Prevalence of Thyroid Dysfunction in Irritable Bowel Syndrome

INTRODUCTION: Irritable bowel syndrome (IBS) is a common public health problem. The condition is characterized by a scarcity of biological markers; thus, diagnostic definitions and classifications have relied to a large extent on symptoms, gastrointestinal manifestations of patients. While thyroid disorder should be considered in the differential diagnosis of patients with IBS symptoms, it is not clear if thyroid disturbances amongst patients with IBS are high enough to warrant routine screening. This study was done to see the prevalence of thyroid dysfunction in IBS patients and hence its significance. MATERIALS AND METHODS: A cross-sectional study conducted at the Gastroenterology OPD of the Tribhuvan University Teaching Hospital, Kathmandu, Nepal between March 2015 and April 2016. All the consecutive patients presumed to be Irritable bowel syndrome by Rome III criteria were enrolled in the study. Thyroid Function Test (TFT) was performed in all patients in addition to routine investigations for the study group that include measurement of thyroid hormones (T3 and T4) together with thyrotropin stimulating hormone (TSH). RESULTS: Thyroid dysfunction particularly subclinical hypothyroidism was substantially found among patients with IBS. CONCLUSION: Routine TFTs in patients with presumed IBS seems reasonable. Journal of Universal College of Medical Sciences (2016) Vol.04 No.02 Issue 14, page: 1-5

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Irritable Bowel Syndrome Among University Students in Jordan

10.21203/rs.2.11508/v1 ◽

2019 ◽

Author(s):

Amjad Al-Shdaifat ◽

Anwar Al-Kassar ◽

Asgeir Johannessen ◽

Zaid Al-Dabbagh ◽

Mohamed Al-Ethawi ◽

...

Keyword(s):

Irritable Bowel Syndrome ◽

University Students ◽

Multivariable Analysis ◽

Cross Sectional Study ◽

Poor Sleep ◽

Rome Iii Criteria ◽

Cross Sectional ◽

Rome Iii ◽

Irritable Bowel ◽

Hashemite University

Abstract Background Irritable bowel syndrome (IBS) is one of the commonest diagnosed gastrointestinal disorders (GI) in primary care and gastroenterology practices. This study aimed to explore the prevalence of IBS, and identify associated factors, among university students in Jordan. Methods A cross-sectional study was conducted among students at the Hashemite University in Jordan. A validated, confidential, self-administered data collection questionnaire was used for the collection of personal and sociodemographic data, and the Rome III criteria were used to define IBS. Logistic regression analysis was done to identify factors associated with IBS. Results A total of 198 students participated in the study, of whom 163 had complete data and could be assessed by the Rome III criteria. The age range of the students was 18 to 35 years, and 91 (55.8%) were women. Overall, 26 (16.0%) of the respondents were diagnosed with IBS. Poor sleep (Adjusted Odds Ratio [AOR] 3.9; 95% confidence interval [CI] 1.5-10.4; p<0.01), being married (AOR 7.6; 95% CI 2.0-28.8; p<0.01) and a family history of IBS (AOR 2.9; 95% CI 1.1-7.7; p=0.03) were independently associated with IBS in multivariable analysis. Conclusion IBS was common among otherwise healthy university student in Jordan. Lifestyle factors such as poor sleep appeared to be associated with IBS symptoms.

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Patients Suspected of Irritable Bowel Syndrome—Cross-Sectional Study Exploring the Sensitivity of Rome III Criteria in Primary Care

The American Journal of Gastroenterology ◽

10.1038/ajg.2013.15 ◽

2013 ◽

Vol 108 (6) ◽

pp. 972-980 ◽

Cited By ~ 37

Author(s):

Anne Line Engsbro ◽

Luise Mølenberg Begtrup ◽

Jens Kjeldsen ◽

Pia Veldt Larsen ◽

Ove Schaffalitzky de Muckadell ◽

...

