Antibiotic Resistance: A Threat to Global Health

2020 ◽  
Author(s):  
Shweta Gupta ◽  
Keyword(s):  
Antibiotic Resistance ◽  
Global Health

Recent Review on Subclass B1 Metallo-β-lactamases Inhibitors: Sword for Antimicrobial Resistance

2019 ◽  
Vol 20 (7) ◽  
pp. 756-762 ◽  
Author(s):  
Aditi Kaushik ◽  
Manish Kaushik ◽  
Viney Lather ◽  
J.S. Dua
Keyword(s):  
Antibiotic Resistance ◽  
Multidrug Resistance ◽  
Antimicrobial Resistance ◽  
Global Health ◽  
Human Health ◽  
Microbial Pathogens ◽  
Present Review ◽  
Drug Molecules ◽  
Global Threat ◽  
Powerful Strategy

An emerging crisis of antibiotic resistance for microbial pathogens is alarming all the nations, posing a global threat to human health. The production of the metallo-β-lactamase enzyme is the most powerful strategy of bacteria to produce resistance. An efficient way to combat this global health threat is the development of broad/non-specific type of metallo-β-lactamase inhibitors, which can inhibit the different isoforms of the enzyme. Till date, there are no clinically active drugs against metallo- β-lactamase. The lack of efficient drug molecules against MBLs carrying bacteria requires continuous research efforts to overcome the problem of multidrug-resistance bacteria. The present review will discuss the clinically potent molecules against different variants of B1 metallo-β-lactamase.

scholarly journals Antibacterial Compounds from Mushrooms: A Lead to Fight ESKAPEE Pathogenic Bacteria?

Planta Medica ◽  
2020 ◽  
Author(s):  
Violette Hamers ◽  
Clément Huguet ◽  
Mélanie Bourjot ◽  
Aurélie Urbain
Keyword(s):  
Antibiotic Resistance ◽  
Global Health ◽  
Pathogenic Bacteria ◽  
Resistance Mechanisms ◽  
Pathogenic Microorganisms ◽  
Bacterial Strains ◽  
Antibacterial Compounds ◽  
New Antibiotics ◽  
Hospital Stays ◽  
Antibacterial Potential

AbstractInfectious diseases are among the greatest threats to global health in the 21st century, and one critical concern is due to antibiotic resistance developed by an increasing number of bacterial strains. New resistance mechanisms are emerging with many infections becoming more and more difficult if not impossible to treat. This growing phenomenon not only is associated with increased mortality but also with longer hospital stays and higher medical costs. For these reasons, there is an urgent need to find new antibiotics targeting pathogenic microorganisms such as ESKAPEE bacteria. Most of currently approved antibiotics are derived from microorganisms, but higher fungi could constitute an alternative and remarkable reservoir of anti-infectious compounds. For instance, pleuromutilins constitute the first class of antibiotics derived from mushrooms. However, macromycetes still represent a largely unexplored source. Publications reporting the antibacterial potential of mushroom extracts are emerging, but few purified compounds have been evaluated for their bioactivity on pathogenic bacterial strains. Therefore, the aim of this review is to compile up-to-date data about natural products isolated from fruiting body fungi, which significantly inhibit the growth of ESKAPEE pathogenic bacteria. When available, data regarding modes of action and cytotoxicity, mandatory when considering a possible drug development, have been discussed in order to highlight the most promising compounds.

scholarly journals Aminoglycoside Antibiotics Inhibit Mycobacteriophage Infection

Antibiotics ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 714 ◽  
Author(s):  
Zheng Jiang ◽  
Junwei Wei ◽  
Yunxiang Liang ◽  
Nan Peng ◽  
Yingjun Li
Keyword(s):  
Antibiotic Resistance ◽  
Mycobacterium Tuberculosis ◽  
Structural Analysis ◽  
Global Health ◽  
Broad Spectrum ◽  
Phage Therapy ◽  
Amino Sugar ◽  
Aminoglycoside Antibiotics ◽  
Phage Infection ◽  
Drug Resistant

