scholarly journals Effect of Electrospinning Parameters on the Fiber Diameter and Morphology of PLGA Nanofibers

2021 ◽  
pp. 1-7
Author(s):  
Yuanyuan Duan ◽  
Lohitha Kalluri ◽  
Megha Satpathy ◽  
Yuanyuan Duan
Keyword(s):  
Bone Regeneration ◽  
Flow Rate ◽  
Applied Voltage ◽  
Fiber Diameter ◽  
Solution Concentration ◽  
Electrospun Fibers ◽  
High Porosity ◽  
The Mean ◽  
Nanoscale Fibers ◽  
One Way Anova

Background: Poly lactic-co-glycolic acid (PLGA) has been widely investigated for various biomedical applications, such as craniofacial bone regeneration, wound dressing and tissue engineering. Electrospinning is a versatile technology used to produce micro/nanoscale fibers with large specific surface area and high porosity. Purpose: The aim of the current study is to prepare PLGA nanofibers using electrospinning for guided tissue regeneration/guided bone regeneration applications. The objective of this study is to determine the appropriate electrospinning parameters such as applied voltage, flow rate, spinneret-collector distance and polymer solution concentration for preparation of PLGA fibrous membrane and their effect on the mean fiber diameter of the electrospun fibers. Method: PLGA pellets were dissolved in Hexafluoroisopropanol (HFIP) in various concentrations overnight using a bench rocker. The resulting PLGA solution was then loaded into a syringe and electrospinning was done by maintaining the other parameters constant. Similarly, various fibrous mats were collected by altering the specific electrospinning parameter inputs such as applied voltage, flow rate and spinneret-collector distance. The morphology of the fibrous mats was characterized using Scanning Electron Microscope. The mean fiber diameter was assessed using ImageJ software and the results were compared using one-way ANOVA. Results: We obtained bead-free uniform fibers with various tested solution concentrations. One-way ANOVA analysis demonstrated significant variation in mean fiber diameter of the electrospun fibers with altering applied voltage, solution concentration, flow rate and spinneret-collector distance. Conclusion: The above-mentioned electrospinning parameters and solution concentration influence the mean fiber diameter of electrospun PLGA nanofibers.

An Investigation Effects of Electrospinning Parameters: Process Optimization by Application of Response Surface Methodology

2014 ◽  
Vol 660 ◽  
pp. 140-144
Author(s):  
A. Mataram ◽  
Ahmad Fauzi Ismail ◽  
A.S. Mohruni ◽  
T. Matsura
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Applied Voltage ◽  
Fiber Diameter ◽  
Solution Concentration ◽  
Response Surfaces ◽  
Nano Scale ◽  
The Mean ◽  
Nanoscale Fibers ◽  
Parameter Interactions

Effects of material and process parameters on the electrospun polyacrylonitrile fibers were experimentally investigated. Response surface methodology (RSM) was utilized to design the experiments at the setting of solution concentration, voltage and the collector distance. It also imparted the evaluation of the significance of each parameter on pore size, contact angle, modulus young and clean water permeability. Effect of applied voltage in micron-scale fiber diameter was observed to be almost negligible when solution concentration and collector distance were high. However, all three factors were found statistically significant in the production of nano-scale fibers. The response surface predictions revealed the parameter interactions for the resultant fiber diameter, and showed that there is negative correlation between the mean diameter and coefficient of variation for the fiber diameters were in agreement with the experimental results. Response surfaces were constructed to identify the processing window suitable for producing nanoscale fibers. A sub-domain of the parameter space consisting of the solution concentration, applied voltage and collector distance, was suggested for the potential nano scale fiber production.

