. Maximum number of deaths occurred in the month of August 2020 and September 2020 were 372 (31.26%) and 477 (40.08%). It was higher in the males 791 (66.47%) as compared to females 399 (33.53%), but the difference was not significant. The most common symptom was fever on hospitalization 924 (77.65%), followed by generalized weakness 771 (64.79%). 352 (29.58%) patients died within 24 hours of the admission to hospital. Hypertension and type 2 diabetes mellitus were the most prevalent morbidity in 557 (46.80%) and 357 (30.00%). It was found that 232 (19.50%) deceased patients had oxygen saturation less than 50% on admission.Conclusions: Higher age and presence of co-morbidities at the time of admission were significantly associated with mortality.

CLINICAL CHARACTERISTICS AND OUTCOME OF PATIENTS WITH SEVERE ACUTE RESPIRATORY INFECTION (SARI) DURING COVID PANDEMIC OF A TERTIARY CARE HOSPITAL IN CHENNAI

2021 ◽  
pp. 29-31
Author(s):  
Vengada Krishnaraj S.P ◽  
Roshan Kumar. M ◽  
Vinod Kumar. V ◽  
Reetu Singh G
Keyword(s):  
Respiratory Infection ◽  
Acute Respiratory Infection ◽  
Clinical Characteristics ◽  
Care Center ◽  
Tertiary Care ◽  
Clinical Manifestations ◽  
Common Symptom ◽  
Care Hospital ◽  
Cross Sectional ◽  
Severe Acute Respiratory Infection

BACKGROUND: SARI is one of the clinical manifestations of COVID-19 disease. As per WHO SARI is dened as an acute respiratory infection with a history of fever or measured fever of ≥ 38 C°; and cough with onset within the last 10 days and requires hospitalization. AIMS/OBJECTIVES: To describe clinical characteristics and factors associated with the clinical outcome of patients presenting with SARI at our hospital. METHODOLOGY: This is a record-based cross-sectional study that included all cases admitted in the SARI ward in Government Stanley Hospital, a tertiary care center in Chennai designated for the management of case denition and screened for SARS-CoV-2/COVID-19 between 15th March 2020 and 15th December 2020.RESULTS:Atotal of 246 patients were included in the study period from 15th March to 15th May 2020. The median age was 49.4 years and 56.9% were males. The most common symptom was fever (69.1%) followed by cough (62.6% ), Breathlessness (62.6%), and sore throat (52.8%) in our study. Of this 4 (1.8%) were tested positive for COVID-19. Of the 5 (2.1 %) patients who expired. CONCLUSION: In our single-center tertiary the incidence of COVID-19 among the SARI patients done between March-May 2020 showed an incidence rate of 1.8%

scholarly journals Demographic Profile and Extra Intestinal Manifestations of Ulcerative Colitis in Nepalese population: Study from TUTH a Tertiary Care Centre, Kathmandu, Nepal

2015 ◽  
Vol 4 (1) ◽  
pp. 1-5
Author(s):  
Shaneel Harsh ◽  
Ananya Adhikari ◽  
Parmatma Parazuli ◽  
Rahul Pathak ◽  
Prem K Khadga ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Age Of Onset ◽  
Severe Disease ◽  
Tertiary Care ◽  
Data Bank ◽  
Health Care Facilities ◽  
University Teaching ◽  
Cultural Variation ◽  
Tertiary Care Centre ◽  
Demographic Profile