Antibiotic resistance is becoming the biggest threat to global health. At the same time, phage therapy is witnessing a return of interest. The therapeutic use of bacteriophages that infect and kill bacteria is a suitable strategy to combat antibiotic resistance. Furthermore, bacteriophages are increasingly used in combination with standard antibiotics against drug-resistant pathogens. Interestingly, we found that the engineered mycobacteriophage phAE159 and natural phage D29 cannot infect the Mycobacterium tuberculosis in the presence of kanamycin, hygromycin or streptomycin, but the phage infection was not affected in the presence of spectinomycin. Based on a series of studies and structural analysis of the above four aminoglycoside antibiotics, it could be speculated that the amino sugar group of aminoglycoside might selectively inhibit mycobacteriophage DNA replication. Our discovery that broad-spectrum antibiotics inhibit phage infection is of great value. This study will provide guidance for people to combine phage and antibiotics to treat M. tuberculosis.

scholarly journals What Will it Take to Address the Global Threat of Antibiotic Resistance?

2015 ◽  
Vol 43 (2) ◽  
pp. 363-368 ◽  
Author(s):  
Steven J. Hoffman ◽  
Kevin Outterson
Keyword(s):  
Public Health ◽  
Antibiotic Resistance ◽  
Collective Action ◽  
Global Health ◽  
Global Strategy ◽  
World Today ◽  
The World ◽  
The Many ◽  
Global Threat ◽  
Economic Tools

Of the many global health challenges facing the world today, only a small number require global collective action. Most health challenges can be fully addressed through action at local, regional or national levels.What kind of actions must be taken to address the global threat of antibiotic resistance (ABR)? What legal, political and economic tools might be needed to achieve this level of action?In March 2015 the Dag Hammarskjöld Foundation convened a workshop in Uppsala, Sweden to address these questions in partnership with the Global Strategy Lab, the Journal of Law, Medicine & Ethics (JLME), the Norwegian Institute of Public Health, and ReAct — Action on Antibiotic Resistance. Eleven concise articles were commissioned to explore whether ABR depended on global collective action, and if so, what tools could help states and non-state actors to achieve it.

scholarly journals Antibiotic resistance is a global health problem

BDJ ◽  
2020 ◽  
Vol 229 (7) ◽  
pp. 473-473
Author(s):  
Paul Hellyer
Keyword(s):  
Antibiotic Resistance ◽  
Global Health ◽  
Health Problem ◽  
Global Health Problem

scholarly journals Antibiotic Resistance: One Health One World Outlook

2021 ◽  
Vol 11 ◽  
Author(s):  
Bilal Aslam ◽  
Mohsin Khurshid ◽  
Muhammad Imran Arshad ◽  
Saima Muzammil ◽  
Maria Rasool ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Global Health ◽  
One Health ◽  
Animal Health ◽  
Significant Risk ◽  
World Health ◽  
Health Concern ◽  
Antibiotic Resistant ◽  
Human Animal ◽  
The One

Antibiotic resistance (ABR) is a growing public health concern worldwide, and it is now regarded as a critical One Health issue. One Health’s interconnected domains contribute to the emergence, evolution, and spread of antibiotic-resistant microorganisms on a local and global scale, which is a significant risk factor for global health. The persistence and spread of resistant microbial species, and the association of determinants at the human-animal-environment interface can alter microbial genomes, resulting in resistant superbugs in various niches. ABR is motivated by a well-established link between three domains: human, animal, and environmental health. As a result, addressing ABR through the One Health approach makes sense. Several countries have implemented national action plans based on the One Health approach to combat antibiotic-resistant microbes, following the Tripartite’s Commitment Food and Agriculture Organization (FAO)-World Organization for Animal Health (OIE)-World Health Organization (WHO) guidelines. The ABR has been identified as a global health concern, and efforts are being made to mitigate this global health threat. To summarize, global interdisciplinary and unified approaches based on One Health principles are required to limit the ABR dissemination cycle, raise awareness and education about antibiotic use, and promote policy, advocacy, and antimicrobial stewardship.