Research on Electrospinning Process of Pullulan Nanofibers

2012 ◽  
Vol 268-270 ◽  
pp. 198-201 ◽  
Author(s):  
Xiao Bin Sun ◽  
D. Jia ◽  
Wei Min Kang ◽  
Bo Wen Cheng ◽  
Ya Bin Li
Keyword(s):  
Flow Rate ◽  
Applied Voltage ◽  
Great Influence ◽  
Solution Concentration ◽  
Electrospinning Process ◽  
Diameter Distribution ◽  
Optimal Parameters ◽  
Redistilled Water ◽  
Water As Solvent

A kind of pullulan biopolymer nanofibers with diameter of 100～700nm were obtained using redistilled water as solvent through electrospinning technology in this paper. The effects of the spinning solution concentration, applied voltage, flow rate and capillary–screen distance on morphology and diameter distribution of pullulan nanofiber were studied by SEM. The results show that, different parameters had great influence on nanofibers’ morphology and diameter. The optimal parameters of pullulan nanofibers electrospinning were: 22wt.% spinning solution concentration, 31 kV voltage, 20 cm capillary–screen distance and 0.5ml/h flow rate.

Effect of Electrospinning Parameters Setting towards Fiber Diameter

2013 ◽  
Vol 845 ◽  
pp. 985-988 ◽  
Author(s):  
N.H.A. Ngadiman ◽  
M.Y. Noordin ◽  
Ani Idris ◽  
Denni Kurniawan
Keyword(s):  
Flow Rate ◽  
Applied Voltage ◽  
Fiber Diameter ◽  
Volume Flow Rate ◽  
Electrospinning Process ◽  
Volume Flow ◽  
Fiber Volume ◽  
Nanofiber Diameter ◽  
New Process

Fabrication of nanofibers using electrospinning has recently attracted much attention for various applications due to its simplicity. Electrospinning has the ability to produce nanofibers within 100-500 nm. Some applications require certain fiber diameter. As a relatively new process, there are many electrospinning parameters that are believed to influence the nanofibers diameter. The purpose of this review is to identify and discuss the effect of some of those parameters, i.e. concentration, spinning distance, and applied voltage, and volume flow rate, to the nanofiber diameter during electrospinning process. It was concluded that fiber volume flow rate is proportional to fiber diameter while there is no agreement in reports on other parameters.

scholarly journals Characterization, Biocompatibility, and Optimization of Electrospun SF/PCL/CS Composite Nanofibers

Polymers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1439
Author(s):  
Hua-Wei Chen ◽  
Min-Feng Lin
Keyword(s):  
Electron Microscopy ◽  
Flow Rate ◽  
Applied Voltage ◽  
Composite Nanofibers ◽  
Fiber Diameter ◽  
Design Method ◽  
Signal To Noise Ratio ◽  
L929 Cell ◽  
Mouse Fibroblast ◽  
Cytotoxicity Test

In this study, composite nanofibers (SF/PCL/CS) for the application of dressings were prepared with silk fibroin (SF), polycaprolactone (PCL), and chitosan (CS) by electrospinning techniques, and the effect of the fiber diameter was investigated using the three-stage Taguchi experimental design method (L9). Nanofibrous scaffolds were characterized by the combined techniques of scanning electron microscopy (SEM) and transmission electron microscopy (TEM), a cytotoxicity test, proliferation tests, the antimicrobial activity, and the equilibrium water content. A signal-to-noise ratio (S/N) analysis indicated that the contribution followed the order of SF to PCL > flow rate > applied voltage > CS addition, possibly owing to the viscosity and formation of the beaded fiber. The optimum combination for obtaining the smallest fiber diameter (170 nm) with a smooth and uniform distribution was determined to be a ratio of SF to PCL of 1:2, a flow rate of 0.3 mL/hr, and an applied voltage of 25 kV at a needle tip-to-collector distance of 15 cm (position). The viability of these mouse fibroblast L929 cell cultures exceeded 50% within 24 hours, therefore SF/PCL/CS could be considered non-toxic according to the standards. The results proposed that the hydrophilic structure of SF/PCL/CS not only revealed a highly interconnected porous construction but also that it could help cells promote the exchange of nutrients and oxygen. The SF/PCL/CS scaffold showed a high interconnectivity between pores and porosity and water uptake abilities able to provide good conditions for cell infiltration and proliferation. The results from this study suggested that SF/PCL/CS could be suitable for skin tissue engineering.