Background and Aims: This study aims at determining the demographic profile and extra-intestinal manifestations of Ulcerative Colitis in the Nepalese patients treated in a tertiary referral centre.Methods: The study was conducted between February 1, 2014 and January 31, 2015 at the Department of Gastroenterology Tribhuvan University Teaching Hospital, Kathmandu, Nepal. The clinical and epidemiologic data from patients diagnosed to have Ulcerative Colitis were obtained and analysed.Results: During the study period, 60 patients were identified as having ulcerative colitis. Mean age at diagnosis was 34.6 years. The mean duration of illness at diagnosis was 3.7 years. Extra-intestinal manifestations (EIM) were seen in 16.6% of the patients. Sacroilitis was the most common EIM seen in11.6% followed by peripheral arthritis in 6.6% of the patients. Episcleritis, Primary Sclerosing Cholangitis and Erythema Nodosum were seen only in 1.6% each. At the time of presentation, 38.3% (n=23) had proctosigmoiditis , 50% (n=30) left sided colitis and pancolitis was seen in 11.7% (n=7).53.3% patients had mild disease, 38.3% and 8.3 % presented with moderate to severe disease respectively.Conclusion: Peak age of onset for UC in the study was third and fourth decade which was similar to the various studies from Asia and West. Musculoskeletal manifestation was the most common extra- intestinal manifestation of UC in Nepalese population. As Nepal is perhaps the most diverse country in terms of ethnicity, cultural variation, socio-economic status and health care facilities, a comprehensive nationwide data bank involving ethnicity and geographical variation is needed for a better definition of the disease characteristics.Journal of Advances in Internal Medicine 2015;04(01):1-5.

scholarly journals Maternal and perinatal morbidity and mortality in COVID-19 positive obstetrics patients in tertiary care centre

2021 ◽  
Vol 10 (7) ◽  
pp. 2676
Author(s):  
Medha . ◽  
Neeta Chaudhary ◽  
Smita Tyagi ◽  
Kirtigiri G. Goswami
Keyword(s):  
Intensive Care ◽  
Neonatal Outcome ◽  
Tertiary Care ◽  
Common Symptom ◽  
Tertiary Care Centre ◽  
Cross Sectional ◽  
Health Crisis ◽  
Medical College ◽  
Satisfactory Condition ◽  
Fluctuating Course

Background: COVID-19 disease had been declared as a public health crisis by WHO by the end of 2019. The effect of SARS-CoV-2 infection on pregnancy including symptoms, disease severity, risk of vertical transmission and perinatal and neonatal outcome have been the subject of research. Preliminary studies showed a fluctuating course of the disease ranging from asymptomatic or mild symptoms to even maternal death. However, recent evidences suggest that effect of COVID-19 infection during pregnancy may not lead to adverse maternal and neonatal outcome.Methods: In this cross sectional prospective observational study, we analysed 60 pregnant women infected with SARS- CoV-2 and their neonatal outcome, who tested positive for COVID-19 at district hospital, and were referred to Muzaffarnagar Medical College, were enrolled in this study.Results: The majority 96.7% (58) of these women were asymptomatic with cough being the most common symptom which was present in 3.3% (2) of the women. 24(75%) women developed pneumonitis radiologically, but they were asymptomatic, so intensive care was not required. Along with 76.08% (35) perinatal/neonatal outcomes were observed normal.Conclusions: In this study we observed that most of the women with COVID-19 were asymptomatic or with mild symptoms. Even though they were asymptomatic, most of the patients showed pneumonitis changes radiologically but still they didn’t require any intensive care, had good recovery postpartum and were discharged under satisfactory condition. The neonatal outcome was highly favourable.

scholarly journals Evaluation of mineral status in hypothyroidism in a tertiary care centre

2020 ◽  
Vol 8 (2) ◽  
pp. 667
Author(s):  
Shikha Saxena ◽  
Prem Chandra Srivastava ◽  
Rashmi Katyal ◽  
Biswajit Das ◽  
Sileena Jaideep Pannu
Keyword(s):  
Serum Calcium ◽  
Serum Magnesium ◽  
Tertiary Care ◽  
Clinical Manifestations ◽  
Serum Zinc ◽  
The Body ◽  
Endocrine Disorders ◽  
Tertiary Care Centre ◽  
Cross Sectional ◽  
Mineral Status

