A Study to Test Different Doses of BI 1701963 Alone and Combined With Trametinib in Patients With Different Types of Advanced Cancer (Solid Tumours With KRAS Mutation)

The effect of prenatal administration of different doses of cortisone, corticosterone, dexamethasone, triamcinolone and prednisolone on the fetus and its palatal development was studied. All the glucocorticoids, except cortisone, produced cleft palate in the fetuses. Both the total frequency and morphologically different types of cleft palate were related to the dose of the teratogen. Triamcinolone appeared to be more potent than other glucocorticoid in inducing cleft palate. An association was noted between fetal growth inhibition, the dose of the teratogen and the frequency and type of cleft palate.

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Rubber Modified Asphalt Storage Stabilizer Option

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.311-313.1136 ◽

2011 ◽

Vol 311-313 ◽

pp. 1136-1139

Author(s):

Zhong He Chen ◽

Zheng Qian Zhang ◽

Hua Lin Luo ◽

Ning Ning Dong

Keyword(s):

Storage Stability ◽

Experimental Methods ◽

Modified Asphalt ◽

The Poor ◽

Different Types ◽

And Storage ◽

Different Doses

In order to improve the poor compatibility and storage stability of rubber modified asphalt,authors using theoretical and experimental methods, to investigate the influence of the stabilizer on the storage stability and the using performance of rubber modified asphalt, through adding the different types and different doses of stabilizer, to improve its storage stability and using performance of modified asphalt.

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The teratogenic effects of hydrocortisone on palatal development in the hamster

Development ◽

10.1242/dev.35.1.213 ◽

1976 ◽

Vol 35 (1) ◽

pp. 213-224

Author(s):

Ravindra M. Shah ◽

Anthony A. Travill

Keyword(s):

Cleft Palate ◽

Close Association ◽

Fetal Growth Retardation ◽

Placental Barrier ◽

Teratogenic Effects ◽

Different Types ◽

Palatal Development ◽

Two Peaks ◽

Different Doses ◽

Hydrocortisone Treatment

The effect of different doses of hydrocortisone, administered at various times during gestation, on the fetal hamster and its palatal development was studied. Both the frequency of cleft palate and that of resorption depended upon the dose of hydrocortisone and the time of its administration. Two peaks in the incidence of cleft palate were observed, which appeared to be due to inhibition of different events. Incidence of morphologically different types of cleft palate was related to the doses and gestational time of hydrocortisone treatment. A close association was observed between the frequency of cleft palate and fetal growth retardation and between the latter and the dose and time of drug administration. It was suggested that maternal physiology and the placental barrier may play a crucial role in cleft palate induction.

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Nanoscale porous organic polymers for drug delivery and advanced cancer theranostics

Chemical Society Reviews ◽

10.1039/d1cs00559f ◽

2021 ◽

Author(s):

Nem Singh ◽

Subin Son ◽

Jusung An ◽

Ilwha Kim ◽

Minhyeok Choi ◽

...

Keyword(s):

Drug Delivery ◽

Advanced Cancer ◽

Organic Polymers ◽

Porous Organic Polymers ◽

Diagnosis And Therapy ◽

Different Types ◽

Cancer Theranostics

This tutorial review highlights the potential of nanoscale porous organic polymers in diagnosis and therapy of different types of cancers.

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Immersive technology in ophthalmology education: a systematic review

BMJ Simulation and Technology Enhanced Learning ◽

10.1136/bmjstel-2021-000906 ◽

2021 ◽

pp. bmjstel-2021-000906

Author(s):

Shakeel Lowe ◽

Kathryn Mares ◽

Zarnie Khadjesari

Keyword(s):

Systematic Review ◽

Teaching Practices ◽

Conventional Teaching ◽

Different Types ◽

Standard Training ◽

And Performance ◽

Randomised Controlled ◽

Value Of It ◽

Different Doses ◽

Immersive Technology

BackgroundDespite the increasing use of immersive technology (IT) in ophthalmology, the effectiveness of this approach compared to other teaching practices is unclear. This systematic review aimed to determine the value of IT to teach students ophthalmic skills and whether it can supplement or replace conventional teaching practices.MethodsA systematic search was performed of CENTRAL, MEDLINE, EMBASE, ERIC and PsychINFO databases. Randomised controlled trials comparing IT interventions versus (1) no training, (2) standard training, (3) different types of IT interventions, (4) different doses of IT interventions were eligible for inclusion.ResultsSeven trials involving 177 participants were included. IT offered some benefit compared to standard training as most trials demonstrated evidence of learning represented by composite performance score and performance time. Repetitive training with IT displayed similar results.ConclusionIT appears to improve the ophthalmic skill of healthcare trainees and should be considered as a supplement to training.

