Market Structure of Scooter Segment of Two Wheeler Industry in India

Transportation system of a country has a noteworthy role to play in the development of an economy and its sectors. Automobile sector occupies a prominent place in the fabric of Indian economy. Presently, India has already touched the threshold of a major take off in the next decade and beyond to becoming one of the largest automotive (vehicle and component makers) manufacturers in the world. The objective of study was to measure the market structure of scooter segment of two wheeler industry in India for eight financial years, i.e. from the year 2011-12 to the year 2018-19. Descriptive analysis was conducted to present a profile of the industry which included analysis of average, standard deviation, compound annual growth rate, frequency, percentage of data value for each of the variables. The results of the study revealed that overall, there is existence of oligopoly form of market structure in the scooter segment of two wheeler industry in India.

Efficacy and safety of single-step transepithelial photorefractive keratectomy with the all-surface laser ablation SCHWIND platform without mitomycin-C for high myopia: A retrospective study of 69 eyes

Background Studies suggest that transepithelial photorefractive keratectomy (TransPRK) with the all-surface laser ablation (ASLA)-SCHWIND platform is effective and safe for both low-moderate myopia and high myopia. In most studies, mitomycin-C is administered immediately after surgery to prevent corneal opacification (haze), which is a significant complication of photorefractive keratectomy in general. However, there is evidence that adjuvant mitomycin-C induces endothelial cytotoxicity. Moreover, a recent study showed that omitting adjuvant mitomycin-C did not increase haze in low-moderate myopia. The present case-series study examined the efficacy, safety, and haze rates of eyes with high myopia that underwent ASLA-SCHWIND TransPRK without adjuvant mitomycin-C. Methods All consecutive eyes with high myopia (≤-6 D) that were treated in 2018–2020 with the SCHWIND Amaris 500E® TransPRK excimer laser without adjuvant mitomycin-C in a tertiary-care hospital (France) and were followed up for 6 months were identified. Uncorrected visual acuity (UCVA), best spectacle-corrected visual acuity (BSCVA), and spherical equivalent (SE) were recorded before and after surgery. Postoperative haze was graded using the 4-grade Fantes scale. Efficacy rate (frequency of eyes with 6-month UCVA ≤0.1 logMAR), safety rate (frequency of eyes that lost <2 BSCVA lines), predictability (frequency of eyes with 6-month SE equal to target SE±0.5 D), efficacy index (mean UCVA at 6 months/preoperative BSCVA), and safety index (BSCVA at 6 months/preoperative BSCVA) were computed. Results Sixty-nine eyes (38 patients) were included. Mean preoperative and 6-month SE were -7.44 and -0.05 D, respectively. Mean 6-month UCVA and BSCVA were 0.00 and -0.02 logMAR, respectively. Efficacy rate and index were 95.7% and 1.08, respectively. Safety rate and index were 95.7% and 1.13, respectively. Predictability was 85.5%. Grade 3–4 haze never arose. At 6 months, the haze rate was zero. Conclusions ASLA-SCHWIND TransPRK without mitomycin-C appears to be safe as well as effective and accurate for high myopia.

Bronco T (Shirisadi kasaya), a polyherbal formulation ameliorates LPS induced septicemia in rats

Septicemia is a life-threatening state, leading to multi-organ failure, ARDS and death. So, efforts are being made to identify novel therapies. Here, Bronco T (BT), a polyherbal formulation developed in 1984 for treating asthma, has been repurposed against septicemia induced ALI. The LPS (3mg/kg BW) was injected intraperitoneally before 24 hours, of surgery to assess the cardiorespiratory parameters, blood PaO2/FiO2, pulmonary water content and histological changes in the lungs. The pentoxifylline (PTX) (25 mg/kg b.w.) was used as the positive control. The PTX was given one hour before LPS and BT was given 3 hours (orally in different doses of 3, 1.5 and 0.75 gm/kg BW) to maintain the Cmax of the drug. The LPS treated group showed significant bradypnea, bradycardia and low heart rate frequency as observed, through elongated peaks (RR) and (MAP) respectively and finally death after 95 minutes of LPS injection. The PTX and BT (3gm/kg) pretreatment significantly prevented these changes (dose-dependent in the BT group). The survival was maintained up to 190 min after LPS. The Pentoxifylline showed a better response (75%) than Bronco T (72%). In both the treatments, a significant decrease in pulmonary water content and minimal neutrophil infiltration and intact alveoli-capillary membrane was seen in the transverse section (T.S) of the lungs. Conclusion: Significant improvement was noted in survival time, lesser tissue damage and better lung physiology by treating with Bronco T in LPS induced septicemia.

