scholarly journals MORPHOFUNCTIONAL CHARACTERISTICS THYROID GLAND OF WHITE-BREASTED MALE HEDGEHOG IN THE PERIOD OF PUBERTY

2021 ◽  
Vol 248 (4) ◽  
pp. 233-237
Author(s):  
D.N. Fiadotau ◽  
◽  
◽  
Keyword(s):  
Thyroid Gland ◽  
Sexual Maturation ◽  
Stage I ◽  
Stage Ii ◽  
Stage Iii ◽  
Three Stages ◽  
Morphological State ◽  
End Of Puberty

The issue of the morphofunctional characteristics of the thyroid gland of male white-breasted hedgehogs during puberty on the territory of Belarus was studied. Material for the study was taken from 15 males, who were divided into three stages of studying the sexual maturation of hedgehogs: stage I - prepubertal period, stage II - the beginning of puberty, and stage III - activation of the gonads and the end of puberty. The results obtained characterize the morphological state of the thyroid gland of male white-breasted hedgehogs during puberty, and thus makes it possible to use morphometric indicators of structures as indicators of the environment and physiological states (for assessing puberty).

Frontal osteomas: standardising therapeutic indications

2011 ◽  
Vol 125 (10) ◽  
pp. 1020-1027 ◽  
Author(s):  
L M Gil-Carcedo ◽  
E S Gil-Carcedo ◽  
L A Vallejo ◽  
J M de Campos ◽  
D Herrero
Keyword(s):  
Classification System ◽  
Bone Destruction ◽  
Stage I ◽  
Stage Ii ◽  
Stage Iii ◽  
Tumour Mass ◽  
Surgical Indications ◽  
Monitoring Protocol ◽  
Three Stages ◽  
Relationship Of

AbstractBackground:We believe the currently accepted indications for frontal osteoma surgery are inappropriate. We propose a new osteoma classification system, below, in order to standardise surgical decisions.Method:Osteomas were classified based on: relationship of tumour mass to sinus size; tumour proximity to the infundibulum, destruction of sinus walls, and complications. Forty-five osteoma cases were thus classified (1971–2007), 29 of which underwent surgery (64.44 per cent).Results:Three stages were thus derived: I, tumour/air fraction less than one-third, tumour distant from the infundibulum, no sinusitis, and no complications (18 patients (40 per cent)); II, tumour/air fraction one-third to one-half, no infundibular obstruction, no bone destruction, no sinusitis, and no complications (six (13.33 per cent)); and III, tumour/air fraction more than one-half, partial or total infundibular obstruction, sinusitis, bone destruction, and/or complications (21 (46.67 per cent)).Conclusion:Study findings suggest the following surgical indications: stage I, no surgery required, implement monitoring protocol; stage II, implement monitoring protocol, surgery may be required depending on tumour severity and general patient condition; and stage III, surgery always required. This system provides a method of standardising osteoma surgical decisions.

scholarly journals Influences of High-Speed Train Speed on Tunnel Aerodynamic Pressures

2021 ◽  
Vol 12 (1) ◽  
pp. 303
Author(s):  
Jianming Du ◽  
Qian Fang ◽  
Jun Wang ◽  
Gan Wang
Keyword(s):  
High Speed ◽  
Peak Pressure ◽  
Stage I ◽  
Stage Ii ◽  
Stage Iii ◽  
High Speed Train ◽  
Railway Tunnel ◽  
Maximum Peak ◽  
Train Speed ◽  
Three Stages

To comprehensively investigate the characteristics of aerodynamic pressures on a tunnel caused by the whole tunnel passage of a high-speed train at different speeds, we conduct a series of three-dimensional numerical simulations. Based on the field test results obtained by other researchers, the input parameters of our numerical simulation are determined. The process of a high-speed train travelling through a railway tunnel is divided into three stages according to the spatial relationship between the train and tunnel. Stage I: before train nose enters the entrance; Stage II: while the train body runs inside the tunnel; Stage III: after the train tail leaves the exit. The influences of high-speed train speed on the tunnel aerodynamic pressures of these three stages are systematically investigated. The results show that the maximum peak pressure value decreases with increasing distance from the entrance and increases with increasing train speed in Stage I. There is an approximately linear relationship between the three types of maximum peak pressure (positive peak, negative peak, and peak-to-peak pressures) and the power of the train speed in Stage II. These three types of maximum peak pressure values of the points near tunnel portals increase with increasing train speed in Stage III. Moreover, these three types of maximum peak pressure in the tunnel’s middle section at different train speeds are more complex than those near the tunnel portals, and there is one or more turning points due to the superimposed effects of different pressure waves.

Growth of crop communities and the production of yield.

