scholarly journals Depression among Chronic Kidney Diseases Patients Receiving Hemodialysis

2020 ◽  
Vol 3 (2) ◽  
pp. 73-79
Author(s):  
Shanti Khadka ◽  
Rita Adhikari ◽  
Tarun Paudel
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Kidney Diseases ◽  
Cross Sectional ◽  
Prevalence Of Depression ◽  
Depression Level ◽  
Western Regional ◽  
Stage Renal Disease ◽  
End Stage

Background: Chronic Kidney Disease (CKD) is a progressive irreversible loss of renal function over a period of months or years. When kidney disease progresses, it may eventually lead to kidney failure, which requires dialysis or a kidney transplant to maintains life. Hemodialysis is used for patients who require short term dialysis (days to weeks) and for patients with advanced CKD and End Stage renal Disease (ESRD) who require long term or permanent renal replacement therapy. Hemodialysis significantly and adversely affects the lives of patients, both physically and psychologically. Depression is the most common psychological condition among patients with ESRD. Depression in dialysis patients not only effect mortality, but increased rate of hospitalizations and dialysis withdrawal is also very common. Methods: A descriptive cross sectional research design was carried out to identify the depression level of chronic kidney disease patients receiving Hemodialysis in Western Regional Hospital, Pokhara using Beck Depression Inventory among forty six patients. Results: The study findings revealed that majority of the patients (84.8%) has various degree of depression i.e. mild (21.7%), moderate (30.8%) and severe (32.6%). Only fifteen percent of patient has no depression. There was no statistical association between the level of depression and socio-demographic variables. It can be concluded that the prevalence of depression is high among patients receiving Hemodialysis. Conclusion: The prevalence of depression is high among patients receiving Hemodialysis. It is effective to provide mental health services to the CKD patients receiving Hemodialysis which help them better psychologically adaptation to their disease and improve their quality of life.  

scholarly journals PROTON PUMP INHIBITORS AND THE RISK OF CHRONIC KIDNEY DISEASES: A CRITICAL REVIEW

2020 ◽  
pp. 11-14
Author(s):  
SHAREEF J. ◽  
SRIDHAR S. B. ◽  
SHARIFF A.
Keyword(s):  
Chronic Kidney Disease ◽  
Acute Kidney Injury ◽  
Kidney Disease ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
End Stage Renal Disease ◽  
Kidney Diseases ◽  
Kidney Injury ◽  
Stage Renal Disease ◽  
End Stage

Proton pump inhibitors (PPIs) are most widely used medications for acid related gastrointestinal disorders. Accessible evidence based studies suggest that the increased use of PPI is linked to a greater risk of developing kidney diseases. This review aims to determine the association of kidney disease with the use of proton pump inhibitor with various study designs. PubMed, Scopus and Google Scholar databases as well as a reference list of relevant articles were systematically searched for studies by using the following search terms; ‘proton pump inhibitors’, ‘acute kidney injury’, ‘chronic kidney disease’ and ‘end stage renal disease’. Both observational and randomized controlled trials (RCTs) exploring the association of PPI use with kidney disease were eligible for inclusion. A total of 8 articles, including 9 studies (n = 794,349 participants) were identified and included in the review. Majority of the studies showed a higher risk of kidney outcomes in patients taking PPIs, with effect higher of acute kidney injury (4-to 6-fold) compared with chronic kidney disease and end stage renal disease (1.5-to 2.5-fold). However, the studies suggest that the strength of evidence is weak and could not prove causation. The risk increased considerably with the use of high dose of PPIs and prolonged duration of exposure necessitates the monitoring of renal function. Exercising vigilance in PPI use and cessation of proton pump inhibitor when there is no clear indication may be a reasonable approach to reduce the population burden of kidney diseases.

scholarly journals The role of hemostatic disorders in the progression of chronic kidney disease

2019 ◽  
pp. 49-55
Author(s):  
I. Dudar ◽  
I. Mykhaloiko
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Kidney Diseases ◽  
Public Health Problem ◽  
Premature Death ◽  
Coagulation System ◽  
Global Public Health ◽  
Stage Renal Disease ◽  
End Stage ◽  
Hemostatic Disorders

