scholarly journals Use of Molecular Genetic Methods for Investigation of Outbreaks of Enterovirus Infection in the Subjects of the Far Eastern Federal District

2016 ◽  
Vol 15 (2) ◽  
pp. 43-47
Author(s):  
L. V. Butakova ◽  
O. E. Trotsenko ◽  
E. Yu. Sapega ◽  
V. O. Kotova ◽  
L. A. Balakhontseva ◽  
...  
Keyword(s):  
Molecular Genetic ◽  
Federal District ◽  
Clinical Samples ◽  
Enterovirus Infection ◽  
Amur Oblast ◽  
Genetic Studies ◽  
Khabarovsk Krai ◽  
Imported Cases ◽  
Far Eastern ◽  
Rural Locality

The results of molecular genetic studies of clinical samples taken from three foci of outbreaks of enterovirus infection, registered on the territory of Khabarovsk Krai and Amur Oblast from 2012 through 2013 were reported. Several strains of enteroviruses were obtained: strains of Coxsackie A-4 and Coxsackie A-16 from De-Kastri rural locality, strains of ECHO-6 from Ust’-Urikma (Amur Oblast) and strains of Coxsackie A-6 from Raichihisnsk (Amur Oblast). Use of molecular genetic methods for investigation of collective morbidity and outbreaks of enterovirus infection help to confirm the identity of enteroviruses, isolated from patients and to identify the imported cases of infection.

Tuberculosis epidemic situation in the Khabarovsk Krai: status and trends

2021 ◽  
Vol 87 (1) ◽  
pp. 17-24
Author(s):  
K.P. Topalov ◽  
◽  
O.L. Karpenko ◽  
E.G. Kovalyova ◽  
◽  
...  
Keyword(s):  
Population Density ◽  
Federal District ◽  
Khabarovsk Krai ◽  
Its Regions ◽  
Status And Trends ◽  
The Russian Federation ◽  
Far Eastern ◽  
Statistical Indicators ◽  
Tuberculosis Care

The article presents an overview of the data of statistical observation of the Khabarovsk Krai, the Russian Federation and the Far Eastern Federal District (Okrug) on tuberculosis; their significance for assessing the epidemic situation and the quality of anti-tuberculosis care in these territories in 2002–2019 is studied. The dynamics of statistical indicators for 18 years is given using the methodology for calculating rank values. The dependence of the incidence of tuberculosis on the population density in the constituent entities of the country, the Far Eastern Federal District and its regions has been determined

The result of 10 years of experience in monitoring indicators of infant and perinatal mortality in Khabarovsk Krai

GYNECOLOGY ◽  
2020 ◽  
Vol 22 (5) ◽  
pp. 12-16
Author(s):  
Tatyana Yu. Pestrikova
Keyword(s):  
Neonatal Mortality ◽  
Perinatal Mortality ◽  
Care Service ◽  
Obstetric Care ◽  
Federal District ◽  
Mortality Rates ◽  
Infant Mortality Rate ◽  
Khabarovsk Krai ◽  
Early Neonatal Mortality ◽  
Far Eastern

Aim.To evaluate the effectiveness of the obstetric care service in Khabarovsk Krai, based on a comparison of the dynamics of infant and perinatal mortality rates for the period 20092018. Materials and methods.A comparative analysis of official statistics of the Ministry of Health of Khabarovsk Krai and other territories of the Far Eastern Federal District was carried out using the Rosstat database for the period 20092018, taking into account the indicators of infant, perinatal mortality, and preterm birth. The trend of the dynamics was determined in the process of graphical analysis of the chart and by modeling trends. The results of the studies were subjected to methods of statistical processing of information. Results.The results revealed in our study indicate that over the 10-year interval, the infant and perinatal mortality rates in Khabarovsk Krai decreased by 2 times, the rate of decrease was higher than similar processes in the Far Eastern Federal District and the Russian Federation. A graphical representation of infant and perinatal mortality rates underlines the instability of these values in Khabarovsk Krai. Тhe decrease in infant and perinatal mortality in Khabarovsk Krai is mainly due to a decrease in early neonatal mortality. The ratio of stillbirth to early neonatal mortality indicates an excess of stillbirth by 7.88 and 6.95 times in 20172018. The relatively high stillbirth rate in Khabarovsk Krai indicates the instability of the results in providing assistance to pregnant women and women in childbirth. Conclusion.The infant mortality rate is the main quality indicator recommended by WHO for assessing the level of care. This indicator must be considered in conjunction with the indicator of perinatal mortality, especially its constituent components of stillbirth and early neonatal mortality, namely the ratio of stillbirth to early neonatal mortality. The deformation of this proportion towards a multiple increase in stillbirth, against the background of a progressive decrease in early neonatal mortality, indicates the presence of an inadequate assessment of the organization of medical care in the obstetric care service.