Keyword(s):

Primary Care ◽

Irritable Bowel Syndrome ◽

Cross Sectional Study ◽

Sectional Study ◽

Rome Iii Criteria ◽

Cross Sectional ◽

Rome Iii ◽

Irritable Bowel

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Adherence to the pro-inflammatory diet in relation to prevalence of irritable bowel syndrome

Nutrition Journal ◽

10.1186/s12937-019-0487-6 ◽

2019 ◽

Vol 18 (1) ◽

Cited By ~ 2

Author(s):

Asma Salari-Moghaddam ◽

Ammar Hassanzadeh Keshteli ◽

Ahmad Esmaillzadeh ◽

Peyman Adibi

Keyword(s):

Irritable Bowel Syndrome ◽

Cross Sectional Study ◽

Dietary Intakes ◽

Dietary Inflammatory Index ◽

Sectional Study ◽

Cross Sectional ◽

Inflammatory Index ◽

Persian Version ◽

Rome Iii ◽

Irritable Bowel

Abstract Objective There is no prior study that examined the association between nutrient-based dietary inflammatory index (DII) and odds of Irritable Bowel Syndrome (IBS). We examined the association between DII score and odds of IBS and its severity among Iranian adults. Methods In this cross-sectional study, dietary intakes of 3363 Iranian adults were examined using a validated Dish-based 106-item Semi-quantitative Food Frequency Questionnaire (DS-FFQ). DII was calculated based on dietary intakes derived from DS-FFQ. IBS was assessed using a modified Persian version of Rome III questionnaire. Results After adjustment for potential confounders, we found that participants in the highest quintile of DII score had greater chance for IBS compared with those in the lowest quintile (OR: 1.36; 95% CI: 1.03–1.80). By gender, we found a significant association between DII score and IBS among women (OR: 1.41; 95% CI: 1.00–2.00). By BMI status, overweight or obese (BMI ≥ 25 kg/m2) individuals in top quintile of DII score had greater odds for IBS than those in the bottom quintile (OR: 1.64; 95% CI: 1.07–2.53). No significant association was observed between a pro-inflammatory diet and severity of IBS symptoms. Conclusions Consumption of a pro-inflammatory diet was associated with increased odds of IBS, in particular among women and those with BMI ≥ 25 kg/m2.

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High-Fat Foods and FODMAPs Containing Gluten Foods Primarily Contribute to Symptoms of Irritable Bowel Syndrome in Korean Adults

Nutrients ◽

10.3390/nu13041308 ◽

2021 ◽

Vol 13 (4) ◽

pp. 1308

Author(s):

Woori Na ◽

Yeji Lee ◽

Hyeji Kim ◽

Yong Sung Kim ◽

Cheongmin Sohn

Keyword(s):

Irritable Bowel Syndrome ◽

Dietary Intake ◽

Cross Sectional Study ◽

Dietary Control ◽

Fat Intake ◽

High Fat ◽

Cross Sectional ◽

Korean Adults ◽

Rome Iii ◽

Irritable Bowel

Dietary control plays an important role in the treatment of irritable bowel syndrome (IBS). However, few studies have examined the relationship between dietary intake and symptoms of IBS in Koreans. The current cross-sectional study aimed to examine the diet in food consumption and nutrient intake in Korean adults aged 20 to 40 with IBS. The data collected were completed by 857 subjects using a community-based web survey. The questionnaire covered functional bowel disorders based on Rome III, the semi-quantitative Food Frequency Questionnaire (SQ-FFQ), and the food items causing symptoms. In total, 186 of 857 subjects (21.7%) were diagnosed with IBS. The non-IBS group had a fat intake of 76.9 ± 47.9 g/day, while the IBS group had a fat intake of 86.6 ± 55.1 g/day (p = 0.014). The non-IBS group had a total fermentable oligosaccharide, disaccharide, monosaccharide, and polyol (FODMAP) intake of 12.6 ± 9.7 g/day, whereas the IBS group had a total FODMAP intake of 13.9 ± 9.9 g/day (p = 0.030). Foods that contributed to the onset of symptoms in the IBS group were instant noodles (70.8%), Chinese noodles with vegetables and seafood (68.7%), pizza (67.2%), and black bean sauce noodles (66.3%) which are mostly classified as high fat and high gluten foods. The dietary intake of IBS patients differs from that of non-IBS subjects. Increased intake of gluten-containing or high-fat foods due to the westernized diet caused more IBS symptoms than high FODMAPs and dairy products in Korean adults in their 20 s to 40 s.