Chronic kidney disease (CKD) has become a global public health problem because of its high prevalence and the accompanying increase in the risk of end-stage renal disease, cardiovascular disease, and premature death. At present there is a number of experimental and clinical data that show that one of the important mechanisms of the pathogenesis of CKD is a violation of the blood coagulation system (hemostasis) both locally in the kidneys and with the capture of the microcirculatory channel of other organs, therefore an important task for specialists in the  nephrology, as well as doctors of other specialties is  understanding  the functioning of the system of hemostasis in normal and in various kidney diseases and the correction of this pathology with drugs. There are several types of haemostasis disorders that may occur in CKD: disseminated intravascular coagulation syndrome (DIC), arterial and venous thrombosis and bleeding. In this review, we tried to determine the place of the DIC in the development and progress of the CKD and to assess the prospects for further research.

scholarly journals Diálise Peritoneal nos Dois Primeiros Anos de Vida: Experiência de uma Unidade de Nefrologia e Transplantação Renal Pediátrica

2016 ◽  
Vol 29 (9) ◽  
pp. 525
Author(s):  
Sofia Deuchande ◽  
Tânia Mano ◽  
Cristina Novais ◽  
Rute Machado ◽  
Rosário Stone ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Peritoneal Dialysis ◽  
Renal Transplantation ◽  
Kidney Disease ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Term Survival ◽  
Stage Renal Disease ◽  
End Stage

Introduction: Peritoneal dialysis is the dialytic method of choice in chronic end-stage renal disease in children. This study main purposewas to characterize the long-term survival of a pediatric population who began peritoneal dialysis within the first two years of life.Material and Methods: A descriptive and retrospective study was performed in a portuguese nephrology and renal transplantation pediatric unit, between January 1991 and August 2014. End-stage renal disease etiology, mortality, comorbidities and complications of peritoneal dialysis and end-stage renal disease, growth and psychomotor development were evaluated.Results: Twenty children started peritoneal dialysis within the first two years of life. There were six deaths, but no deaths of children with primary chronic kidney disease were registered over the past decade. The 14 living children were characterized; 13 were males. Congenital abnormalities of the kidney and urinary tract were the leading etiology of chronic kidney disease (45%). The average age start of peritoneal dialysis was 6.1 months; six children started before 30 days of life. Peritonitis was the most frequent cause of hospitalization. Ten children were transplanted at an average age of 5.3 years. All of the children who are still in peritoneal dialysis have short stature, but nine of the transplanted have final height within the expected for their mid-parental height target range. Nine (64%)had some type of neurodevelopmental delay.Discussion: Peritoneal dialysis is a technique possible and feasible since birth, as evidenced in the study, as more than half of children successfully started it before 6 months of life. It allows long-term survival until the possibility of renal transplantation despite the associated morbidity, including peritonitis and complications of chronic renal disease. The ten transplanted children improved their growth, recovered from chronic anemia and improved dyslipidemia, compared with the period of dialysis. However, the average waiting time until the renal transplant was 5.3 years higher than other international centers.Conclusion: These data support the use of peritoneal dialysis from birth, but complications and the worst growth reflect the need to develop strategies to optimize care relating to nutrition, growth and development and to reduce pre-transplant time.

scholarly journals Polymorphisms inPPARGenes (PPARD,PPARG, andPPARGC1A) and the Risk of Chronic Kidney Disease in Japanese: Cross-Sectional Data from the J-MICC Study

PPAR Research ◽  
2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Asahi Hishida ◽  
Kenji Wakai ◽  
Mariko Naito ◽  
Takashi Tamura ◽  
Sayo Kawai ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Risk Estimation ◽  
Cross Sectional ◽  
Increased Risk ◽  
Invader Assay ◽  
Study Population ◽  
Stage Renal Disease ◽  
End Stage ◽  
Study Participants