Organization of work of the Khabarovsk branch of the The S. Fyodorov Eye Microsurgery Fedaral State Institution the Ministry of Health of Russia in the context of the spread of a new coronavirus infection

2021 ◽  
Vol 89 (3) ◽  
pp. 4-8
Author(s):  
O.V. Kolenko ◽  
◽  
V. V. Yegorov ◽  
M.V. Pshenichnov ◽  
O.B. Baleva ◽  
...  
Keyword(s):  
Federal District ◽  
Well Being ◽  
State Institution ◽  
High Tech ◽  
Ministry Of Health ◽  
Khabarovsk Krai ◽  
Regulatory Documents ◽  
Coronavirus Infection ◽  
The Russian Federation ◽  
Far Eastern

The article provides information and analyzes the regulatory documents adopted in the Russian Federation, the Khabarovsk Krai, and the orders of the director of the Khabarovsk branch of the. 1The S. Fyodorov Eye Microsurgery Fedaral State Institution, the Khabarovsk Branch, of the Ministry of Health of Russia on ensuring epidemiological well-being by organizing assistance to patients with diseases of the organ of vision and adnexa in the context of the spread of a new coronavirus infection. The developed complex of anti-epidemic measures in the provision of emergency and planned ophthalmological care to residents of the Far Eastern Federal District made it possible in 100% of cases to fulfill the state task for the provision of high-tech medical care

THE ROLE OF SMALL AND MEDIUM BUSINESS IN THE EXPORT OF KHABAROVSK KRAI

2020 ◽  
pp. 14-21
Author(s):  
E. A. Aleksandrova ◽  
T. S. Boiko
Keyword(s):  
Economic Activity ◽  
Federal District ◽  
Khabarovsk Krai ◽  
Far Eastern ◽  
Small And Medium Business

The article presents the results of the analysis considering foreign economic activity of Khabarovsk Krai. The role of small and medium business in the export of Russia, Far Eastern Federal District and Khabarovsk Krai is shown

scholarly journals Phylogenetic analysis and distribution of far eastern tick-borne encephalitis virus subtype (Flaviridae, Flavirus, TBEV-FE) from Asia

2019 ◽  
Vol 64 (5) ◽  
pp. 250-256 ◽  
Author(s):  
G. N. Leonova ◽  
S. I. Belikov
Keyword(s):  
Molecular Genetic ◽  
Primorsky Krai ◽  
Khabarovsk Krai ◽  
Genetic Characteristics ◽  
Tick Borne Encephalitis ◽  
Tbe Virus ◽  
Tick Borne Encephalitis Virus ◽  
Far Eastern ◽  
Virus Strains ◽  
Virus Subtype

To date, a lot of data on molecular genetic characteristics of different tick-borne encephalitis virus strains has appeared. Only on the basis of the E protein genome, sequences of about 1,500 TBEV strains were registered in GenBank.The purpose of the work – revision and comparative analysis of data on complete genomes sequences of the Far Eastern subtype of TBE virus strains distributed in the Asian part of Eurasian continent.Material and methods. The data on the complete genomes of 84 strains of TBEV isolated in Asia were used; phylogenetic analysis was performed.Results and discussion: it was shown that variants of the TBEV of the Far Eastern subtype are circulating here and form three separate clusters (Sofjin, Senzhang- и Shkotovo-like strains). Sofjin strain (Sofjin-1953, Sofjin-Chumakov, Sofjin-KSY) was considered to be the reference for Far Eastern TBE virus subtype strains and a cluster of Sofjin-like strains. Sofjin-like strains were not found in China and Japan, but widely distributed throughout the area of Primorsky and Khabarovsk krai. The group of Senzhang-like strains was distributed in China, Eastern Siberia, Khabarovsk krai and northern Primorsky krai, but was not found in Japan (Hokkaido). According to molecular genetic characteristics the youngest and more genetically homogeneous group was the Shkotovo-like strains, isolated in the southern part of Primorsky krai, however not found on Hokkaido Island (Japan).Conclusion: revision of the complete genome characteristics of TBEV strains revealed the features of micro-evolutionary process of viral populations in the Asian part of Eurasia, show the individual affection of strains to certain territories, as well as detect random finds of such strains in the territories of other natural foci.

scholarly journals Concerning imported cases of cholera in the city of Almaty, Kazakhstan, 2017