2021 ◽  
pp. 50-88
Author(s):  
Dennis B. Egli
Keyword(s):  
Production Process ◽  
Leaf Area ◽  
Stage I ◽  
Stage Ii ◽  
Stage Iii ◽  
Species Variation ◽  
Seed Number ◽  
Yield Production ◽  
Three Stages ◽  
Community Growth

Abstract This chapter focuses on developing general model of community growth and the production of yield by grain crops. Murata's (1969) three-stage system provides such a model. It is useful because it is simple (only three stages), it applies equally well to all grain crop species (although there are some species variation in minor details), it clearly identifies the sequential nature of the yield production process and the three stages relate to the primary drivers of the yield production process at the community level. First, the crop must accumulate the leaf area that drives community photosynthesis (Stage I), then seed number is determined (Stage II), and finally seed filling occurs (Stage III) and the production of yield is finished. High yield of any variety/location combination requires, at a minimum: (i) the production of enough leaf area index (LAI) during Stage I to maximize solar radiation interception and community photosynthesis; and (ii) an absence of stress during Stage II to maximize seed number and during Stage III to allow the seeds to fill to their maximum potential size. The scheme provides a powerful framework for us to think about how management decisions and environmental conditions affect yield.

A survey of white mica crystallinity and polytypes in pelitic rocks of Snowdonia and Llŷn, North Wales

1985 ◽  
Vol 49 (352) ◽  
pp. 305-319 ◽  
Author(s):  
R. J. Merriman ◽  
B. Roberts
Keyword(s):  
Regional Metamorphism ◽  
Xrd Analysis ◽  
White Mica ◽  
Stage I ◽  
Stage Ii ◽  
Stage Iii ◽  
North Wales ◽  
Volcaniclastic Rocks ◽  
Three Stages ◽  
Pelitic Rocks

AbstractPelitic rocks in North Wales, ranging in age from late Precambrian to Silurian were sampled. XRD analysis was used to determine the mineralogy and white mica crystallinity of separated < 2 µm fractions. Results show that three stages of metapelite recrystallization can be distinguished. Stage I metapelites are uncleaved or feebly cleaved with crystallinities > 0.43Δ°2θ; the 1Md polytype dominates < 2 µm fractions, occurring as K-and Na-micas. Stage II metapelites show variable cleavage development and crystallinities in the range 0.26-0.43Δ°2θ; 1Md and 2M1 polytypes occur and K- and Na-micas are commonly regularly interstratified. Stage III metapelites are strongly cleaved with crystallinities < 0.26Δ°2θ; the 2M1 polytype is dominant, occurring as K-mica and paragonite. Pelites bearing pyrophyllite, rectorite, and corrensite are found close to plug-like intrusions and were contact altered prior to regional metamorphism. 1M mica is common in deeply buried but relatively undeformed volcaniclastic rocks of the Arfon Group.Contours of equal crystallinity (isocrysts) are plotted with metabasite zones on a metamorphic map. This shows that stage I metapelites are equivalent to the subpumpellyite zone (≡?laumontite zone). Stage II metapelites are equivalent to the prehnite-pumpellyite facies and stage III metapelites to the clinozoisite and biotite zones of the greenschist facies.

Postcriterion Insertion of a Second Relevant Dimension in a Simple Discrimination Problem

1966 ◽  
Vol 18 (2) ◽  
pp. 547-551 ◽  
Author(s):  
B. R. Hergenhahn ◽  
Charles Myers ◽  
Jack Capehart
Keyword(s):  
Irrelevant Dimension ◽  
Discrimination Problem ◽  
Relevant Dimension ◽  
Stage I ◽  
Stage Ii ◽  
Stage Iii ◽  
Control Group ◽  
Simple Discrimination ◽  
Three Stages

Thirty-one human Ss participated in a discrimination problem having three stages. Stage I involved one relevant dimension and one irrelevant dimension. Ss were trained to a criterion of eight successive correct responses. After reaching criterion on Stage I, Ss began Stage II, in which both the relevant and irrelevant cues from Stage I were maintained, and one more relevant and one more irrelevant dimension were added. At this point, it was possible for Ss to solve the problem by responding to the “old” relevant cue, the new cue, or both. Certain theories predict a sampling of the inserted cues; others predict they will not be sampled. In Stage III, the relevant and irrelevant cues from Stage I were dropped out. Solution of the problem could be gained only by responding to the cues inserted in Stage II. A control group was overtrained on Stage I and then went directly to Stage III. The data supported theories predicting sampling of all cues in Stage II.