scholarly journals Analysis of the Process Parameters for Obtaining a Stable Electrospun Process in Different Composition Epoxy/Poly ε-Caprolactone Blends with Shape Memory Properties

Polymers ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 475 ◽  
Author(s):  
Alvaro Iregui ◽  
Lourdes Irusta ◽  
Loli Martin ◽  
Alba González
Keyword(s):  
Shape Memory ◽  
Flow Rate ◽  
Composition Dependence ◽  
Fiber Diameter ◽  
Stable Process ◽  
Solution Concentration ◽  
Diglycidyl Ether ◽  
Process Variables ◽  
Shape Memory Properties

In this work Poly ε-caprolactone (PCL)/ Diglycidyl ether of bisphenol A (DGEBA) blends were electrospun and the obtained mats were UV cured to achieve shape memory properties. In the majority of studies, when blends with different compositions are electrospun, the process variables such as voltage or flow rate are fixed independently of the composition and consequently the quality of the fibers is not optimized in all of the range studied. In the present work, using the design of experiments methodology, flow rate and voltage required to obtain a stable process were evaluated as responses in addition to the fiber diameter and shape memory properties. The results showed that the solution concentration and amount of PCL played an important role in the voltage and flow rate. For the shape memory properties excellent values were achieved and no composition dependence was observed. In the case of fiber diameter, similar results to previous works were observed.

Development of Electrospun Shellac and Hydroxypropyl Cellulose Blended Nanofibers for Drug Carrier Application

2020 ◽  
Vol 859 ◽  
pp. 239-243
Author(s):  
Nawinda Chinatangkul ◽  
Sirikarn Pengon ◽  
Suchada Piriyaprasarth ◽  
Chutima Limmatvapirat ◽  
Sontaya Limmatvapirat
Keyword(s):  
Drug Delivery ◽  
Antimicrobial Agent ◽  
Flow Rate ◽  
Applied Voltage ◽  
Infusion Rate ◽  
Fiber Diameter ◽  
Electrospun Fiber ◽  
Drug Carrier ◽  
Hydroxypropyl Cellulose ◽  
Electrospinning Process

The aim of this study was to develop the electrospun shellac (SHL) and hydroxypropyl cellulose (HPC) blended nanofibers for drug carrier application. The effects of polymer solution and electrospinning parameters, including SHL-HPC ratio, HPC concentration, applied voltage and flow rate, on the appearance of fibers were investigated. Based on the results, electrospun fiber was not obtained when a solution of HPC alone was employed. However, the fibers would be obviously fabricated as SHL was added to the HPC solution. An increase in the SHL ratio in SHL-HPC blended solution could accordingly lead to a remarkable enhance in the fiber diameter. In addition, the continuous nanofibers with less beads were gradually formulated when the HPC concentration was increased. The electrospinning parameters seemed to be significant. The elevation of infusion rate from 0.5 to 1 mL/h would contribute to the preparation of thick fibers with the diameters enlarging from 666.9 to 843.5 nm. With the applied voltage increasing from 15 to 30 kV during the electrospinning process, the fabrication of small nanofibers with the diameters reducing from 843.5 to 741.6 nm would be conducted. In this study, monolaurin (ML), a broad antimicrobial agent, was encapsulated into the SHL-HPC carrier for the purpose of drug delivery application. Regarding the result, the loaded concentration of ML could not be enhanced by introducing HPC to the SHL fibers.

scholarly journals Effect of parameters on the morphology and fibre diameters of edible electrospun chitosan-cellulose acetate-gelatin hybrid nanofibres