2018 ◽  
pp. 83-87 ◽  
Author(s):  
Z. A. Sagiev ◽  
R. S. Musagalieva ◽  
A. A. Abdirasilova ◽  
T. Z. Ayazbaev ◽  
M. M. Kul’baeva ◽  
...  
Keyword(s):  
Vibrio Cholerae ◽  
Molecular Genetic ◽  
Laboratory Diagnosis ◽  
Genetic Studies ◽  
Cholera Vibrio ◽  
Group I ◽  
Highly Sensitive ◽  
Imported Cases ◽  
Methodological Guidelines ◽  
The City

In 2017, from October 15 to November 21, 5 cholera cases imported from India – 3 patients and 2 carriers of V. cholerae – were recorded in Almaty. The patients recovered from the disease. Objective of the study was to characterize the imported cases of cholera and investigate the properties of cholera vibrio strains isolated from patients and carriers of V. cholerae. Materials and methods. Revised were the medical records; blood sera, feces from patients and contact persons were assayed. Studied were sensitivity spectrum to antibacterial preparations of isolated V. cholerae strains according to the “Methodological guidelines on laboratory diagnosis of cholera”, dated September 27, 2010; No 252. Epidemiological, microbiological, immunological and molecular-genetic methods were applied for investigation. Results and conclusions. Consequently to molecular genetic studies, genes of specificity, wbeN and toxicity (epidemic significance), ctxA, tcpA were detected in samples from 3 patients and 2 contact persons. The isolated strains were identified as Vibrio cholerae O1 Eltor Inaba in two cases, and in one case – as Vibrio cholerae O1 Eltor Hykoshima, Heiberg group I, toxigenic, hemolysis negative in Greig test, virulent, highly sensitive to ciprofloxacin, doxycilin, erythromycin, tetracycline and moderately sensitive to levomycetin. It was established that the country of export in all the cases was India. Relevant anti-epidemic and preventive measures were undertaken to localize and eradicate the foci in order to prevent possible threat of epidemic spread of infections among the population.

scholarly journals MOLECULAR GENETIC CHARACTERISTICS OF HIV-1 VARIANTS ISOLATED IN THE SUBJECTS OF THE RUSSIAN FAR EAST

2019 ◽  
Vol 64 (2) ◽  
pp. 79-89
Author(s):  
V. O. Kotova ◽  
O. E. Trotsenko ◽  
L. A. Balakhontseva ◽  
E. A. Bazykina
Keyword(s):  
Genetic Variants ◽  
Russian Far East ◽  
Molecular Genetic ◽  
Far East ◽  
Federal District ◽  
Genetic Monitoring ◽  
Hiv Positive ◽  
Far Eastern ◽  
Hiv 1 ◽  
The Russian Far East

Introduction. Molecular-genetic monitoring of human immunodeficiency virus (HIV) drug-resistant strains circulation as well as analysis of territorial peculiarities of different genetic variants prevalence of the virus is a crucial part of epidemiological surveillance over HIV-infection spread. Objective of the research - to analyze the prevalence of HIV-1 genetic variants among HIV-positive people living in different constituent entities of the Far Eastern Federal District. Material and methods. Molecular-genetic analysis of the Pol-gene that is coding protease and a part of reverse transcriptase of HIV-1 was performed for a total number of 206 blood plasma samples. The biological material was collected from HIV-positive people living in Sakhalin, Magadan and Amur regions, Jewish Autonomous District, Khabarovsk region, Republic of Sakha (Yakutia) and Chukotka Autonomous Region (constituent entities of the Russian Federation in the Russian Far East). Results. The research demonstrated that HIV-1 sub-subtype A6 continues to be dominant and comprises 72.1±3.1% of all isolated subtypes in the regions of the Russian Far East. HIV-1 subtype B was identified in 14 cases (6.8±1.8%) and subtype C in 4 cases (1.9±1.0%). Spectrum of HIV-1 recombinant forms was determined for some regions. We identified five types of HIV-1 circulating recombinant forms (CRF): CRF03_AB - 2 (0.9±0.7%), CRF02_AG - 8 (3.9±1.3%), CRF63_02A1 - 27 (13.1±2.4%), CRF11_cpx - 1 (0.5±0.5%), CRF01_AE - 3 (1.5±0.8%). High heterogeneity of the virus was registered in the Jewish Autonomous District. Discussion. The conducted research revealed genetic differences in the landscape of HIV-1 subtypes circulation as well as differences in HIV-1 recombinant forms distribution frequency in the Russian Far East. Current findings are due to expansion of migration flows that promote cross-border importation and further spread of different HIV-1 genetic variants among population of the Far Eastern Federal District. Conclusion. The conducted research revealed that the molecular-genetic monitoring of HIV-1 genovariants should involve not only regions with high HIV-abundance but also with low HIV-prevalence and incidence.