Pengaruh Pemberian Ekstrak Daun Gaharu (Grynops versteegii) terhadap Stres Transportasi pada Broiler Jantan

ABSTRACT. Penelitian bertujuan mengetahui pengaruh penambahan ekstrak daun Gaharu (Grynops verstegii) sebelum transportasi terhadap stres transportasi dan penyusutan bobot badan pada broiler jantan. Materi yang digunakan sebagai sampel yaitu 60 ekor dari 200 ekor broiler jantan yang dipelihara, dan ekstrak daun Gaharu dari hasil destilasi. Penelitian menggunakan metode eksperimental dengan Rancangan Acak Lengkap (RAL) dengan uji lanjut Duncan’s. Broiler jantan yang digunakan dalam penelitian terbagi menjadi 4 perlakuan level pemberian ekstrak daun Gaharu yang berbeda. Pemberian ekstrak daun Gaharu berdasarkan pada bobot badan (BB) broiler, yaitu P0 (tanpa pemberian ekstrak daun Gaharu sebagai kontrol ), P1 (250 mg/kg BB), P2 (300 mg/kg BB), P3 (350 mg/kg BB), setiap perlakuan memiliki lima ulangan dan setiap ulangan menggunakan 3 ekor. Parameter yang diamati adalah penyusutan bobot badan, frekuensi denyut jantung, suhu tubuh, dan frekuensi Pernafasan. Hasil penelitian menunjukkan bahwa penambahan ekstrak daun Gaharu (Grynops verstegii) tidak berpengaruh nyata (P0,05) terhadap persentase susut bobot badan broiler, frekuensi denyut jantung, suhu tubuh dan frekuensi pernafasan. Disimpulkan bahwa pemberian ekstrak daun Gaharu sebelum transportasi pada broiler tidak berpengaruh terhadap penurunan stres setelah transportasi hal ini ditunjukkan oleh perubahan suhu tubuh, frekuensi pernafasan, peningkatan denyut jantung dan penyusutan bobot badan yang tidak berbeda nyata (P0.05) dibandingkan dengan kontrol. (The effect of agarwood leaf extract (Grynops versteegii) on transport stress in male broilers) ABSTRAK. This study aims to determine the effect of adding agarwood leaf extract a source of antioxidants before transportation on body weight loss and the physiological conditions of broilers. The materials used were 60 male broilers as samples and agarwood leaf extract obtained through the extraction process using the distillation method. This study used experimental methods with a completely randomized design (CRD) with Duncan's test. The broilers used in the study consisted of 4 treatment groups with different levels of Gaharu leaf extract, they were P0 (control), P1 (250 mg/kg body weight, P2 (300 mg/kg body weight), P3 (350 mg/kg body weight), each treatment was repeated five times and each repetition used 3 individuals. The parameters observed were weight loss, heart rate frequency, increase in body temperature, and respiratory rate. The results showed that the addition of agarwood leaf extract (Grynops verstegii) had no significant effect (P 0.05) on the percentage of broiler body weight loss, heart rate frequency, increased body temperature and respiratory frequency. It was concluded that the addition of agarwood leaf extract before transportation could not reduce body weight loss and the physiological conditions of broilers.

PENGARUH METODE PEMBERIAN RANSUM PADA SIANG DAN MALAM HARI TERHADAP RESPON FISIOLOGIS AYAM JANTAN TIPE MEDIUM DI KANDANG POSTAL

This study aimed to determine the effect of the method of giving rations during the day and night on the physiological response (respiratory rate, rectal temperature, and heart rate) of medium type roosters in postal cages and to determine the effect of the best day and night ration methods on physiological response of medium type rooster in postal cage. This study used a Completely Randomized Design (CRD), consisting of three treatments with six replications, those were P1: 30% day and 70% night ration; P2: 50% day and 50% night ration; P3: 70% day and 30% night ration. The chicken used was male Lohman strain medium type of 144 chickens. The resulting data were analyzed with variance at 5% level. The results showed that the influence of day and night administration method was not different (P > 0.05) on the frequency of breath (51.73 to 55.27 Times/min), rectal temperature (41.13 to 41.16oC), and heart rate frequency (421.2 to 434.7 times/minute). Keywords: Day and night rationing, Medium type rooster, Physiological response, Postal cage