Chronic kidney disease (CKD) is well known as a strong risk factor for both end stage renal disease and cardiovascular disease. To clarify the association of polymorphisms in thePPARgenes (PPARD,PPARG, andPPARGC1A) with the risk of CKD in Japanese, we examined this association among the Japanese subjects using the cross-sectional data of J-MICC (Japan Multi-Institutional Collaborative Cohort) Study. The subjects for this analysis were 3,285 men and women, aged 35–69 years, selected from J-MICC Study participants; genotyping was conducted by multiplex polymerase chain reaction-based Invader assay. The prevalence of CKD was determined for CKD stages 3–5 (defined as eGFR < 60 ml/min/1.73 m2). Participants with CKD accounted for 17.3% of the study population. When those withPPARDT-842CT/Twere defined as reference, those withPPARDT-842CT/CandC/Cdemonstrated the OR for CKD of 1.26 (95%CI 1.04–1.53) and 1.31 (95%CI 0.83–2.06), respectively. There were no significant associations between the polymorphisms in otherPPARgenes and the risk of CKD. The present study found a significantly increased risk of CKD in those with theCallele ofPPARDT-842C, which may suggest the possibility of personalized risk estimation of this life-limiting disease in the near future.

scholarly journals Causes of End Stage Kidney Disease in Maintenance Hemodialysis Patients in District Swat, Khyber Pukhtonkhwa Pakistan

2021 ◽  
Vol 5 (02) ◽  
Author(s):  
Fawad Khalid ◽  
Asad ullah Khan ◽  
Adnan Fazal
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Kidney Diseases ◽  
Cross Sectional Study ◽  
Maintenance Hemodialysis ◽  
Cross Sectional ◽  
Hospital District ◽  
High Prevalence ◽  
One Year ◽  
End Stage

Chronic kidney disease (CKD) affects 10–15% of the population worldwide and its prevalence is increasing. Objective: To find the frequency of common diseases causing chronic kidney diseases (CKD) in dialysis dependent patients in District Swat, Khyber Pukhtonkhwa. Methodology: Cross sectional study at Department of Nephrology Nawaz Sharif Kidney Hospital, District Swat, Khyber Pukhtonkhwa, Pakistan. Results: Total of 110 patients were undergoing maintenance hemodialysis. There were 53(48.2%) male and mean age was 54.40+ 16.32 years. Among 110 patients, only 9 (8.2%) had dialysis once per week and 101(91.8%) had dialysis twice per week hemodialysis. Majority, 64(58.2%) patients were undergoing dialysis less than one year. 6(5.5 %) had hypertension, 33(30%) had diabetes and 68(61.8%) patients had both Diabetes and Hypertension. Out of 110, 39(35.5%) patients were Hepatitis B positive, and 28(25.5%) patients had Hepatitis C. Conclusion:  Results of this study showed that the leading cause of chronic kidney disease (CKD) among dialysis patients was diabetes mellitus with or without hypertension and a high prevalence of both HBV and HCV.

scholarly journals Harmonizing Formula Prescription Patterns for Chronic Kidney Disease: A Population-Based Cross-Sectional Study

2020 ◽  
Author(s):  
Hung-Lung Lin ◽  
Ming-Yen Lin ◽  
Cheng-Hsun Tasi ◽  
Yi-Hsiu Wang ◽  
Chung-Jen Chen ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Patient Characteristics ◽  
Target Population ◽  
Population Based ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Stage Renal Disease ◽  
End Stage

