Development of Electrospun Shellac and Hydroxypropyl Cellulose Blended Nanofibers for Drug Carrier Application

2020 ◽  
Vol 859 ◽  
pp. 239-243
Author(s):  
Nawinda Chinatangkul ◽  
Sirikarn Pengon ◽  
Suchada Piriyaprasarth ◽  
Chutima Limmatvapirat ◽  
Sontaya Limmatvapirat
Keyword(s):  
Drug Delivery ◽  
Antimicrobial Agent ◽  
Flow Rate ◽  
Applied Voltage ◽  
Infusion Rate ◽  
Fiber Diameter ◽  
Electrospun Fiber ◽  
Drug Carrier ◽  
Hydroxypropyl Cellulose ◽  
Electrospinning Process

The aim of this study was to develop the electrospun shellac (SHL) and hydroxypropyl cellulose (HPC) blended nanofibers for drug carrier application. The effects of polymer solution and electrospinning parameters, including SHL-HPC ratio, HPC concentration, applied voltage and flow rate, on the appearance of fibers were investigated. Based on the results, electrospun fiber was not obtained when a solution of HPC alone was employed. However, the fibers would be obviously fabricated as SHL was added to the HPC solution. An increase in the SHL ratio in SHL-HPC blended solution could accordingly lead to a remarkable enhance in the fiber diameter. In addition, the continuous nanofibers with less beads were gradually formulated when the HPC concentration was increased. The electrospinning parameters seemed to be significant. The elevation of infusion rate from 0.5 to 1 mL/h would contribute to the preparation of thick fibers with the diameters enlarging from 666.9 to 843.5 nm. With the applied voltage increasing from 15 to 30 kV during the electrospinning process, the fabrication of small nanofibers with the diameters reducing from 843.5 to 741.6 nm would be conducted. In this study, monolaurin (ML), a broad antimicrobial agent, was encapsulated into the SHL-HPC carrier for the purpose of drug delivery application. Regarding the result, the loaded concentration of ML could not be enhanced by introducing HPC to the SHL fibers.

Effect of Electrospinning Parameters Setting towards Fiber Diameter

2013 ◽  
Vol 845 ◽  
pp. 985-988 ◽  
Author(s):  
N.H.A. Ngadiman ◽  
M.Y. Noordin ◽  
Ani Idris ◽  
Denni Kurniawan
Keyword(s):  
Flow Rate ◽  
Applied Voltage ◽  
Fiber Diameter ◽  
Volume Flow Rate ◽  
Electrospinning Process ◽  
Volume Flow ◽  
Fiber Volume ◽  
Nanofiber Diameter ◽  
New Process

Fabrication of nanofibers using electrospinning has recently attracted much attention for various applications due to its simplicity. Electrospinning has the ability to produce nanofibers within 100-500 nm. Some applications require certain fiber diameter. As a relatively new process, there are many electrospinning parameters that are believed to influence the nanofibers diameter. The purpose of this review is to identify and discuss the effect of some of those parameters, i.e. concentration, spinning distance, and applied voltage, and volume flow rate, to the nanofiber diameter during electrospinning process. It was concluded that fiber volume flow rate is proportional to fiber diameter while there is no agreement in reports on other parameters.

Research on Electrospinning Process of Pullulan Nanofibers

2012 ◽  
Vol 268-270 ◽  
pp. 198-201 ◽  
Author(s):  
Xiao Bin Sun ◽  
D. Jia ◽  
Wei Min Kang ◽  
Bo Wen Cheng ◽  
Ya Bin Li
Keyword(s):  
Flow Rate ◽  
Applied Voltage ◽  
Great Influence ◽  
Solution Concentration ◽  
Electrospinning Process ◽  
Diameter Distribution ◽  
Optimal Parameters ◽  
Redistilled Water ◽  
Water As Solvent

A kind of pullulan biopolymer nanofibers with diameter of 100～700nm were obtained using redistilled water as solvent through electrospinning technology in this paper. The effects of the spinning solution concentration, applied voltage, flow rate and capillary–screen distance on morphology and diameter distribution of pullulan nanofiber were studied by SEM. The results show that, different parameters had great influence on nanofibers’ morphology and diameter. The optimal parameters of pullulan nanofibers electrospinning were: 22wt.% spinning solution concentration, 31 kV voltage, 20 cm capillary–screen distance and 0.5ml/h flow rate.