Background: Hypothyroidism is known to be the commonest form of endocrine disorders and has been linked with disturbances in various minerals metabolism. Calcium, phosphorus and magnesium and trace element zinc are required for many enzymes in various metabolic pathways which are directly or indirectly regulated by thyroid hormones. Aim and objectives of the study was to estimate serum zinc, calcium, magnesium and phosphorus in hypothyroid patients, with the objectives to evaluate any relationship with TSH and to compare them with euthyroid controls.Methods: The analytical cross-sectional study included 50 hypothyroid subjects with TSH levels >4.5 mcg IU/mL and 50 euthyroid subjects of 20-50 years in RMCH, Bareilly. TSH was estimated by ECLIA, serum calcium and phosphorus were estimated by autoanalyzer and serum zinc & magnesium by the kit method using semi autoanalyzer. All the biochemical parameters were expressed as median with Interquartile Range (IQR). Mann-Whitney test was applied to compare the parameters of cases and control. Spearman’s rank correlation coefficient 2-tailed was used to correlate the parameters among the cases.Results: A significantly decreased level of serum calcium and increased level of serum magnesium and phosphorus were observed in hypothyroid cases. A significant negative correlation between TSH and serum calcium while a significant positive correlation of serum magnesium and phosphorus with TSH was observed.Conclusions: The indexed study indicates the significant effect of overt or subclinical hypothyroidism over the mineral status of the body which may have inconsistent effect over the various metabolism and enzymes and thereby clinical manifestations.

scholarly journals Profile of COVID-19 patients in COVID dedicated tertiary care centre in Himachal Pradesh: a prospective observational cross sectional study

2021 ◽  
Vol 9 (11) ◽  
pp. 3284
Author(s):  
Roshan Lal ◽  
Rajesh K. Bhawani ◽  
Santosh K. Dheer ◽  
Nitesh Kumar ◽  
Soni Kumar
Keyword(s):  
Senior Citizens ◽  
Severe Disease ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Shortness Of Breath ◽  
Tertiary Care Centre ◽  
Specific Therapy ◽  
Cross Sectional ◽  
Poor Outcome ◽  
Initial Stage

Background: COVID-19 pandemic originated in China in December 2019 and fumed in whole world over few months. Millions of deaths have occurred worldwide till now because of this pandemic. Causative agent was identified as severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) causing viral pneumonia and serious manifestations were seen in association with increased age and comorbidies.Methods: This study was planned in very initial stage of pandemic in our country to study the profile of COVID-19 patients. This study was conducted over a period of six months from April 2020 to September 2020 at SLBSGMCH, Mandi at Nerchowk.Results: 202 patients were enrolled for this study with mean age of presentation 48 years, 61 were females, 147 (72%) were senior citizens, most patients were from district Mandi and most common symptoms were fever (58%), cough (46%), shortness of breath (35%) and associated commonest comorbidities were hypertension (HTN) (29%) and diabetes (23%). Median neutrophil to lymphocyte ratio (NLR) was higher (5.47) in moderate to severe disease and associated with poor outcome. All the 11 patients who were put on support of ventilator, succumbed to death.Conclusions: Most common symptoms were fever, cough, shortness of breath and most common comorbidty was HTN. Comorbidity, increased age and higher NLR were risk factors for severity and poor outcome. More research is needed to save mankind from this pandemic as still no specific therapy is available against this virus.

scholarly journals Mycological Profile in Otomycosis Patients: A Cross Sectional Hospital Based Study in Tertiary Care Centre

2019 ◽  
Vol 27 (3) ◽  
pp. 193-197
Author(s):  
Nitin Ankale ◽  
Jyoti M Nagmoti ◽  
Utkarsh Anand
Keyword(s):  
Fungal Pathogens ◽  
Tertiary Care ◽  
Fungal Species ◽  
Tropical Region ◽  
Common Symptom ◽  
Tertiary Care Centre ◽  
Humid Climate ◽  
Cross Sectional ◽  
Agar Media ◽  
Hot Humid Climate

