scholarly journals Experimental Hookworm Infection in Laboratory animals: Parasite behavior, Immune response and Chemotherapeutic Studies

2021 ◽  
Vol 2 (5) ◽  
pp. 01-03
Author(s):  
Mahendra Bhopale
Keyword(s):  
Vaccine Development ◽  
Laboratory Animals ◽  
Preventive Chemotherapy ◽  
Main Research ◽  
Main Research Interest ◽  
Parasite Relationship ◽  
Ancylostoma Duodenale ◽  
Host Parasite ◽  
Parasite Behavior ◽  
Laboratory Models

Hookworm disease is known to be caused allergic manifestation and severe anemic pathogenicity in man and canine hosts. Attempts have been made to establish laboratory models of Necator americaus, Ancylostoma duodenale, and Ancylostoma ceylanicum, together with canine parasite, Ancylostoma caninum. The studies include pathophysiological aspects of the host-parasite relationship, and develop to establish patent infection. Immunological approach to selecting antigen for diagnosis and protective immunity purpose using larval and adult worm antigens and their secretions became the focus with the subsequent discovery of cloning in vaccine development as main research interest. Chemotherapy of newer drug screening in laboratory models ultimately selected to use for preventive chemotherapy in hookworm endemic areas using recommended drugs.

Cyclosporin A: antiparasite drug, modulator of the host-parasite relationship and immunosuppressant

Parasitology ◽  
1992 ◽  
Vol 105 (S1) ◽  
pp. S25-S40 ◽  
Author(s):  
L. H. Chappell ◽  
J. M. Wastling
Keyword(s):  
Cyclosporin A ◽  
Drug Administration ◽  
Gastrointestinal Nematodes ◽  
Laboratory Animals ◽  
Parasitic Infections ◽  
Filarial Nematodes ◽  
Host Parasite Relationship ◽  
Parasite Relationship ◽  
Host Parasite

SUMMARYCyclosporin A (CsA), a cyclic undecapeptide with powerful properties of immunosuppression, acts on parasitic infections in laboratory animals in various ways. The outcome of drug administrationin vivovaries with timing of treatment relative to infection, route of administration, dose and number of treatments applied. CsA is clearly antiparasitic against malaria, schistosomes, adult tapeworms, metacestodes and filarial nematodes. By contrast, it acts as an immunomodulator against trypanosomes andGiardia, by exacerbating infection; in the case ofLeishmaniaspp. the drug acts variously. In some other infections CsA acts both as an antiparasite drug and as an immunosuppressant (Toxoplasma, avian coccidiosis and gastrointestinal nematodes).

scholarly journals Immunogenicity of specificBordetella pertussissurface antigens in diphtheria-tetanus-pertussis (DTP) vaccines

1988 ◽  
Vol 100 (3) ◽  
pp. 335-344 ◽  
Author(s):  
Alan C. Blaskett ◽  
John C. Cox
Keyword(s):  
Bordetella Pertussis ◽  
Whooping Cough ◽  
Laboratory Animals ◽  
Major Type ◽  
Causative Organism ◽  
Human Host ◽  
Host Parasite Relationship ◽  
Parasite Relationship ◽  
Dtp Vaccine ◽  
Host Parasite

SUMMARYThe predominant causative organism of whooping cough in Australia is of a serotype which has normally been associated overseas with unvaccinated communities. Australian DTP vaccines pass the statutory mouse test forBordetella pertussispotency but this test is now believed to be relatively insensitive to certain factors, especially the major type-specific agglutinogens, which are presumably also important in the human host-parasite relationship. Because endemicB. bronchisepticainfections make some laboratory animals unsatisfactory for testingB. pertussisagglutinin responses, we have developed a test in which young farm sheep were immunized with vaccines. Type-specific agglutinins in their sera were assayed after absorption of non-specific agglutinins by suspensions of selected bordetella strains. Three well-reputed European DTP vaccines and two recent batches of Australian DTP vaccine were tested and compared thus. All evoked significant agglutinin responses to the main agglutinogens.