Contemporary development of the Russian Far Eastern regions in the format of green economy model: Ecological aspects

2021 ◽  
Vol 17 (4) ◽  
pp. 739-757
Author(s):  
Zoya G. MIRZEKHANOVA
Keyword(s):  
Economic Development ◽  
Raw Materials ◽  
Federal District ◽  
Green Economy ◽  
Economic Activities ◽  
Environmental Preferences ◽  
Khabarovsk Krai ◽  
Social And Economic Development ◽  
First Results ◽  
Far Eastern

Subject. This article deals with the issues of environmental preferences in the field of functioning of the priority social and economic development areas in the Far Eastern Federal District of Russia. Objectives. The article aims to show the current situation in the formation of priority social and economic development territories on the basis of a brief analysis of the green economy conceptual provisions, taking into account the region's particular nature. Results. The article presents the results of a brief analysis of certain provisions of the concept of green economy from ecological position. It shows that the perspective plans of development of the Far Eastern regions practically ignore the principles of green economy. The article considers the actual situation in the development of priority social and economic development areas in the Khabarovsk Krai. Conclusions. The development of a green economy of regions with a high share of raw materials in the structure of the economy introduces fundamentally new approaches to the formation of a strategy for their development, focused on strengthening the importance of the ecosystem organization of economic activities. At present, the priority social and economic development areas are the basis for solving the government's problems in diversifying the region's economy. The first results of realization of the projects of creation of the priority social and economic development areas in the Khabarovsk Krai allow to note the progress in transformation of the production structure.

scholarly journals Prevalence and molecular-genetic characteristics of hepatitis B virus in HIV-positive individuals at the Far Eastern Federal District

2019 ◽  
Vol 9 (1) ◽  
pp. 183-192 ◽  
Author(s):  
E. A. Bazykina ◽  
V. B. Turkutyukov ◽  
O. E. Trotsenko ◽  
V. O. Kotova ◽  
L. A. Balakhontseva ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Molecular Genetic ◽  
Federal District ◽  
Hiv Positive ◽  
Genetic Characteristics ◽  
B Virus ◽  
Far Eastern

scholarly journals State-of-the-art molecular genetic techniques in surveillance over intensity of enterovirus infection epidemic process in some constituent entities of the Siberian Federal District of the Russian Federation

2019 ◽  
pp. 42-50
Author(s):  
E.Yu. Sapega ◽  
L.V. Butakova ◽  
Trotsenko ◽  
Lapa ◽  
Perezhogin ◽  
...  
Keyword(s):  
Russian Federation ◽  
State Of The Art ◽  
Molecular Genetic ◽  
Clinical Manifestations ◽  
Federal District ◽  
Enterovirus Infection ◽  
Siberian Federal District ◽  
Epidemic Process ◽  
Epidemiologic Surveillance ◽  
The Russian Federation

Background. Enterovirus infection is widely spread around the world. It has different epidemiologic and clinical manifestations. However, to date, the amount of accumulated information on the epidemic process of enterovirus infection in different constituent entities of the Siberian Federal district of the Russian Federation is insufficient. Objectives. Our objectives were to investigate characteristics of the enterovirus infection epidemic process in Siberian constituent entities subjected to surveillance using the innovative molecular genetic analysis. Materials and methods. The analysis of long-term enterovirus infection incidence in the investigated constituent entities of Siberia was performed. The total number of 237 enterovirus strains circulating during 2017-2018 epidemic seasons in the analyzed regions were isolated using sequencing technique. A phylogenetic analysis of the obtained nucleotide sequences was performed. Results. The epidemiologic situation related to enterovirus infection was unfavorable in the majority of the Siberian constituent entities in the past two years. A significant increase in incidence rates was registered in the Irkutsk Region, Zabaykalsky Krai and Altai Republic. We distinguished major manifestations of the enterovirus infection epidemic process including a years-long excess of the national average and a rising trend in the annual incidence rate, prevalence of herpangina, exanthema and enterovirus meningitis in the clinical course of the disease among children aged 3–6. Prevalence of Coxsackievirus A-6 and Coxsackievirus A-9 in the landscape of circulation was revealed in a number of Siberian regions. Group incidence and imported cases were also registered. Discussion. Our results demonstrated the importance of molecular genetic monitoring of circulating enteroviruses as part of the epidemiologic surveillance. This state-of-the-art approach can reveal potential epidemiologic links between cases of the disease.

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