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Anger Mediates the Relationship between Pain and Depression in Irritable Bowel Syndrome

Journal of Gastrointestinal and Liver Diseases ◽

10.15403/jgld-533 ◽

2019 ◽

Vol 28 (4) ◽

pp. 415-419

Author(s):

Mihaela Fadgyas Stanculete ◽

Octavia Capatina ◽

Cristina Pojoga ◽

Teodora Surdea Blaga

Keyword(s):

Irritable Bowel Syndrome ◽

Anger Expression ◽

Cross Sectional Study ◽

Pain Severity ◽

Trait Anger ◽

Cross Sectional ◽

Rome Iii ◽

Pain State ◽

Irritable Bowel ◽

The Relationship

Background and Aims: Anger has been linked to irritable bowel syndrome (IBS), but the mechanism underlying this relationship is still unknown. This cross-sectional study explores the possibility that anger mediates the relationship between pain severity and depression in IBS patients. Methods: The sample included 70 consecutively evaluated patients who met Rome III criteria for IBS diagnosis and 55 healthy controls. All participants completed measures of depression, pain, state and trait anger, and anger expression style. Results: Using a mediational model involving a series of linear regressions we found that trait anger and anger expression index partially mediated the association between depression and abdominal pain severity. The IBS patients with significant pain reported higher depressive symptoms; these results could be partially explained by their tendency to experience angry feelings generated by pain. Conclusions: The relation between pain and depression is not a direct and linear one, but works partly through patients’ tendency to become angry and through anger expression style regarding their pain.

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Thyroid Disorders and Prolactin Hormone and Their Association with Obesity in Infertile Women in a Tertiary Hospital of Nepal

Journal of Institute of Medicine ◽

10.3126/jiom.v42i3.37569 ◽

2020 ◽

Vol 42 (3) ◽

pp. 7-11

Author(s):

Suvana Maskey ◽

Hima Rijal

Keyword(s):

Thyroid Function Test ◽

Tertiary Hospital ◽

Cross Sectional Study ◽

Thyroid Stimulating Hormone ◽

University Teaching ◽

Serum Prolactin ◽

Thyroid Disorders ◽

Thyroid Disorder ◽

Cross Sectional ◽

Infertile Women

Introduction Thyroid dysfunction has profound effects on menstrual function and female fertility. Hypothyroidism is often associated with increased prolactin level which again worsens the problem. This study was done to evaluate the prevalence of thyroid disorders in infertile women attending infertility outpatient department (OPD) in Tribhuvan University Teaching Hospital (TUTH) and to determine the association of hypothyroidism and hyperprolactenemia with obesity which is not well studied in our population. MethodsA hospital-based cross-sectional study was conducted in infertility OPD of TUTH reviewing women’s records who underwent infertility workup and relevant history, clinical finding and results of investigations including thyroid function test (TFT) and serum prolactin (PRL) level were documented. Descriptive and inferential statistical analyses were used to identify the prevalence and associations of predictors and outcome variables. ResultsOut of 213 participants, the majority of the participants were obese (90; 42.3%) with mean (±SD) body mass index (BMI) being 24.8 ± 4.5 kg/m2. The prevalence of thyroid disorder was 18.4% including hypothyroidism 13.6% and hyperthyroidism 4.8%. There was no significant association of BMI and hyperprolactinemia with thyroid disorder as well as of BMI with hyperprolactinemia however the thyroid stimulating hormone (TSH) had significant positive correlation with prolactin (r=0.23, p<0.001). ConclusionThyroid disorders and hyperprolactinemia are commonly observed in infertile women, so they should be routinely screened during initial evaluation of infertility. As majority of the study population were obese, despite no significant association of BMI with thyroid disorder and hyperprolactinemia, the effect of weight gain on infertility cannot be overlooked.

