Associating Physical Activity Levels with Motor Performance and Physical Function in Childhood Survivors of Acute Lymphoblastic Leukemia

Abstract Objective The aim was systematically to identify and evaluate factors related to fatigue in individuals with hip and/or knee OA. Methods A systematic literature search was conducted using AMED, CINAHL, MEDLINE, ProQuest and Web of Science Core Collections databases. Inclusion criteria comprised cross-sectional, case–control or longitudinal studies on patients with a diagnosis of hip and/or knee OA that included self-reported fatigue measures. Study quality was assessed using the National Heart, Lung and Blood Institute quality appraisal tool, and factors were synthesized within a bio-behavioural framework. Study designs and quality were combined to determine current evidence levels using best evidence synthesis grading. The full review protocol is available from PROSPERO (PROSPERO 2019: CRD42019138571). Results Twenty-four studies were included, of which 19 were high, 4 moderate and 1 low quality. There was strong evidence of an association between poor self-reported physical function and high depressive symptoms with higher fatigue. Moderate evidence of an association was found between severe pain, high numbers of co-morbidities and low physical activity levels with higher fatigue. There was moderate or limited evidence of no association between most sociodemographic factors and radiographic OA severity with fatigue. Conclusion Targets for fatigue management might include improving physical function, reducing depressive symptoms, pain and co-morbidities, and increasing physical activity levels. There is a need for more rigorous longitudinal studies to understand the causal effect of fatigue determinants within the hip and knee OA populations.

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Volunteer Impact on Health-Related Outcomes for Seniors: a Systematic Review And Meta-Analysis

Canadian Geriatrics Journal ◽

10.5770/cgj.24.434 ◽

2021 ◽

Vol 24 (1) ◽

pp. 44-72

Author(s):

Ainsley Moore ◽

Shahrzad Motaghi ◽

Behnam Sadeghirad ◽

Housne Begum ◽

John J. Riva ◽

...

Keyword(s):

Physical Activity ◽

Systematic Review ◽

Physical Function ◽

Meta Analysis ◽

Community Dwelling ◽

Physical Component Score ◽

Trial Participant ◽

Activity Levels ◽

Physical Activity Levels ◽

Health Related

Background Volunteers are increasingly promoted to improve health-related outcomes for community-dwelling elderly without synthesized evidence for effectiveness. This systematic review and meta-analysis evaluates the effects of unpaid volunteer interventions on health-related outcomes for such seniors. Methods MEDLINE, EMBASE and Cochrane (CENTRAL) were searched up to November 2018. We included English language, randomized trials. Two reviewers independently identified studies, extracted data, and assessed evidence certainty (using GRADE). Meta-analysis used random-effects models. Univariate meta-regressions investigated the relationship between volunteer intervention effects and trial participant age, percentage females, and risk of bias. Results 28 included studies focussed on seniors with a variety of chronic conditions (e.g., dementia, diabetes) and health states (e.g., frail, palliative). Volunteers provided a range of roles (e.g., counsellors, educators and coaches). Low certainty evidence found that volunteers may improve both physical function (MD = 3.2 points on the 100-point SF-36 physical component score [PCS]; 95% CI: 1.09, 5.27) and physical activity levels (SMD = 0.5, 95% CI: 0.14 to 0.83). Adverse events were not increased. Conclusion Volunteers may increase physical activity levels and subjective ratings of physical function for seniors without apparent harm. These findings support the WHO call to action on evidence-based policies to align health systems in support of older adults.

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The comparative ability of three physical function tests for predicting physical activity levels in people with parkinson's disease

Physiotherapy ◽

10.1016/j.physio.2015.03.3607 ◽

2015 ◽

Vol 101 ◽

pp. e742-e743

Author(s):

H. Khalil ◽

A. Al-Shorman ◽

M. Alomari ◽

A. Aburub ◽

W. Batayha ◽

...

Keyword(s):

Physical Activity ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Physical Function ◽

Activity Levels ◽

Function Tests ◽

Physical Activity Levels

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Habitual Physical Activity Levels Are Associated with Performance in Measures of Physical Function and Mobility in Older Men

Journal of the American Geriatrics Society ◽

10.1111/j.1532-5415.2010.03012.x ◽

2010 ◽

Vol 58 (9) ◽

pp. 1727-1733 ◽

Cited By ~ 86

Author(s):

Marina Morie ◽

Kieran F. Reid ◽

Renee Miciek ◽

Newsha Lajevardi ◽

Karen Choong ◽

...

Keyword(s):

Physical Activity ◽

Physical Function ◽

Older Men ◽

Habitual Physical Activity ◽

Activity Levels ◽

Physical Activity Levels

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The impact of maintenance therapy on sleep-wake rhythms and cancer-related fatigue in pediatric acute lymphoblastic leukemia

Supportive Care in Cancer ◽

10.1007/s00520-020-05444-7 ◽

2020 ◽

Vol 28 (12) ◽

pp. 5983-5993

Author(s):

L. M. H. Steur ◽

G. J. L. Kaspers ◽

E. J. W. van Someren ◽

N. K. A. van Eijkelenburg ◽

I. M. van der Sluis ◽

...

Keyword(s):

Physical Activity ◽

Maintenance Therapy ◽

Lymphoblastic Leukemia ◽

Activity Levels ◽

Healthy Children ◽

Dexamethasone Treatment ◽

Pediatric Acute Lymphoblastic Leukemia ◽

Cancer Related Fatigue ◽

Physical Activity Levels ◽

The Impact

Abstract Purpose To assess the impact of maintenance therapy and the additional impact of dexamethasone treatment on cancer-related fatigue and sleep-wake rhythms in pediatric acute lymphoblastic leukemia (ALL) patients and to determine the association between these outcomes. Methods A national cohort of pediatric ALL patients (≥ 2 years) was included (± 1 year post-diagnosis). Patients receiving dexamethasone were assessed twice (assessment with and without dexamethasone). Actigraphy assessments were used to calculate sleep-wake outcomes with nonparametric methods. Cancer-related fatigue was assessed with the PedsQL Multidimensional Fatigue Scale. Sleep-wake rhythms and cancer-related fatigue were compared between patients participating in the assessment without dexamethasone and healthy children (linear regression) and between assessments with and without dexamethasone (mixed models). Using linear regression, associations between sleep-wake outcomes and cancer-related fatigue were determined during assessments with and without dexamethasone. Results Responses were collected for 125 patients (113 assessments with and 81 without dexamethasone). The sleep-wake rhythm was less stable (p = 0.03) and less robust (p = 0.01), with lower physical activity levels (p < 0.001) and higher cancer-related fatigue levels (p < 0.001) in ALL patients compared to healthy children. Physical activity was lower (p = 0.001) and cancer-related fatigue more severe (p ≤ 0.001) during assessments with dexamethasone compared to without dexamethasone. Sleep-wake outcomes were significantly associated with cancer-related fatigue during periods without dexamethasone, but not during periods with dexamethasone. Conclusion Sleep-wake rhythms are disturbed, physical activity levels lower, and cancer-related fatigue levels higher during maintenance therapy. Interventions aimed to enhance sleep-wake rhythms during maintenance therapy could improve cancer-related fatigue. Families should be supported in coping with the additional burden of dexamethasone treatment to improve well-being of ALL patients.

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