Abstract Background Harmonizing formulas have been demonstrated to be associated with reduced risk of end-stage renal disease in patients with chronic kidney disease (CKD). However, the target population and indications of harmonizing formulas in CKD remain unknown. Methods We conducted a population-based cross-sectional study to explore factors associated with harmonizing formulas prescription. Patients who had been prescribed harmonizing formulas after CKD diagnosis were defined as the using harmonizing formulas group. Disease diagnoses for harmonizing formula prescriptions and patient characteristics related to the prescriptions were collected. Results In total, 24,971 patients were enrolled in this analysis, and 5,237 (21%) patients were prescribed harmonizing formulas after CKD diagnosis. The three most frequent systematic diseases and related health problems for which harmonizing formula prescriptions were issued in CKD were symptoms, signs, and ill-defined conditions (24.5%), diseases of the digestive system, (20.67%), and diseases of the musculoskeletal system (12.9%). Higher likelihoods of harmonizing formula prescriptions were associated with young age (adjusted odds ratio: 0.98, 95% confidence interval: 0.97–0.98), female sex (1.79, 1.68–1.91), no diabetes (1.20, 1.06–1.35), no hypertension (1.38, 1.26–1.50), no cerebrovascular disease (1.34, 1.14–1.56), less disease severity (0.86, 0.83–0.89), using nonsteroidal anti-inflammatory drugs (NSAIDs) (1.65, 1.54–1.78), and using analgesic drugs other than NSAIDs (1.46, 1.35–1.59). Conclusions Harmonizing formulas are commonly used for treating symptoms of the digestive and musculoskeletal systems in CKD cases. Further research on harmonizing formula effectiveness with regard to particular characteristics of CKD patients is warranted.

scholarly journals FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN KEPATUHAN PEMBATASAN CAIRAN PASIEN GAGAL GINJAL TERMINAL YANG MENJALANI HEMODIALISIS DI SATU RUMAH SAKIT SWASTA DI INDONESIA BARAT [FACTORS ASSOCIATED WITH ADHERENCE TO FLUID RESTRICTION TOWARDS PATIENTS WITH END STAGE RENAL DISEASE UNDERGOING HEMODIALYSIS IN A PRIVATE HOSPITAL, WEST INDONESIA]

2020 ◽  
Vol 8 (1) ◽  
pp. 56
Author(s):  
Eva Chris Veronica Gultom ◽  
I Made Kariasa ◽  
Masfuri Masfuri
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Fluid Restriction ◽  
Cross Sectional ◽  
Self Compassion ◽  
Fluid Adherence ◽  
Stage Renal Disease ◽  
End Stage