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Irritable bowel syndrome and its associated factors in adolescents

Paediatrica Indonesiana ◽

10.14238/pi54.6.2014.344-50 ◽

2014 ◽

Vol 54 (6) ◽

pp. 344 ◽

Cited By ~ 2

Author(s):

Lara Fillekes ◽

Ari Prayogo ◽

Fatima Safira Alatas ◽

Badriul Hegar

Keyword(s):

Irritable Bowel Syndrome ◽

Lower Abdominal Pain ◽

Gastrointestinal Disorder ◽

Cross Sectional Study ◽

Rome Iii Criteria ◽

Parental Form ◽

Cross Sectional ◽

Rome Iii ◽

Irritable Bowel ◽

Upper Abdominal

Background Irritable bowel syndrome (IBS) is a commonfunctional gastrointestinal disorder. Increasing prevalences havebeen reported in Asian adolescent populations, however, therehave been few reports on Indonesian adolescents.Objective To investigate the prevalence of IBS and associatedfactors among adolescents in Jakarta.Methods This cross-sectional study included senior high schoolstudents in a district of Jakarta. Students were asked to fillquestionnaires based on the Rome III criteria for IBS. They werethen divided into groups: those with IBS and those without IBS,for the purposes of comparison.Results Out of 232 adolescents (145 females and 87 males) withmean age of 16.06 (SD 0.91) years, 14 (6.0%) had IBS. Elevenout of 14 adolescents with IBS reported upper abdominal painas well as periumbilical/lower abdominal pain. Irritable bowelsyndrome was not associated with socioeconomic status, food anddrink habits, the use of antibiotics, or scolding as a parental formof discipline. However, a significant higher proportion in the useof corporal punishment was found in IBS adolescents comparedto the non-IBS (P=0.034). In addition, stress related to scolding,as a parental form of discipline was more likely to be found in theIBS group than in the non-IBS group (P=0.019).Conclusion The prevalence of IBS among adolescents in Jakartais 6%, which is lower compared to those of other Asian countries.Corporal punishment at home and stress related to scolding athome are found to be associated with IBS.

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Association between Self-Reported Gluten Avoidance and Irritable Bowel Syndrome: Findings of the NutriNet-Santé Study

Nutrients ◽

10.3390/nu13114147 ◽

2021 ◽

Vol 13 (11) ◽

pp. 4147

Author(s):

Anouk Reuzé ◽

Rosalie Delvert ◽

Laëtitia Perrin ◽

Robert Benamouzig ◽

Jean-Marc Sabaté ◽

...

Keyword(s):

Irritable Bowel Syndrome ◽

Scientific Evidence ◽

Gastrointestinal Disorder ◽

Cross Sectional Study ◽

Dietary Guidelines ◽

Dietary Interventions ◽

Cross Sectional ◽

Logistic Regression Models ◽

Rome Iii ◽

Irritable Bowel

Self-management of irritable bowel syndrome (IBS) is increasingly focusing on exclusion diets. In particular; patients are showing a significant interest in the gluten-free diet for the treatment of IBS. However; the lack of scientific evidence prevents the establishment of clear dietary guidelines and attention is needed as dietary restriction can lead to potentially adverse effects. This cross-sectional study aims to explore the practice of gluten avoidance in participants identified with IBS in a large cohort of non-celiac French adults. The population included 15,103 participants of the NutriNet-Santé study who completed a functional gastrointestinal disorder questionnaire based on the Rome III criteria to identify IBS in 2013 and a food avoidance questionnaire in 2016. Data on diet and anthropometric and sociodemographic characteristics were collected. Multivariate logistic regression models were used to compare the avoidance of gluten between IBS and non-IBS participants. Participants were mainly women (73.4%) and the mean age in this population was 55.8 ± 13.2 years. Among these individuals, 804 (5.4%) participants were identified as IBS cases. Among them, the prevalence of gluten avoidance was estimated at 14.8%, of which 3.0% reported total avoidance; versus 8.8% and 1.6% in non-IBS participants. After adjustments; gluten avoidance was higher in IBS participants compared to their non-IBS counterparts: (OR = 1.86; 95%CI = 1.21, 2.85) for total and (OR = 1.71; 95%CI = 1.36, 2.14) for partial avoidance. Participants identified with IBS were more associated with gluten avoidance than non-IBS participants. Further studies are needed to explore the long-term consequences of dietary interventions and to provide consistent dietary guidance connected to patient perception.