scholarly journals Characterization, Biocompatibility, and Optimization of Electrospun SF/PCL/CS Composite Nanofibers

Polymers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1439
Author(s):  
Hua-Wei Chen ◽  
Min-Feng Lin
Keyword(s):  
Electron Microscopy ◽  
Flow Rate ◽  
Applied Voltage ◽  
Composite Nanofibers ◽  
Fiber Diameter ◽  
Design Method ◽  
Signal To Noise Ratio ◽  
L929 Cell ◽  
Mouse Fibroblast ◽  
Cytotoxicity Test

In this study, composite nanofibers (SF/PCL/CS) for the application of dressings were prepared with silk fibroin (SF), polycaprolactone (PCL), and chitosan (CS) by electrospinning techniques, and the effect of the fiber diameter was investigated using the three-stage Taguchi experimental design method (L9). Nanofibrous scaffolds were characterized by the combined techniques of scanning electron microscopy (SEM) and transmission electron microscopy (TEM), a cytotoxicity test, proliferation tests, the antimicrobial activity, and the equilibrium water content. A signal-to-noise ratio (S/N) analysis indicated that the contribution followed the order of SF to PCL > flow rate > applied voltage > CS addition, possibly owing to the viscosity and formation of the beaded fiber. The optimum combination for obtaining the smallest fiber diameter (170 nm) with a smooth and uniform distribution was determined to be a ratio of SF to PCL of 1:2, a flow rate of 0.3 mL/hr, and an applied voltage of 25 kV at a needle tip-to-collector distance of 15 cm (position). The viability of these mouse fibroblast L929 cell cultures exceeded 50% within 24 hours, therefore SF/PCL/CS could be considered non-toxic according to the standards. The results proposed that the hydrophilic structure of SF/PCL/CS not only revealed a highly interconnected porous construction but also that it could help cells promote the exchange of nutrients and oxygen. The SF/PCL/CS scaffold showed a high interconnectivity between pores and porosity and water uptake abilities able to provide good conditions for cell infiltration and proliferation. The results from this study suggested that SF/PCL/CS could be suitable for skin tissue engineering.

scholarly journals ELECTROSPRAY METHOD: PROCESSING PARAMETERS INFLUENCE ON MORPHOLOGY AND SIZE OF PCL PARTICLES

2018 ◽  
Vol 55 (1B) ◽  
pp. 209
Author(s):  
Linh Viet Nguyen Vu
Keyword(s):  
Flow Rate ◽  
Applied Voltage ◽  
Drug Carrier ◽  
Processing Parameters ◽  
Release Profile ◽  
Polymeric Microparticles ◽  
Size And Morphology ◽  
Imagej Software ◽  
H 20 ◽  
Scanning Electron

The polymeric microparticles using electrospray technique have been used effectively as the drug carrier, whereby controlled release of drug. The electrosprayed particles morphology and size dictated the degradation of polymer matrix, therefore they influenced the release profile from drug loaded microparticles. The effects of electrospray processing parameters (flow rate, applied voltage and distance from the tip of needle to collector) on morphology and size of polycaprolactone (PCL) particles were investigated by scanning electron microscopy (SEM) and ImageJ software. In this research, the PCL solution was prepared by dissolving PCL in Dichloromethane at 4.5 % solution. In addition, processing parameters such as the flow rate (0.5 mL/h, 1 mL/h, 1.5 mL/h, 2 mL/h and 4 mL/h), the applied voltage (15 kV, 18 kV and 24 kV) and the collecting distance (15 cm, 20 cm, and 25 cm) were changed to examine the effects of them on size and morphology of PCL particles. The results indicated that at the suitable electrospraying parameters (18 kV, 1.5 mL/h, 20–25 cm), microparticles have obtained the uniform and stable morphology while at higher flow rate (2 mL/h and 4 mL/h), the particles were deformed and had bigger size. 

scholarly journals Effect of Electrospinning Parameters on the Fiber Diameter and Morphology of PLGA Nanofibers

2021 ◽  
pp. 1-7
Author(s):  
Yuanyuan Duan ◽  
Lohitha Kalluri ◽  
Megha Satpathy ◽  
Yuanyuan Duan
Keyword(s):  
Bone Regeneration ◽  
Flow Rate ◽  
Applied Voltage ◽  
Fiber Diameter ◽  
Solution Concentration ◽  
Electrospun Fibers ◽  
High Porosity ◽  
The Mean ◽  
Nanoscale Fibers ◽  
One Way Anova