Introduction This study was conducted to study the fungal profile in otomycosis patients in the tropical region of North Karnataka. A total of 108 samples of symptomatic otomycosis were investigated in this study. Materials and Methods Aural swabs were collected on 1st visit and these swabs were immediately inoculated over Sabouraud’s dextrose agar media and incubated at 37 degree Celsius for culture of fungi. Results Fungal pathogens were isolated in 89 samples, 18 samples were negative and 1 sample was reported as being contaminated. Fungi belonging to genus Aspergillus was isolated in 92.11% of cases of which Aspergillus niger was commonest isolated in 38(41.57%) followed br Aspergillus flavus 32(35.95%) and Aspergillus fumigatus 7(7.86%). Candida species were found in 2(2.24%) and Mucor in 1(1.12%). The most common symptom was Itching 91(84.25%). In this study ear discharge was the commonest finding (44.44%) followed by Black mycotic plug (28.70%). Conclusion Otomycosis is a condition encountered in hot, humid climate with symptoms like itching and ear discharge. Aspergillus and Candida are the fungal species responsible for majority of cases. Local antifungal treatment with measures like keeping the ear dry resolves most of the cases.

scholarly journals Clinical Characteristics of Ulcerative Colitis in Nepalese Population: Experience from a Tertiary Care Center TUTH, Kathmandu, Nepal

2015 ◽  
Vol 4 (1) ◽  
pp. 1-6
Author(s):  
Shaneel Harsh ◽  
Ananya Adhikari ◽  
Rahul Pathak ◽  
Prem K Khadga ◽  
Sashi Sharma
Keyword(s):  
Ulcerative Colitis ◽  
Clinical Characteristics ◽  
Care Center ◽  
Tertiary Care ◽  
Epidemiological Data ◽  
Cross Sectional Study ◽  
Western World ◽  
Asian Countries ◽  
Cross Sectional ◽  
Duration Of Disease

Background and Aim: Rising incidence and prevalence of ulcerative colitis (UC) had been observed in Asian countries. We conducted a study in our center, aiming to describe the demographic and clinical characteristics of UC in Nepalese population.Method: This is a cross sectional study of patients with diagnosis of UC in our hospital from Feb 2014 to Jan 2015. The diagnosis of UC has to satisfy the internationally accepted criteria. All patients were Nepalese and Clinical and epidemiological data were obtained and analysed through SPSS version 20.Results: 60 patients were included in the study. Mean age at diagnosis was 34.6 years. Male had slight preponderance with M:F (1.06:1). Mean duration of disease at diagnosis was 3.7 years. 83% had rectal bleed, Diarrhoea was seen in 77.3%, Tenesmus and Urgency in 70%, Mucus in stool was found in 65%, abdominal pain in 55%. 16.7% had weight loss and extraintestinal manifestations whereas fever was seen in 8.3%. In our patients 38.3% had ulcerative proctitis and 50% had left-sided UC, whereas 11.7% had extensive UC at presentation. The majority presented with mild (53.3%) or moderate (38.3%) disease activity, only 8.3% with severe disease.Conclusions: The peak age of UC was similar to other Western and Asian countries but second peak reported in western countries have not been seen in this study. This finding is similar to reports from East Asia. Similarly the proportion of patients with extra intestinal manifestations was low in our study as compared to studies reported from western world. Our study also showed that it takes longer to diagnose UC in Nepal. This might be related to the unawareness of the patients’ and lack of availability of the diagnostic resources.Journal of Nobel College of Medicine Vol.4(1) 2015: 1-5

scholarly journals Disease Severity, Clinical Characteristics and Outcome of Patients Hospitalized with Novel Coronavirus Disease at a Tertiary Care Hospital, Rawalpindi

2021 ◽  
Vol 2 (4) ◽  
pp. 6
Author(s):  
Muhammad Mahtab Shabir ◽  
Shazia Nisar ◽  
Zobia Urooj ◽  
Uzma Qayyum ◽  
Fozia Fatima ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Pulmonary Disease ◽  
Disease Severity ◽  
Clinical Characteristics ◽  
Severe Disease ◽  
Tertiary Care ◽  
Care Hospital ◽  
Cross Sectional ◽  
Number Of Patients ◽  
Novel Coronavirus