Mechanisms of immunity to malaria and the possibilities of a blood-stage vaccine: a critical appraisal

Parasitology ◽  
1989 ◽  
Vol 98 (2) ◽  
pp. 315-327 ◽  
Author(s):  
G. A. Butcher
Keyword(s):  
Immune System ◽  
Protective Immunity ◽  
Critical Appraisal ◽  
Vaccine Development ◽  
Blood Stage ◽  
Relative Importance ◽  
Host Parasite ◽  
Laboratory Models ◽  
Blood Stage Malaria

SUMMARYResistance developed by the immune system in response to blood-stage malaria is complex in nature, involving humoral and non-antibody effector mechnisms. Different species of malarial parasites may vary in their ability to elicit, or their susceptibility to, those immune effectors. This complexity is enhanced by the different results obtained in vaccinated as opposed to drug-controlled infections. It is therefore important that some attempt be made to unravel these interactions. This is particularly so when we have to decide on methods for assessing the potentiality of antigens to induce protective immunity. In this review the limitations of somein vitroassays of immunity, as well as those of various host–parasite models, are discussed. The relative importance of cell-mediated and humoral immunity in laboratory models and natural infections is also considered in the context of vaccine development.

‘More Product, Less Process’ (MPLP): An early printed book project

2021 ◽  
pp. 096100062110267
Author(s):  
Karen Attar
Keyword(s):  
18Th Century ◽  
The United States ◽  
Global Changes ◽  
Main Research ◽  
Advantages And Disadvantages ◽  
Main Research Interest ◽  
Printed Books ◽  
Starting Point ◽  
19Th And 20Th Century

This article addresses the challenge to make printed hidden collections known quickly without sacrificing ultimate quality. It takes as its starting point the archival mantra ‘More product, less process’ and explores its application to printed books, mindful of projects in the United States to catalogue 19th- and 20th-century printed books quickly and cheaply with the help of OCLC. A problem is lack of time or managerial inclination ever to return to ‘quick and dirty’ imports. This article is a case study concerning a collection of 18th-century English imprints, the Graveley Parish Library, at Senate House Library, University of London. Faced with the need to provide metadata as quickly as possible for digitisation purposes, Senate House Library decided, in contrast to its normal treatment of early printed books, to download records from the English Short Title Catalogue and amend them only very minimally before releasing them for public view, and to do this work from catalogue cards rather than the books themselves. The article describes the Graveley Parish collection, the project method’s rationale, and the advantages and disadvantages of sourcing the English Short Title Catalogue for metadata. It discusses the drawbacks of retrospective conversion (cataloguing from cards, not books): insufficient detail in some cases to identify the relevant book, and ignorance of the copy-specific elements of books which can constitute the main research interest. The method is compared against cataloguing similar books from photocopies of title pages, and retrospective conversion using English Short Title Catalogue is compared against retrospective conversion of early printed Continental books from cards using Library Hub Discover or OCLC. The control groups show our method’s effectiveness. The project succeeded by producing records fast that fulfilled their immediate purpose and simultaneously would obviously require revisiting. The uniform nature of the collection enabled the saving of time through global changes.

Susceptibilities of Various Snail Intermediate Hosts of Schistosoma mansoni to Different Strains of the Parasite

1965 ◽  
Vol 39 (4) ◽  
pp. 363-376 ◽  
Author(s):  
M.F.A. Saoud
Keyword(s):  
Puerto Rico ◽  
Schistosoma Mansoni ◽  
Intermediate Hosts ◽  
Considerable Evidence ◽  
The Past ◽  
Host Parasite Relationship ◽  
Parasite Relationship ◽  
Different Strains ◽  
Host Parasite ◽  
Comprehensive Studies

In the past two decades, considerable evidence has accumulated in the literature about the differences in the susceptibility of various intermediate hosts of Schistosoma mansoni to different strains of the parasite. Comprehensive studies on this aspect of host-parasite relationship have been published by Files & Cram (1949), Abdel-Malek (1950) and Files (1951). The results of more recent studies have been reported by Wright (1962) and Saoud (1964).In the present paper, the writer has studied the susceptibility of four intermediate hosts of S. mansoni from Brazil, Puerto Rico, Egypt and Tanganyika to some strains of the parasite.

