Expanding the Role of N-of-1 Trials in the Precision Medicine Era: Action Priorities and Practical Considerations

2018 ◽  
Author(s):  
Karina W. Davidson ◽  
Ying Kuen Cheung ◽  
Thomas McGinn ◽  
Y. Claire Wang
Keyword(s):  
Precision Medicine

scholarly journals Precision Medicine, Developmental Plasticity and Prevention of Non-Communicable Disease

2020 ◽  
Author(s):  
Carol Wang ◽  
John Attia ◽  
Stephen Lye ◽  
Wendy Oddy ◽  
Lawrence Beilin ◽  
...  
Keyword(s):  
Precision Medicine ◽  
Early Life ◽  
Developmental Plasticity ◽  
Communicable Disease ◽  
Adult Health ◽  
Lower Systolic Blood Pressure ◽  
Adult Disease ◽  
Healthy Nutrition ◽  
Non Communicable Disease

Abstract Background: It is well established that genetics, environment, and interplay between them play crucial roles in adult disease. We aimed to evaluate the role of genetics, early life nutrition, and interaction between them, on optimal adult health. Methods: As part of a large international consortium (n~154,000), we identified 60 SNPs associated with both birthweight and adult disease. Utilising the Raine Study, we developed a birthweight polygenic score (BW-PGS) based the 60 SNPs and examined relationships between BW-PGS and adulthood cardiovascular risk factors, specifically evaluating interactions with early life nutrition. Findings: Healthy nutrition was beneficial for all individuals; longer duration of any breastfeeding was associated with lower BMI and lower Systolic Blood Pressure in those with higher BW-PGS. Interpretation: Optimal breastfeeding offers the greatest benefit to reduce adult obesity and hypertension in those genetically predisposed to high birthweight. This provides an example of how precision medicine in early life can improve adult health.

scholarly journals Knowledge and awareness of precision medicine among dental students

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 642-647
Author(s):  
Bipin M ◽  
Jeevitha M ◽  
Kavitha S
Keyword(s):  
Precision Medicine ◽  
Dental Students ◽  
Individual Variability ◽  
Medical Field ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Study Population

Precision medicine is an emerging approach for the treatment of diseases and prevention that takes into account individual variability in genes, environment and lifestyle of a person. Although the term precision medicine is relatively new, the concept has been a part of healthcare for many years. This study focuses especially to evaluate the knowledge on characteristics of precision medicine among dental students. The aim of this study is to analyse the knowledge and awareness of Precision medicine among dental students. A descriptive cross-sectional survey was conducted among dental students through a self-administrated questionnaire. The responses had been collected and statistically analysed. 61% of the study population were aware of Precision medicine and surprisingly, 82% of the respondents came across this term precision medicine. This study concludes that the dental students were aware of the term precision medicine, but they were not well aware of the role of precision medicine in the medical field.

scholarly journals Brain Tumor Biobank Development for Precision Medicine: Role of the Neurosurgeon

2021 ◽  
Vol 11 ◽  
Author(s):  
Emilie Darrigues ◽  
Benjamin W. Elberson ◽  
Annick De Loose ◽  
Madison P. Lee ◽  
Ebonye Green ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Next Generation Sequencing ◽  
Precision Medicine ◽  
Critical Role ◽  
First Year ◽  
Histopathological Diagnosis ◽  
Next Generation ◽  
Cancer Predisposition Syndrome ◽  
Generation Sequencing

Neuro-oncology biobanks are critical for the implementation of a precision medicine program. In this perspective, we review our first year experience of a brain tumor biobank with integrated next generation sequencing. From our experience, we describe the critical role of the neurosurgeon in diagnosis, research, and precision medicine efforts. In the first year of implementation of the biobank, 117 patients (Female: 62; Male: 55) had 125 brain tumor surgeries. 75% of patients had tumors biobanked, and 16% were of minority race/ethnicity. Tumors biobanked were as follows: diffuse gliomas (45%), brain metastases (29%), meningioma (21%), and other (5%). Among biobanked patients, 100% also had next generation sequencing. Eleven patients qualified for targeted therapy based on identification of actionable gene mutations. One patient with a hereditary cancer predisposition syndrome was also identified. An iterative quality improvement process was implemented to streamline the workflow between the operating room, pathology, and the research laboratory. Dedicated tumor bank personnel in the department of neurosurgery greatly improved standard operating procedure. Intraoperative selection and processing of tumor tissue by the neurosurgeon was integral to increasing success with cell culture assays. Currently, our institutional protocol integrates standard histopathological diagnosis, next generation sequencing, and functional assays on surgical specimens to develop precision medicine protocols for our patients. This perspective reviews the critical role of neurosurgeons in brain tumor biobank implementation and success as well as future directions for enhancing precision medicine efforts.

scholarly journals Challenges, applications and future directions of precision medicine in prostate cancer - the role of organoids and patient-derived xenografts

2020 ◽  
Vol 126 (1) ◽  
pp. 65-72
Author(s):  
Andre Joshi ◽  
Matthew J. Roberts ◽  
Saeid Alinezhad ◽  
Elizabeth D. Williams ◽  
Ian Vela
Keyword(s):  
Prostate Cancer ◽  
Precision Medicine ◽  
Future Directions

scholarly journals Treatment of epilepsy – towards precision

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 1932 ◽  
Author(s):  
John Paul Leach
Keyword(s):  
Genetic Testing ◽  
Adverse Effects ◽  
Drug Treatment ◽  
Antiepileptic Drug ◽  
Precision Medicine ◽  
Treatment Of Epilepsy ◽  
Antiepileptic Drug Treatment

Epilepsy was among the first disease areas to begin to apply principles of precision medicine to its treatment. This review looks at the role of investigation in ensuring the safety and effectiveness of antiepileptic drug treatment. Using sound principles, we can see that the use of genetic testing will advance treatment of epilepsy in reducing harm and adverse effects and enhancing efficacy.

scholarly journals Cases in Precision Medicine: The Role of Tumor and Germline Genetic Testing in Breast Cancer Management

2019 ◽  
Vol 171 (12) ◽  
pp. 925 ◽  
Author(s):  
Jonah Tischler ◽  
Katherine D. Crew ◽  
Wendy K. Chung
Keyword(s):  
Breast Cancer ◽  
Genetic Testing ◽  
Precision Medicine ◽  
Cancer Management ◽  
Breast Cancer Management

scholarly journals Precision Medicine and the Role of Biomarkers of Radiotherapy Response in Breast Cancer

2020 ◽  
Vol 10 ◽  
Author(s):  
James Meehan ◽  
Mark Gray ◽  
Carlos Martínez-Pérez ◽  
Charlene Kay ◽  
Lisa Y. Pang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Precision Medicine
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