2018 ◽  
Vol 192 ◽  
pp. 03038
Author(s):  
Jaruayporn Somsap ◽  
Kobsak Kanjanapongkul ◽  
Racha Tepsorn
Keyword(s):  
Cellulose Acetate ◽  
Flow Rate ◽  
Applied Voltage ◽  
Acetic Acid Solution ◽  
Volume Ratio ◽  
Solution Concentration ◽  
Processing Parameters ◽  
Gelatin Solution ◽  
Electrospun Nanofibres ◽  
Scanning Electron

Electrospinning is the favorite process to fabricate fibres with diameter in the range nanoscale through the action of electric field. In this study, 3-7% chitosan, 18.0% cellulose acetate and 30.0% gelatin solution in aqueous 80% acetic acid solution were blended at the volume ratio of 4:1:5 have been successfully electrospun. The effect of processing parameters and the concentration of the polymer solution on the morphology and diameter of electrospun were investigated. The morphology and diameter of electrospun fibres were observed by scanning electron microscope. The diameters of chitosan-cellulose acetate-gelatin nanofibres ranging from 78.94 to 421.05 nm. The results showed that the fibre diameters increased when the solution concentration and flow rate were increased, whereas the fibre diameters decreased when the applied voltage and distance between tip to collector were increased. The conditions of the solution concentration 18.8 %wt, applied voltage at 23 kV, flow rate at 11.67 μL/min and collector distance at 10 cm were selected to prepares the desirable electrospun nanofibres for applications and the further research.

Electrospinning of Polycaprolactone in Dichloromethane/Dimethylformamide Solvent System

2013 ◽  
Vol 849 ◽  
pp. 337-342 ◽  
Author(s):  
Narissara Kulpreechanan ◽  
Tanom Bunaprasert ◽  
Ratthapol Rangkupan
Keyword(s):  
Flow Rate ◽  
Applied Voltage ◽  
Mixed Solvent ◽  
Solution Concentration ◽  
Solvent System ◽  
Fiber Formation ◽  
Solution Flow Rate ◽  
Fiber Morphology ◽  
Solution Flow ◽  
Fiber Size

Electrospinning of polycaprolactone (PCL) in a mixed solvent of dichloromethane (DCM)/dimethylformamide (DMF) with 1:1 volumetic mixing ratio was studied. The effects of solution concentration (5-30 %w/v), applied voltage (10-25 kV), solution flow rate (0.1-2.0 mL/h) and collecting distance (10, 20 cm) on fiber formation and morphology were investigated. The size of PCL fibers obtained were in the range of 10s nm-2.6 μm with either bead on string or smooth fiber morphology. In this study, the solution concentration strongly affected fiber size exponentially. The fiber size also increased with an increase in solution flow rate. The applied voltage and the collecting distance have no or minimal effect on PCL fiber size.

Morphology of Biodegradable Poly(hexamethylene Adipate)(PHMA) Nanofibers Prepared by Electrospinning

2009 ◽  
Vol 87-88 ◽  
pp. 555-560
Author(s):  
Wei Min Kang ◽  
Bo Wen Cheng ◽  
Quan Xiang Li ◽  
Xu Pin Zhuang
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Flow Rate ◽  
Applied Voltage ◽  
Mixed Solvent ◽  
Solution Concentration ◽  
Electrospinning Process ◽  
Solvent Ratio ◽  
Biodegradable Poly ◽  
Scanning Electron

A kind of novel biodegradable poly(hexamethylene adipate) (PHMA) nanofibers with diameter of 100～700nm using a mixed solvent of 1,2-dichloroethane (DCE ) and trifluoroacetic acid (TFA) were obtained by electrospinning process in this paper. The morphology of electropun PHMA nanofibers were investigated by scanning electron microscopy (SEM). The results showed that the morphology, diameter and uniformity of the fibers were influenced by solvent ratio, solution concentration, applied voltage, capillary–screen distance and flow rate greatly. The finer and uniform nanofibers were electrospun from a mixed solvent of DCE and TFA with ratio of 70/30(w/w).

Sign in / Sign up

Export Citation Format

Share Document