Certain aspects of the host-parasite relationship ofNematospiroides dubius(Baylis). II. The effect of sex on experimental infections in the rat (an abnormal host)

Parasitology ◽  
1961 ◽  
Vol 51 (3-4) ◽  
pp. 499-510 ◽  
Author(s):  
Colin Dobson
Keyword(s):  
Male Rats ◽  
Male Rat ◽  
Normal Male ◽  
Female Rat ◽  
Castrate Male ◽  
Parasite Relationship ◽  
Nematospiroides Dubius ◽  
Resistance To Infection ◽  
Host Parasite ◽  
The Relationship

1. The male rat is more susceptible to infections ofNematospiroides dubiusthan the female. As the rat grows older the resistance of the female rat to infection increases at a greater rate than that of the male.2. The course of the infection is modified by the sex of the host.3. More larvae penetrated the intestinal mucosa to encyst in the male than in the female. More larvae, however, formed cysts in the female than in the male rat by the fifth day.4. The male harboured more adult worms than the female rat, although this difference was not significant in the immature animals.5. The sex resistance of the rat toN. dubiusinfections was removed by bilateral gonadectomy. Castration decreased the susceptibility of the male rat, while spaying increased it in the female compared with the susceptibility in the respective normal hosts.6. Subsequent replacement of the homologous sex hormone in the gonadectomized rat restores the sex resistance, and may even increase it (particularly in the immature animals). Oestradiol increased the resistance of the spayed female rat, while testosterone increased the susceptibility of the castrate male rat to infection.7. Oestradiol implanted in castrate male rats increased the resistance of these hosts to a greater level than was shown in the normal male rat.8. The rat shows a marked age resistance over which the sex resistance is superimposed.9. The relationship between the sex of the host and its resistance to infection is discussed.This work was done during the tenure of a Department of Scientific and Industrial Research Studentship. My thanks are due to Dr E. T. B. Francis for his helpful and critical supervision and to Professor I. Chester Jones, in whose department the work was done, for the facilities he provided.

Social determinants of mental well-being: senses of powerlessness and empowerment among Romani in Ukraine

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Viktoriia Gorbunova ◽  
Natalia Gusak ◽  
Vitalii Klymchuk ◽  
Valeriia Palii ◽  
Vitalina Ustenko ◽  
...  
Keyword(s):  
Social Determinants ◽  
Local Community ◽  
Extended Family ◽  
Well Being ◽  
Structured Interview ◽  
Research Strategy ◽  
Content Type ◽  
Main Research ◽  
Main Research Interest ◽  
Mental Well Being

Purpose The purpose of this paper is to explore senses of powerlessness and empowerment among Romani in Ukraine in relation to such social circles as the extended family, the Romani local community and the whole Ukrainian society. The main research interest is focused on situations and factors that make people feel powerless or empowered. Design/methodology/approach The study was conducted using a semi-structured interview method via telephone. Romani NGO experts approved the interview content. Trained Roma-facilitators were interviewers. Every interview was transcribed for further thematic analysis. Findings The most prominent empowerment factors for Romani people are located within their families and local communities, while the bigger society (Ukrainians themselves and Ukrainian public institutions) is a main source of powerlessness. At the same time, the rigid role of family and community expectations is seen as detrimental for both males and females. Originality/value The paper is original in terms of its topic (senses of powerlessness and empowerment among Romani in Ukraine as social determinants of mental well-being) and research strategy (engagement of Roma-facilitators as interviewers).

Sign in / Sign up

Export Citation Format

Share Document