Background: Poly lactic-co-glycolic acid (PLGA) has been widely investigated for various biomedical applications, such as craniofacial bone regeneration, wound dressing and tissue engineering. Electrospinning is a versatile technology used to produce micro/nanoscale fibers with large specific surface area and high porosity. Purpose: The aim of the current study is to prepare PLGA nanofibers using electrospinning for guided tissue regeneration/guided bone regeneration applications. The objective of this study is to determine the appropriate electrospinning parameters such as applied voltage, flow rate, spinneret-collector distance and polymer solution concentration for preparation of PLGA fibrous membrane and their effect on the mean fiber diameter of the electrospun fibers. Method: PLGA pellets were dissolved in Hexafluoroisopropanol (HFIP) in various concentrations overnight using a bench rocker. The resulting PLGA solution was then loaded into a syringe and electrospinning was done by maintaining the other parameters constant. Similarly, various fibrous mats were collected by altering the specific electrospinning parameter inputs such as applied voltage, flow rate and spinneret-collector distance. The morphology of the fibrous mats was characterized using Scanning Electron Microscope. The mean fiber diameter was assessed using ImageJ software and the results were compared using one-way ANOVA. Results: We obtained bead-free uniform fibers with various tested solution concentrations. One-way ANOVA analysis demonstrated significant variation in mean fiber diameter of the electrospun fibers with altering applied voltage, solution concentration, flow rate and spinneret-collector distance. Conclusion: The above-mentioned electrospinning parameters and solution concentration influence the mean fiber diameter of electrospun PLGA nanofibers.

Morphology of Biodegradable Poly(hexamethylene Adipate)(PHMA) Nanofibers Prepared by Electrospinning

2009 ◽  
Vol 87-88 ◽  
pp. 555-560
Author(s):  
Wei Min Kang ◽  
Bo Wen Cheng ◽  
Quan Xiang Li ◽  
Xu Pin Zhuang
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Flow Rate ◽  
Applied Voltage ◽  
Mixed Solvent ◽  
Solution Concentration ◽  
Electrospinning Process ◽  
Solvent Ratio ◽  
Biodegradable Poly ◽  
Scanning Electron

A kind of novel biodegradable poly(hexamethylene adipate) (PHMA) nanofibers with diameter of 100～700nm using a mixed solvent of 1,2-dichloroethane (DCE ) and trifluoroacetic acid (TFA) were obtained by electrospinning process in this paper. The morphology of electropun PHMA nanofibers were investigated by scanning electron microscopy (SEM). The results showed that the morphology, diameter and uniformity of the fibers were influenced by solvent ratio, solution concentration, applied voltage, capillary–screen distance and flow rate greatly. The finer and uniform nanofibers were electrospun from a mixed solvent of DCE and TFA with ratio of 70/30(w/w).

scholarly journals Electrospinning of Cyclodextrin Nanofibers: The Effect of Process Parameters

2020 ◽  
Vol 2020 ◽  
pp. 1-10 ◽  
Author(s):  
Fuat Topuz ◽  
Tamer Uyar
Keyword(s):  
Process Parameters ◽  
Flow Rate ◽  
High Performance ◽  
Fiber Diameter ◽  
Volume Ratio ◽  
Electrospinning Process ◽  
Electrical Field ◽  
Different Types ◽  
Solvent Systems ◽  
Needle Diameter

Cyclodextrin (CD) nanofibers have recently emerged as high-performance materials owing to their large surface area-to-volume ratio, along with the presence of high active CD content for their applications in drug delivery and water treatment. Even though there are several studies on the polymer-free electrospinning of CD molecules of different types, the effects of electrospinning process parameters on the morphology and diameter of the resultant fibers have not addressed yet. In this study, the influence of electrospinning process variables on the morphology and diameter of the resultant CD nanofibers is systematically studied using two different solvent systems, i.e., water and N, N-dimethylformamide (DMF). On adjusting the electrospinning process parameters (i.e., electrical field, flow rate, tip-to-collector distance (TCD), and needle diameter), uniform CD nanofibers could be produced from aqueous and DMF solutions. Generally, the electrospinning of thicker fibers was observed by increasing the applied voltage and flow rate due to higher mass flow. Increasing TCD boosted the fiber diameter. Likewise, the use of needles with larger diameters resulted in the electrospinning of thicker fibers from DMF solutions, which might be attributed to higher viscosity due to reduced shear rate.