Pharmacist intervention on prescribing errors: Use of a standardized approach in the inpatient setting

Disclaimer In an effort to expedite the publication of articles related to the COVID-19 pandemic, AJHP is posting these manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. Purpose The objective of this study was to implement a standardized process across health systems to determine the prevalence and clinical relevance of prescribing errors intercepted by pharmacists. Methods This prospective, multicenter, observational study was conducted across 11 hospitals. Pharmacist-intercepted prescribing errors were collected during inpatient order verification over 6 consecutive weeks utilizing a standardized documentation process. The potential harm of each error was evaluated using a modified National Coordinating Council for Medication Error Reporting and Prevention (NCC-MERP) index with physician validation, and errors were stratified into those with potentially low, serious, or life-threatening harm. Endpoints included the median error rate per 1,000 patient days, error type, and potential harm with correlating cost avoidance. Results Pharmacists intervened on 7,187 errors, resulting in a mean error rate of 39 errors per 1,000 patient days. Among the errors, 46.6% (n = 3,349) were determined to have potentially serious consequences and 2.4% (n = 175) could have been life-threatening if not intercepted. This equates to $874,000 in avoided cost. The top 3 error types occurring with the highest frequency were "wrong dose/rate/frequency” (n = 2,298, 32.0%), “duplicate therapy” (n = 1,431, 19.9%), and "wrong timing” (n = 960, 13.4%). “Wrong dose/rate/frequency” (n = 49, 28%), “duplicate therapy” (n = 26, 14.9%), and “drug-disease interaction” (n = 24, 13.7%) errors occurred with the highest frequency among errors with potential for life-threatening harm. “Wrong dose/rate/frequency” (n = 1,028, 30.7%), “wrong timing” (n = 573, 17.1%), and “duplicate therapy” (n = 482, 14.4%) errors occurred with the highest frequency among errors with potentially serious harm. Conclusion Documentation of pharmacist intervention on prescribing errors via a standardized process creates a platform for multicenter analysis of prescribing error trends and an opportunity for development of system-wide solutions to reduce potential harm from prescribing errors.

POS0800 VISUAL ISCHEMIA DURING RELAPSE AND FOLLOW-UP OF GIANT CELL ARTERITIS: A SYSTEMATIC REVIEW

Background:Visual ischemia (VI) is one of the most feared complications in giant cell arteritis (GCA). While the frequencies of VI development at or near diagnosis are better studied, limited information is available regarding the frequency of VI during relapse.Objectives:The purpose of this study was to characterize the frequency of visual ischemia (VI) as a manifestation of relapse or during follow-up in patients with GCA through performance of a systematic literature review.Methods:Potentially eligible studies were identified from Medline and EMBASE databases from inception to November 31, 2019 using a search strategy that comprised of terms for “giant cell arteritis,” “temporal arteritis,” or “Horton’s disease,” with “relapse,” “recurrence,” “flare,” “outcome,” “follow-up,” or “prognosis.” VI was defined as transient or permanent, full or partial, monocular or binocular visual field loss. VI occurring within 4 wks of GCA diagnosis was considered due to active disease and not included as a relapse event. Inclusion criteria used: (1) original research reported in English, (2) GCA definition provided, (3) VI outcome described as one of the following: (a) relapse rate/frequency denoting the presence or absence of VI, or (b) absolute number of VI events (> 4 weeks after GCA diagnosis) even if total cohort relapse rate/frequency was not provided. In order to reduce bias from under-reporting of negative results, studies that reported relapse rates/frequencies with accompanying relapse characteristics but did not provide initial detail regarding the presence/absence of VI were also identified. In such circumstances, the primary authors were directly contacted for patient-level data regarding VI and these studies were included in the final analysis if such data were available and provided.Results:A total of 913 unique articles were identified and underwent screening. Among these, 148 articles underwent independent full-text review by two physicians (K.B. and M.J.K). 33 articles met full inclusion criteria and an additional 21 articles included data on relapse but did not report VI patient data in the publication. Responses were received from authors of 11 of these 21 studies allowing for inclusion. 44 studies accounting for 3,649 patients with GCA were identified. Average percentage of baseline VI was 19% (range 0-66%). The average length of follow-up was 3.4 years (range 0.4 to 8.7). VI developing > 4 weeks after GCA diagnosis was recorded in a total of 53 patients (1.5%).Study-defined relapses were reported in 36 studies. A total of 1,215 patients with at least one or more relapses were recorded among 2,592 patients under observation (47%). Among these 36 studies, VI occurred in 37 patients (3.0%) with at least one study defined relapse event.Comparing trial design, retrospective studies (n=25) reported 27 of 2,718 (1%) patients developed VI during follow-up whereas 19 of 541 (3.5%) patients in randomized controlled trials (n=8) developed VI during the trial or post-trial follow-up.Conclusion:This report outlines the first systematic review evaluating VI as a manifestation of relapse and during follow-up in GCA. Overall, VI > 4 weeks after GCA diagnosis is uncommon (1.5%) but is noted in up to 3% of patients with at least one relapse event. Frequencies of reported VI were 3.5 times higher in randomized controlled trials compared to retrospective studies.Disclosure of Interests:Kubra Bugdayli: None declared, Patompong Ungprasert: None declared, Kenneth J Warrington Grant/research support from: Financial support for research from Kiniksa, Eli Lilly, Matthew Koster: None declared