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Latest Evidence on Using Hormone Replacement Therapy in the Menopause

Journal of Bangladesh College of Physicians and Surgeons ◽

10.3329/jbcps.v36i1.35508 ◽

2018 ◽

Vol 36 (1) ◽

pp. 26-32

Author(s):

Mst Jesmin Akter ◽

Eliza Shirin

Keyword(s):

Hormone Replacement Therapy ◽

Replacement Therapy ◽

Multidisciplinary Approach ◽

Hormone Replacement ◽

Individual Decision ◽

Ovarian Insufficiency ◽

Menopausal Women ◽

Different Types ◽

Different Doses

Hormone replacement therapy (HRT) is the most effective therapy of menopausal symptoms for perimenopausal and menopausal women. When HRT is individually tailored women gain maximum advantages and the risk are minimized. There are different types of hormones with different doses and different routes of delivery exist. . The use of HRT is an individual decision which women can only make once she has been given correct information and advice from healthcare professionals. HRT should be recommended in women with premature ovarian insufficiency with advice to continue until the average age of menopause at 51.4 years. This review item promotes confidence in prescribing HRT in most symptomatic women. Prescribing HRT in women with relative contraindication where evidence is limited. Quality of life is priority. Multidisciplinary approach may be necessary and informed written consent documented.J Bangladesh Coll Phys Surg 2018; 36(1): 26-32

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Studies on the effects of mutagens on cytotoxicity behaviour in Pigeon pea (Cajanus cajan (L.) Millsp) Var.CO-7.

Journal of Applied and Advanced Research ◽

10.21839/jaar.2016.v1i1.10 ◽

2016 ◽

Vol 1 (1) ◽

pp. 25

Author(s):

M. Ariraman ◽

T. Bharathi ◽

D. Dhanavel

Keyword(s):

Gamma Rays ◽

Cajanus Cajan ◽

Pigeon Pea ◽

Ethyl Methane Sulphonate ◽

Relative Deviation ◽

Methane Sulphonate ◽

Deviation Rate ◽

Different Types ◽

Rate Frequency ◽

Different Doses

The cytological studies provide more information regarding the response of a genotype to the particular mutagen and also provide chances to select desirable characters. The seeds of pigeon pea were subjected to different doses and concentrations of gamma rays and ethyl methane sulphonate (EMS). The effects of different mutagenic treatments on mitosis chromosomal behavior have been studied in both the mutagens. Different types of mitotic aberrations like stickiness, precocious movement, bridge, clumping of chromosome and laggards, etc., were observed in all the treatments. However, the gamma rays treatments proved to be more effective in inducing mitotic aberrations as compared to EMS. The frequency of laggard was high when compared to other mitotic aberrations. The reduction in mitotic index and relative deviation rate frequency were observed with increase in doses and conc. of both the mutagenic treatments and gamma rays were found to be more effective than EMS treatments.

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Synthesis and applications of nanoparticles: State of the Art and Future Perspective

Nanoscience &Nanotechnology-Asia ◽

10.2174/2210681211666210224154613 ◽

2021 ◽

Vol 11 ◽

Author(s):

Smriti Shukla ◽

Mitali Sharma ◽

Sapna Yadav ◽

Avinash Raghupathy ◽

Kartikeya Shukla ◽

...

Keyword(s):

Water Quality ◽

Human Health ◽

State Of The Art ◽

Crop Plants ◽

The Other ◽

Future Perspective ◽

Different Types ◽

Different Doses ◽

Soil And Water

: Nanoparticles are being extensively studied these days to grab more knowledge on how they can be used in various fields to increase the yields and hence be beneficial for biotic components of the ecosystem. Chemicals being used in agriculture have caused a lot of damage to the soil and water quality along with the crop plants, ultimately affecting human health severely. Better alternatives are thus required to get higher yields with a better quality of crop plants that enhance human health. A variety of nanoparticles exists in nature, while others have been manufactured accidentally or engineered purposefully. These can play many beneficial roles in the crop plants, increasing the yield of crops and quality of the grains. They can be applied at various stages and in different doses. The effect they exhibit would be dependent on many factors. Different nanoparticles have diverse effects on different plants. Some nanoparticles may be beneficial to one species of crop plant and disadvantageous to the other one. Therefore, an elaborative study is required on all the types of nanoparticles exhibiting their advantageous and disadvantageous impacts on different species of crop plants for the dose and stage in which they have been applied. This review explains the different types of nanoparticles categorized based on their manufacture and the different effects they cause in different plant species. More research and knowledge is yet to be obtained before using nanoparticles in crop plants since the way they affect human health is a serious matter of concern.

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