Investigation of a New Needleless Electrospinning Method for the Production of Nanofibers

2013 ◽  
Vol 8 (4) ◽  
pp. 155892501300800 ◽  
Author(s):  
Deogratias Nurwaha ◽  
Wanli Han ◽  
Xinhou Wang
Keyword(s):  
Strong Interaction ◽  
Applied Voltage ◽  
Fiber Diameter ◽  
Electrospun Fiber ◽  
Scaling Up ◽  
Processing Parameters ◽  
Needleless Electrospinning ◽  
Electrospinning Method ◽  
Multiple Jets ◽  
Productivity Rate

This paper presents the possibility of nanofiber formation by a new multiple jet method. A novel needleless electrospinning apparatus was used to produce nanofibers. This employs a new design for supplying solution to a metal roller spinneret. The advantage of this setup is its ease of scaling-up for increased output. Using this new method it was possible to increase the nanofiber production rate because of the multiple jets. The productivity rate has been significantly enhanced and was 24–30 times higher than single needle electrospinning. It was also possible to produce thinner fibers than the single needle method. It was found that fibers produced by this novel needleless electrospinning had fewer beadings than fibers produced by the conventional electrospinning method. The effects of processing parameters including applied voltage and spinning electrospinning distance on eletrospun fiber diameter were also investigated. The study showed that the electrospun fiber diameter was strongly governed by the processing parameters. It was observed that there was a strong interaction between these parameters.

scholarly journals Evaluation of Process Parameters for Fiber Alignment of Electrospun Tubular Nanofibrous Matrices: A DoE Approach

2020 ◽  
Author(s):  
Rossella Dorati ◽  
Enrica Chiesa ◽  
Silvia Pisani ◽  
Ida Genta ◽  
Tiziana Modena ◽  
...  
Keyword(s):  
Process Parameters ◽  
Flow Rate ◽  
Electrospun Fiber ◽  
Environmental Parameters ◽  
Electrospinning Process ◽  
Sem Images ◽  
Fiber Alignment ◽  
Rotating Speed ◽  
Set Up ◽  
The Impact

Electrospinning is known to be an effective and straightforward technique to fabricate polymer non woven matrices made of nano and microfibers. Micro patterned morphology of electrospun matrices results to be outmost advantageous in the biomedical field, since it is able to mimic extracellular matrix (ECM), and favors cell adhesion and proliferation. Controlling electrospun fibers alignment is crucial for the regenerative purposes of certain tissues, such as neuronal and vascular. In this study we investigated the impact of electrospinning process parameters on fiber alignment in tubular nanofibrous matrices made of Poly (L-lactide-co-ε-caprolactone) (PLA-PCL); a Design of Experiments (DoE) approach is here proposed in order to statistically set up the process parameters. The DoE was studied keeping constants the previously set material and environmental parameters; voltage, flow rate and mandrel rotating speed were the process parameters here investigated as variables. Orientation analysis was based on ImageJ and plugin Orientation J analysis of SEM images. The results show that voltage combined with flow rate has significant impact on electrospun fiber orientation, and the greatest orientation is achieved when all the three input parameters (voltage, flow rate and mandrel rotation speed) are at their maximum value.

scholarly journals Dropping in electrospinning process: A general strategy for fabrication of microspheres

2021 ◽  
pp. 25-25
Author(s):  
Leigen Liu ◽  
Yan-Qing Liu ◽  
Yun-Yu Li ◽  
Yue Shen ◽  
Ji-Huan He
Keyword(s):  
Flow Rate ◽  
Applied Voltage ◽  
Electrostatic Force ◽  
Electrospinning Process ◽  
General Strategy ◽  
Initial Stage ◽  
Moving Jet

The dropping mechanism in the electrospinning process is elucidated. A moving jet becomes thinner at the initial stage due to the acceleration caused by the electrostatic force. When the jet diameter reaches a threshold, beyond which the jet breaks into drops and daughter jets, dropping occurs. The drops will finally form microspheres. Effects of applied voltage, flow rate, polymer?s concentration and receptor?s distance on the dropping process are theoretically analyzed and experimentally verified. This paper gives a general strategy for fabrication of smooth fiber, microspheres, and their mixture.

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