Risk Factors for Severe Hypocalcemia in Patients with Secondary Hyperparathyroidism after Total Parathyroidectomy

Background. Hypocalcemia is the most common complication of total parathyroidectomy in secondary hyperparathyroidism (SHPT) and is associated with adverse consequences such as spasms, epilepsy, and arrhythmia and even death if the serum calcium level decreases rapidly. Previous studies have identified several risk factors for postoperative severe hypocalcemia (SH) in patients with SHPT, but the sample sizes were small and thus the results may not be reliable. Objectives. This study was performed to investigate the risk factors for SH after total parathyroidectomy without autotransplantation (tPTX) in a large sample of patients with uremic hyperparathyroidism. Methods. We retrospectively investigated the records of 1,095 patients with SHPT treated with tPTX between January 2008 and December 2018. Based on the postoperative serum calcium concentration, the patients were grouped into SH and non-SH groups. The clinical characteristics and biochemical results were analyzed, and binary logistic regression analysis was used to identify the risk factors for SH. Results. After surgery, 25.9% of the patients developed SH. Age, diastolic blood pressure (DBP), heart rate, frequency of bone pain, weight of resected glands, preoperative serum calcium, intact parathyroid hormone (iPTH), alkaline phosphatase (ALP), and hemoglobin levels differed between the two groups. Binary logistic regression analyses identified preoperative serum calcium, iPTH, and ALP levels as independent predictors of SH after surgery. Conclusions. The preoperative serum calcium, iPTH, and ALP levels can be used to assess the risk of postoperative SH in patients with SHPT. Such patients should thus be monitored closely in order to initiate prompt interventions to avoid SH.

PENGARUH MANIPULASI IKLIM KANDANG MELALUI PENGKABUTAN TERHADAP RESPON FISIOLOGIS DAN KETAHANAN PANAS KAMBING SAPERA DAN PERANAKAN ETTAWA

This study aimed to determine the effect of cage microclimate manipulation with misting on physiological responses and heat resistance of goats (Sapera and Ettawa Grade). This research was conducted in April - May 2020 at Telaga Rizki People's Farm, Metro City, Lampung Province. This study used an experimental method, Split Plot design with a completely randomized design (CRD). This study used two treatments, namely modification of the pen consisting of pens without misting (K0) and pens with misting (K1) and two breed of goats, namely Sapera and Ettawa Grade (PE) goats. Each treatment was carried out 3 times. Goats as subplots and microclimate modification of the pen as the main plot. In this study, twelve female goats were used, namely 6 Sapera goats and 6 Ettawa Grade (PE) goats aged 2-3 years. The parameters observed were microclimate condition, namely air temperature, relative humidity (RH), and Temperature Humidity Index (THI), and physiological responses including rectal temperature, respiration frequency, heart rate frequency, and heat tolerance (HTC). The results of the research showed that there was significant effect (P<0.05) of treatments on RH and THI. The resilts also showed that there was no significant effect (P>0.05) of treatments on rectal temperature, heart rate, respiration frequency, HTC and environment temperature. Keywords : Misting, Pens microclimate, Physiological responses