scholarly journals Conjugation Inhibitors Effectively Prevent Plasmid Transmission in Natural Environments

mBio ◽  
2021 ◽  
Author(s):  
Carolina Palencia-Gándara ◽  
María Getino ◽  
Gabriel Moyano ◽  
Santiago Redondo ◽  
Raúl Fernández-López ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Global Health ◽  
Natural Environments

The spread of antibiotic resistance is considered one of the major threats for global health in the immediate future. A key reason for the speed at which antibiotic resistance spread is the ability of bacteria to share genes with each other.

scholarly journals Using a cultural contexts of health approach to address the challenge of antibiotic resistance

2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
K Ledingham
Keyword(s):  
Antibiotic Resistance ◽  
Global Health ◽  
Health Outcomes ◽  
Cultural Factors ◽  
Regional Office ◽  
Cultural Contexts ◽  
Technological Factors ◽  
Health Challenge ◽  
Standards Of Living ◽  
Global Health Challenge

Abstract This presentation will provide an overview of key findings from a 2019 policy brief published by the WHO Regional Office for Europe using a cultural contexts of health approach to address the global health challenge of antibiotic resistance (ABR; see publication http://www.euro.who.int/en/publications/abstracts/antibiotic-resistance-using-a-cultural-contexts-of-health-approach-to-address-a-global-health-challenge-2019). It will delineate what a cultural contexts of health approach is and why it matters for tackling the contemporary threat of ABR. It is now increasingly recognized that the systematic neglect of cultural factors is one of the biggest obstacles to achieving better health outcomes and better standards of living worldwide. Using a cultural contexts of health approach, the presentation will describe how the prescription and use of antibacterial medicines, the transmission of resistance, and the regulation and funding of research are influenced by cultural, social and commercial, as well as biological and technological factors. The presentation will demonstrate how culture can serve as an enabler of health and provides new possibilities for change.

The Ethics of Antibiotic Resistance: Towards an Agenda for Feasible and Justified Global Health Policy

Bioethics ◽  
2019 ◽  
Vol 33 (7) ◽  
pp. 731-733 ◽  
Author(s):  
Christian Munthe ◽  
Niels Nijsingh ◽  
Karl Fine Licht ◽  
D.G. Joakim Larsson
Keyword(s):  
Antibiotic Resistance ◽  
Health Policy ◽  
Global Health ◽  
Global Health Policy

scholarly journals Aminoglycoside antibiotics inhibit mycobacteriophage infection

2020 ◽  
Author(s):  
Zheng Jiang ◽  
Junwei Wei ◽  
Nan Peng ◽  
Yingjun Li
Keyword(s):  
Antibiotic Resistance ◽  
Mycobacterium Tuberculosis ◽  
Structural Analysis ◽  
Global Health ◽  
Phage Therapy ◽  
Amino Sugar ◽  
Aminoglycoside Antibiotics ◽  
Phage Infection ◽  
Drug Resistant ◽  
Good Strategy

AbstractAntibiotic resistance is becoming the biggest current threat to global health. At the same time, phage therapy is witnessing a return of interest. The therapeutic use of bacteriophages, that infect and kill bacteria, is well suited to be a good strategy to combat antibiotic resistance. Furthermore, bacteriophages are increasingly used in combination with standard antibiotics against the drug-resistant pathogens. Interestingly, we found that the engineered mycobacteriophage phAE159 and natural phage D29 can not infect the Mycobacterium tuberculosis in the presence of kanamycin, hygromycin or streptomycin, but there is no effect on the phage infection in the presence of spectinomycin. Based on a series of studies and structural analysis of the above four aminoglycoside antibiotics, we can speculate as to the mechanism by which amino sugar group of aminoglycoside was able to selectively inhibit mycobacteriophage DNA replication. This is a rare discovery that broad-spectrum antibiotics inhibit phage infection. We envisioned that this study will provide guidance for people to combine phage and antibiotics to treat M. tuberculosis.

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