<p><em>End Stage Renal Disease is the final stage of the Chronic Kidney Disease (CKD) with a Glomerular Filtration Rate (GFR) value of less than 15 ml / min / 1.73m². End Stage Renal Disease can be treated with hemodialysis therapy </em>(<em>National Kidney Foundation</em>, <em>2015</em>; <em>Thomas, 2014</em>).<em> The hemodialysis provides fluid resctrictions for patients who undergo. There are many factors that make fluid restrictions adherence difficult to do. (Chironda&amp;Bhengu, 2015). The biggest and dominant factor is psychological factor, which is self compassion. </em><em>Self compassion is the attitude of giving compassion to oursel</em><em>ves</em><em>, so that when a patient undergoing hemodialysis in difficult conditions is able to assume the situation is the same as other people, and does not punish themselves and have motivation in undergoing a therapeutic regimen.</em><em> </em><em>The purpose of this study was to identify </em><em>factors</em><em> </em><em>that have corelation to </em><em>fluid adherence in end stage renal disease patients undergoing hemodialysis. This study used a cross sectional method, with 89 end stage renal disease patients who underwent hemodialysis three times a week</em><em> </em><em>and who were selected using a purposive sampling technique. The results showed that the majority of patients had high self compassion (69.7%). The corelation of self compassion with fluid adherence was not significant (p=0,076), other factors affecting fluid adherence were age (p=0.033), gender (p= 0,937), marital status (p = 0.473), working status ( p = 0,885), level of education (p= 0,126), length of undergoing hemodialysis (p = 0,425), and social support (p =0,206) The results of multivariate analysis showed that the most dominant facto</em><em>r</em><em>s related to fluid restriction adherence was age. This research is expected to be a reference for nurses in developing nursing studies in end stage renal disease patients undergoing hemodialysis</em><em></em></p><p><strong>BAHASA INDONESIA ABSTRAK: </strong>Gagal ginjal terminal merupakan tahap akhir dari kondisi <em>Chronic Kidney Disease</em> (CKD) dengan nilai <em>Glomerulus Filtrasi Rate</em> (GFR) kurang dari 15 ml/menit/1,73m². Gagal ginjal terminal dapat ditangani dengan terapi hemodialisis. Adanya hemodialisis ini memberikan pembatasan cairan pada pasien yang menjalaninya. Kepatuhan pembatasan cairan pada sebagian pasien sulit untuk dilakukan dengan alasan banyak faktor, yakni usia, jenis kelamin, tingkat pendidikan, status bekerja, lama menjalani hemodialisis, status menikah, dan dukungan sosial. Faktor yang terbesar dan dominan adalah faktor psikologis, yakni <em>self compassion.</em> <em>Self compassion</em> merupakan sikap memberikan belas kasih kepada diri sendiri, sehingga ketika seorang pasien yang menjalani hemodialisis dalam kondisi sulit mampu menganggap situasinya adalah sama dengan orang lain, dan tidak menghukum diri sendiri serta memiliki motivasi dalam menjalani regimen terapi. Tujuan penelitian ini adalah untuk mengidentifikasi faktor-faktor yang berhubungan dengan kepatuhan pembatasan cairan pasien gagal ginjal terminal yang menjalani hemodialisis. Penelitian ini menggunakan metode <em>cross sectional, </em>sebanyak 89 pasien pasien gagal ginjal terminal yang menjalani hemodialisis dalam tiga kali seminggu yang dipilih menggunakan teknik <em>purposive sampling. </em>Hasil penelitian menunjukkan bahwa mayoritas pasien memiliki <em>self compassion</em> tinggi (69,7%). Hubungan <em>self compassion</em> dengan kepatuhan pembatasan cairan tidak signifikan (p=0,076), faktor lain yang mempengaruhi kepatuhan pembatasan cairan adalah adalah usia (p=0,033), jenis kelamin (p=0,937), status menikah (p=0,473), status bekerja<em> </em>(p=0,885), tingkat pendidikan (p=0,126), lama menjalani hemodialisis (p=0,425), dan dukungan sosial (p=0,206). Hasil analisis multivariat menunjukkan faktor yang paling dominan berhubungan dengan kepatuhan pembatasan cairan adalah usia. Penelitian ini diharapkan dapat menjadikan acuan bagi perawat dalam mengembangkan pengkajian keperawatan pada pasien gagal ginjal terminal yang menjalani hemodialisis.</p>

scholarly journals Neutrophil Lymphocyte Ratio and C-Reactive Protein in Nondialysis Chronic Kidney Disease

2021 ◽  
Vol 1 (1) ◽  
pp. 112-119
Author(s):  
Acang Nuzirwan ◽  
Budiman. S ◽  
Sussylawati. K ◽  
Vidia. T
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Composite Endpoint ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Reactive Protein ◽  
Stage Renal Disease ◽  
End Stage

Background: Chronic kidney disease (CKD) occurs when a disease or condition impairs kidney function, causing kidney damage to worsen over several months. Inflammatory markers such as C-reactive protein (CRP), Interleukine are widely used in CKD. However, those traditional biomarkers have their limitations because of its measurement is costly or inaccessible. Recently, the Neutrophil-to-lymphocyte ratio (NLR) was reported to be associated with inflammation in End-stage renal disease (ESRD). Its measurement is simpler and cheaper4.5. The aim of the present study was to determine whether NLR is associated with CRP in CKD patients. Methods: This cross-sectional and observational analytic study was conducted 12 consecutive Pre Hemodialysis patients ESRD between Mei 2021 and Augustus 2021. Subjects were divided into two groups according to the results of the examination of the CRP and NLR levels. Then analyzed whether there is have a correlation. Results: The composite endpoint was observed in 12 patients with ESRD; it was found that both of the values of NLR and CRP were equally increased in ESRD patients, although they were not statistically significant. Conclusion: The present study demonstrated that a high NLR in ESDR and suggesting that NLR may be a useful marker for the prediction of infection in patients with CKD.

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