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Semiquantitative fecal calprotectin test in postinfectious and non-postinfectious irritable bowel syndrome: cross-sectional study

Sao Paulo Medical Journal ◽

10.1590/1516-3180.2014.8000815 ◽

2014 ◽

Vol 133 (4) ◽

pp. 343-349 ◽

Cited By ~ 5

Author(s):

Liliana-Elisabeta David ◽

Teodora Surdea-Blaga ◽

Dan-Lucian Dumitrascu

Keyword(s):

Irritable Bowel Syndrome ◽

Intestinal Inflammation ◽

Fecal Calprotectin ◽

Cross Sectional Study ◽

Positive Test ◽

Sectional Study ◽

Cross Sectional ◽

Bowel Diseases ◽

Rome Iii ◽

Irritable Bowel

CONTEXT AND OBJECTIVE:The presence of a certain degree of inflammation in the gut wall is now accepted in irritable bowel syndrome (IBS). Fecal calprotectin is considered to be a reliable test for detecting intestinal inflammation. Our aim was to assess the presence of inflammation in postinfectious IBS (PI-IBS), compared with non-postinfectious IBS (NPI-IBS). A secondary objective was to determine the usefulness of a rapid fecal calprotectin test in inflammatory bowel diseases (IBD).DESIGN AND SETTING:This was a cross-sectional study. Patients with IBS and IBD at a single tertiary gastroenterology center were prospectively included in this study.METHODS:116 patients with Rome III IBS score (76 females; 48 ± 12 years) were investigated; 24 patients (15 females) had PI-IBS. Intestinal inflammation was assessed using the semiquantitative fecal calprotectin test. The results were expressed as T1, T2 or T3 according to the severity of inflammation (< 15 μg/g; 15-60 μg/g; > 60 μg/g). Using the same test, we evaluated 20 patients with IBD (12 males; 47 ± 13 years).RESULTS:None of the patients with IBS had a T2 or T3 positive test. Among PI-IBS patients, 33% had a T1 positive test. Among NPI-IBS patients, 9.8% had a T1 positive test, which was significantly different to PI-IBS. The calprotectin test was positive in all IBD patients: 80% with T3, 10% with T2 and 10% with T1.CONCLUSIONS:Using a semiquantitative test for fecal calprotectin, positive tests were more frequent in PI-IBS patients than in NPI-IBS patients.

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Thyroid Profile in Infertile Women

Nepal Medical Journal ◽

10.37080/nmj.6 ◽

2018 ◽

Vol 1 (01) ◽

pp. 5-10

Author(s):

Rojina Manandhar ◽

Bekha Laxmi Manandhar ◽

Jyoti Sharma

Keyword(s):

Thyroid Dysfunction ◽

Cross Sectional Study ◽

University Teaching ◽

Thyroid Disorders ◽

Thyroid Disorder ◽

Subclinical Hyperthyroidism ◽

Secondary Infertility ◽

Cross Sectional ◽

Infertile Women ◽

Thyroid Profile

Introduction: Infertility is defined as inability to conceive after one year of regular unprotected intercourse. Thyroid disorders can lead to infertility arising from different pathophysiological mechanisms. The aim of this study is to determine the prevalence and type of thyroid disorder in infertile women and to compare the prevalence of thyroid disorder in primary and secondary infertility. Methods: A hospital-based descriptive cross-sectional study conducted in the Department of Obstetrics and Gynecology, Tribhuvan University Teaching Hospital, Kathmandu, Nepal from 1st Baishak 2068 to 30th Chaitra 2068 (14th April 2011 to 12th April 2012). Results: Among 156 infertile women enrolled and analyzed in the present study, thyroid disorder was found in 12 women giving the prevalence of thyroid disorder in infertile women as 7.7%. Hypothyroidism was more common comprising 6.4% of all infertile women, out of which subclinical hypothyroidism was 3.8% and clinical hypothyroidism was 2.6%. Hyperthyroidism was seen in 1.3% of all infertile women of which subclinical hyperthyroidism was 0.64% and clinical hyperthyroidism was 0.64%. Prevalence of thyroid disorder in primary infertility was 9.8% and in secondary infertility it was 3.7%. Among the 12 infertile women with thyroid disorder, four infertile women (33%) conceived. Three cases of hypothyroidism conceived after treatment and one case of subclinical hyperthyroidism conceived without any treatment. Conclusions: This study shows that thyroid dysfunction shows a significant role in infertility. Proper management of the thyroid dysfunction can result regain of fertility. Therefore, routine screening is required to all cases of infertility for possible thyroid disorders.

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