Identification of biomarkers and functional modules from genomic data in stage-wise breast cancer

2020 ◽  
Vol 15 ◽  
Author(s):  
Athira K ◽  
Vrinda C ◽  
Sunil Kumar P V ◽  
Gopakumar G
Keyword(s):  
Breast Cancer ◽  
Expression Patterns ◽  
Differential Expression Analysis ◽  
Predictive Biomarkers ◽  
Stage I ◽  
Stage Ii ◽  
Stage Iii ◽  
Functional Modules ◽  
Incidence And Mortality ◽  
Multiple Stages

Background: Breast cancer is the most common cancer in women across the world, with high incidence and mortality rates. Being a heterogeneous disease, gene expression profiling based analysis plays a significant role in understanding breast cancer. Since expression patterns of patients belonging to the same stage of breast cancer vary considerably, an integrated stage-wise analysis involving multiple samples is expected to give more comprehensive results and understanding of breast cancer. Objective: The objective of this study is to detect functionally significant modules from gene co-expression network of cancerous tissues and to extract prognostic genes related to multiple stages of breast cancer. Methods: To achieve this, a multiplex framework is modelled to map the multiple stages of breast cancer, which is followed by a modularity optimization method to identify functional modules from it. These functional modules are found to enrich many Gene Ontology terms significantly that are associated with cancer. Result and Discussion: predictive biomarkers are identified based on differential expression analysis of multiple stages of breast cancer. Conclusion: Our analysis identified 13 stage-I specific genes, 12 stage-II specific genes, and 42 stage-III specific genes that are significantly regulated and could be promising targets of breast cancer therapy. That apart, we could identify 29, 18 and 26 lncRNAs specific to stage I, stage II and stage III respectively.

Cardiac transthyretin wild-type amyloidosis (ATTRwt): a prospective study of 400 patients followed at the Italian referral center

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
P Milani ◽  
L Obici ◽  
R Mussinelli ◽  
M Basset ◽  
G Manfrinato ◽  
...  
Keyword(s):  
Natural History ◽  
Median Survival ◽  
Troponin I ◽  
Stage I ◽  
Stage Ii ◽  
Stage Iii ◽  
Wild Type ◽  
Staging Systems ◽  
Significant Difference ◽  
History Of

Abstract Background Cardiac wild type transthyretin (ATTRwt) amyloidosis, formerly known as senile systemic amyloidosis, is an increasingly recognized, progressive, and fatal cardiomyopathy. Two biomarkers staging systems were proposed based on NT-proBNP (in both cases) and troponin or estimated glomerular filtration rate, that are able to predict survival in this population. The availability of novel effective treatments requires large studies to describe the natural history of the disease in different populations. Objective To describe the natural history of the disease in a large, prospective, national series. Methods Starting in 2007, we protocolized data collection in all the patients diagnosed at our center (n=400 up to 7/2019). Results The referrals to our center increased over time: 5 cases (1%) between 2007–2009, 33 (9%) in 2010–2012, 90 (22%) in 2013–2015 and 272 (68%) in 2016–2019. Median age was 76 years [interquartile range (IQR): 71–80 years] and 372 patients (93%) were males. One hundred and seventy-three (43%) had atrial fibrillation, 63 (15%) had a history of ischemic cardiomyopathy and 64 (15%) underwent pacemaker or ICD implantation. NYHA class was I in 58 subjects (16%), II in 225 (63%) and III in 74 (21%). Median NT-proBNP was 3064 ng/L (IQR: 1817–5579 ng/L), troponin I 0.096 ng/mL (IQR: 0.063–0.158 ng/mL), eGFR 62 mL/min (IQR: 50–78 mL/min). Median IVS was 17 mm (IQR: 15–19 mm), PW 16 mm (IQR: 14–18 mm) and EF 53% (IQR: 45–57%). One-hundred and forty-eight subjects (37%) had a concomitant monoclonal component in serum and/or urine and/or an abnormal free light chain ratio. In these patients, the diagnosis was confirmed by immunoelectron microscopy or mass spectrometry. In 252 (63%) the diagnosis was based on bone scintigraphy. DNA analysis for amyloidogenic mutations in transthyretin and apolipoprotein A-I genes was negative in all subjects. The median survival of the whole cohort was 59 months. The Mayo Clinic staging based on NT-proBNP (cutoff: 3000 ng/L) and troponin I (cutoff: 0.1 ng/mL) discriminated 3 different groups [stage I: 131 (35%), stage II: 123 (32%) and stage III: 127 (33%)] with different survival between stage I and II (median 86 vs. 81 months, P=0.04) and between stage II and III (median 81 vs. 62 months, P&lt;0.001). The UK staging system (NT-proBNP 3000 ng/L and eGFR 45 mL/min), discriminated three groups [stage I: 170 (45%), stage II: 165 (43%) and stage III: 45 (12%)] with a significant difference in survival: between stage I and stage II (86 vs. 52 months, P&lt;0.001) and between stage II and stage III (median survival 52 vs. 33 months, P=0.045). Conclusions This is one of the largest series of patients with cardiac ATTRwt reported so far. Referrals and diagnoses increased exponentially in recent years, One-third of patients has a concomitant monoclonal gammopathy and needed tissue typing. Both the current staging systems offered good discrimination of staging and were validated in our independent cohort. Funding Acknowledgement Type of funding source: None

Single Ventricle Palliation in a Developing Sub-Saharan African Country: What Should be Improved?