Objective: To describe the clinical characteristics, signs & symptoms, disease severity, and outcome of patientsadmitted with novel coronavirus infection.Study Design: Comparative cross-sectional study.Place and Duration of Study: The study was conducted in the Department of Medicine of Pak-Emirates Militaryst th Hospital, (PEMH), Rawalpindi from May 1 , 2020 to June 30 , 2020.Materials and Methods: Patients hospitalized with novel corona virus infection during the study period wereprospectively enrolled in this study. Patients at least 15 years and above, either gender, hospitalized withconfirmed diagnosis of covid-19 (SARS-CoV-2) were eligible to be enrolled. The study outcomes includeddisease presentation, severity at time of reporting, admission to critical care or intensive care unit andmortality. Patients were identified as mild, moderate, severe and critical in accordance with World HealthOrganization guidelines, based on symptom severity, laboratory and imaging findings.Results: There were 400 hospitalized patients with confirmed SARS-CoV-2, out of which 51 (12.8%) werefemales, while 349 (87.3%) were males with overall mean age of 48.45±16.2 years. There were 300 (75.0%)patients with mild disease severity, while 65 (16.3%), 20 (5.0%) and 15 (3.8%) with moderate, severe and criticaldisease condition, respectively. The number of patients died were 22, with fatality rate of 5.5%. Age andpresence of comorbidities (cardiac disease, diabetes, hypertension, pulmonary disease, kidney disease) weresignificantly associated with disease severity and death due to novel coronavirus infection.Conclusion: Patients with older age, diabetes, hypertension, pulmonary disease, kidney disease were at higherrisk of developing severe disease condition and death due to novel coronavirus infection.

scholarly journals Hospital Based Prevalence of SARS-CoV-2 and Clinico-Demographic Profile of COVID-19 Patients: A Study from a Tertiary Care Hospital of North India

2021 ◽  
pp. 126-136
Author(s):  
Anjum Farhana ◽  
Shoaib Khan ◽  
Reyaz Khan ◽  
Umara Amin
Keyword(s):  
Severe Disease ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
North India ◽  
Common Symptom ◽  
Care Hospital ◽  
Cross Sectional ◽  
Medical College ◽  
History Of ◽  
One Year

Aims: To find out the prevalence, predominant risk factors and various clinico-demographic variables among patients infected with SARS-CoV-2 during the first year of the pandemic. Study Design: Hospital based, cross sectional study. Place and Duration of Study: Postgraduate department of Microbiology, Government Medical College, Srinagar, and associated hospitals, between March 2020 and March 2021. Methodology: Individuals with acute respiratory infection (ILI and SARI), high risk contacts and asymptomatic close contacts of COVID-19 positive patients, hospitalized patients dated for surgeries, pregnant women near expected date of deliveries, travellers were screened. A confirmed case of Covid-19 was defined as a positive result on real-time RT-PCR assay of nasopharyngeal and or Oropharyngeal swab specimens. A total of 2,17,665 samples were collected and processed over a period of one year. Results: Out of 2,17,665 samples, 61.3% were males and 38.7% were females, overall mean age was 34.3 years. 24,009 (11%) tested positive for SARS-CoV-2 infection, among them 63.5% were males while 36.5% were females, the mean age observed was 35.3 years. Highest positivity was observed in the age group of 30 – 39 years (22%), followed by 20 -29 years (20.4%), 12 (0.1%). Among positive cases, 19.4% had a history of contact with a lab confirmed case of SARS-CoV-2, 4.3% were HCW’s and 2.6% were pregnant females. 929 (3.9%) patients who tested positive had presented with SARI. Fever was the most common symptom (62%), followed by cough (41%) and fatigue was reported by 37% patients. Comorbidities were present in 23.2% patients, of which Hypertension 10.8% was the most common, followed by COPD 4.9% and Diabetes mellitus 4%. Conclusion: As evident from our study, COVID-19 has a high positivity (11%) in our region, with males twice more likely susceptible than females. High percentages (62%) of people were symptomatic at presentation, while severe disease was seen in only 3.9% patients. Early aggressive testing is essential to decrease the morbidity and mortality rates associated with COVID-19.

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