2019 ◽  
Vol 10 (2) ◽  
pp. 164-170 ◽  
Author(s):  
Valdano Manuel ◽  
Humberto Morais ◽  
Aida L. R. Turquetto ◽  
Gade Miguel ◽  
Leonardo A. Miana ◽  
...  
Keyword(s):  
Confidence Interval ◽  
African Country ◽  
Single Ventricle ◽  
Hazard Ratio ◽  
Stage I ◽  
Stage Ii ◽  
Stage Iii ◽  
Lost To Follow Up ◽  
Single Ventricle Palliation

Introduction: Single ventricle physiology management is challenging, especially in low-income countries. Objective: To report the palliation outcomes of single ventricle patients in a developing African country. Methods: We retrospectively studied 83 consecutive patients subjected to single ventricle palliation in a single center between March 2011 and December 2017. Preoperative data, surgical factors, postoperative results, and survival outcomes were analyzed. The patients were divided by palliation stage: I (pulmonary artery banding [PAB] or Blalock–Taussig shunt [BTS]), II (Glenn procedure), or III (Fontan procedure). Results: Of the 83 patients who underwent palliation (stages I-III), 38 deaths were observed (31 after stage I, six after stage II, and one after stage III) for an overall mortality of 45.7%. The main causes of operative mortality were multiple organ dysfunction due to sepsis, shunt occlusion, and cardiogenic shock. Twenty-eight survivors were lost to follow-up (22 after stage I, six after stage II). Thirteen stage II survivors are still waiting for stage III. The mean follow-up was 366 ± 369 days. Five-year survival was 28.4 % for PAB and 30.1% for BTS, while that for stage II and III was 49.8% and 57.1%, respectively. Age (hazard ratio, 0.61; 95% confidence interval: 0.47-0.7; P = .000) and weight at surgery (hazard ratio, 0.45; 95% confidence interval: 0.31-0.64; P = .002) impacted survival. Conclusion: A high-mortality rate was observed in this initial experience, mainly in stage I patients. A large number of patients were lost to follow-up. A task force to improve outcomes is urgently required.

scholarly journals Impact of the Number of Dissected Lymph Nodes on Survival for Gastric Cancer after Distal Subtotal Gastrectomy

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Chang-Ming Huang ◽  
Jian-Xian Lin ◽  
Chao-Hui Zheng ◽  
Ping Li ◽  
Jian-Wei Xie ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Survival Rate ◽  
Lymph Nodes ◽  
Distal Gastrectomy ◽  
Stage I ◽  
Stage Ii ◽  
Stage Iii ◽  
Prognostic Impact ◽  
Term Survival

Objectives. To investigate the prognostic impact of the number of dissected lymph nodes (LNs) in gastric cancer after curative distal gastrectomy.Methods. The survival of 634 patients who underwent curative distal gastrectomy from 1995 to 2004 was retrieved. Long-term surgical outcomes and associations between the number of dissected LNs and the 5-year survival rate were investigated.Results. The number of dissected LNs was one of the most important prognostic indicators. Among patients with comparable T category, the larger the number of dissected LNs was, the better the survival would be (). The linear regression showed that a significant survival improvement based on increasing retrieved LNs for stage II, III and IV (). A cut-point analysis yields the greatest variance of survival rate difference at the levels of 15 LNs (stage I), 25 LNs (stage II) and 30 LNs (stage III).Conclusion. The number of dissected LNs is an independent prognostic factor for gastric cancer. To improve the long-term survival of patients with gastric cancer, removing at least 15 LNs for stage I, 25 LNs for stage II, and 30 LNs for stage III patients during curative distal gastrectomy is recommended.

High Risk Status for Stage I Palliation Increases Mortality Following Stage II But Not Stage III

2021 ◽  
Author(s):  
Garrett N. Coyan ◽  
Carlos Diaz-Castrillon ◽  
Mario Castro-Medina ◽  
Luciana Da Fonseca Da Silva ◽  
Melita Viegas ◽  
...  
Keyword(s):  
High Risk ◽  
Stage I ◽  
Stage Ii ◽  
Stage Iii ◽  
Risk Status
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